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Volumn 116, Issue 4, 2016, Pages 669-678

Peptides inhibiting heparanase procoagulant activity significantly reduce tumour growth and vascularisation in a mouse model

Author keywords

Heparanase; Inhibitory peptides; Tissue factor; Tumour

Indexed keywords

HEPARANASE; PEPTIDE; PROCOAGULANT; THROMBIN ANTITHROMBIN COMPLEX; THROMBOPLASTIN; BETA GLUCURONIDASE;

EID: 84989196026     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH16-02-0119     Document Type: Article
Times cited : (20)

References (20)
  • 1
    • 0032521630 scopus 로고    scopus 로고
    • Human platelet heparanase: Purification, characterisation and catalytic activity
    • Freeman C, Parish CR. Human platelet heparanase: purification, characterisation and catalytic activity. Biochem J 1998; 330: 1341–1350.
    • (1998) Biochem J , vol.330 , pp. 1341-1350
    • Freeman, C.1    Parish, C.R.2
  • 2
    • 0032563303 scopus 로고    scopus 로고
    • Substrate specificity of heparanases from human hepatoma and platelets
    • Pikas DS, Li JP, Vlodavsky I, et al. Substrate specificity of heparanases from human hepatoma and platelets. J Biol Chem 1998; 273: 18770–18777.
    • (1998) J Biol Chem , vol.273 , pp. 18770-18777
    • Pikas, D.S.1    Li, J.P.2    Vlodavsky, I.3
  • 3
    • 0035091164 scopus 로고    scopus 로고
    • Heparanase: A key enzyme involved in cell invasion
    • Parish CR, Freeman C, Hulett MD. Heparanase: a key enzyme involved in cell invasion. Biochim Biophys Acta 2001; 1471: M99–108.
    • (2001) Biochim Biophys Acta , vol.1471 , pp. M99-108
    • Parish, C.R.1    Freeman, C.2    Hulett, M.D.3
  • 4
    • 0034904048 scopus 로고    scopus 로고
    • Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis
    • Vlodavsky I, Friedmann Y. Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J Clin Invest 2001; 108: 341–347.
    • (2001) J Clin Invest , vol.108 , pp. 341-347
    • Vlodavsky, I.1    Friedmann, Y.2
  • 5
    • 2542494203 scopus 로고    scopus 로고
    • Heparanase induces endothelial cell migration via protein kinase B/Akt activation
    • Gingis-Velitski S, Zetser A, Flugelman MY, et al. Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem 2004; 279: 23536–23541.
    • (2004) J Biol Chem , vol.279 , pp. 23536-23541
    • Gingis-Velitski, S.1    Zetser, A.2    Flugelman, M.Y.3
  • 6
    • 33646879997 scopus 로고    scopus 로고
    • Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence
    • Doviner V, Maly B, Kaplan V, et al. Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence. Mod Pathol 2006; 19: 878–888.
    • (2006) Mod Pathol , vol.19 , pp. 878-888
    • Doviner, V.1    Maly, B.2    Kaplan, V.3
  • 7
    • 0345275871 scopus 로고    scopus 로고
    • Heparanase affects adhesive and tumourigenic potential of human glioma cells
    • Zetser A, Bashenko Y, Miao HQ, et al. Heparanase affects adhesive and tumourigenic potential of human glioma cells. Cancer Res 2003; 63: 7733–7741.
    • (2003) Cancer Res , vol.63 , pp. 7733-7741
    • Zetser, A.1    Bashenko, Y.2    Miao, H.Q.3
  • 8
    • 57349130481 scopus 로고    scopus 로고
    • Heparanase induces VEGF C and facilitates tumour lymphangiogenesis
    • Cohen-Kaplan V, Naroditsky I, Zetser A, et al. Heparanase induces VEGF C and facilitates tumour lymphangiogenesis. Int J Cancer 2008; 123: 2566–2573.
    • (2008) Int J Cancer , vol.123 , pp. 2566-2573
    • Cohen-Kaplan, V.1    Naroditsky, I.2    Zetser, A.3
  • 9
    • 33750075728 scopus 로고    scopus 로고
    • Heparanase induces tissue factor expression in vascular endothelial and cancer cells
    • Nadir Y, Brenner B, Zetser A, et al. Heparanase induces tissue factor expression in vascular endothelial and cancer cells. J Thromb Haemost 2006; 4: 2443–2451.
    • (2006) J Thromb Haemost , vol.4 , pp. 2443-2451
    • Nadir, Y.1    Brenner, B.2    Zetser, A.3
  • 10
    • 38349148914 scopus 로고    scopus 로고
    • Heparanase induces tissue factor pathway inhibitor expression and extracellular accumulation in endothelial and tumour cells
    • Nadir Y, Brenner B, Gingis-Velitski S, et al. Heparanase induces tissue factor pathway inhibitor expression and extracellular accumulation in endothelial and tumour cells. Thromb Haemost 2008; 99: 133–141.
    • (2008) Thromb Haemost , vol.99 , pp. 133-141
    • Nadir, Y.1    Brenner, B.2    Gingis-Velitski, S.3
  • 11
    • 78149241704 scopus 로고    scopus 로고
    • Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII
    • Nadir Y, Brenner B, Fux L, et al. Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII. Haema-tologica 2010; 95: 1927–1934.
    • (2010) Haema-Tologica , vol.95 , pp. 1927-1934
    • Nadir, Y.1    Brenner, B.2    Fux, L.3
  • 12
    • 84933055934 scopus 로고    scopus 로고
    • Novel peptides that inhibit heparanase activation of the coagulation system
    • Axelman E, Henig I, Crispel Y, et al. Novel peptides that inhibit heparanase activation of the coagulation system. Thromb Haemost 2014; 112: 466–477.
    • (2014) Thromb Haemost , vol.112 , pp. 466-477
    • Axelman, E.1    Henig, I.2    Crispel, Y.3
  • 13
    • 3042637381 scopus 로고    scopus 로고
    • Processing and activation of latent heparanase occurs in lysosomes
    • Zetser A, Levy-Adam F, Kaplan V, et al. Processing and activation of latent heparanase occurs in lysosomes. J Cell Sci 2004; 117: 2249–2258.
    • (2004) J Cell Sci , vol.117 , pp. 2249-2258
    • Zetser, A.1    Levy-Adam, F.2    Kaplan, V.3
  • 14
    • 80054881473 scopus 로고    scopus 로고
    • An assay to evaluate heparanase procoagulant activity
    • Nadir Y, Kenig Y, Drugan A, et al. An assay to evaluate heparanase procoagulant activity. Thromb Res 2011; 128: e3–8.
    • (2011) Thromb Res , vol.128 , pp. e3-e8
    • Nadir, Y.1    Kenig, Y.2    Drugan, A.3
  • 15
    • 70449670332 scopus 로고    scopus 로고
    • Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening
    • Hammond E, Li CP, Ferro V. Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening. Anal Biochem 2010; 396: 112–116.
    • (2010) Anal Biochem , vol.396 , pp. 112-116
    • Hammond, E.1    Li, C.P.2    Ferro, V.3
  • 16
    • 0042366191 scopus 로고    scopus 로고
    • Biochemical characterisation of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells
    • McKenzie E, Young K, Hircock M, et al. Biochemical characterisation of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells. Biochem J 2003; 373: 423–435.
    • (2003) Biochem J , vol.373 , pp. 423-435
    • McKenzie, E.1    Young, K.2    Hircock, M.3
  • 17
    • 0035109328 scopus 로고    scopus 로고
    • The complex effects of heparins on cancer progression and metastasis in experimental studies
    • Smorenburg SM, Van Noorden CJ. The complex effects of heparins on cancer progression and metastasis in experimental studies. Pharmacol Rev 2001; 53: 93–105.
    • (2001) Pharmacol Rev , vol.53 , pp. 93-105
    • Smorenburg, S.M.1    Van Noorden, C.J.2
  • 18
    • 20244376337 scopus 로고    scopus 로고
    • The effect of low molecular weight heparin on survival in patients with advanced malignancy
    • Klerk CP, Smorenburg SM, Otten HM, et al. The effect of low molecular weight heparin on survival in patients with advanced malignancy. J Clin Oncol 2005; 23: 2130–2135.
    • (2005) J Clin Oncol , vol.23 , pp. 2130-2135
    • Klerk, C.P.1    Smorenburg, S.M.2    Otten, H.M.3
  • 19
    • 17144385138 scopus 로고    scopus 로고
    • Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism
    • Lee AY, Rickles FR, Julian JA, et al. Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism. J Clin Oncol 2005; 23: 2123–2129.
    • (2005) J Clin Oncol , vol.23 , pp. 2123-2129
    • Lee, A.Y.1    Rickles, F.R.2    Julian, J.A.3
  • 20
    • 84939998578 scopus 로고    scopus 로고
    • Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patients
    • Nadir Y, Sarig G, Axelman E, et al. Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patients. Thromb Res 2014; 134: 639–642.
    • (2014) Thromb Res , vol.134 , pp. 639-642
    • Nadir, Y.1    Sarig, G.2    Axelman, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.