A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways

Fitoterapia

Volumn 115, Issue , 2016, Pages 37-45

  Yan, Ting ^a,b   Yu, Xiangyong ^a   Sun, Xianduo ^c   Meng, Dali ^a   Jia, Jing ming ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b JINZHOU MEDICAL UNIVERSITY   (China)

^c GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti inflammatory; Furotrilliumoside; Nrf2 HO 1; PI3K Akt; RAW264.7; Trillium tschonoskii

Indexed keywords

AGLYCONE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; ENZYME; FUROTRILLIUMOSIDE; GLUCOPYRANOSIDE; GLUCOSE; HEME OXYGENASE 1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; METHYL GROUP; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROTEIN KINASE B; RHAMNOSE; SAPONIN DERIVATIVE; TETRASACCHARIDE; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE; SAPONIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; DOWN REGULATION; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; ELECTROSPRAY MASS SPECTROMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; RAW 264.7 CELL LINE; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRILLIUM; TRILLIUM TSCHONOSKII; UPREGULATION; ANIMAL; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; PLANT ROOT; RHIZOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLOOXYGENASE 2; HEME OXYGENASE-1; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHATIDYLINOSITOL 3-KINASES; PLANT ROOTS; PROTO-ONCOGENE PROTEINS C-AKT; RAW 264.7 CELLS; RHIZOME; SAPONINS; SIGNAL TRANSDUCTION; TRILLIUM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84989323285     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2016.09.012     Document Type: Article

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