The effects of fat loss after bariatric surgery on inflammation, serum hepcidin, and iron absorption: A prospective 6-mo iron stable isotope study

American Journal of Clinical Nutrition

Volumn 104, Issue 4, 2016, Pages 1030-1038

  Cepeda Lopez, Ana C ^a,b   Allende Labastida, Javier ^b   Melse Boonstra, Alida ^a   Osendarp, Saskia J M ^a,c   Herter Aeberli, Isabelle ^d   Moretti, Diego ^d   Rodriguez Lastra, Ramiro ^b   Gonzalez Salazar, Francisco ^b   Villalpando, Salvador ^e   Zimmermann, Michael B ^d  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b UNIVERSIDAD DE MONTERREY   (Mexico)

^c MICRONUTRIENT INITIATIVE   (Canada)

^d ETH ZURICH   (Switzerland)

^e INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

Author keywords

Hepcidin; Inflammation; Iron absorption; Iron deficiency; Obesity; Stable isotopes

Indexed keywords

ALPHA1 GLYCOPROTEIN; BIOLOGICAL MARKER; FERRIC CITRATE FE 58; FERRITIN; FERROUS SULFATE FE 57; HEMOGLOBIN; HEPCIDIN; INTERLEUKIN 6; IRON; LEPTIN; STABLE ISOTOPE; TRANSFERRIN RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; FERROUS ION; FERROUS SULFATE;

ADULT; ANEMIA; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; CLINICAL ARTICLE; ERYTHROCYTE; FAT MASS; FEMALE; FERRITIN BLOOD LEVEL; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFLAMMATION; IRON ABSORPTION; IRON BLOOD LEVEL; IRON DEFICIENCY; LAPAROSCOPIC SURGERY; MALE; MEAN CORPUSCULAR VOLUME; OBESITY; PROSPECTIVE STUDY; SLEEVE GASTRECTOMY; TREATMENT DURATION; UPREGULATION; WEIGHT REDUCTION; ADIPOSE TISSUE; ANEMIA, IRON-DEFICIENCY; BARIATRIC SURGERY; BLOOD; COMPLICATION; DEFICIENCY; INTESTINE ABSORPTION; METABOLISM; NUTRITIONAL STATUS; PATHOLOGY; PHYSIOLOGY; REFERENCE VALUE;

ADIPOSE TISSUE; ADIPOSITY; ADULT; ANEMIA, IRON-DEFICIENCY; BARIATRIC SURGERY; BODY COMPOSITION; BODY MASS INDEX; ERYTHROCYTES; FEMALE; FERROUS COMPOUNDS; HEPCIDINS; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTESTINAL ABSORPTION; IRON; IRON ISOTOPES; MALE; NUTRITIONAL STATUS; OBESITY; PROSPECTIVE STUDIES; REFERENCE VALUES; WEIGHT LOSS;

EID: 84990059026     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.115.115592     Document Type: Article

References (42)

1. Popkin BM, Slining MM. New dynamics in global obesity facing lowand middle-income countries. Obes Rev 2013;14(Suppl 2):11-20.
2. Griffiths PL, Bentley ME. The nutrition transition is underway in India. J Nutr 2001;131:2692-700.
3. Doak CM, Adair L, Bentley M, Monteiro C, Popkin BM. The dual burden household and the nutrition transition paradox. Int J Obes (Lond) 2005;29:129-36.
4. Brotanek JM, Gosz J, Weitzman M, Flores G. Iron deficiency in early childhood in the United States: risk factors and racial/ethnic disparities. Pediatrics 2007;120:568-75.
5. Chandra RK, Kutty KM. Immunocompetence in obesity. Acta Paediatr Scand 1980;69:25-30.
6. Moayeri H, Bidad K, Zadhoush S, Gholami N, Anari S. Increasing prevalence of iron deficiency in overweight and obese children and adolescents (Tehran Adolescent Obesity Study). Eur J Pediatr 2006; 165:813-4.
7. Nead KG, Halterman JS, Kaczorowski JM, Auinger P, Weitzman M. Overweight children and adolescents: a risk group for iron deficiency. Pediatrics 2004;114:104-8.
8. Pinhas-Hamiel O, Newfield RS, Koren I, Agmon A, Lilos P, Phillip M. Greater prevalence of iron deficiency in overweight and obese children and adolescents. Int J Obes Relat Metab Disord 2003;27:416-8.
9. Scheer JC, Guthrie HA. Hemoglobin criteria with respect to obesity. Am J Clin Nutr 1981;34:2748-51.
10. Seltzer CC, Mayer J. Serum iron and iron-binding capacity in adolescents. Comparison of obese and nonobese subjects. Am J Clin Nutr 1963;13:354-61.
11. Wenzel BJ, Stults H, Mayer J. Hypoferraemia in obese adolescents. Lancet 1962;2:327-8.
12. Haas JD, Brownlie T. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr 2001;131(2s-2):676S-88S; discussion 88S-90S.
13. Mejía-Rodriguez F, Shamah-Levy T, Villalpando S, Garcia-Guerra A, Mendez-Gomez Humaran I. Iron, zinc, copper and magnesium deficiencies in Mexican adults from the National Health and Nutrition Survey 2006. Salud Publica Mex 2013;55:275-84.
14. Barquera S, Campos-Nonato I, Hernández-Barrera L, Pedroza-Tobías A, Rivera-Dommarco J. Prevalencia de obesidad en adultos mexicanos, ENSANUT 2012. [Prevalence of obesity in Mexican adults, ENSANUT 2012.] Salud Publica Mex 2013;55:151-60 (in Spanish).
15. Food and Agriculture Organization of the United Nations. The state of food and agriculture 2013: Food Systems for Better Nutrition. Rome: Food and Agriculture Organization of the United Nations; 2013. Available from: http://www.fao.org/docrep/018/i3300e/i3300e.pdf.
16. Rivera JA, Pedraza LS, Martorell R, Gil A. Introduction to the double burden of undernutrition and excess weight in Latin America. Am J Clin Nutr 2014;100:1613S-6S.
17. Menzie CM, Yanoff LB, Denkinger BI, McHugh T, Sebring NG, Calis KA, Yanovski JA. Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption. J Am Diet Assoc 2008; 108:145-8.
18. Yanoff LB, Menzie CM, Denkinger B, Sebring NG, McHugh T, Remaley AT, Yanovski JA. Inflammation and iron deficiency in the hypoferremia of obesity. Int J Obes (Lond) 2007;31:1412-9.
19. Aeberli I, Hurrell R, Zimmermann M. Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children. Int J Obes (Lond) 2009;33:1111-7.
20. Cepeda-Lopez AC, Osendarp SJ, Melse-Boonstra A, Aeberli I, Gonzalez-Salazar F, Feskens E, Villalpando S, Zimmermann MB. Sharply higher rates of iron deficiency in obese Mexican women and children are predicted by obesity-related inflammation rather than by differences in dietary iron intake. Am J Clin Nutr 2011;93:975-83.
21. Zimmermann MB, Zeder C, Muthayya S, Winichagoon P, Chaouki N, Aeberli I, Hurrell RF. Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification. Int J Obes (Lond) 2008;32:1098-104.
22. del Giudice EM, Santoro N, Amato A, Brienza C, Calabro P, Wiegerinck E, Cirillo G, Tartaglione N, Grandone A, Swinkels D, et al. Hepcidin in obese children as a potential mediator of the association between obesity and iron deficiency. J Clin Endocrinol Metab 2009;94:5102-7.
23. Tussing-Humphreys LM, Nemeth E, Fantuzzi G, Freels S, Guzman G, Holterman AX, Braunschweig C. Elevated systemic hepcidin and iron depletion in obese premenopausal females. Obesity (Silver Spring) 2010;18:1449-56.
24. Tussing-Humphreys LM, Nemeth E, Fantuzzi G, Freels S, Holterman AX, Galvani C, Ayloo S, Vitello J, Braunschweig C. Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery. Obesity (Silver Spring) 2010;18:2010-6.
25. Fidler MC, Davidsson L, Zeder C, Walczyk T, Marti I, Hurrell RF. Effect of ascorbic acid and particle size on iron absorption from ferric pyrophosphate in adult women. Int J Vitam Nutr Res 2004;74:294-300.
26. Moretti D, ZimmermannMB, Wegmuller R, Walczyk T, Zeder C, Hurrell RF. Iron status and food matrix strongly affect the relative bioavailability of ferric pyrophosphate in humans. Am J Clin Nutr 2006;83:632-8.
27. Gibson RS. Principles of nutritional assessment, 2nd ed. New York: Oxford University Press; 2005.
28. World Health Organization/Centers for Disease Control and Prevention. Assessing the iron status of populations: report of a joint World Health Organization/Centers for Disease Control and Prevention technical consultation on the assessment of iron status at the population level. Geneva (Switzerland): World Health Organization; 2004. Available from: http://www.who.int/nutrition/publications/micronutrients/ anaemia-iron-deficiency/9789241596107.pdf.
29. Barrett JF, Whittaker PG, Williams JG, Lind T. Absorption of nonhaem iron in normal women measured by the incorporation of two stable isotopes into erythrocytes. Clin Sci (Lond) 1992;83:213-9.
30. Fairweather-Tait SJ, Dainty J. Use of stable isotopes to assess the bioavailability of trace elements: a review. Food Addit Contam 2002;19:939-47.
31. Walczyk T, Davidsson L, Zavaleta N, Hurrell RF. Stable isotope labels as a tool to determine the iron absorption by Peruvian school children from a breakfast meal. Fresenius J Anal Chem 1997;359:445-9.
32. Mujica-Coopman MF, Brito A, Lopez de Romana D, Pizarro F, Olivares M. Body mass index, iron absorption and iron status in childbearing age women. J Trace Elem Med Biol 2015;30:215-9.
33. Cepeda-Lopez AC, Melse-Boonstra A, Zimmermann MB, Herter- Aeberli I. In overweight and obese women, dietary iron absorption is reduced and the enhancement of iron absorption by ascorbic acid is one-half that in normal-weight women. Am J Clin Nutr 2015;102: 1389-97.
34. Amato A, Santoro N, Calabro P, Grandone A, Swinkels D, Perrone L, del Giudice E. Effect of body mass index reduction on serum hepcidin levels and iron status in obese children. Int J Obes (Lond) 2010;34:1772-4.
35. Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol 2009;122:78-86.
36. Mraz M, Haluzik M. The role of adipose tissue immune cells in obesity and low-grade inflammation. J Endocrinol 2014;222:R113-R127.
37. van Santen S, de Mast Q, Oosting JD, van Ede A, Swinkels DW, van der Ven AJ. Hematological parameters predicting a response to oral iron therapy in chronic inflammation. Haematologica 2014;99:e171-3.
38. Baynes R, Bezwoda W, Bothwell T, Khan Q, Mansoor N. The nonimmune inflammatory response: serial changes in plasma iron, ironbinding capacity, lactoferrin, ferritin and C-reactive protein. Scand J Clin Lab Invest 1986;46:695-704.
39. Pasricha SR, McQuilten Z, Westerman M, Keller A, Nemeth E, Ganz T, Wood E. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica 2011;96:1099-105.
40. Ruz M, Carrasco F, Rojas P, Codoceo J, Inostroza J, Basfi-fer K, Valencia A, Csendes A, Papapietro K, Pizarro F, et al. Heme- and nonheme-iron absorption and iron status 12 mo after sleeve gastrectomy and Roux-en-Y gastric bypass in morbidly obese women. Am J Clin Nutr 2012;96:810-7.
41. Popkin BM, Adair LS, Ng SW. Global nutrition transition and the pandemic of obesity in developing countries. Nutr Rev 2012;70:3-21.
42. Baumgartner J, Smuts CM, Aeberli I, Malan L, Tjalsma H, Zimmermann MB. Overweight impairs efficacy of iron supplementation in iron-deficient South African children: a randomized controlled intervention. Int J Obes (Lond) 2013;37:24-30.