Variation in the Williams syndrome GTF2I gene and anxiety proneness interactively affect prefrontal cortical response to aversive stimuli

Translational Psychiatry

Volumn 5, Issue 8, 2015, Pages

  Jabbi, M ^a   Chen, Q ^b   Turner, N ^a   Kohn, P ^a   White, M ^b   Kippenhan, J S ^a   Dickinson, D ^a   Kolachana, B ^a   Mattay, V ^b,c   Weinberger, D R ^b,c   Berman, K F ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENERAL TRANSCRIPTION FACTOR; GENERAL TRANSCRIPTION FACTOR GTF2I; UNCLASSIFIED DRUG; GTF2I PROTEIN, HUMAN; TRANSCRIPTION FACTOR II;

ADULT; ANXIETY DISORDER; ARTICLE; AVERSIVE BEHAVIOR; BOLD SIGNAL; CHROMOSOME 7Q; COPY NUMBER VARIATION; DORSOLATERAL PREFRONTAL CORTEX; DSM-IV; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; GENE DOSAGE; GENE DUPLICATION; GENETIC ASSOCIATION; GENETIC VARIATION; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; NERVE POTENTIAL; PREFRONTAL CORTEX; SINGLE NUCLEOTIDE POLYMORPHISM; TASK PERFORMANCE; WILLIAMS BEUREN SYNDROME; ADOLESCENT; ANGER; ANXIETY; COMPLICATION; FEAR; GENETICS; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; ANGER; ANXIETY; DNA COPY NUMBER VARIATIONS; FEAR; FEMALE; HUMANS; MALE; MIDDLE AGED; PREFRONTAL CORTEX; TRANSCRIPTION FACTORS, TFII; WILLIAMS SYNDROME; YOUNG ADULT;

EID: 84991010759     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2015.98     Document Type: Article

References (34)

1. Hudson JI, Mangweth B, Pope HG Jr, De Col C, Hausmann A, Gutweniger S et al. Family study of affective spectrum disorder. Arch Gen Psychiatry 2003; 60: 170-177.
2. Smoller JW, Faraone SV. Genetics of anxiety disorders: Complexities and opportunities. Am J Med Genet C Semin Med Genet 2008; 148: 85-88.
3. Osborne LR, Mervis CB. Rearrangements of the Williams-Beuren syndrome locus: Molecular basis and implications for speech and language development. Expert Rev Mol Med 2007; 9: 1-16.
4. Schubert C. The genomic basis of the Williams-Beuren syndrome. Cell Mol Life Sci 2009; 66: 1178-1197.
5. Somerville MJ, Mervis CB, Young EJ, Seo EJ, del Campo M, Bamforth S et al. Severe expressive-language delay related to duplication of the Williams-Beuren locus. N Engl J Med 2005; 353: 1694-1701.
6. Klein-Tasman BP, Mervis CB. Distinctive personality characteristics of 8-, 9-, and 10-year-olds with Williams syndrome. Dev Neuropsychol 2003; 23: 269-290.
7. Meyer-Lindenberg A, Hariri AR, Munoz KE, Mervis CB, Mattay VS, Morris CA et al. Neural correlates of genetically abnormal social cognition in Williams syndrome. Nat Neurosci 2005; 8: 991-993.
8. Järvinen A, Korenberg JR, Bellugi U. The social phenotype of Williams syndrome. Curr Opin Neurobiol 2013; 23: 414-422.
9. Dodd HF, Schniering CA, Porter MA. Beyond behaviour: Is social anxiety low in Williams syndrome? J Autism Dev Disord 2009; 39: 1673-1681.
10. Mervis CB, Dida J, Lam E, Crawford-Zelli NA, Young EJ, Henderson DR et al. Duplication of GTF2I results in separation anxiety in mice and humans. Am J Hum Genet 2012; 90: 1064-1070.
11. Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D et al. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron 2011; 70: 863-885.
12. Sakurai T, Dorr NP, Takahashi N, McInnes LA, Elder GA, Buxbaum JD. Haploinsufficiency of GTF2I, a gene deleted in Williams Syndrome, leads to increases in social interactions. Autism Res 2011; 4: 28-39.
13. Roy AL. Biochemistry and biology of the inducible multifunctional transcription factor TFII-I. Gene 2001; 274: 1-13.
14. Dida J Effect of GTF2I gene on anxiety. MSc thesis, Institute of Medical Science, University of Toronto, Toronto, ON, 2013; https: //tspace.library.utoronto.ca/han dle/1807/42815.
15. Rose EJ, Donohoe G. Brain vs behavior: An effect size comparison of neuroimaging and cognitive studies of genetic risk for schizophrenia. Schizophr Bull 2013; 39: 518-526.
16. Jabbi M, Kippenhan JS, Kohn P, Marenco S, Mervis CB, Morris CA et al. The Williams syndrome chromosome 7q11.23 hemideletion confers hypersocial, anxious personality coupled with altered insula structure and function. Proc Natl Acad Sci USA 2012; 109: E860-E866.
17. Cloninger CR. A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 1987; 44: 573-588.
18. Hariri AR, Bookheimer SY, Mazziotta JC. Modulating emotional responses: Effects of a neocortical network on the limbic system. Neuroreport 2000; 11: 43-48.
19. Ekman P Friesen WV. Pictures of Facial Affect. Consulting Psychologists Press: Palo Alto, CA, USA, 1976.
20. Terburg D, Morgan BE, Montoya ER, Hooge IT, Thornton HB, Hariri AR et al. Hypervigilance for fear after basolateral amygdala damage in humans. Transl Psychiatry 2012; 2: E115.
21. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002a; 297: 400-403.
22. Brown SM, Peet E, Manuck SB, Williamson DE, Dahl RE, Ferrell RE et al. A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Mol Psychiatry 2005; 10: 884-888.
23. Meyer-Lindenberg A, Kolachana B, Gold B, Olsh A, Nicodemus KK, Mattay V et al. Genetic variants in AVPR1 A linked to autism predict amygdala activation and personality traits in healthy humans. Mol Psychiatry 2009; 14: 968-975.
24. Hariri AR, Tessitore A, Mattay VS, Fera F, Weinberger DR. The amygdala response to emotional stimuli: A comparison of faces and scenes. Neuroimage 2002b; 17: 317-323.
25. Arnsten AF, Rubia K. Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: Disruptions in neurodevelopmental psychiatric disorders. J Am Acad Child Adolescent Psychiatry 2012; 51: 356-367.
26. Krawczyk DC. Contributions of the prefrontal cortex to the neural basis of human decision-making. Neurosci Biobehav Rev 2002; 26: 631-664.
27. Shackman AJ, McMenamin BW, Maxwell JS, Greischar LL, Davidson RJ. Right dorsolateral prefrontal cortical activity and behavioral inhibition. Psychol Sci 2009; 20: 1500-1506.
28. Lei X, Chen C, Xue F, He Q, Chen C, Liu Q et al. Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males. NeuroImage 2014; 89: 226-234.
29. Baeken C, Marinazzo D, Van Schuerbeek P, Wu GR, De Mey J, Luypaert R et al. Left and right amygdala-mediofrontal cortical functional connectivity is differentially modulated by harm avoidance. PLoS One 2014; 9: E95740.
30. Prater KE, Hosanagar A, Klumpp H, Angstadt M, Phan KL. Aberrant amygdalafrontal cortex connectivity during perception of fearful faces and at rest in generalized social anxiety disorder. Depress Anxiety 2013; 30: 234-241.
31. Birn RM, Shackman AJ, Oler JA, Williams LE, McFarlin DR, Rogers GM et al. Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety. Mol Psychiatry 2014; 19: 915-922.
32. Copeland WE, Angold A, Shanahan L, Costello EJ. Longitudinal patterns of anxiety from childhood to adulthood: The Great Smoky Mountains Study. J Am Acad Child Adolesc Psychiatry 2014; 53: 21-33.
33. Milrod B, Markowitz JC, Gerber AJ, Cyranowski J, Altemus M, Shapiro T et al. Childhood separation anxiety and the pathogenesis and treatment of adult anxiety. Am J Psychiatry 2014; 171: 34-43.
34. Hirshfeld-Becker DR, Micco JA, Simoes NA, Henin A. High risk studies and developmental antecedents of anxiety disorders. Am J Med Genet C Semin Med Genet 2008; 148: 99-117.