The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies

American Journal of Obstetrics and Gynecology

Volumn 214, Issue 2, 2016, Pages 273.e1-273.e8

  Sciascia, S ^a,b   Hunt, B J ^a   Talavera Garcia, E ^a   Lliso, G ^a   Khamashta, M A ^a   Cuadrado, M J ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

antiphospholipid antibodies; antiphospholipid syndrome; hydroxychloroquine; pregnancy

Indexed keywords

ACETYLSALICYLIC ACID; HEPARIN; HYDROXYCHLOROQUINE; PHOSPHOLIPID ANTIBODY; STEROID; ANTINUCLEAR ANTIBODY; ANTIRHEUMATIC AGENT; AZATHIOPRINE; GLUCOCORTICOID; PREDNISOLONE;

ADULT; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FETUS WASTAGE; HUMAN; LABOR COMPLICATION; LIVE BIRTH; LOW DRUG DOSE; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; OBSERVATIONAL STUDY; PREGNANCY; PREGNANCY OUTCOME; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SPONTANEOUS VAGINAL LABOR; SYSTEMIC LUPUS ERYTHEMATOSUS; ADOLESCENT; CASE CONTROL STUDY; COMORBIDITY; IMMUNOLOGY; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIVARIATE ANALYSIS; OBSTETRIC DELIVERY; ODDS RATIO; PREGNANCY COMPLICATIONS; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; ANTIRHEUMATIC AGENTS; AZATHIOPRINE; CASE-CONTROL STUDIES; COHORT STUDIES; COMORBIDITY; DELIVERY, OBSTETRIC; FEMALE; GLUCOCORTICOIDS; HUMANS; HYDROXYCHLOROQUINE; LOGISTIC MODELS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIVARIATE ANALYSIS; ODDS RATIO; PREDNISOLONE; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84989803072     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2015.09.078     Document Type: Article

References (36)

1. S. Miyakis, M.D. Lockshin, T. Atsumi, and et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) J Thromb Haemost 4 2006 295 306
2. G. Ruiz-Irastorza, M. Crowther, W. Branch, and M.A. Khamashta Antiphospholipid syndrome Lancet 376 2010 1498 1509
3. M. Petri Epidemiology of the antiphospholipid antibody syndrome J Autoimmun 15 2000 145 151
4. E. Papadopolous, L. Magder, and M. Petri Antiphospholipid antibodies and venous thrombosis (VT) in SLE Arthritis Rheum 42 suppl 9 1999 S369
5. R.G. Farquharson, S. Quenby, and M. Greaves Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment Obstet Gynecol 100 2002 408 413
6. R. Rai, and L. Regan Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment Obstet Gynecol 100 2002 1354
7. K. Bramham, B.J. Hunt, S. Germain, and et al. Pregnancy outcome in different clinical phenotypes of antiphospholipid syndrome Lupus 19 2010 58 64
8. S. Bouvier, E. Cochery-Nouvellon, G. Lavigne-Lissalde, and et al. Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study Blood 123 2014 404 413
9. K. Bramham, M. Thomas, C. Nelson-Piercy, M. Khamashta, and B.J. Hunt First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss Blood 117 2011 6948 6951
10. A. Tincani, W. Branch, R.A. Levy, and et al. Treatment of pregnant patients with antiphospholipid syndrome Lupus 12 2003 524 529
11. G. Ruiz-Irastorza, M.V. Egurbide, J.I. Pijoan, and et al. Effect of antimalarials on thrombosis and survival in patients with systemic lupus erythematosus Lupus 15 2006 577 583
12. G. Ruiz-Irastorza, M. Ramos-Casals, P. Brito-Zeron, and M.A. Khamashta Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review Ann Rheum Dis 69 2010 20 28
13. S.K. Shinjo, E. Bonfa, D. Wojdyla, and et al. Antimalarial treatment may have a time-dependent effect on lupus survival: data from a multinational Latin American inception cohort Arthritis Rheum 62 2010 855 862
14. J. Alijotas-Reig Treatment of refractory obstetric antiphospholipid syndrome: the state of the art and new trends in the therapeutic management Lupus 22 2013 6 17
15. A. Tincani, G. Balestrieri, E. Danieli, and et al. Pregnancy complications of the antiphospholipid syndrome Autoimmunity 36 2003 27 32
16. M.J. Mulla, J.J. Brosens, L.W. Chamley, and et al. Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway Am J Reprod Immunol 62 2009 96 111
17. C.R. Albert, W.J. Schlesinger, C.A. Viall, and et al. Effect of hydroxychloroquine on antiphospholipid antibody-induced changes in first trimester trophoblast function Am J Reprod Immunol 71 2014 154 164
18. T. Marchetti, A. Ruffatti, C. Wuillemin, P. de Moerloose, and M. Cohen Hydroxychloroquine restores trophoblast fusion affected by antiphospholipid antibodies J Thromb Haemost 12 2014 910 920
19. B.J. Hunt A novel antiphospholipid antibody agent? Blood 115 2010 2124 2125
20. A. Parke Antimalarial drugs and pregnancy Am J Med 85 1988 30 33
21. A.L. Parke Antimalarial drugs, systemic lupus erythematosus and pregnancy J Rheumatol 15 1988 607 610
22. N.M. Buchanan, E. Toubi, M.A. Khamashta, F. Lima, S. Kerslake, and G.R. Hughes Hydroxychloroquine and lupus pregnancy: review of a series of 36 cases Ann Rheum Dis 55 1996 486 488
23. M.E. Clowse, L. Magder, F. Witter, and M. Petri Hydroxychloroquine in lupus pregnancy Arthritis Rheum 54 2006 3640 3647
24. G. Bertsias, J.P. Ioannidis, J. Boletis, and et al. EULAR recommendations for the management of systemic lupus erythematosus: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics Ann Rheum Dis 67 2008 195 205
25. A. Mekinian, M.G. Lazzaroni, A. Kuzenko, and et al. The efficacy of hydroxychloroquine for obstetrical outcome in anti-phospholipid syndrome: data from a European multicenter retrospective study Autoimmun Rev 14 2015 498 502
26. V. Pengo, A. Tripodi, G. Reber, and et al. Update of the guidelines for lupus anticoagulant detection: Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis J Thromb Haemost 7 2009 1737 1740
27. NICE guidelines. Hypertension: clinical management of primary hypertension in adults. Available at: http://www.nice.org.uk/guidance/cg127. Accessed January 2015.
28. NICE quality standard. Cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease. Available at: http://www.nice.org.uk/guidance/qs28. Accessed January 2015.
29. NICE guidelines. Type 2 diabetes: the management of type 2 diabetes. Available at: http://www.nice.org.uk/guidance/CG87. Accessed January 2015.
30. M.C. Hochberg Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 40 1997 1725
31. A. Mekinian, N. Costedoat-Chalumeau, A. Masseau, and et al. Obstetrical APS: Is there a place for hydroxychloroquine to improve the pregnancy outcome? Autoimmun Rev 14 2015 23 29
32. N. Costedoat-Chalumeau, J.S. Hulot, Z. Amoura, and et al. Heart conduction disorders related to antimalarials toxicity: an analysis of electrocardiograms in 85 patients treated with hydroxychloroquine for connective tissue diseases Rheumatology (Oxford) 46 2007 808 810
33. A. Osadchy, T. Ratnapalan, and G. Koren Ocular toxicity in children exposed in utero to antimalarial drugs: review of the literature J Rheumatol 38 2011 2504 2508
34. N. Costedoat-Chalumeau, Z. Amoura, P. Duhaut, and et al. Safety of hydroxychloroquine in pregnant patients with connective tissue diseases: a study of one hundred thirty-three cases compared with a control group Arthritis Rheum 48 2003 3207 3211
35. X.X. Wu, S. Guller, and J.H. Rand Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression Am J Obstet Gynecol 205 2011 576.e7 576.e14
36. J.H. Rand, X.X. Wu, A.S. Quinn, P.P. Chen, J.J. Hathcock, and D.J. Taatjes Hydroxychloroquine directly reduces the binding of antiphospholipid antibody-beta2-glycoprotein I complexes to phospholipid bilayers Blood 112 2008 1687 1695