Assessment of actual significance levels for covariate effects in NONMEM

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 28, Issue 3, 2001, Pages 231-252

  Wahlby U ^a   Jonsson, E N ^a   Karlsson, M O ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Covariate; Likelihood ratio test; NONMEM; Population pharmacokinetics; Randomization test

Indexed keywords

ARTICLE; CALCULATION; DATA ANALYSIS; ERROR; HYPOTHESIS; PHARMACODYNAMICS; POPULATION RESEARCH; PRIORITY JOURNAL; SIMULATION;

ADULT; AGED; ANTIHYPERTENSIVE AGENTS; COMPUTER SIMULATION; FEMALE; HUMANS; LIKELIHOOD FUNCTIONS; MALE; MIDDLE AGED; MODELS, CHEMICAL; NONLINEAR DYNAMICS; PHARMACOKINETICS;

EID: 0034954242     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011527125570     Document Type: Article

References (14)

1. The use of population pharmacokinetics in drug development
2. A note on confidence intervals with extended least squares parameter estimates
3. An evaluation of point and interval estimates in population pharmacokinetics using NONMEM analysis
4. Evaluation of hypothesis testing for comparing two populations using NONMEM analysis
5. Estimating population kinetics
6. Population pharmacokinetic data and parameter estimation based on their first two statistical moments
7. The importance of modeling interoccasion variability in population pharmacokinetic analyses
8. Automated covariate model building within NON-MEM
9. Building population pharmacokinetic-pharmacodynamic models. I. Models for covariate effects
10. Three new residual error models for population PK/PD analyses