Vaccination is more effective than prophylactic oseltamivir in preventing cns invasion by h5n1 virus via the olfactory nerve

Journal of Infectious Diseases

Volumn 214, Issue 4, 2016, Pages 516-524

  Siegers, Jurre Y ^a   Van Den Brand, Judith M ^a   Leijten, Lonneke M ^a   Van De Bildt, Marco M W ^a   Van Run, Peter R ^a   Van Amerongen, Geert ^b   Stittelaar, Koert J ^b   Koopmans, Marion P ^a   Osterhaus, Albert D M E ^b,c,d   Kuiken, Thijs ^a   Van Riel, Debby ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Viroclinics Biosciences BV   (Netherlands)

^c Artemis One Health   (Netherlands)

^d UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Encephalitis; Ferret; H5N1; Influenza; Olfactory mucosa; Olfactory nerve; Oseltamivir; Vaccine; Virus

Indexed keywords

INFLUENZA VACCINE; OSELTAMIVIR; VIRUS ANTIGEN; ANTIVIRUS AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; DISEASE SEVERITY; DOMESTIC FERRET; DRUG EFFICACY; FEMALE; HUMAN; INFLUENZA A (H5N1); INFLUENZA A VIRUS (H5N1); INFLUENZA VACCINATION; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION; VIRUS SHEDDING; VIRUS TITRATION; ANIMAL; CHEMOPROPHYLAXIS; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; INTRAMUSCULAR DRUG ADMINISTRATION; ISOLATION AND PURIFICATION; MENINGOENCEPHALITIS; MUSTELA PUTORIUS FURO; OLFACTORY NERVE; ORTHOMYXOVIRUS INFECTION; PATHOLOGY; PROCEDURES; TREATMENT OUTCOME; VIROLOGY;

ANIMALS; ANTIVIRAL AGENTS; CHEMOPREVENTION; DISEASE MODELS, ANIMAL; FEMALE; FERRETS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; INJECTIONS, INTRAMUSCULAR; MENINGOENCEPHALITIS; OLFACTORY NERVE; ORTHOMYXOVIRIDAE INFECTIONS; OSELTAMIVIR; TREATMENT OUTCOME;

EID: 84988925089     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiw123     Document Type: Article

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