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Volumn 34, Issue 10, 2016, Pages 2525-2535

Stromal Tissue Rigidity Promotes Mesenchymal Stem Cell-Mediated Corneal Wound Healing Through the Transforming Growth Factor β Signaling Pathway

Author keywords

Corneal stroma; Matrix rigidity; Mesenchymal stem cells; Transforming growth factor ; Wound healing

Indexed keywords

BETA1 INTEGRIN; COLLAGENASE 3; GELATINASE A; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

EID: 84990858716     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2405     Document Type: Article
Times cited : (22)

References (61)
  • 1
    • 79951886109 scopus 로고    scopus 로고
    • Anatomy and physiology of the cornea
    • DelMonte DW, Kim T. Anatomy and physiology of the cornea. J Cataract Refract Surg 2011;37:588–598.
    • (2011) J Cataract Refract Surg , vol.37 , pp. 588-598
    • DelMonte, D.W.1    Kim, T.2
  • 3
    • 0033991556 scopus 로고    scopus 로고
    • Growth factors: Importance in wound healing and maintenance of transparency of the cornea
    • Imanishi J, Kamiyama K, Iguchi I et al. Growth factors: Importance in wound healing and maintenance of transparency of the cornea. Prog Retin Eye Res 2000;19:113–129.
    • (2000) Prog Retin Eye Res , vol.19 , pp. 113-129
    • Imanishi, J.1    Kamiyama, K.2    Iguchi, I.3
  • 4
    • 0035188727 scopus 로고    scopus 로고
    • How matrix metalloproteinases regulate cell behavior
    • Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001;17:463–516.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 463-516
    • Sternlicht, M.D.1    Werb, Z.2
  • 6
    • 4344679317 scopus 로고    scopus 로고
    • TGF-beta1 stimulates production of gelatinase (MMP-9), collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, -11) by human corneal epithelial cells
    • Kim HS, Shang T, Chen Z et al. TGF-beta1 stimulates production of gelatinase (MMP-9), collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, -11) by human corneal epithelial cells. Exp Eye Res 2004;79:263–274.
    • (2004) Exp Eye Res , vol.79 , pp. 263-274
    • Kim, H.S.1    Shang, T.2    Chen, Z.3
  • 7
    • 84874485626 scopus 로고    scopus 로고
    • Evaluation and management of corneal abrasions
    • Wipperman JL, Dorsch JN. Evaluation and management of corneal abrasions. Am Fam Phys 2013;87:114–120.
    • (2013) Am Fam Phys , vol.87 , pp. 114-120
    • Wipperman, J.L.1    Dorsch, J.N.2
  • 9
    • 77649285139 scopus 로고    scopus 로고
    • Stem cell paracrine actions and tissue regeneration
    • Baraniak PR, McDevitt TC. Stem cell paracrine actions and tissue regeneration. Regen Med 2010;5:121–143.
    • (2010) Regen Med , vol.5 , pp. 121-143
    • Baraniak, P.R.1    McDevitt, T.C.2
  • 10
    • 84920806291 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Potential role in corneal wound repair and transplantation
    • Li F, Zhao SZ. Mesenchymal stem cells: Potential role in corneal wound repair and transplantation. World J Stem Cells 2014;6:296–304.
    • (2014) World J Stem Cells , vol.6 , pp. 296-304
    • Li, F.1    Zhao, S.Z.2
  • 11
    • 84878894865 scopus 로고    scopus 로고
    • Topical administration of orbital fat-derived stem cells promotes corneal tissue regeneration
    • Lin KJ, Loi MX, Lien GS et al. Topical administration of orbital fat-derived stem cells promotes corneal tissue regeneration. Stem Cell Res Ther 2013;4:72.
    • (2013) Stem Cell Res Ther , vol.4 , pp. 72
    • Lin, K.J.1    Loi, M.X.2    Lien, G.S.3
  • 12
    • 80052402855 scopus 로고    scopus 로고
    • Mesenchymal stem cells for the treatment of systemic lupus erythematosus: Is the cure for connective tissue diseases within connective tissue?
    • Carrion FA, Figueroa FE. Mesenchymal stem cells for the treatment of systemic lupus erythematosus: Is the cure for connective tissue diseases within connective tissue? Stem Cell Res Ther 2011;2:23.
    • (2011) Stem Cell Res Ther , vol.2 , pp. 23
    • Carrion, F.A.1    Figueroa, F.E.2
  • 13
    • 84928204723 scopus 로고    scopus 로고
    • Niche-dependent regulations of metabolic balance in high-fat diet-induced diabetic mice by mesenchymal stromal cells
    • Ji AT, Chang YC, Fu YJ et al. Niche-dependent regulations of metabolic balance in high-fat diet-induced diabetic mice by mesenchymal stromal cells. Diabetes 2015;64:926–936.
    • (2015) Diabetes , vol.64 , pp. 926-936
    • Ji, A.T.1    Chang, Y.C.2    Fu, Y.J.3
  • 14
    • 84921689036 scopus 로고    scopus 로고
    • Oscillatory shear stress mediates directional reorganization of actin cytoskeleton and alters differentiation propensity of mesenchymal stem cells
    • Kuo YC, Chang TH, Hsu WT et al. Oscillatory shear stress mediates directional reorganization of actin cytoskeleton and alters differentiation propensity of mesenchymal stem cells. Stem Cells 2015;33:429–442.
    • (2015) Stem Cells , vol.33 , pp. 429-442
    • Kuo, Y.C.1    Chang, T.H.2    Hsu, W.T.3
  • 15
    • 84896721884 scopus 로고    scopus 로고
    • The effects of actin cytoskeleton perturbation on keratin intermediate filament formation in mesenchymal stem/stromal cells
    • Chang TH, Huang HD, Ong WK et al. The effects of actin cytoskeleton perturbation on keratin intermediate filament formation in mesenchymal stem/stromal cells. Biomaterials 2014;35:3934–3944.
    • (2014) Biomaterials , vol.35 , pp. 3934-3944
    • Chang, T.H.1    Huang, H.D.2    Ong, W.K.3
  • 16
    • 80054082015 scopus 로고    scopus 로고
    • Synergistic regulation of cell function by matrix rigidity and adhesive pattern
    • Weng S, Fu J. Synergistic regulation of cell function by matrix rigidity and adhesive pattern. Biomaterials 2011;32:9584–9593.
    • (2011) Biomaterials , vol.32 , pp. 9584-9593
    • Weng, S.1    Fu, J.2
  • 17
    • 59549095389 scopus 로고    scopus 로고
    • Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: Scar-like rigidity inhibits beating
    • Engler AJ, Carag-Krieger C, Johnson CP et al. Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: Scar-like rigidity inhibits beating. J Cell Sci 2008;121:3794–3802.
    • (2008) J Cell Sci , vol.121 , pp. 3794-3802
    • Engler, A.J.1    Carag-Krieger, C.2    Johnson, C.P.3
  • 18
    • 34547687519 scopus 로고    scopus 로고
    • Mechanobiology of mesenchymal stem cells and their use in cardiovascular repair
    • Park JS, Huang NF, Kurpinski KT et al. Mechanobiology of mesenchymal stem cells and their use in cardiovascular repair. Front Biosci 2007;12:5098–5116.
    • (2007) Front Biosci , vol.12 , pp. 5098-5116
    • Park, J.S.1    Huang, N.F.2    Kurpinski, K.T.3
  • 19
    • 79953066426 scopus 로고    scopus 로고
    • Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells
    • Shih YR, Tseng KF, Lai HY et al. Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells. J Bone Miner Res 2011;26:730–738.
    • (2011) J Bone Miner Res , vol.26 , pp. 730-738
    • Shih, Y.R.1    Tseng, K.F.2    Lai, H.Y.3
  • 20
    • 84865810238 scopus 로고    scopus 로고
    • Compliance profile of the human cornea as measured by atomic force microscopy
    • Last JA, Thomasy SM, Croasdale CR et al. Compliance profile of the human cornea as measured by atomic force microscopy. Micron 2012;43:1293–1298.
    • (2012) Micron , vol.43 , pp. 1293-1298
    • Last, J.A.1    Thomasy, S.M.2    Croasdale, C.R.3
  • 21
    • 78650896406 scopus 로고    scopus 로고
    • Isolation and characterization of multi-potent stem cells from human orbital fat tissues
    • Ho JH, Ma WH, Tseng TC et al. Isolation and characterization of multi-potent stem cells from human orbital fat tissues. Tissue Eng Part A 2011;17:255–266.
    • (2011) Tissue Eng Part A , vol.17 , pp. 255-266
    • Ho, J.H.1    Ma, W.H.2    Tseng, T.C.3
  • 22
    • 84930486276 scopus 로고    scopus 로고
    • Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: Roles of Ras and oxidative stress
    • Ho JH, Chen YF, Ma WH et al. Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: Roles of Ras and oxidative stress. Cell Transplant 2011;20:1209–1220.
    • (2011) Cell Transplant , vol.20 , pp. 1209-1220
    • Ho, J.H.1    Chen, Y.F.2    Ma, W.H.3
  • 23
    • 0028953829 scopus 로고
    • An SV40-immortalized human corneal epithelial cell line and its characterization
    • Araki-Sasaki K, Ohashi Y, Sasabe T et al. An SV40-immortalized human corneal epithelial cell line and its characterization. Invest Ophthalmol Vis Sci 1995;36:614–621.
    • (1995) Invest Ophthalmol Vis Sci , vol.36 , pp. 614-621
    • Araki-Sasaki, K.1    Ohashi, Y.2    Sasabe, T.3
  • 24
    • 84930423883 scopus 로고    scopus 로고
    • Regulation of metastatic ability and drug resistance in pulmonary adenocarcinoma by matrix rigidity via activating c-Met and EGFR
    • Chang CC, Hsieh TL, Tiong TY et al. Regulation of metastatic ability and drug resistance in pulmonary adenocarcinoma by matrix rigidity via activating c-Met and EGFR. Biomaterials 2015;60:141–150.
    • (2015) Biomaterials , vol.60 , pp. 141-150
    • Chang, C.C.1    Hsieh, T.L.2    Tiong, T.Y.3
  • 25
    • 0036333993 scopus 로고    scopus 로고
    • A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair
    • Grose R, Hutter C, Bloch W et al. A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development 2002;129:2303–2315.
    • (2002) Development , vol.129 , pp. 2303-2315
    • Grose, R.1    Hutter, C.2    Bloch, W.3
  • 26
    • 0028168899 scopus 로고
    • TGF-beta 1 stimulates expression of keratinocyte integrins during re-epithelialization of cutaneous wounds
    • Gailit J, Welch MP, Clark RA. TGF-beta 1 stimulates expression of keratinocyte integrins during re-epithelialization of cutaneous wounds. J Invest Dermatol 1994;103:221–227.
    • (1994) J Invest Dermatol , vol.103 , pp. 221-227
    • Gailit, J.1    Welch, M.P.2    Clark, R.A.3
  • 27
    • 0034994719 scopus 로고    scopus 로고
    • TGF-beta receptor types I and II are differentially expressed during corneal epithelial wound repair
    • Zieske JD, Hutcheon AE, Guo X et al. TGF-beta receptor types I and II are differentially expressed during corneal epithelial wound repair. Invest Ophthalmol Vis Sci 2001;42:1465–1471.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1465-1471
    • Zieske, J.D.1    Hutcheon, A.E.2    Guo, X.3
  • 28
    • 0030768644 scopus 로고    scopus 로고
    • TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
    • Nakao A, Imamura T, Souchelnytskyi S et al. TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J 1997;16:5353–5362.
    • (1997) EMBO J , vol.16 , pp. 5353-5362
    • Nakao, A.1    Imamura, T.2    Souchelnytskyi, S.3
  • 29
    • 12344256548 scopus 로고    scopus 로고
    • Cell migration: Mechanisms of rear detachment and the formation of migration tracks
    • Kirfel G, Rigort A, Borm B et al. Cell migration: Mechanisms of rear detachment and the formation of migration tracks. Eur J Cell Biol 2004;83:717–724.
    • (2004) Eur J Cell Biol , vol.83 , pp. 717-724
    • Kirfel, G.1    Rigort, A.2    Borm, B.3
  • 30
    • 0032815514 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases and their inhibition in cutaneous wound healing and allergic contact hypersensitivity
    • Pilcher BK, Wang M, Qin XJ et al. Role of matrix metalloproteinases and their inhibition in cutaneous wound healing and allergic contact hypersensitivity. Ann NY Acad Sci 1999;878:12–24.
    • (1999) Ann NY Acad Sci , vol.878 , pp. 12-24
    • Pilcher, B.K.1    Wang, M.2    Qin, X.J.3
  • 31
    • 84889639006 scopus 로고    scopus 로고
    • Contributions of ocular surface components to matrix-metalloproteinases (MMP)−2 and MMP-9 in feline tears following corneal epithelial wounding
    • Petznick A, Madigan MC, Garrett Q et al. Contributions of ocular surface components to matrix-metalloproteinases (MMP)−2 and MMP-9 in feline tears following corneal epithelial wounding. PLoS One 2013;8:e71948.
    • (2013) PLoS One , vol.8
    • Petznick, A.1    Madigan, M.C.2    Garrett, Q.3
  • 32
    • 0033827730 scopus 로고    scopus 로고
    • Differential expression of MT1-MMP (MMP-14) and collagenase III (MMP-13) genes in normal and wounded rat corneas
    • Ye HQ, Maeda M, Yu FS et al. Differential expression of MT1-MMP (MMP-14) and collagenase III (MMP-13) genes in normal and wounded rat corneas. Invest Ophthalmol Vis Sci 2000;41:2894–2899.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 2894-2899
    • Ye, H.Q.1    Maeda, M.2    Yu, F.S.3
  • 33
    • 77954954424 scopus 로고    scopus 로고
    • Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells: Lumican null mice
    • Liu H, Zhang J, Liu CY et al. Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells: Lumican null mice. PLoS One 2010;5:e10707.
    • (2010) PLoS One , vol.5
    • Liu, H.1    Zhang, J.2    Liu, C.Y.3
  • 34
    • 84860323376 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells can differentiate and assume corneal keratocyte phenotype
    • Liu H, Zhang J, Liu CY et al. Bone marrow mesenchymal stem cells can differentiate and assume corneal keratocyte phenotype. J Cell Mol Med 2012;16:1114–1124.
    • (2012) J Cell Mol Med , vol.16 , pp. 1114-1124
    • Liu, H.1    Zhang, J.2    Liu, C.Y.3
  • 35
    • 0025905809 scopus 로고
    • EGF and TGF-alpha in wound healing and repair
    • Schultz G, Rotatori DS, Clark W. EGF and TGF-alpha in wound healing and repair. J Cell Biochem 1991;45:346–352.
    • (1991) J Cell Biochem , vol.45 , pp. 346-352
    • Schultz, G.1    Rotatori, D.S.2    Clark, W.3
  • 36
    • 0029842617 scopus 로고    scopus 로고
    • Synergistic effects of substance P with insulin-like growth factor-1 on epithelial migration of the cornea
    • Nishida T, Nakamura M, Ofuji K et al. Synergistic effects of substance P with insulin-like growth factor-1 on epithelial migration of the cornea. J Cell Physiol 1996; 169:159–166.
    • (1996) J Cell Physiol , vol.169 , pp. 159-166
    • Nishida, T.1    Nakamura, M.2    Ofuji, K.3
  • 37
    • 33646891980 scopus 로고    scopus 로고
    • Correlation of proliferative and anti-apoptotic effects of HGF, insulin, IGF-1, IGF-2, and EGF in SV40-transformed human corneal epithelial cells
    • Yanai R, Yamada N, Inui M et al. Correlation of proliferative and anti-apoptotic effects of HGF, insulin, IGF-1, IGF-2, and EGF in SV40-transformed human corneal epithelial cells. Exp Eye Res 2006;83:76-83.
    • (2006) Exp Eye Res , vol.83 , pp. 76-83
    • Yanai, R.1    Yamada, N.2    Inui, M.3
  • 38
    • 15044357457 scopus 로고    scopus 로고
    • Hepatocyte growth factor and keratinocyte growth factor regulation of epithelial and stromal corneal wound healing
    • Carrington LM, Boulton M. Hepatocyte growth factor and keratinocyte growth factor regulation of epithelial and stromal corneal wound healing. J Cataract Refract Surg 2005;31:412–423.
    • (2005) J Cataract Refract Surg , vol.31 , pp. 412-423
    • Carrington, L.M.1    Boulton, M.2
  • 39
    • 0028567793 scopus 로고
    • Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells
    • Wilson SE, He YG, Weng J et al. Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells. Exp Eye Res 1994;59:665–678.
    • (1994) Exp Eye Res , vol.59 , pp. 665-678
    • Wilson, S.E.1    He, Y.G.2    Weng, J.3
  • 40
    • 84891792459 scopus 로고    scopus 로고
    • Differential effects of hepatocyte growth factor and keratinocyte growth factor on corneal epithelial cell cycle protein expression, cell survival, and growth
    • Chandrasekher G, Pothula S, Maharaj G et al. Differential effects of hepatocyte growth factor and keratinocyte growth factor on corneal epithelial cell cycle protein expression, cell survival, and growth. Mol Vis 2014;20:24–37.
    • (2014) Mol Vis , vol.20 , pp. 24-37
    • Chandrasekher, G.1    Pothula, S.2    Maharaj, G.3
  • 41
    • 0028170226 scopus 로고
    • Mechanism of activation of the TGF-beta receptor
    • Wrana JL, Attisano L, Wieser R et al. Mechanism of activation of the TGF-beta receptor. Nature 1994;370:341–347.
    • (1994) Nature , vol.370 , pp. 341-347
    • Wrana, J.L.1    Attisano, L.2    Wieser, R.3
  • 43
    • 3242802874 scopus 로고    scopus 로고
    • TGF-beta-induced SMAD signaling and gene regulation: Consequences for extracellular matrix remodeling and wound healing
    • Schiller M, Javelaud D, Mauviel A. TGF-beta-induced SMAD signaling and gene regulation: Consequences for extracellular matrix remodeling and wound healing. J Dermatol Sci 2004;35:83–92.
    • (2004) J Dermatol Sci , vol.35 , pp. 83-92
    • Schiller, M.1    Javelaud, D.2    Mauviel, A.3
  • 44
    • 84907509309 scopus 로고    scopus 로고
    • Preclinical efficacy and mechanisms of mesenchymal stem cells in animal models of autoimmune diseases
    • Lee HK, Lim SH, Chung IS et al. Preclinical efficacy and mechanisms of mesenchymal stem cells in animal models of autoimmune diseases. Immune Netw 2014;14:81–88.
    • (2014) Immune Netw , vol.14 , pp. 81-88
    • Lee, H.K.1    Lim, S.H.2    Chung, I.S.3
  • 45
    • 79955930739 scopus 로고    scopus 로고
    • Low levels of hydrogen peroxide stimulate corneal epithelial cell adhesion, migration, and wound healing
    • Pan Q, Qiu WY, Huo YN et al. Low levels of hydrogen peroxide stimulate corneal epithelial cell adhesion, migration, and wound healing. Invest Ophthalmol Vis Sci 2011;52:1723–1734.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 1723-1734
    • Pan, Q.1    Qiu, W.Y.2    Huo, Y.N.3
  • 46
    • 0027412698 scopus 로고
    • Integrins in the wounded and unwounded stratified squamous epithelium of the cornea
    • Stepp MA, Spurr-Michaud S, Gipson IK. Integrins in the wounded and unwounded stratified squamous epithelium of the cornea. Invest Ophthalmol Vis Sci 1993;34:1829–1844.
    • (1993) Invest Ophthalmol Vis Sci , vol.34 , pp. 1829-1844
    • Stepp, M.A.1    Spurr-Michaud, S.2    Gipson, I.K.3
  • 47
    • 2942552111 scopus 로고    scopus 로고
    • TGF-beta signal transduction in corneal wound healing as a therapeutic target
    • Saika S. TGF-beta signal transduction in corneal wound healing as a therapeutic target. Cornea 2004;23:S25–S30.
    • (2004) Cornea , vol.23 , pp. S25-S30
    • Saika, S.1
  • 48
    • 79958734839 scopus 로고    scopus 로고
    • Enhanced functional properties of corneal epithelial cells by coculture with embryonic stem cells via the integrin beta1-FAK-PI3K/Akt pathway
    • Zhou J, Chen F, Xiao J et al. Enhanced functional properties of corneal epithelial cells by coculture with embryonic stem cells via the integrin beta1-FAK-PI3K/Akt pathway. Int J Biochem Cell Biol 2011;43:1168–1177.
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 1168-1177
    • Zhou, J.1    Chen, F.2    Xiao, J.3
  • 49
    • 59149104284 scopus 로고    scopus 로고
    • Proteinases in cutaneous wound healing
    • Toriseva M, Kahari VM. Proteinases in cutaneous wound healing. Cell Mol Life Sci 2009;66:203–224.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 203-224
    • Toriseva, M.1    Kahari, V.M.2
  • 50
    • 33847683870 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase gene expression
    • Yan C, Boyd DD. Regulation of matrix metalloproteinase gene expression. J Cell Physiol 2007;211:19–26.
    • (2007) J Cell Physiol , vol.211 , pp. 19-26
    • Yan, C.1    Boyd, D.D.2
  • 51
    • 43049092274 scopus 로고    scopus 로고
    • Metalloproteinases and their inhibitors: Regulators of wound healing
    • Gill SE, Parks WC. Metalloproteinases and their inhibitors: Regulators of wound healing. Int J Biochem Cell Biol 2008;40:1334–1347.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 1334-1347
    • Gill, S.E.1    Parks, W.C.2
  • 52
    • 0037127214 scopus 로고    scopus 로고
    • Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration
    • Mohan R, Chintala SK, Jung JC et al. Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration. J Biol Chem 2002;277:2065–2072.
    • (2002) J Biol Chem , vol.277 , pp. 2065-2072
    • Mohan, R.1    Chintala, S.K.2    Jung, J.C.3
  • 53
    • 84864683850 scopus 로고    scopus 로고
    • MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability
    • Toriseva M, Laato M, Carpen O et al. MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability. PLoS One 2012;7:e42596.
    • (2012) PLoS One , vol.7
    • Toriseva, M.1    Laato, M.2    Carpen, O.3
  • 54
    • 65349103543 scopus 로고    scopus 로고
    • Matrix metalloproteinase (MMP) and TGF beta 1-stimulated cell migration in skin and cornea wound healing
    • Joo CK, Seomun Y. Matrix metalloproteinase (MMP) and TGF beta 1-stimulated cell migration in skin and cornea wound healing. Cell Adhes Migr 2008;2:252–253.
    • (2008) Cell Adhes Migr , vol.2 , pp. 252-253
    • Joo, C.K.1    Seomun, Y.2
  • 55
    • 10344255835 scopus 로고    scopus 로고
    • TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells
    • Kim ES, Kim MS, Moon A. TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells. Int J Oncol 2004;25:1375–1382.
    • (2004) Int J Oncol , vol.25 , pp. 1375-1382
    • Kim, E.S.1    Kim, M.S.2    Moon, A.3
  • 56
    • 84878779764 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases
    • Swamydas M, Ricci K, Rego SL et al. Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases. Cell Adhes Migr 2013;7:315–324.
    • (2013) Cell Adhes Migr , vol.7 , pp. 315-324
    • Swamydas, M.1    Ricci, K.2    Rego, S.L.3
  • 57
    • 33646361074 scopus 로고    scopus 로고
    • Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells
    • Leivonen SK, Ala-Aho R, Koli K et al. Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells. Oncogene 2006;25:2588–2600.
    • (2006) Oncogene , vol.25 , pp. 2588-2600
    • Leivonen, S.K.1    Ala-Aho, R.2    Koli, K.3
  • 58
    • 79960838436 scopus 로고    scopus 로고
    • The TGF-beta/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system
    • Wiercinska E, Naber HP, Pardali E et al. The TGF-beta/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system. Breast Cancer Res Treat 2011;128:657–666.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 657-666
    • Wiercinska, E.1    Naber, H.P.2    Pardali, E.3
  • 59
    • 0026708922 scopus 로고
    • Transforming growth factor-beta modulates effects of epidermal growth factor on corneal epithelial cells
    • Mishima H, Nakamura M, Murakami J et al. Transforming growth factor-beta modulates effects of epidermal growth factor on corneal epithelial cells. Curr Eye Res 1992;11:691–696.
    • (1992) Curr Eye Res , vol.11 , pp. 691-696
    • Mishima, H.1    Nakamura, M.2    Murakami, J.3
  • 60
    • 0024313708 scopus 로고
    • EGF does not enhance corneal epithelial cell motility
    • Soong KH, NcClenic B, Varani J et al. EGF does not enhance corneal epithelial cell motility. Invest Ophthalmol Vis Sci 1989;30:1808–1812.
    • (1989) Invest Ophthalmol Vis Sci , vol.30 , pp. 1808-1812
    • Soong, K.H.1    NcClenic, B.2    Varani, J.3
  • 61
    • 0026481075 scopus 로고
    • Effects of epidermal growth factor, fibroblast growth factor, and transforming growth factor-beta on corneal cell chemotaxis
    • Grant MB, Khaw PT, Schultz GS et al. Effects of epidermal growth factor, fibroblast growth factor, and transforming growth factor-beta on corneal cell chemotaxis. Invest Ophthalmol Vis Sci 1992;33:3292–3301.
    • (1992) Invest Ophthalmol Vis Sci , vol.33 , pp. 3292-3301
    • Grant, M.B.1    Khaw, P.T.2    Schultz, G.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.