Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study

Supportive Care in Cancer

Volumn 25, Issue 2, 2017, Pages 459-464

  Thamlikitkul, Lucksamon ^a   Srimuninnimit, Vichien ^a   Akewanlop, Charuwan ^a   Ithimakin, Suthinee ^a   Techawathanawanna, Sirisopa ^a   Korphaisarn, Krittiya ^a   Chantharasamee, Jomjit ^a   Danchaivijitr, Pongwut ^a   Soparattanapaisarn, Nopadol ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Anthracycline; Breast cancer; Chemotherapy; Ginger; Nausea; Vomiting

Indexed keywords

ANTIEMETIC AGENT; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOMPERIDONE; DOXORUBICIN; HERBACEOUS AGENT; METOCLOPRAMIDE; ONDANSETRON; PLACEBO; ANTINEOPLASTIC AGENT;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; BREAST CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CHEMOTHERAPY INDUCED NAUSEA AND VOMITING; CLINICAL ARTICLE; CONSTIPATION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; FEVER; GINGER; HUMAN; MEDICATION COMPLIANCE; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTOPENIA; BREAST NEOPLASMS; CHEMICALLY INDUCED; MIDDLE AGED; NAUSEA; PHYTOTHERAPY; VOMITING;

ADULT; AGED; ANTIEMETICS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CROSS-OVER STUDIES; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOUBLE-BLIND METHOD; DOXORUBICIN; FEMALE; GINGER; HUMANS; MIDDLE AGED; NAUSEA; ONDANSETRON; PHYTOTHERAPY; VOMITING;

EID: 84990838731     PISSN: 09414355     EISSN: 14337339     Source Type: Journal    
DOI: 10.1007/s00520-016-3423-8     Document Type: Article

References (21)

1. Griffin AM, Butow PN, Coates AS, Childs AM, Ellis PM, Dunn SM, Tattersall MH (1996) On the receiving end. V: Patient perceptions of the side effects of cancer chemotherapy in 1993. Ann Oncol 7(2):189–195
2. de Boer-Dennert M, de Wit R, Schmitz PI, Djontono J, v Beurden V, Stoter G, Verweij J (1997) Patient perceptions of the side-effects of chemotherapy: the influence of 5HT3 antagonists. Br J Cancer 76(8):1055–1061
3. Osoba D, Zee B, Warr D, Kaizer L, Latreille J, Pater J (1996) Quality of life studies in chemotherapy-induced emesis. Oncology 53(Suppl 1):92–95
4. NCCN (2015) Guidelines® Antiemesis., http://www.nccn.org/professionals/physician_gls/pdf/antiemesis.pdf. Accessed 26 February 2016
5. MASCC/ESMO Antiemetic Guideline 2016 (2016) http://www.mascc.org/assets/Guidelines-Tools/mascc_antiemetic_guidelines_english_2016_v.1.0.pdf. Accessed 26 February 2016
6. Meattini I, Francolini G, Scotti V, De Luca CC, Cappelli S, Meacci F, Furfaro IF, Muntoni C, Scoccianti S, Detti B, Mangoni M, Nori J, Orzalesi L, Fambrini M, Bianchi S, Livi L (2015) Aprepitant as prophylaxis of chemotherapy-induced nausea and vomiting in anthracyclines and cyclophosphamide-based regimen for adjuvant breast cancer. Med Oncol 32(3):80. doi:10.1007/s12032-015-0535-9
7. Warr DG, Hesketh PJ, Gralla RJ, Muss HB, Herrstedt J, Eisenberg PD, Raftopoulos H, Grunberg SM, Gabriel M, Rodgers A, Bohidar N, Klinger G, Hustad CM, Horgan KJ, Skobieranda F (2005) Efficacy and tolerability of aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with breast cancer after moderately emetogenic chemotherapy. J Clin Oncol 23(12):2822–2830. doi:10.1200/JCO.2005.09.050
8. Giacosa A, Morazzoni P, Bombardelli E, Riva A, Bianchi Porro G, Rondanelli M (2015) Can nausea and vomiting be treated with ginger extract? Eur Rev Med Pharmacol Sci 19(7):1291–1296
9. Chrubasik S, Pittler MH, Roufogalis BD (2005) Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 12(9):684–701. doi:10.1016/j.phymed.2004.07.009
10. Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, Leeprakobboon K, Leelasettagool C (2006) The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis. Am J Obstet Gynecol 194(1):95–99. doi:10.1016/j.ajog.2005.06.046
11. Viljoen E, Visser J, Koen N, Musekiwa A (2014) A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutr J 13:20. doi:10.1186/1475-2891-13-20
12. Thomson M, Corbin R, Leung L (2014) Effects of ginger for nausea and vomiting in early pregnancy: a meta-analysis. J Am Board Fam Med 27(1):115–122. doi:10.3122/jabfm.2014.01.130167
13. Ryan JL, Heckler CE, Roscoe JA, Dakhil SR, Kirshner J, Flynn PJ, Hickok JT, Morrow GR (2012) Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer 20(7):1479–1489. doi:10.1007/s00520-011-1236-3
14. Manusirivithaya S, Sripramote M, Tangjitgamol S, Sheanakul C, Leelahakorn S, Thavaramara T, Tangcharoenpanich K (2004) Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin. Int J Gynecol Cancer 14(6):1063–1069. doi:10.1111/j.1048-891X.2004.14603.x
15. Panahi Y, Saadat A, Sahebkar A, Hashemian F, Taghikhani M, Abolhasani E (2012) Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: a pilot, randomized, open-label clinical trial. Integr Cancer Ther 11(3):204–211. doi:10.1177/1534735411433201
16. Pillai AK, Sharma KK, Gupta YK, Bakhshi S (2011) Anti-emetic effect of ginger powder versus placebo as an add-on therapy in children and young adults receiving high emetogenic chemotherapy. Pediatr Blood Cancer 56(2):234–238. doi:10.1002/pbc.22778
17. Sontakke S, Thawani V, Naik M (2003) Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: a randomized, cross-over, double blind study. Indian J Pharmacol 35:32–36
18. Zick SM, Ruffin MT, Lee J, Normolle DP, Siden R, Alrawi S, Brenner DE (2009) Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting. Support Care Cancer 17(5):563–572. doi:10.1007/s00520-008-0528-8
19. Lee J, Oh H (2013) Ginger as an antiemetic modality for chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis. Oncol Nurs Forum 40(2):163–170. doi:10.1188/13.ONF.163-170
20. Schwertner HA, Rios DC (2007) High-performance liquid chromatographic analysis of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in ginger-containing dietary supplements, spices, teas, and beverages. J Chromatogr B Analyt Technol Biomed Life Sci 856(1-2):41–47. doi:10.1016/j.jchromb.2007.05.011
21. Mandal P, Das A, Majumdar S, Bhattacharyya T, Mitra T, Kundu R (2014) The efficacy of ginger added to ondansetron for preventing postoperative nausea and vomiting in ambulatory surgery. Pharmacognosy Res 6(1):52–57. doi:10.4103/0974-8490.122918