Glucose homeostasis and insulin resistance: Prevalence, gender differences and predictors in adolescents

Diabetology and Metabolic Syndrome

Volumn 6, Issue 1, 2014, Pages

  Aldhoon Hainerová, Irena ^a,b   Zamrazilová, Hana ^a   Dušátková, Lenka ^a,b   Sedláčková, Barbora ^a,b   Hlavatý, Petr ^a   Hill, Martin ^a   Hampl, Richard ^a   Kunešová, Marie ^a   Hainer, Vojtěch ^a  

^a INSTITUTE OF ENDOCRINOLOGY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Adolescence; Glucose homeostasis; HOMA IR prediction; Insulin resistance; Metabolic syndrome; Obesity; Type 2 diabetes

Indexed keywords

GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; LIOTHYRONINE; SEX HORMONE BINDING GLOBULIN; THYROXINE; TRIACYLGLYCEROL;

ADOLESCENCE; ADOLESCENT; AGE; ARTICLE; BODY MASS; CARDIOMETABOLIC RISK; COHORT ANALYSIS; DISORDERS OF CARBOHYDRATE METABOLISM; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; IMPAIRED FASTING GLUCOSE; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE;

EID: 84989172825     PISSN: None     EISSN: 17585996     Source Type: Journal    
DOI: 10.1186/1758-5996-6-100     Document Type: Article

References (46)

1. Lee JM, Okumura MJ, Davis MM, Herman WH, Gurney JG: Prevalence and determinants of insulin resistance among U.S. adolescents: A population-based study. Diabetes Care 2006, 29:2427-2432.
2. Caprio S, Cline G, Boulware S, Permnente C, Shulman GI, Sherwin RS, Tamborlane WV: Effects of puberty and diabetes on metabolism of insulin-sensitive fuels. Am J Physiol 1994, 266:E885-E891.
3. Travers SH, Jeffers BW, Bloch CA, Hill JO, Eckel RH: Gender and Tanner stage differences in body composition and insulin sensitivity in early pubertal children. J Clin Endocrinol Metab 1995, 80:172-178.
4. Moran A, Jacobs DR Jr, Steinberger J, Hong C-P, Prineas R, Luepker RV, Sinaiko AR: Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes 1999, 48:2039-2044.
5. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
6. Conwell LS, Trost SG, Brown WJ, Batch JA: Indexes of insulin resistance and secretion in obese children and adolescents: A validation study. Diabetes Care 2004, 27:314-319.
7. Haymond MW: Measuring insulin resistance: A task worth doing: but how? Pediatr Diabetes 2003, 4:115-118.
8. Tresaco B, Bueno G, Pineda I, Moreno LA, Garagorri JM, Bueno M: Homeostatic model assessment (HOMA) index cut off values to identify the metabolic syndrome in children. J Physiol Biochem 2005, 61:381-388.
9. Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C: Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005, 115:e500-e503.
10. Kurtoǧlu S, Hatipoǧlu N, Mazicioǧlu M, Kendirici M, Keskin M, Kondolot M: Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods. J Clin Res Pediatr Endocrinol 2010, 2:100-106.
11. Rodden AM, Diaz VA, Mainous AG 3rd, Koopman RJ, Geesey ME: Insulin resistance in adolescents. J Pediatr 2007, 151:275-279.
12. Jiang X, Srinivasan SR, Radhakrishnamurthy B, Dalferes ER, Berenson GS: Racial (black-white) differences in insulin secretion and clearance in adolescents: The Bogalusa Heart Study. Pediatrics 1996, 97:357-360.
13. American Diabetes Association: Standards of medical care in diabetes-2010. Diabetes Care 2010, 33(Suppl 1):S11-S61.
14. Williams DE, Cadwell BL, Cheng YJ, Cowie CC, Gregg EW, Geiss LS, Engelgau MM, Narayan KM, Imperatore G: Prevalence of impaired fasting glucose and its relationship with cardiovascular disease risk factors in US adolescents, 1999-2000. Pediatrics 2005, 116:1122-1126.
15. Writing Group for the SEARCH for Diabetes in Youth Study Group, Dabelea D, Bell RA, D'Agostino RB Jr, Imperatore G, Johansen JM, Linder B, Liu LL, Loots B, Marcovina S, Mayer-Davis EJ, Pettitt DJ, Waitzfelder B: Incidence of diabetes in youth in the United States. JAMA 2007, 97:2716-2724.
16. Wiegand S, Maikowski U, Blankenstein O, Biebermann H, Tarnow P, Gröters A: Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity-A problem that is no longer restricted to minority groups. Eur J Endocrinol 2004, 151:199-206.
17. Mazur A, Grzywa M, Małecka-Tendera E, Telega G: Prevalence of glucose intolerance in school age children. Population based cross-sectional study. Acta Paediatr 2007, 96:1799-1802.
18. Malecka-Tendera E, Erhardt E, Molnár D: Type 2 diabetes mellitus in European children and adolescents. Acta Paediatr 2005, 94:543-546.
19. Lee S, Bacha F, Gungor N, Arslanian SA: Waist circumference is an independent predictor of insulin resistance in black and white youths. J Pediatr 2006, 148:188-194.
20. Xu L, Li M, Yin J, Cheng H, Yu M, Zhao X, Xiao X, Mi J: Change of body composition and adipokines and their relationship with insulin resistance across pubertal development in obese and nonobese Chinese children: The BCAMS study. Int J Endocrinol 2012, 2012:389108.
21. Bush NC, Darnell BE, Oster RA, Goran MI, Gower BA: Adiponectin is lower among African Americans and is independently related to insulin sensitivity in children and adolescents. Diabetes 2005, 54:2772-2778.
22. Lee S, Bacha F, Gungor N, Arslanian SA: Racial differences in adiponectin in youth: relationship to visceral fat and insulin sensitivity. Diabetes Care 2006, 29:51-56.
23. Bacha F, Arslanian SA: Ghrelin suppression in overweight children: A manifestation of insulin resistance? J Clin Endocrinol Metab 2005, 90:2725-2730.
24. Lambadiari V, Mitrou P, Maratou E, Raptis AE, Tountas N, Raptis SA, Dimitriadis G: Thyroid hormones are positively associated with insulin resistance early in the development of type 2 diabetes. Endocrine 2011, 39:28-32.
25. Kobzova J, Vignerova J, Blaha P, Krejcovsky L, Riedlova J: The 6th nationwide anthropological survey of children and adolescents in the Czech Republic in 2001. Cent Eur J Public Health 2004, 12:126-130.
26. Aldhoon-Hainerová I, Zamrazilová H, Atkinson RL, Dušátková L, Sedláčková B, Hlavatý P, Lee ZP, Kunešová M, Hainer V: Clinical and laboratory characteristics of 1179 Czech adolescents evaluated for antibodies to human adenovirus 36. Int J Obes (Lond) 2014, 38:285-291.
27. Haffner SM, Kennedy E, Gonzalez C, Stern MP, Miettinen H: A prospective analysis of the HOMA model. The Mexico City Diabetes Study. Diabetes Care 1996, 19:1138-1141.
28. Isomaa B, Almgren P, Tuomi T, Forsén B, Lahti K, Nissén M, Taskinen MR, Groop L: Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001, 24:683-689.
29. Alberti KG, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group: The metabolic syndrome-A new worldwide definition. Lancet 2005, 366:1059-1062.
30. Hill M, Parízek A, Kancheva R, Dusková M, Velíková M, Kríz L, Klímková M, Pasková A, Zizka Z, Matucha P, Meloun M, Stárka L: Steroid metabolome in plasma from the umbilical artery, umbilical vein, maternal cubital vein and in amniotic fluid in normal and preterm labor. J Steroid Biochem Mol Biol 2010, 21:594-610.
31. Brandou F, Brun JF, Mercier J: Limited accuracy of surrogates of insulin resistance during puberty in obese and lean children at risk for altered glucoregulation. J Clin Endocrinol Metab 2005, 90:761-767.
32. Kuhl J, Hilding A, Ostenson CG, Grill V, Efendic S, Bavenholm P: Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: The impact of sex and type 2 diabetes heredity. Diabetologia 2005, 48:35-40.
33. DECODE Study Group: Age-And sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts. Diabetes Care 2003, 26:61-69.
34. Brufani C, Tozzi A, Fintini D, Ciampalini P, Grossi A, Fiori R, Kiepe D, Manco M, Schiaffini R, Porzio O, Cappa M, Barbetti F: Sexual dimorphism of body composition and insulin sensitivity across pubertal development in obese Caucasian subjects. Eur J Endocrinol 2009, 160:769-775.
35. Yin J, Li M, Xu L, Wang Y, Cheng H, Zhao X, Mi J: Insulin resistance determined by Homeostasis Model Assessment (HOMA) and associations with metabolic syndrome among Chinese children and teenagers. Diabetol Metab Syndr 2013, 15:71.
36. Bosy-Westphal A, Geisler C, Onur S, Korth O, Selberg O, Schrezenmeir J, Möller MJ: Value of body fat mass vs anthropometric obesity indices in the assessment of metabolic risk factors. Int J Obes (Lond) 2006, 30:475-483.
37. Bao W, Srinivasan SR, Berenson G: Persistent elevation of plasma insulin levels is associated with increased cardiovascular risk in children and young adults. The Bogalusa Heart Study. Circulation 1996, 93:54-59.
38. Kelishadi R, Cook SR, Amra B, Adibi A: Factors associated with insulin resistance and non-Alcoholic fatty liver disease among youths. Atherosclerosis 2009, 204:538-543.
39. Denzer C, Thiere D, Muche R, Koenig W, Mayer H, Kratzer W, Wabitsch M: Gender-specific prevalences of fatty liver in obese children and adolescents: roles of body fat distribution, sex steroids, and insulin resistance. J Clin Endocrinol Metab 2009, 94:3872-3881.
40. Mason JE, Starke RD, Van Kirk JE: Gamma-glutamyl transferase: A novel cardiovascular risk biomarker. Prev Cardiol 2010, 13:36-41.
41. Moriarty-Kelsey M, Harwood JE, Travers SH, Zeitler PS, Nadeau KJ: Testosterone, obesity and insulin resistance in young males: evidence for an association between gonadal dysfunction and insulin resistance during puberty. J Pediatr Endocrinol Metab 2010, 23:1281-1287.
42. Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ: Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol 2003, 149:331-335.
43. Cnop M, Landchild MJ, Vidal J, Havel PJ, Knowles NG, Carr DR, Wang F, Hull RL, Boyko EJ, Retzlaff BM, Walden CE, Knopp RH, Kahn SE: The concurrent accumulation of intra-Abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments. Diabetes 2002, 51:1005-1015.
44. Pannacciulli N, De Mitrio V, Marino R, Giorgino R, De Pergola G: Effect of glucose tolerance status on PAI-1 plasma levels in overweight and obese subjects. Obes Res 2002, 10:717-725.
45. Roef GL, Rietzschel ER, Van Daele CM, Taes YE, De Buyzere ML, Gillebert TC, Kaufman JM: Triiodothyronine and free thyroxine levels are differentially associated with metabolic profile and adiposity-related cardiovascular risk markers in euthyroid middle-Aged subjects. Thyroid 2014, 24:223-231.
46. Bouchalová M: Development during childhood and its influences: Brno growth study. Prague: Avicenum; 1987.