Sharply higher rates of iron deficiency in obese Mexican women and children are predicted by obesity-related inflammation rather than by differences in dietary iron intake

American Journal of Clinical Nutrition

Volumn 93, Issue 5, 2011, Pages 975-983

  Cepeda Lopez, Ana C ^a,f   Osendarp, Saskia J M ^a,b   Melse Boonstra, Alida ^a   Aeberli, Isabelle ^c   Gonzalez Salazar, Francisco ^e,f   Feskens, Edith ^a   Villalpando, Salvador ^d   Zimmermann, Michael B ^a,c  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

^c Institute of Food Science and Nutrition   (Switzerland)

^d INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

^e INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^f UNIVERSIDAD DE MONTERREY   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN;

ADULT; ARTICLE; BIOAVAILABILITY; BODY MASS; CHILD; CONTROLLED STUDY; FEMALE; HUMAN; INFLAMMATION; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON DEFICIENCY; IRON INTAKE; MAJOR CLINICAL STUDY; MALE; MEXICO; NUTRITIONAL ASSESSMENT; OBESITY; PRESCHOOL CHILD; PREVALENCE; PROTEIN BLOOD LEVEL; SCHOOL CHILD;

EID: 79955418372     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.110.005439     Document Type: Article

References (51)

1. Chandra RK, Kutty KM. Immunocompetence in obesity. Acta Paediatr Scand 1980;69:25-30. (Pubitemid 10205490)
2. Scheer JC, Guthrie HA. Hemoglobin criteria with respect to obesity. Am J Clin Nutr 1981;34:2748-51. (Pubitemid 12223921)
3. Micozzi MS, Albanes D, Stevens RG. Relation of body size and composition to clinical biochemical and hematologic indices in US men and women. Am J Clin Nutr 1989;50:1276-81. (Pubitemid 20013307)
4. Rossi E, Bulsara MK, Olynyk JK, Cullen DJ, Summerville L, Powell LW. Effect of hemochromatosis genotype and lifestyle factors on iron and red cell indices in a community population. Clin Chem 2001 ;47: 202-8. (Pubitemid 32142917)
5. Pinhas-Hamiel O, Newfield RS, Koren I, Agmon A, Lilos P, Phillip M. Greater prevalence of iron deficiency in overweight and obese children and adolescents. Int J Obes Relat Metab Disord 2003;27:416-8. (Pubitemid 36384882)
6. Whitfield JB, Treloar S, Zhu G, Powell LW, Martin NG. Relative importance of female-specific and non-female-specific effects on variation in iron stores between women. Br J Haematol 2003;120:860-6. (Pubitemid 36315112)
7. Nead KG, Halterman JS, Kaczorowski JM, Auinger P, Weitzman M. Overweight children and adolescents: a risk group for iron deficiency. Pediatrics 2004;114:104-8. (Pubitemid 38857573)
8. Lecube A, Carrera A, Losada E, Hernandez C, Simo R, Mesa J. Iron deficiency in obese postmenopausal women. Obesity (Silver Spring) 2006;14:1724-30. (Pubitemid 46214794)
9. Moayeri H, Bidad K, Zadhoush S, Gholami N, Anari S. Increasing prevalence of iron deficiency in overweight and obese children and adolescents (Tehran Adolescent Obesity Study). Eur J Pediatr 2006;165:813-4. (Pubitemid 44440523)
10. Yanoff LB, Menzie CM, Denkinger B, et al. Inflammation and iron deficiency in the hypoferremia of obesity. Int J Obes (Lond) 2007;31: 1412-9. (Pubitemid 47339930)
11. Brotanek JM, Gosz J, Weitzman M, Flores G. Iron deficiency in early childhood in the United States: risk factors and racial/ethnic disparities. Pediatrics 2007;120:568-75. (Pubitemid 47358300)
12. Menzie CM, Yanoff LB, Denkinger BI, et al. Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption. J Am Diet Assoc 2008;108:145-8. (Pubitemid 350301976)
13. Ausk KJ, Ioannou GN. Is obesity associated with anemia of chronic disease? A population-based study. Obesity (Silver Spring) 2008;16: 2356-61.
14. Tussing-Humphreys LM, Liang H, Nemeth E, Freels S, Braunschweig CA. Excess adiposity, inflammation, and iron-deficiency in female adolescents. J Am Diet Assoc 2009;109:297-302.
15. Aeberli I, Hurrell RF, Zimmermann MB. Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children. Int J Obes (Lond) 2009;33:1111-7.
16. Seltzer CC, Mayer J. Serum iron and iron-binding capacity in adolescents. 2. comparison of obese and nonobese subjects. Am J Clin Nutr 1963;13:354-61.
17. Zimmermann MB, Zeder C, Muthayya S, et al. Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification. Int J Obes (Lond) 2008;32:1098-104. (Pubitemid 351986198)
18. Food and Agriculture Organization of the United Nations. The double burden of malnutrition. Case studies from six developing countries. FAO Food Nutr Pap 2006;84:1-334.
19. Rivera JA, Sepulveda Amor J. Conclusions from the Mexican National Nutrition Survey 1999: translating results into nutrition policy. Salud Publica Mex 2003;45:S565-75. (Pubitemid 38055245)
20. Stoltzfus RJ. Iron deficiency: global prevalence and consequences. Food Nutr Bull 2003;24:S99-103.
21. Saloojee H, Pettifor JM. Iron deficiency and impaired child development. BMJ 2001;323:1377-8. (Pubitemid 33152485)
22. Prentice AM, Moore SE. Early programming of adult diseases in resource poor countries. Arch Dis Child 2005;90:429-32. (Pubitemid 40488690)
23. Adair LS, Prentice AM. A critical evaluation of the fetal origins hypothesis and its implications for developing countries. J Nutr 2004;134: 191-3. (Pubitemid 38057447)
24. Fair SA, Yamada KA, Butterfield DA, et al. Obesity and hypertriglyceridemia produce cognitive impairment. Endocrinology 2008; 149:2628-36. (Pubitemid 351574482)
25. Instituto Nacional de Salud Pública. Encuesta Nacional de Nutrición 1999. [The 1999 Mexican National Nutrition Survey] Cuernavaca Morelos, Mexico: INSP, 2000 (in Spanish).
26. Resano-Pérez E, Méndez-Ramírez I, Shamah-Levy T, Rivera JA, Sepúlveda-Amor J. Methods of the National Nutrition Survey 1999. Salud Publica Mex 2003;45:S558-64. (Pubitemid 38055244)
27. Instituto Nacional de Estadistica Geografía e Informática. Resultados del Conteo de Población y Vivienda de 1995. [Census of Population and Housing 1995, Final Results.] Mexico City, Mexico: INEGI, 1995 (in Spanish).
28. Villalpando SA, García-Guerra CI, Ramírez-Silva F, et al. Iron, zinc and iodide status in Mexican children under 12 years and women 12-49 years of age. A probabilistic national survey. Salud Publica Mex 2003; 45:S520-9.
29. Barquera S, Rivera JA, Safdie M, Flores M, Campos-Nonato I, Campirano F. Energy and nutrient intake in preschool and school age Mexican children: National Nutrition Survey 1999. Salud Publica Mex 2003;45:S540-50. (Pubitemid 38055242)
30. Reyment R, Jöreskog K. Applied factor analysis in the natural sciences. Cambridge, United Kingdom: Cambridge University Press, 1996:371.
31. US Department of Agriculture, Agricultural Research Service. USDA nutrient database for standard reference, release 13. Washington, DC: USDA, 1999.
32. Food composition database. Davis, CA: University of California-Davis, 1998.
33. Instituto de Nutrición de Centroamérica y Panamá INCAP-ICNND. Tabla de composición de alimentos para uso en América Latina. [Food composition table for use in Latin America.] Guatamala: PAHO, IN-CAP, Ed, 1961:98.
34. Morales J, Babinsky V, Bourges H, Camacho M. Tablas de Composición de Alimentos Mexicanos del Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubirán. [Mexican food composition tables of the National Institute of Medical Sciences and Nutrition Salvador Zubirán.] Mexico City, Mexico: Instituto Nacional de Nutrición, 1999.
35. WHO. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 2000;894:1-253.
36. De Onis M, Onyango A, Borghi E, Siyam A, Nishida C, Siekmann J. The new WHO child growth standards. Bull World Health Organ 2007; 85:660-7.
37. National Academy of Sciences. Dietary Reference Intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: Institute of Medicine Food and Nutrition Board, 2001.
38. Wenzel B, Stults H, Mayer J. Hypoferremia in obese adolescents. Lancet 1962;280:327-8.
39. Chambers EC, Heshka S, Gallagher D, Wang J, Pi-Sunyer FX, Pierson JRN. Serum iron and body fat distribution in a multiethnic cohort of adults living in New York City. J Am Diet Assoc 2006;106:680-4.
40. Aeberli I, Kaspar M, Zimmermann MB. Dietary intake and physical activity of normal weight and overweight 6- to 14-year-old Swiss children. Swiss Med Wkly 2007;137:424-30. (Pubitemid 47195515)
41. Barquera S, Rivera JA, Espinosa-Montero J, Safdie M, Campirano F, Monterrubio EA. Energy and nutrient consumption in Mexican women 12-49 years of age: analysis of the National Nutrition Survey 1999. Salud Publica Mex 2003;45:S530-9. (Pubitemid 38063070)
42. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults. JAMA 1999; 282:2131-5.
43. Chen SB, Lee YC, Ser KH, Chen SC, Hsieh HF, Lee WJ. Serum C-reactive protein and white blood cell count in morbidly obese surgical patients. Obes Surg 2009;19:461-6.
44. Bekri S, Gual P, Anty R, et al. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 2006; 131:788-96. (Pubitemid 44316823)
45. Tussing-Humphreys LM, Nemeth E, Fantuzzi G, et al. Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery. Obesity (Silver Spring) 2010;18: 2010-6.
46. Amato A, Santoro N, Calabrò P, et al. Effect of body mass index reduction on serum hepcidin levels and iron status in obese children. Int J Obes (Lond) 2010;34:1772-4.
47. Nemeth ER, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004;113:1271-6. (Pubitemid 39069926)
48. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003;101:2461-3. (Pubitemid 36857598)
49. Wang Y, Lam KSL, Kraegen EW, et al. Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin Chem 2007;53:34-41. (Pubitemid 46047761)
50. Tseng M, Chakraborty H, Robinson DT, Mendez M, Kohlmeier L. Adjustment of iron intake for dietary enhancers and inhibitors in population studies: bioavailable iron in rural and urban residing russian women and children. J Nutr 1997;127:1456-68. (Pubitemid 27323454)
51. Rivera J, Shamah T, Villalpando S, Monterrubio E. Effectiveness of a large-scale iron-fortified milk distribution program on anemia and iron deficiency in low-income young children in Mexico. Am J Clin Nutr 2010;91:431-9.