Improving the estimation of parameter uncertainty distributions in nonlinear mixed effects models using sampling importance resampling

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 43, Issue 6, 2016, Pages 583-596

  Dosne, Anne Gaëlle ^a   Bergstrand, Martin ^a   Harling, Kajsa ^a   Karlsson, Mats O ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Asymptotic covariance matrix; Bootstrap; Confidence intervals; Nonlinear mixed effects models; Parameter uncertainty; Sampling importance resampling

Indexed keywords

MOXONIDINE; PEFLOXACIN; PHENOBARBITAL; IMIDAZOLE DERIVATIVE;

ABSORPTION PARAMETERS; ARTICLE; BOOTSTRAPPING; CHI SQUARE DISTRIBUTION; CONFIDENCE INTERVAL; NONLINEAR MIXED EFFECT MODEL; PRIORITY JOURNAL; PROBABILITY; SAMPLING; SIMULATION; STATISTICAL MODEL; UNCERTAINTY; WORKFLOW; ALGORITHM; BIOLOGICAL MODEL; COMPUTER SIMULATION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; NONLINEAR SYSTEM; ORAL DRUG ADMINISTRATION; SOFTWARE;

ADMINISTRATION, ORAL; ALGORITHMS; COMPUTER SIMULATION; CONFIDENCE INTERVALS; HUMANS; IMIDAZOLES; INJECTIONS, INTRAVENOUS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; NONLINEAR DYNAMICS; PEFLOXACIN; PHENOBARBITAL; SOFTWARE; UNCERTAINTY;

EID: 84991093377     PISSN: 1567567X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/s10928-016-9487-8     Document Type: Article

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