Successful treatment with anti-CC chemokine receptor 4 MoAb of relapsed adult T-cell leukemia/lymphoma after umbilical cord blood transplantation

Bone Marrow Transplantation

Volumn 48, Issue 7, 2013, Pages 998-999

  Ito, Y ^a   Miyamoto, T ^b   Chong, Y ^a   Aoki, T ^a   Kato, K ^b   Akashi, K ^b   Kamimura, T ^a  

^a HARASANSHIN HOSPITAL   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR4; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; FLUDARABINE; MELPHALAN; MITOXANTRONE; MOGAMULIZUMAB; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; RANIMUSTINE; TACROLIMUS; VINCRISTINE; VINDESINE; VIRUS DNA;

AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CASE REPORT; COLON BIOPSY; CORD BLOOD STEM CELL TRANSPLANTATION; DRUG EFFICACY; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LETTER; LEUKEMIA RELAPSE; MALE; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; REDUCED INTENSITY CONDITIONING; SKIN BIOPSY; SKIN TUMOR; T CELL LEUKEMIA; WHOLE BODY RADIATION;

AGED; ALLOGRAFTS; ANTIBODIES, MONOCLONAL, HUMANIZED; CORD BLOOD STEM CELL TRANSPLANTATION; HUMANS; LEUKEMIA-LYMPHOMA, ADULT T-CELL; MALE; RECEPTORS, CCR4; RECURRENCE;

EID: 84880196551     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2012.268     Document Type: Letter

References (10)

1. Yoshida M, Seiki M, Yamaguchi K, Takatsuki K. Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci USA 1984; 81: 2534-2537.
2. Ishitsuka K, Tamura K. Treatment of adult T-cell leukemia/lymphoma: past, present, and future. Eur J Haematol 2008; 80: 185-196.
3. Ishida T, Joh T, Uike N, Yamamoto K, Utsunomiya A, Yoshida S et al. Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemialymphoma: a multicenter phase II study. J Clin Oncol 2012; 30: 837-842.
4. Baatar D, Olkhanud P, Sumitomo K, Taub D, Gress R, Biragyn A. Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4- Tregs, regulate effector T cells using FasL. J Immunol 2007; 178: 4891-4900.
5. Ishida T, Utsunomiya A, Iida S, Inagaki H, Takatsuka Y, Kusumoto S et al. Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome. Clin Cancer Res 2003; 9: 3625-3634.
6. Fukushima T, Miyazaki Y, Honda S, Kawano F, Moriuchi Y, Masuda M et al. Allogeneic hematopoietic stem cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia/lymphoma. Leukemia 2005; 19: 829-834.
7. Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H et al. Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo. J Immunol 2009; 183: 4782-4791.
8. Beziat V, Nguyen S, Lapusan S, Hervier B, Dhedin N, Bories D et al. Fully functional NK cells after unrelated cord blood transplantation. Leukemia 2009; 23: 721-728.
9. Mielke S, Rezvani K, Savani BN, Nunes R, Yong AS, Schindler J et al. Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantation in elderly patients and association with acute graft-versus-host disease. Blood 2007; 110: 1689-1697.
10. Kanda J, Hishizawa M, Utsunomiya A, Taniguchi S, Eto T, Moriuchi Y et al. Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study. Blood 2012; 119: 2141-2148.