Fully Zwitterionic Nanoparticle Antimicrobial Agents through Tuning of Core Size and Ligand Structure

ACS Nano

Volumn 10, Issue 9, 2016, Pages 8732-8737

  Huo, Shuaidong ^a,b,c   Jiang, Ying ^a   Gupta, Akash ^a   Jiang, Ziwen ^a   Landis, Ryan F ^a   Hou, Singyuk ^a   Liang, Xing Jie ^b,c   Rotello, Vincent M ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

antimicrobial activity; charge orientation; size; zwitterionic gold nanoparticles

Indexed keywords

BIOACTIVITY; FIBER OPTIC SENSORS; GOLD; LIGANDS; METAL NANOPARTICLES; MICROORGANISMS; NANOPARTICLES; PARTICLE SIZE;

ANTI-MICROBIAL ACTIVITY; BACTERIAL MEMBRANES; GOLD NANOPARTICLE; GOLD NANOPARTICLES; LIGAND STRUCTURE; LOW HEMOLYTIC ACTIVITIES; NONINTERACTING; SIZE;

ANTIMICROBIAL AGENTS;

ANTIINFECTIVE AGENT; GOLD; LIGAND; METAL NANOPARTICLE;

CHEMISTRY; PARTICLE SIZE;

ANTI-INFECTIVE AGENTS; GOLD; LIGANDS; METAL NANOPARTICLES; PARTICLE SIZE;

EID: 84989154378     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.6b04207     Document Type: Article

References (39)

1. Gerner-Smidt, P.; Kincaid, J.; Kubota, K.; Hise, K.; Hunter, S. B.; Fair, M. A.; Norton, D.; Woo-Ming, A.; Kurzynski, T.; Sotir, M. J.; Head, M.; Holt, K.; Swaminathan, B. Molecular Surveillance of Shiga Toxigenic Escherichia coli O157 by PulseNet USA J. Food Prot. 2005, 68, 1926-1931
2. Lushniak, B. D. Antibiotic Resistance: A Public Health Crisis Public Health Rep. 2014, 129, 314-316
3. De, M.; Ghosh, P. S.; Rotello, V. M. Applications of Nanoparticles in Biology Adv. Mater. 2008, 20, 4225-4241 10.1002/adma.200703183
4. Miller, K. P.; Wang, L.; Benicewicz, B. C.; Decho, A. W. Inorganic Nanoparticles Engineered to Attack Bacteria Chem. Soc. Rev. 2015, 44, 7787-7807 10.1039/C5CS00041F
5. Richter, A. P.; Brown, J. S.; Bharti, B.; Wang, A.; Gangwal, S.; Houck, K.; Cohen Hubal, E. A.; Paunov, V. N.; Stoyanov, S. D.; Velev, O. D. An Environmentally Benign Antimicrobial Nanoparticle Based on a Silver-Infused Lignin Core Nat. Nanotechnol. 2015, 10, 817-823 10.1038/nnano.2015.141
6. Li, X.; Robinson, S. M.; Gupta, A.; Saha, K.; Jiang, Z.; Moyano, D. F.; Sahar, A.; Riley, M. A.; Rotello, V. M. Functional Gold Nanoparticles as Potent Antimicrobial Agents Against Multi-Drug-Resistant Bacteria ACS Nano 2014, 8, 10682-10686 10.1021/nn5042625
7. Zhao, Y. Y.; Ye, C. J.; Liu, W. W.; Chen, R.; Jiang, X. Y. Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application Angew. Chem., Int. Ed. 2014, 53, 8127-8131 10.1002/anie.201401035
8. Zhao, Y.; Tian, Y.; Cui, Y.; Liu, W.; Ma, W.; Jiang, X. Small Molecule-Capped Gold Nanoparticles as Potent Antibacterial Agents that Target Gram-Negative Bacteria J. Am. Chem. Soc. 2010, 132, 12349-12356 10.1021/ja1028843
9. Nirmala Grace, A.; Pandian, K. Antibacterial Efficacy of Aminoglycosidic Antibiotics Protected Gold Nanoparticles-A Brief Study Colloids Surf., A 2007, 297, 63-70 10.1016/j.colsurfa.2006.10.024
10. Gu, H.; Ho, P.; Tong, E.; Wang, L.; Xu, B. Presenting Vancomycin on Nanoparticles to Enhance Antimicrobial Activities Nano Lett. 2003, 3, 1261-1263 10.1021/nl034396z
11. Feng, Z. V.; Gunsolus, I. L.; Qiu, T. A.; Hurley, K. R.; Nyberg, L. H.; Frew, H.; Johnson, K. P.; Vartanian, A. M.; Jacob, L. M.; Lohse, S. E. Impacts of Gold Nanoparticle Charge and Ligand Type on Surface Binding and Toxicity to Gram-Negative and Gram-Positive Bacteria Chem. Sci. 2015, 6, 5186-5196 10.1039/C5SC00792E
12. Carmona-Ribeiro, A. M.; de Melo Carrasco, L. D. Cationic Antimicrobial Polymers and Their Assemblies Int. J. Mol. Sci. 2013, 14, 9906-9946 10.3390/ijms14059906
13. Fang, B.; Jiang, Y.; Rotello, V. M.; Nusslein, K.; Santore, M. M. Easy Come Easy Go: Surfaces Containing Immobilized Nanoparticles or Isolated Polycation Chains Facilitate Removal of Captured Staphylococcus Aureus by Retarding Bacterial Bond Maturation ACS Nano 2014, 8, 1180-1190 10.1021/nn405845y
14. Fang, B.; Jiang, Y.; Nusslein, K.; Rotello, V. M.; Santore, M. M. Antimicrobial Surfaces Containing Cationic Nanoparticles: How Immobilized, Clustered, and Protruding Cationic Charge Presentation Affects Killing Activity and Kinetics Colloids Surf., B 2015, 125, 255-263 10.1016/j.colsurfb.2014.10.043
15. Goodman, C. M.; McCusker, C. D.; Yilmaz, T.; Rotello, V. M. Toxicity of Gold Nanoparticles Functionalized with Cationic and Anionic Side Chains Bioconjugate Chem. 2004, 15, 897-900 10.1021/bc049951i
16. Zhang, Z.; Zhang, M.; Chen, S.; Horbett, T. A.; Ratner, B. D.; Jiang, S. Blood Compatibility of Surfaces with Superlow Protein Adsorption Biomaterials 2008, 29, 4285-4291 10.1016/j.biomaterials.2008.07.039
17. Jiang, S.; Cao, Z. Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications Adv. Mater. 2010, 22, 920-932 10.1002/adma.200901407
18. Cheng, G.; Zhang, Z.; Chen, S. F.; Bryers, J. D.; Jiang, S. Y. Inhibition of Bacterial Adhesion and Biofilm Formation on Zwitterionic Surfaces Biomaterials 2007, 28, 4192-4199 10.1016/j.biomaterials.2007.05.041
19. Bresee, J.; Maier, K. E.; Boncella, A. E.; Melander, C.; Feldheim, D. L. Growth Inhibition of Staphylococcus Aureus by Mixed Monolayer Gold Nanoparticles Small 2011, 7, 2027-2031 10.1002/smll.201100420
20. Adhikari, M. D.; Goswami, S.; Panda, B. R.; Chattopadhyay, A.; Ramesh, A. Membrane-Directed High Bactericidal Activity of (Gold Nanoparticle) Polythiophene Composite for Niche Applications Against Pathogenic Bacteria Adv. Healthcare Mater. 2013, 2, 599-606 10.1002/adhm.201200278
21. Yamamoto, O. Influence of Particle Size on the Antibacterial Activity of Zinc Oxide Int. J. Inorg. Mater. 2001, 3, 643-646 10.1016/S1466-6049(01)00197-0
22. Raghupathi, K. R.; Koodali, R. T.; Manna, A. C. Size-Dependent Bacterial Growth Inhibition and Mechanism of Antibacterial Activity of Zinc Oxide Nanoparticles Langmuir 2011, 27, 4020-4028 10.1021/la104825u
23. Hayden, S. C.; Zhao, G. X.; Saha, K.; Phillips, R. L.; Li, X. N.; Miranda, O. R.; Rotello, V. M.; El-Sayed, M. A.; Schmidt-Krey, I.; Bunz, U. H. F. Aggregation and Interaction of Cationic Nanoparticles on Bacterial Surfaces J. Am. Chem. Soc. 2012, 134, 6920-6923 10.1021/ja301167y
24. Mi, L.; Jiang, S. Y. Integrated Antimicrobial and Nonfouling Zwitterionic Polymers Angew. Chem., Int. Ed. 2014, 53, 1746-1754 10.1002/anie.201304060
25. Huo, S. D.; Jin, S. B.; Ma, X. W.; Xue, X. D.; Yang, K. N.; Kumar, A.; Wang, P. C.; Zhang, J. C.; Hu, Z. B.; Liang, X. J. Ultrasmall Gold Nanoparticles as Carriers for Nucleus-Based Gene Therapy Due to Size-Dependent Nuclear Entry ACS Nano 2014, 8, 5852-5862 10.1021/nn5008572
26. Huang, K. Y.; Ma, H. L.; Liu, J.; Huo, S. D.; Kumar, A.; Wei, T.; Zhang, X.; Jin, S. B.; Gan, Y. L.; Wang, P. C.; He, S. T.; Zhang, X. N.; Liang, X. J. Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo ACS Nano 2012, 6, 4483-4493 10.1021/nn301282m
27. Jiang, Y.; Huo, S. D.; Mizuhara, T.; Das, R.; Lee, Y. W.; Hou, S.; Moyano, D. F.; Duncan, B.; Liang, X. J.; Rotello, V. M. The Interplay of Size and Surface Functionality on the Cellular Uptake of Sub-10 nm Gold Nanoparticles ACS Nano 2015, 9, 9986-9993 10.1021/acsnano.5b03521
28. Mizuhara, T.; Saha, K.; Moyano, D. F.; Kim, C. S.; Yan, B.; Kim, Y. K.; Rotello, V. M. Acylsulfonamide-Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH Angew. Chem., Int. Ed. 2015, 54, 6567-6570 10.1002/anie.201411615
29. Nikaido, H. Multidrug Efflux Pumps of Gram-Negative Bacteria J. Bacteriol. 1996, 178, 5853-5859
30. Phillips, R. L.; Miranda, O. R.; You, C. C.; Rotello, V. M.; Bunz, U. H. F. Rapid and Efficient Identification of Bacteria Using Gold-Nanoparticle-Poly(para-phenyleneethynylene) Constructs Angew. Chem., Int. Ed. 2008, 47, 2590-2594 10.1002/anie.200703369
31. Wiegand, I.; Hilpert, K.; Hancock, R. E. W. Agar and Broth Dilution Methods to Determine the Minimal Inhibitory Concentration (MIC) of Antimicrobial Substances Nat. Protoc. 2008, 3, 163-175 10.1038/nprot.2007.521
32. Cabeen, M. T.; Jacobs-Wagner, C. Bacterial Cell Shape Nat. Rev. Microbiol. 2005, 3, 601-610 10.1038/nrmicro1205
33. Rizzello, L.; Cingolani, R.; Pompa, P. P. Nanotechnology Tools for Antibacterial Materials Nanomedicine 2013, 8, 807-821 10.2217/nnm.13.63
34. Duncan, B.; Li, X.; Landis, R. F.; Kim, C. S.; Gupta, A.; Wang, L.-S.; Ramanathan, R.; Tang, R.; Boerth, J. A.; Rotello, V. M. Nanoparticle-Stabilized Capsules for the Treatment of Bacterial Biofilms ACS Nano 2015, 9, 7775-7782 10.1021/acsnano.5b01696
35. Dobrovolskaia, M. A.; Clogston, J. D.; Neun, B. W.; Hall, J. B.; Patri, A. K.; McNeil, S. E. Method for Analysis of Nanoparticle Hemolytic Properties in Vitro Nano Lett. 2008, 8, 2180-2187 10.1021/nl0805615
36. Lin, Y. S.; Haynes, C. L. Impacts of Mesoporous Silica Nanoparticle Size, Pore Ordering, and Pore Integrity on Hemolytic Activity J. Am. Chem. Soc. 2010, 132, 4834-4842 10.1021/ja910846q
37. Hostetler, M. J.; Wingate, J. E.; Zhong, C. J.; Harris, J. E.; Vachet, R. W.; Clark, M. R.; Londono, J. D.; Green, S. J.; Stokes, J. J.; Wignall, G. D.; Glish, G. L.; Porter, M. D.; Evans, N. D.; Murray, R. W. Alkanethiolate Gold Cluster Molecules with Core Diameters from 1.5 to 5.2 nm: Core and Monolayer Properties as a Function of Core Size Langmuir 1998, 14, 17-30 10.1021/la970588w
38. Andrews, J. M. Determination of Minimum Inhibitory Concentrations J. Antimicrob. Chemother. 2001, 48, 5-16 10.1093/jac/48.suppl-1.5
39. Saha, K.; Moyano, D. F.; Rotello, V. M. Protein Coronas Suppress the Hemolytic Activity of Hydrophilic and Hydrophobic Nanoparticles Mater. Horiz. 2014, 1, 102-105 10.1039/C3MH00075C