Corrigendum: EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance (Nature Communications (2016) 7 (13045) DOI: 10.1038/ncomms13045);EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance

Nature Communications

Volumn 7, Issue , 2016, Pages

  Jiang, Lingling ^a   Shen, Yingying ^a   Guo, Danfeng ^a   Yang, Diya ^a   Liu, Jiajun ^a   Fei, Xuefeng ^a   Yang, Yunshan ^b   Zhang, Buyi ^a   Lin, Zhendong ^c   Yang, Fei ^d   Wang, Xiaojian ^a   Wang, Keyi ^e   Wang, Jianli ^a   Cai, Zhijian ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG CANCER HOSPITAL   (China)

^c WENZHOU MEDICAL UNIVERSITY   (China)

^d ZHEJIANG UNIVERSITY   (China)

^e NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; DEXTRAN SULFATE; EPITHELIAL CELL ADHESION MOLECULE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1;

ANTIGEN; CELLS AND CELL COMPONENTS; DIGESTIVE SYSTEM; DIGESTIVE SYSTEM DISORDER; GENETIC ENGINEERING; IMMUNE RESPONSE; IMMUNE SYSTEM; PROTEIN; RODENT; TOLERANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED DENDRITIC CELL; CD4+ T LYMPHOCYTE; CELL PROTECTION; CELL TRANSFER; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; ENZYME ACTIVATION; EXOSOME; EXPERIMENTAL INFLAMMATORY BOWEL DISEASE; FEMALE; GENE SILENCING; HUMAN; HUMAN TISSUE; IMMUNE BALANCE; IMMUNITY; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; INTESTINE; INTESTINE EPITHELIUM CELL; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; CELL PROLIFERATION; CYTOLOGY; DENDRITIC CELL; EPITHELIUM CELL; IMMUNOLOGY; INFLAMMATORY BOWEL DISEASE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SEVERITY OF ILLNESS INDEX; ULTRASTRUCTURE;

MURINAE; MUS;

ANIMALS; CELL PROLIFERATION; DENDRITIC CELLS; EPITHELIAL CELL ADHESION MOLECULE; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; EXTRACELLULAR VESICLES; FEMALE; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINES; MICE, INBRED C57BL; PHOSPHORYLATION; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84990898303     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms16006     Document Type: Erratum

References (44)

1. Cobbold, S. P. Future therapeutics for the induction of peripheral immune tolerance in autoimmune disease and organ transplantation. Immunotherapy 1, 447-460 (2009).
2. Van Parijs, L. and Abbas, A. K. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 280, 243-248 (1998).
3. Brandtzaeg, P. Development and basic mechanisms of human gut immunity. Nutr. Rev. 56, S5-S18 (1998).
4. Omata, N. et al. Ovalbumin-specific IgE modulates ovalbumin-specific T-cell response after repetitive oral antigen administration. J. Allergy Clin. Immunol. 115, 822-827 (2005).
5. Fallarino, F. et al. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J. Immunol. 176, 6752-6761 (2006).
6. Brimnes, J. et al. Defects in CD8 regulatory T cells in the lamina propria of patients with inflammatory bowel disease. J. Immunol. 174, 5814-5822 (2005).
7. Bol-Schoenmakers, M. et al. Regulation by intestinal gammadelta T cells during establishment of food allergic sensitization in mice. Allergy 66, 331-340 (2011).
8. Mauri, C. and Ehrenstein, M. R. The short history of regulatory B cells. Trends Immunol. 29, 34-40 (2008).
9. Kaser, A., Zeissig, S. and Blumberg, R. S. Inflammatory bowel disease. Annu. Rev. Immunol. 28, 573-621 (2010).
10. Yanez-Mo, M. et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell. Vesicles 4, 27066 (2015).
11. Colombo, M., Raposo, G. and Thery, C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 30, 255-289 (2014).
12. Tkach, M. and Thery, C. Communication by extracellular vesicles: where we are and where we need to go. Cell 164, 1226-1232 (2016).
13. Wolfers, J. et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat. Med. 7, 297-303 (2001).
14. Peinado, H. et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18, 883-891 (2012).
15. Taylor, D. D., Akyol, S. and Gercel-Taylor, C. Pregnancy-associated exosomes and their modulation of T cell signaling. J. Immunol. 176, 1534-1542 (2006).
16. Wang, G. J. et al. Thymus exosomes-like particles induce regulatory T cells. J. Immunol. 181, 5242-5248 (2008).
17. Zhang, H. G. et al. A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death. J. Immunol. 176, 7385-7393 (2006).
18. Lin, X. P., Almqvist, N. and Telemo, E. Human small intestinal epithelial cells constitutively express the key elements for antigen processing and the production of exosomes. Blood Cells Mol. Dis. 35, 122-128 (2005).
19. Karlsson, M. et al. Tolerosomes are produced by intestinal epithelial cells. Eur. J. Immunol. 31, 2892-2900 (2001).
20. Krawisz, J. E., Sharon, P. and Stenson, W. F. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 87, 1344-1350 (1984).
21. Cai, Z. et al. Immunosuppressive exosomes from TGF-beta1 gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells. Cell Res. 22, 607-610 (2012).
22. Steinbach, E. C. and Plevy, S. E. The role of macrophages and dendritic cells in the initiation of inflammation in IBD. Inflamm. Bowel Dis. 20, 166-175 (2014).
23. Mittelbrunn, M. et al. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat. Commun. 2, 282 (2011).
24. Dreux, M. et al. Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity. Cell Host Microbe 12, 558-570 (2012).
25. Han, Y., Guo, Q., Zhang, M., Chen, Z. and Cao, X. CD69 CD4 CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1. J. Immunol. 182, 111-120 (2009).
26. Otsuka, M., Negishi, Y. and Aramaki, Y. Involvement of phosphatidylinositol-3- kinase and ERK pathways in the production of TGF-beta1 by macrophages treated with liposomes composed of phosphatidylserine. FEBS Lett. 581, 325-330 (2007).
27. Meyaard, L. et al. The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). J. Exp. Med. 194, 107-112 (2001).
28. Ouyang, W., Rutz, S., Crellin, N. K., Valdez, P. A. and Hymowitz, S. G. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu. Rev. Immunol. 29, 71-109 (2011).
29. Sugimoto, K. et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118, 534-544 (2008).
30. Hainzl, E. et al. Intestinal epithelial cell tyrosine kinase 2 transduces IL-22 signals to protect from acute colitis. J. Immunol. 195, 5011-5024 (2015).
31. Baumgart, D. C. and Dignass, A. U. Intestinal barrier function. Curr. Opin. Clin. Nutr. Metab. Care 5, 685-694 (2002).
32. Moens, E. and Veldhoen, M. Epithelial barrier biology: good fences make good neighbours. Immunology 135, 1-8 (2012).
33. Uhlig, H. H. and Powrie, F. Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses. J. Clin. Invest. 112, 648-651 (2003).
34. Collins, C. B. et al. Flt3 ligand expands CD103() dendritic cells and FoxP3() T regulatory cells, and attenuates Crohns-like murine ileitis. Gut. 61, 1154-1162 (2012).
35. Siddiqui, K. R., Laffont, S. and Powrie, F. E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. Immunity 32, 557-567 (2010).
36. Tauro, B. J. et al. Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids. Mol. Cell Proteomics 12, 587-598 (2013).
37. Mathivanan, S. et al. Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature. Mol. Cell. Proteomics 9, 197-208 (2010).
38. Cai, Z. et al. Activated T cell exosomes promote tumor invasion via Fas signaling pathway. J. Immunol. 188, 5954-5961 (2012).
39. Dai, S. et al. Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol. Ther. 16, 782-790 (2008).
40. Yu, L. et al. Exosomes with membrane-associated TGF-beta1 from genemodified dendritic cells inhibit murine EAE independently of MHC restriction. Eur. J. Immunol. 43, 2461-2472 (2013).
41. Laping, N. J. et al. Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. Clin. Cancer Res. 13, 3087-3099 (2007).
42. Soutschek, J. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432, 173-178 (2004).
43. Manicassamy, S. and Manoharan, I. Mouse models of acute and chronic colitis. Methods Mol. Biol. 1194, 437-448 (2014).
44. Ostrowski, M. et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. Cell Biol. 12, 19-30 (2010).