메뉴 건너뛰기




Volumn 4, Issue 1, 2016, Pages

The CXCR4 antagonist plerixafor enhances the effect of rituximab in diffuse large B-cell lymphoma cell lines

Author keywords

AMD3100; Anti CD20 antibody; CXCR4; CXCR4 antagonist; Diffuse large B cell lymphoma; DLBCL; Drug combination study; In vitro; Plerixafor; Rituximab

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; PLERIXAFOR; RITUXIMAB;

EID: 84991022228     PISSN: None     EISSN: 20507771     Source Type: Journal    
DOI: 10.1186/s40364-016-0067-2     Document Type: Article
Times cited : (31)

References (61)
  • 3
    • 77957200763 scopus 로고    scopus 로고
    • Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte
    • Coiffier B, Thieblemont C, Van Den NE, et al. Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte. Blood. 2010;116:2040-5.
    • (2010) Blood , vol.116 , pp. 2040-2045
    • Coiffier, B.1    Thieblemont, C.2    Van Den, N.E.3
  • 4
    • 38549147027 scopus 로고    scopus 로고
    • Six versus eight cycles of biweekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60)
    • Pfreundschuh M, Schubert J, Ziepert M, et al. Six versus eight cycles of biweekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60). Lancet Oncol. 2008;9:105-16.
    • (2008) Lancet Oncol , vol.9 , pp. 105-116
    • Pfreundschuh, M.1    Schubert, J.2    Ziepert, M.3
  • 5
    • 33646004738 scopus 로고    scopus 로고
    • CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group
    • Pfreundschuh M, Trümper L, Österborg A, et al. CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol. 2006;7:379-91.
    • (2006) Lancet Oncol , vol.7 , pp. 379-391
    • Pfreundschuh, M.1    Trümper, L.2    Österborg, A.3
  • 6
    • 33745982067 scopus 로고    scopus 로고
    • Rituximab-CHOP Versus CHOP Alone or With Maintenance Rituximab in Older Patients With Diffuse Large B-Cell Lymphoma
    • Habermann TM, Weller EA, Morrison VA, et al. Rituximab-CHOP Versus CHOP Alone or With Maintenance Rituximab in Older Patients With Diffuse Large B-Cell Lymphoma. J Clin Oncol. 2006;24:3121-7.
    • (2006) J Clin Oncol , vol.24 , pp. 3121-3127
    • Habermann, T.M.1    Weller, E.A.2    Morrison, V.A.3
  • 7
    • 84896403797 scopus 로고    scopus 로고
    • Accelerated therapeutic progress in diffuse large B cell lymphoma
    • Cai Q, Westin J, Fu K, et al. Accelerated therapeutic progress in diffuse large B cell lymphoma. Ann Hematol. 2014;93:541-56.
    • (2014) Ann Hematol , vol.93 , pp. 541-556
    • Cai, Q.1    Westin, J.2    Fu, K.3
  • 8
    • 84859413755 scopus 로고    scopus 로고
    • Relapsed/Refractory Diffuse Large B-cell Lymphoma
    • Friedberg JW. Relapsed/Refractory Diffuse Large B-cell Lymphoma. Am Soc Hematol. 2011;498-505.
    • (2011) Am Soc Hematol , pp. 498-505
    • Friedberg, J.W.1
  • 9
    • 0028057250 scopus 로고
    • Depletion of B Cells In Vivo by a Chimeric Mouse Human Monoclonal Antibody to CD20
    • ReffME, Carner K, Chambers KS, et al. Depletion of B Cells In Vivo by a Chimeric Mouse Human Monoclonal Antibody to CD20. Blood. 1994;83:435-45.
    • (1994) Blood , vol.83 , pp. 435-445
    • Reff, M.E.1    Carner, K.2    Chambers, K.S.3
  • 10
    • 84857478229 scopus 로고    scopus 로고
    • Targeting CXCR4 with cellpenetrating pepducins in lymphoma and lymphocytic leukemia
    • O'Callaghan K, Lee L, Nguyen N, et al. Targeting CXCR4 with cellpenetrating pepducins in lymphoma and lymphocytic leukemia. Blood. 2012;119:1717-25.
    • (2012) Blood , vol.119 , pp. 1717-1725
    • O'Callaghan, K.1    Lee, L.2    Nguyen, N.3
  • 11
    • 84855458019 scopus 로고    scopus 로고
    • Enhancement of the anti-tumor activity of therapeutic monoclonal antibodies by CXCR4 antagonists
    • Hu Y, Gale M, Shields J, et al. Enhancement of the anti-tumor activity of therapeutic monoclonal antibodies by CXCR4 antagonists. Leuk Lymphoma. 2012;53:130-8.
    • (2012) Leuk Lymphoma , vol.53 , pp. 130-138
    • Hu, Y.1    Gale, M.2    Shields, J.3
  • 13
    • 84871015161 scopus 로고    scopus 로고
    • Halting metastasis through CXCR4 inhibition
    • Ramsey DM, McAlpine SR. Halting metastasis through CXCR4 inhibition. Bioorg Med Chem Lett. 2013;23:20-5.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 20-25
    • Ramsey, D.M.1    McAlpine, S.R.2
  • 14
    • 0032482926 scopus 로고    scopus 로고
    • Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4-and SDF-1-deficient mice
    • Ma Q, Jones D, Borghesani PR, et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4-and SDF-1-deficient mice. Proc Natl Acad Sci U S A. 1998;95:9448-53.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 9448-9453
    • Ma, Q.1    Jones, D.2    Borghesani, P.R.3
  • 15
    • 0032507962 scopus 로고    scopus 로고
    • Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    • Zou Y-R, Kottmann AH, Kuroda M, et al. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature. 1998;393:595-9.
    • (1998) Nature , vol.393 , pp. 595-599
    • Zou, Y.-R.1    Kottmann, A.H.2    Kuroda, M.3
  • 16
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
    • Burger JA, Kipps TJ. CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood. 2006;107:1761-7.
    • (2006) Blood , vol.107 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 17
    • 1642433313 scopus 로고    scopus 로고
    • SDF-1 and CXCR4 in normal and malignant hematopoiesis
    • Juarez J, Bendall L. SDF-1 and CXCR4 in normal and malignant hematopoiesis. Histol Histopathol. 2004;19:299-309.
    • (2004) Histol Histopathol , vol.19 , pp. 299-309
    • Juarez, J.1    Bendall, L.2
  • 18
    • 84920839603 scopus 로고    scopus 로고
    • CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival
    • Moreno MJ, Bosch R, Dieguez-Gonzalez R, et al. CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival. J Pathol. 2015;235:445-55.
    • (2015) J Pathol , vol.235 , pp. 445-455
    • Moreno, M.J.1    Bosch, R.2    Dieguez-Gonzalez, R.3
  • 19
    • 84925633757 scopus 로고    scopus 로고
    • Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma
    • Chen J, Xu-monette ZY, Deng L, et al. Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma. Oncotarget. 2015;6:5597-614.
    • (2015) Oncotarget , vol.6 , pp. 5597-5614
    • Chen, J.1    Xu-monette, Z.Y.2    Deng, L.3
  • 20
    • 0031738366 scopus 로고    scopus 로고
    • CXCR-4, a Chemokine Receptor, Is Overexpressed in and Required for Proliferation of Glioblastoma Tumor Cells
    • Sehgal A, Keener C, Boynton AL, et al. CXCR-4, a Chemokine Receptor, Is Overexpressed in and Required for Proliferation of Glioblastoma Tumor Cells. J Surg Oncol. 1998;69:99-104.
    • (1998) J Surg Oncol , vol.69 , pp. 99-104
    • Sehgal, A.1    Keener, C.2    Boynton, A.L.3
  • 21
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Müller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001;410:50-6.
    • (2001) Nature , vol.410 , pp. 50-56
    • Müller, A.1    Homey, B.2    Soto, H.3
  • 22
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B-cell malignancies: a target for new treatment strategies
    • Burger JA, Ghia P, Rosenwald A, et al. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood. 2009;114:3367-75.
    • (2009) Blood , vol.114 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3
  • 23
    • 66149150580 scopus 로고    scopus 로고
    • CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
    • Azab AK, Runnels JM, Pitsillides C, et al. CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy. Blood. 2009;113:4341-51.
    • (2009) Blood , vol.113 , pp. 4341-4351
    • Azab, A.K.1    Runnels, J.M.2    Pitsillides, C.3
  • 24
    • 66549113998 scopus 로고    scopus 로고
    • Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting
    • Kurtova AV, Tamayo AT, Ford RJ, et al. Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting. Blood. 2009;113:4604-13.
    • (2009) Blood , vol.113 , pp. 4604-4613
    • Kurtova, A.V.1    Tamayo, A.T.2    Ford, R.J.3
  • 25
    • 33846254013 scopus 로고    scopus 로고
    • Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias
    • Zeng Z, Samudio IJ, Munsell M, et al. Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias. Mol Cancer Ther. 2006;5:3113-21.
    • (2006) Mol Cancer Ther , vol.5 , pp. 3113-3121
    • Zeng, Z.1    Samudio, I.J.2    Munsell, M.3
  • 26
    • 23944488816 scopus 로고    scopus 로고
    • Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells
    • Burger M, Hartmann T, Krome M, et al. Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood. 2005;106:1824-30.
    • (2005) Blood , vol.106 , pp. 1824-1830
    • Burger, M.1    Hartmann, T.2    Krome, M.3
  • 27
    • 84902551463 scopus 로고    scopus 로고
    • Exposure time independent summary statistics for assessment of drug dependent cell line growth inhibition
    • Falgreen S, Laursen MB, Bødker JS, et al. Exposure time independent summary statistics for assessment of drug dependent cell line growth inhibition. BMC Bioinformatics. 2014;15:168.
    • (2014) BMC Bioinformatics , vol.15 , pp. 168
    • Falgreen, S.1    Laursen, M.B.2    Bødker, J.S.3
  • 28
    • 84912127311 scopus 로고    scopus 로고
    • Human B-cell cancer cell lines as a preclinical model for studies of drug effect in diffuse large B-cell lymphoma and multiple myeloma
    • Laursen MB, Falgreen S, Bødker JS, et al. Human B-cell cancer cell lines as a preclinical model for studies of drug effect in diffuse large B-cell lymphoma and multiple myeloma. Exp Hematol. 2014;42:927-38.
    • (2014) Exp Hematol , vol.42 , pp. 927-938
    • Laursen, M.B.1    Falgreen, S.2    Bødker, J.S.3
  • 29
    • 33748794547 scopus 로고    scopus 로고
    • Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
    • Chou T. Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies. Pharmacol Rev. 2006;58:621-81.
    • (2006) Pharmacol Rev , vol.58 , pp. 621-681
    • Chou, T.1
  • 30
    • 1342266138 scopus 로고    scopus 로고
    • Enhanced Cytotoxicity of Rituximab Following Genetic and Biochemical Disruption of Glycosylphosphatidylinositol Anchored Proteins
    • Nagajothi N, Matsui WH, Mukhina GL, et al. Enhanced Cytotoxicity of Rituximab Following Genetic and Biochemical Disruption of Glycosylphosphatidylinositol Anchored Proteins. Leuk Lymphoma. 2004;45:795-800.
    • (2004) Leuk Lymphoma , vol.45 , pp. 795-800
    • Nagajothi, N.1    Matsui, W.H.2    Mukhina, G.L.3
  • 31
    • 0036645577 scopus 로고    scopus 로고
    • Stromal Cell-Derived Factor-1α in Unstable Angina: Potential Antiinflammatory and Matrix-Stabilizing Effects
    • Damås JK, Wæhre T, Yndestad A, et al. Stromal Cell-Derived Factor-1α in Unstable Angina: Potential Antiinflammatory and Matrix-Stabilizing Effects. Circulation. 2002;106:36-42.
    • (2002) Circulation , vol.106 , pp. 36-42
    • Damås, J.K.1    Wæhre, T.2    Yndestad, A.3
  • 32
    • 84901393211 scopus 로고    scopus 로고
    • Decreased Expression of CXCR4 Chemokine Receptor in Bone Marrow after Chemotherapy in Patients with Non-Hodgkin Lymphomas Is a Good Prognostic Factor
    • Mazur G, Butrym A, Kryczek I, et al. Decreased Expression of CXCR4 Chemokine Receptor in Bone Marrow after Chemotherapy in Patients with Non-Hodgkin Lymphomas Is a Good Prognostic Factor. PLoS One. 2014;9, e98194.
    • (2014) PLoS One , vol.9
    • Mazur, G.1    Butrym, A.2    Kryczek, I.3
  • 33
    • 79954606458 scopus 로고    scopus 로고
    • CXCL12 (SDF1α)-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies?
    • Duda DG, Kozin SV, Kirkpatrick ND, et al. CXCL12 (SDF1α)-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies? Clin Cancer Res. 2011;17:2074-80.
    • (2011) Clin Cancer Res , vol.17 , pp. 2074-2080
    • Duda, D.G.1    Kozin, S.V.2    Kirkpatrick, N.D.3
  • 34
    • 84879852840 scopus 로고    scopus 로고
    • Targeting the CD20 and CXCR4 Pathways in Non-Hodgkin Lymphoma with Rituximab and High-Affinity CXCR4 Antagonist BKT140
    • Beider K, Ribakovsky E, Abraham M, et al. Targeting the CD20 and CXCR4 Pathways in Non-Hodgkin Lymphoma with Rituximab and High-Affinity CXCR4 Antagonist BKT140. Clin Cancer Res. 2013;19:3495-507.
    • (2013) Clin Cancer Res , vol.19 , pp. 3495-3507
    • Beider, K.1    Ribakovsky, E.2    Abraham, M.3
  • 35
    • 33750455077 scopus 로고    scopus 로고
    • Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases
    • Lee C-H, Kakinuma T, Wang J, et al. Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases. Mol Cancer Ther. 2006;5:2592-9.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2592-2599
    • Lee, C.-H.1    Kakinuma, T.2    Wang, J.3
  • 36
    • 0038103869 scopus 로고    scopus 로고
    • Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro
    • Juarez J, Bradstock KF, Gottlieb DJ, et al. Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro. Leukemia. 2003;17:1294-300.
    • (2003) Leukemia , vol.17 , pp. 1294-1300
    • Juarez, J.1    Bradstock, K.F.2    Gottlieb, D.J.3
  • 37
    • 84874965345 scopus 로고    scopus 로고
    • Plerixafor (AMD3100) induces prolonged mobilization of acute lymphoblastic leukemia cells and increases the proportion of cycling cells in the blood in mice
    • Welschinger R, Liedtke F, Basnett J, et al. Plerixafor (AMD3100) induces prolonged mobilization of acute lymphoblastic leukemia cells and increases the proportion of cycling cells in the blood in mice. Exp Hematol. 2013;41: 293-302.
    • (2013) Exp Hematol , vol.41 , pp. 293-302
    • Welschinger, R.1    Liedtke, F.2    Basnett, J.3
  • 38
    • 84855463714 scopus 로고    scopus 로고
    • Preliminary results from a phase I dose escalation study to determine the maximum tolerated dose of plerixafor in combination with rituximab in patients with relapsed chronic lymphocytic leukemia
    • Andritsos L, Byrd JC, Jones JA, et al. Preliminary results from a phase I dose escalation study to determine the maximum tolerated dose of plerixafor in combination with rituximab in patients with relapsed chronic lymphocytic leukemia. Blood. 2010;116:Abstract 2450.
    • (2010) Blood , vol.116
    • Andritsos, L.1    Byrd, J.C.2    Jones, J.A.3
  • 39
    • 19144361854 scopus 로고    scopus 로고
    • A pharmacokinetic-pharmacodynamic model for the mobilization of CD34+ hematopoietic progenitor cells by AMD3100
    • Lack NA, Green B, Dale DC, et al. A pharmacokinetic-pharmacodynamic model for the mobilization of CD34+ hematopoietic progenitor cells by AMD3100. Clin Pharmacol Ther. 2005;77:427-36.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 427-436
    • Lack, N.A.1    Green, B.2    Dale, D.C.3
  • 40
    • 77955019652 scopus 로고    scopus 로고
    • Recruitment of myeloid but not endothelial precursor cells facilitates tumor re-growth after local irradiation
    • Kozin SV, Kamoun W, Huang Y, et al. Recruitment of myeloid but not endothelial precursor cells facilitates tumor re-growth after local irradiation. Cancer Res. 2010;70:5679-85.
    • (2010) Cancer Res , vol.70 , pp. 5679-5685
    • Kozin, S.V.1    Kamoun, W.2    Huang, Y.3
  • 41
    • 84855436760 scopus 로고    scopus 로고
    • Disrupting the food chain in B cell lymphomas: co-operation between CXCR4 antagonists and antibodies
    • Burger JA. Disrupting the food chain in B cell lymphomas: co-operation between CXCR4 antagonists and antibodies. Leuk Lymphoma. 2012;53:3-4.
    • (2012) Leuk Lymphoma , vol.53 , pp. 3-4
    • Burger, J.A.1
  • 42
    • 43349106755 scopus 로고    scopus 로고
    • Chemokines and antagonists in non-Hodgkin's lymphoma
    • Golay J, Introna M. Chemokines and antagonists in non-Hodgkin's lymphoma. Expert Opin Ther Targets. 2008;12:621-35.
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 621-635
    • Golay, J.1    Introna, M.2
  • 43
    • 77957367164 scopus 로고    scopus 로고
    • The microenvironment differentially impairs passive and active immunotherapy in chronic lymphocytic leukaemia-CXCR4 antagonists as potential adjuvants for monoclonal antibodies
    • Buchner M, Brantner P, Stickel N, et al. The microenvironment differentially impairs passive and active immunotherapy in chronic lymphocytic leukaemia-CXCR4 antagonists as potential adjuvants for monoclonal antibodies. Br J Haematol. 2010;151:167-78.
    • (2010) Br J Haematol , vol.151 , pp. 167-178
    • Buchner, M.1    Brantner, P.2    Stickel, N.3
  • 44
    • 84856745478 scopus 로고    scopus 로고
    • The CXCR4 Antagonist AMD3100 Has Dual Effects on Survival and Proliferation of Myeloma Cells In Vitro
    • Kim H-Y, Hwang J-Y, Kim S-W, et al. The CXCR4 Antagonist AMD3100 Has Dual Effects on Survival and Proliferation of Myeloma Cells In Vitro. Cancer Res Treat. 2010;42:225-34.
    • (2010) Cancer Res Treat , vol.42 , pp. 225-234
    • Kim, H.-Y.1    Hwang, J.-Y.2    Kim, S.-W.3
  • 45
    • 33746685587 scopus 로고    scopus 로고
    • Characterization of the molecular pharmacology of AMD3100: A specific antagonist of the G-protein coupled chemokine receptor, CXCR4
    • Fricker SP, Anastassov V, Cox J, et al. Characterization of the molecular pharmacology of AMD3100: A specific antagonist of the G-protein coupled chemokine receptor, CXCR4. Biochem Pharmacol. 2006;72:588-96.
    • (2006) Biochem Pharmacol , vol.72 , pp. 588-596
    • Fricker, S.P.1    Anastassov, V.2    Cox, J.3
  • 46
    • 0030835663 scopus 로고    scopus 로고
    • Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4
    • Schols D, Esté JA, Henson G, et al. Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4. Antiviral Res. 1997; 35:147-56.
    • (1997) Antiviral Res , vol.35 , pp. 147-156
    • Schols, D.1    Esté, J.A.2    Henson, G.3
  • 47
    • 0037063329 scopus 로고    scopus 로고
    • Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4
    • Hatse S, Princen K, Bridger G, et al. Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Lett. 2002;527:255-62.
    • (2002) FEBS Lett , vol.527 , pp. 255-262
    • Hatse, S.1    Princen, K.2    Bridger, G.3
  • 48
    • 0037142053 scopus 로고    scopus 로고
    • The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    • Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002;346:1937-47.
    • (2002) N Engl J Med , vol.346 , pp. 1937-1947
    • Rosenwald, A.1    Wright, G.2    Chan, W.C.3
  • 49
    • 84930942915 scopus 로고    scopus 로고
    • Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-cell Lymphoma and Its Therapeutic Implications
    • Lenz G. Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-cell Lymphoma and Its Therapeutic Implications. Cancers (Basel). 2015;7:811-22.
    • (2015) Cancers (Basel) , vol.7 , pp. 811-822
    • Lenz, G.1
  • 50
    • 84952016304 scopus 로고    scopus 로고
    • Perspective: Cooperation of Nanog, NF-kB, and CXCR4 in a regulatory network for directed migration of cancer stem cells
    • Es-haghi M, Soltanian S, Dehghani H. Perspective: Cooperation of Nanog, NF-kB, and CXCR4 in a regulatory network for directed migration of cancer stem cells. Tumor Biol. 2016;37:1559-65.
    • (2016) Tumor Biol , vol.37 , pp. 1559-1565
    • Es-haghi, M.1    Soltanian, S.2    Dehghani, H.3
  • 51
    • 84885237107 scopus 로고    scopus 로고
    • Emerging targets in cancer management: role of the CXCL12/CXCR4 axis
    • Cojoc M, Peitzsch C, Trautmann F, et al. Emerging targets in cancer management: role of the CXCL12/CXCR4 axis. Onco Targets Ther. 2013;6: 1347-61.
    • (2013) Onco Targets Ther , vol.6 , pp. 1347-1361
    • Cojoc, M.1    Peitzsch, C.2    Trautmann, F.3
  • 52
    • 84908500967 scopus 로고    scopus 로고
    • Clinical significance of nuclear factor kB and chemokine receptor CXCR4 expression in patients with diffuse large B-cell lymphoma who received rituximab-based therapy
    • Shin HC, Seo J, Kang BW, et al. Clinical significance of nuclear factor kB and chemokine receptor CXCR4 expression in patients with diffuse large B-cell lymphoma who received rituximab-based therapy. Korean J Intern Med. 2014;29:785-92.
    • (2014) Korean J Intern Med , vol.29 , pp. 785-792
    • Shin, H.C.1    Seo, J.2    Kang, B.W.3
  • 53
    • 69249247048 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kB-dependent pathways
    • Huang C-Y, Lee C-Y, Chen M-Y, et al. Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kB-dependent pathways. J Cell Physiol. 2009;221:204-12.
    • (2009) J Cell Physiol , vol.221 , pp. 204-212
    • Huang, C.-Y.1    Lee, C.-Y.2    Chen, M.-Y.3
  • 54
    • 49649085623 scopus 로고    scopus 로고
    • Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF-kB pathways and promotes osteoclastogenesis in human oral cancer cells
    • Tang C-H, Chuang J-Y, Fong Y-C, et al. Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF-kB pathways and promotes osteoclastogenesis in human oral cancer cells. Carcinogenesis. 2008;29:1483-92.
    • (2008) Carcinogenesis , vol.29 , pp. 1483-1492
    • Tang, C.-H.1    Chuang, J.-Y.2    Fong, Y.-C.3
  • 55
    • 84855345481 scopus 로고    scopus 로고
    • B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome
    • Li S, Lin P, Fayad LE, et al. B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome. Mod Pathol Nat Publ Group. 2012;25:145-56.
    • (2012) Mod Pathol Nat Publ Group , vol.25 , pp. 145-156
    • Li, S.1    Lin, P.2    Fayad, L.E.3
  • 56
    • 84965189694 scopus 로고    scopus 로고
    • ABC, GCB, and Double-Hit Diffuse Large BCell Lymphoma: Does Subtype Make a Difference in Therapy Selection?
    • Nowakowski GS, Czuczman MS. ABC, GCB, and Double-Hit Diffuse Large BCell Lymphoma: Does Subtype Make a Difference in Therapy Selection? Am Soc Clin Oncol Educ B. 2015;35:e449-e457.
    • (2015) Am Soc Clin Oncol Educ B , vol.35 , pp. e449-e457
    • Nowakowski, G.S.1    Czuczman, M.S.2
  • 57
    • 79952154009 scopus 로고    scopus 로고
    • Double-hit B-cell lymphomas
    • Aukema SM, Siebert R, Schuuring E, et al. Double-hit B-cell lymphomas. Blood. 2011;117:2319-31.
    • (2011) Blood , vol.117 , pp. 2319-2331
    • Aukema, S.M.1    Siebert, R.2    Schuuring, E.3
  • 58
    • 0037352170 scopus 로고    scopus 로고
    • Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
    • Chang F, Lee JT, Navolanic PM, et al. Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia. 2003;17:590-603.
    • (2003) Leukemia , vol.17 , pp. 590-603
    • Chang, F.1    Lee, J.T.2    Navolanic, P.M.3
  • 59
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
    • Luo J, Brendan MD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: Rationale and promise. Cancer Cell. 2003;4:257-62.
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1    Brendan, M.D.2    Cantley, L.C.3
  • 60
    • 84884482014 scopus 로고    scopus 로고
    • Residual prostate cancer cells after docetaxel therapy increase the tumorigenic potential via constitutive signaling of CXCR4, ERK1/2 and c-Myc
    • Hatano K, Yamaguchi S, Nimura K, et al. Residual prostate cancer cells after docetaxel therapy increase the tumorigenic potential via constitutive signaling of CXCR4, ERK1/2 and c-Myc. Mol Cancer Res. 2013;11:1088-100.
    • (2013) Mol Cancer Res , vol.11 , pp. 1088-1100
    • Hatano, K.1    Yamaguchi, S.2    Nimura, K.3
  • 61
    • 84895738434 scopus 로고    scopus 로고
    • CXCL12 inhibits cortical neuron apoptosis by increasing the ratio of Bcl-2/Bax after traumatic brain injury
    • Mao W, Yi X, Qin J, et al. CXCL12 inhibits cortical neuron apoptosis by increasing the ratio of Bcl-2/Bax after traumatic brain injury. Int J Neurosci. 2014;124:281-90.
    • (2014) Int J Neurosci , vol.124 , pp. 281-290
    • Mao, W.1    Yi, X.2    Qin, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.