52 Genetic Loci Influencing Myocardial Mass

Journal of the American College of Cardiology

Volumn 68, Issue 13, 2016, Pages 1435-1448

  van der Harst, Pim ^a,b   van Setten, Jessica ^c   Verweij, Niek ^a   Vogler, Georg ^d   Franke, Lude ^a   Maurano, Matthew T ^e,f,g   Wang, Xinchen ^h   Mateo Leach, Irene ^a   Eijgelsheim, Mark ⁱ   Sotoodehnia, Nona ^f   Hayward, Caroline ^j   Sorice, Rossella ^k   Meirelles, Osorio ^l   Lyytikäinen, Leo Pekka ^m,n   Polašek, Ozren ^o,p   Tanaka, Toshiko ^l   Arking, Dan E ^q   Ulivi, Sheila ^r   Trompet, Stella ^s   Müller Nurasyid, Martina ^t,u,v,w   Smith, Albert V ^x,y   Dörr, Marcus ^w,z   Kerr, Kathleen F ^e   Magnani, Jared W ^aa   Del Greco M , Fabiola ^ab   Zhang, Weihua ^ac,ad   Nolte, Ilja M ^a   Silva, Claudia T ^i,ae   Padmanabhan, Sandosh ^af   Tragante, Vinicius ^c   Esko, Tõnu ^ag,ah   Abecasis, Gonçalo R ^ai   Adriaens, Michiel E ^aj,ak   Andersen, Karl ^y,al   Barnett, Phil ^aj   Bis, Joshua C ^f   Bodmer, Rolf ^d   Buckley, Brendan M ^am   Campbell, Harry ^o   Cannon, Megan V ^a   Chakravarti, Aravinda ^q   Chen, Lin Y ^an   Delitala, Alessandro ^ao   Devereux, Richard B ^ap   Doevendans, Pieter A ^c   Dominiczak, Anna F ^af   Ferrucci, Luigi ^l   Ford, Ian ^af   Gieger, Christian ^v   Harris, Tamara B ^l   Haugen, Eric ^e   Heinig, Matthias ^v,aq,ar   Hernandez, Dena G ^l   Hillege, Hans L ^a   Hirschhorn, Joel N ^ah,as,at   Hofman, Albert ⁱ   Hubner, Norbert ^w,aq   Hwang, Shih Jen ^au   Iorio, Annamaria ^av   Kähönen, Mika ^n,aw   Kellis, Manolis ^as,ax   Kolcic, Ivana ^p   Kooner, Ishminder K ^ad   Kooner, Jaspal S ^ad,ay   Kors, Jan A ⁱ   Lakatta, Edward G ^l   Lage, Kasper ^as,at,az   Launer, Lenore J ^l   Levy, Daniel ^au   Lundby, Alicia ^ba,bb   Macfarlane, Peter W ^af   May, Dalit ^bc   Meitinger, Thomas ^v,w,bd   Metspalu, Andres ^ag   Nappo, Stefania ^k   Naitza, Silvia ^ao   Neph, Shane ^e   Nord, Alex S ^be,bf   Nutile, Teresa ^k   Okin, Peter M ^ap   Olsen, Jesper V ^ba   Oostra, Ben A ⁱ   Penninger, Josef M ^bg   Pennacchio, Len A ^be,bh   Pers, Tune H ^ah,as,bi,bj   Perz, Siegfried ^v   Peters, Annette ^v,w   Pinto, Yigal M ^aj   Pfeufer, Arne ^v,ab   Pilia, Maria Grazia ^ao   Pramstaller, Peter P ^ab,bk,bl   Prins, Bram P ^bm   Raitakari, Olli T ^bn,bo   Raychaudhuri, Soumya ^as,bp   Rice, Ken M ^e   Rossin, Elizabeth J ^at,az   Rotter, Jerome I ^bq   Schafer, Sebastian ^w,aq,br   Schlessinger, David ^l   Schmidt, Carsten O ^z   Sehmi, Jobanpreet ^ad,ay   Silljé, Herman H W ^a   Sinagra, Gianfranco ^av   Sinner, Moritz F ^t   Slowikowski, Kamil ^bs   Soliman, Elsayed Z ^bt   Spector, Timothy D ^bu   Spiering, Wilko ^c   Stamatoyannopoulos, John A ^e   Stolk, Ronald P ^a   Strauch, Konstantin ^u,v   Tan, Sian Tsung ^ad,ay   Tarasov, Kirill V ^l   Trinh, Bosco ^d   Uitterlinden, Andre G ⁱ   van den Boogaard, Malou ^aj   van Duijn, Cornelia M ⁱ   van Gilst, Wiek H ^a   Viikari, Jorma S ^bn,bv   Visscher, Peter M ^bw   Vitart, Veronique ^j   Völker, Uwe ^w,z   Waldenberger, Melanie ^v   Weichenberger, Christian X ^ab   Westra, Harm Jan ^as,bp,bx   Wijmenga, Cisca ^a   Wolffenbuttel, Bruce H ^a   Yang, Jian ^bw   Bezzina, Connie R ^aj   Munroe, Patricia B ^by   Snieder, Harold ^a   Wright, Alan F ^j   Rudan, Igor ^o   Boyer, Laurie A ^h   Asselbergs, Folkert W ^b,c,bz   van Veldhuisen, Dirk J ^a   Stricker, Bruno H ⁱ   Psaty, Bruce M ^f,ca   Ciullo, Marina ^k,cb   Sanna, Serena ^ao   Lehtimäki, Terho ^m,n   Wilson, James F ^j,o   Bandinelli, Stefania ^cc   Alonso, Alvaro ^cd   Gasparini, Paolo ^r,av,ce   Jukema, J Wouter ^b,s   Kääb, Stefan ^t,w   Gudnason, Vilmundur ^x,y   Felix, Stephan B ^w,z   Heckbert, Susan R ^e,ca   de Boer, Rudolf A ^a   Newton Cheh, Christopher ^as,az   Hicks, Andrew A ^ab   Chambers, John C ^ac,ad   Jamshidi, Yalda ^bm   Visel, Axel ^be,bh,cf   Christoffels, Vincent M ^aj   Isaacs, Aaron ^i,cg   Samani, Nilesh J ^ch,ci   de Bakker, Paul I W ^c   more..

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d BURNHAM INSTITUTE   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^g NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^h MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

ⁱ ERASMUS MEDICAL CENTER   (Netherlands)

^j UNIVERSITY OF EDINBURGH   (United Kingdom)

^k INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^l NATIONAL INSTITUTE ON AGING   (United States)

^m FIMLAB LABORATORIES   (Finland)

ⁿ TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^o UNIVERSITY OF EDINBURGH   (United Kingdom)

^p UNIVERSITY OF SPLIT   (Croatia)

^q JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^r INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^s LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^t LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^u UNIVERSITY OF MUNICH   (Germany)

^v INSTITUTE OF EPIDEMIOLOGY   (Germany)

^w DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^x ICELANDIC HEART ASSOCIATION   (Iceland)

^y UNIVERSITY OF ICELAND   (Iceland)

^z UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^aa BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ab University of Lubeck   (Italy)

^ac IMPERIAL COLLEGE LONDON   (United Kingdom)

^ad EALING HOSPITAL NHS TRUST   (United Kingdom)

^ae UNIVERSIDAD DEL ROSARIO   (Colombia)

^af UNIVERSITY OF GLASGOW   (United Kingdom)

^ag UNIVERSITY OF TARTU   (Estonia)

^ah BOSTON CHILDREN S HOSPITAL   (United States)

^ai UNIVERSITY OF MICHIGAN   (United States)

^aj UNIVERSITY OF AMSTERDAM   (Netherlands)

^ak MAASTRICHT UNIVERSITY   (Netherlands)

^al LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^am UNIVERSITY COLLEGE CORK   (Ireland)

^an UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^ao Milan Unit   (Italy)

^ap WEILL CORNELL MEDICAL COLLEGE   (United States)

^aq MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^ar MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^as BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^at HARVARD MEDICAL SCHOOL   (United States)

^au NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^av UNIVERSITY OF TRIESTE   (Italy)

^aw TAMPERE UNIVERSITY HOSPITAL   (Finland)

^ax MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^ay NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^az MASSACHUSETTS GENERAL HOSPITAL   (United States)

^ba University of Copenhagen   (Denmark)

^bb UNIVERSITY OF COPENHAGEN   (Denmark)

^bc HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^bd TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^be LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^bf UNIVERSITY OF CALIFORNIA   (United States)

^bg INSTITUTE OF MOLECULAR BIOTECHNOLOGY   (Austria)

^bh DOE JOINT GENOME INSTITUTE   (United States)

^bi University of Copenhagen   (Denmark)

^bj STATENS SERUM INSTITUT   (Denmark)

^bk General Central Hospital   (Italy)

^bl UNIVERSITY OF LÜBECK   (Germany)

^bm ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^bn TURKU UNIVERSITY HOSPITAL   (Finland)

^bo UNIVERSITY OF TURKU   (Finland)

^bp BRIGHAM AND WOMEN S HOSPITAL   (United States)

^bq HARBOR UCLA MEDICAL CENTER   (United States)

^br DEPARTMENT OF CARDIOLOGY   (Singapore)

^bs HARVARD UNIVERSITY   (United States)

^bt WAKE FOREST SCHOOL OF MEDICINE   (United States)

^bu KING'S COLLEGE LONDON   (United Kingdom)

^bv UNIVERSITY OF TURKU   (Finland)

^bw UNIVERSITY OF QUEENSLAND   (Australia)

^bx LABORATORY FOR MOLECULAR MEDICINE   (United States)

^by QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^bz UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ca CENTER FOR HEALTH STUDIES   (United States)

^cb IRCCS NEUROMED   (Italy)

^cc SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

^cd EMORY UNIVERSITY   (United States)

^ce SIDRA MEDICAL AND RESEARCH CENTER   (Qatar)

^cf UNIVERSITY OF CALIFORNIA   (United States)

^cg MAASTRICHT UNIVERSITY   (Netherlands)

^ch UNIVERSITY OF LEICESTER   (United Kingdom)

^ci GLENFIELD HOSPITAL   (United Kingdom)

more..

Author keywords

electrocardiogram; genetic association study; heart failure; left ventricular hypertrophy; QRS

Indexed keywords

SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.8; TRANSCRIPTION FACTOR;

ARTICLE; BIOLOGICAL FUNCTIONS; CARDIAC MUSCLE; CARDIOVASCULAR PARAMETERS; CHROMATIN; DROSOPHILA MELANOGASTER; EUROPEAN; FUNCTIONAL ASSESSMENT; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC PARAMETERS; GENETIC TRAIT; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HEART; HEART VENTRICLE HYPERTROPHY; HISTONE MODIFICATION; HUMAN; HUMAN GENOME; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; META ANALYSIS (TOPIC); MUS MUSCULUS; MYOCARDIAL MASS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; QRS COMPLEX; RELIABILITY; SCN10A GENE; SCN5A GENE; VALIDATION STUDY; ANIMAL; CARDIOMEGALY; GENETICS;

ANIMALS; CARDIOMEGALY; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; HUMANS;

EID: 84990929556     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2016.07.729     Document Type: Article

References (26)

1. 1 Levy, D., Labib, S.B., Anderson, K.M., Christiansen, J.C., Kannel, W.B., Castelli, W.P., Determinants of sensitivity and specificity of electrocardiographic criteria for left ventricular hypertrophy. Circulation 81 (1990), 815–820.
2. 2 Okin, P.M., Roman, M.J., Devereux, R.B., Pickering, T.G., Borer, J.S., Kligfield, P., Time-voltage QRS area of the 12-lead electrocardiogram: detection of left ventricular hypertrophy. Hypertension 31 (1998), 937–942.
3. 3 Kannel, W.B., Gordon, T., Offutt, D., Left ventricular hypertrophy by electrocardiogram. Prevalence, incidence, and mortality in the Framingham study. Ann Intern Med 71 (1969), 89–105.
4. 4 Verdecchia, P., Schillaci, G., Borgioni, C., et al. Prognostic value of a new electrocardiographic method for diagnosis of left ventricular hypertrophy in essential hypertension. J Am Coll Cardiol 31 (1998), 383–390.
5. 5 Usoro, A.O., Bradford, N., Shah, A.J., Soliman, E.Z., Risk of mortality in individuals with low QRS voltage and free of cardiovascular disease. Am J Cardiol 113 (2014), 1514–1517.
6. 6 Kamath, S.A., de P Meo Neto, J., Canham, R.M., et al. Low voltage on the electrocardiogram is a marker of disease severity and a risk factor for adverse outcomes in patients with heart failure due to systolic dysfunction. Am Heart J 152 (2006), 355–361.
7. 7 Yang, J., Ferreira, T., Morris, A.P., et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet 44 (2012), 369–375 S1–3.
8. 8 Abecasis, G.R., Altshuler, D., Auton, A., et al. A map of human genome variation from population-scale sequencing. Nature 467 (2010), 1061–1073.
9. 9 Stergachis, A.B., Neph, S.J., Reynolds, A.P., et al. Epigenetic memory of developmental fate and time encoded in human regulatory DNA landscapes. Cell 154 (2013), 888–903.
10. 10 Maurano, M.T., Humbert, R., Rynes, E., et al. Systematic localization of common disease-associated variation in regulatory DNA. Science 337 (2012), 1190–1195.
11. 11 Thurman, R.E., Rynes, E., Humbert, R., et al. The accessible chromatin landscape of the human genome. Nature 489 (2012), 75–82.
12. 12 Bernstein, B.E., Stamatoyannopoulos, J.A., Costello, J.F., et al. The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol 28 (2010), 1045–1048.
13. 13 Kundaje, A., Meuleman, W., Ernst, J., et al. Integrative analysis of 111 reference human epigenomes. Nature 518 (2015), 317–330.
14. 14 He, A., Kong, S.W., Ma, Q., Pu, W.T., Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proc Natl Acad Sci U S A 108 (2011), 5632–5637.
15. 15 May, D., Blow, M.J., Kaplan, T., et al. Large-scale discovery of enhancers from human heart tissue. Nat Genet 44 (2012), 89–93.
16. 16 van den Boogaard, M., Smemo, S., Burnicka-Turek, O., et al. A common genetic variant within SCN10A modulates cardiac SCN5A expression. J Clin Invest 124 (2014), 1844–1852.
17. 17 van den Boogaard, M., Wong, L.Y., Tessadori, F., et al. Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer. J Clin Invest 122 (2012), 2519–2530.
18. 18 Gieger, C., Radhakrishnan, A., Cvejic, A., et al. New gene functions in megakaryopoiesis and platelet formation. Nature 480 (2011), 201–208.
19. 19 van der Harst, P., Zhang, W., Mateo Leach, I., et al. Seventy-five genetic loci influencing the human red blood cell. Nature 492 (2012), 369–375.
20. 20 Raychaudhuri, S., Plenge, R.M., Rossin, E.J., et al. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet, 5, 2009, e1000534.
21. 21 Hoischen, A., van Bon, B.W., Gilissen, C., et al. De novo mutations of SETBP1 cause Schinzel-Giedion syndrome. Nat Genet 42 (2010), 483–485.
22. 22 Linden, H., Williams, R., King, J., Blair, E., Kini, U., Ulnar Mammary syndrome and TBX3: expanding the phenotype. Am J Med Genet A 149A (2009), 2809–2812.
23. 23 Cannon, M.V., Sillje, H.H.W., Sijbesma, J.W., et al. Cardiac LXRα overexpression protects against pathological hypertrophy and dysfunction by enhancing glucose uptake and utilization. EMBO Mol Med 7 (2015), 1229–1243.
24. 24 Kuipers, I., Li, J., Vreeswijk-Baudoin, I., et al. Activation of liver X receptors with T0901317 attenuates cardiac hypertrophy in vivo. Eur J Heart Fail 12 (2010), 1042–1050.
25. 25 Pers, T.H., Karjalainen, J.M., Chan, Y., et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun, 6, 2015, 5890.
26. 26 Sundstrom, J., Lind, L., Arnlov, J., Zethelius, B., Andren, B., Lithell, H.O., Echocardiographic and electrocardiographic diagnoses of left ventricular hypertrophy predict mortality independently of each other in a population of elderly men. Circulation 103 (2001), 2346–2351.