The multibasic cleavage site in H5N1 virus is critical for systemic spread along the olfactory and hematogenous routes in ferrets

Journal of Virology

Volumn 86, Issue 7, 2012, Pages 3975-3984

  Schrauwen, Eefje J A ^a   Herfst, Sander ^a   Leijten, Lonneke M ^a   van Run, Peter ^a   Bestebroer, Theo M ^a   Linster, Martin ^a   Bodewes, Rogier ^a   Kreijtz, Joost H C M ^a   Rimmelzwaan, Guus F ^a   Osterhaus, Albert D M E ^a   Fouchier, Ron A M ^a   Kuiken, Thijs ^a   van Riel, Debby ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBROSPINAL FLUID; COLON; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA CLEAVAGE; FERRET; HEART; HEMATOPOIETIC SYSTEM; IN VITRO STUDY; INFLUENZA VIRUS A H5N1; INOCULATION; INVASIVE PROCEDURE; LIVER; MULTIBASIC CLEAVAGE SITE; MUTANT; NONHUMAN; OLFACTORY BULB; OLFACTORY EPITHELIUM; OLFACTORY SYSTEM; PANCREAS; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; VIRUS DETECTION; VIRUS REPLICATION; VIRUS TRANSMISSION; WILD TYPE;

AMINO ACID MOTIFS; ANIMALS; BLOOD; CELL LINE; DISEASE MODELS, ANIMAL; FEMALE; FERRETS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA, HUMAN; OLFACTORY PATHWAYS; PROTEIN PROCESSING, POST-TRANSLATIONAL; VIRULENCE; VIRUS REPLICATION;

AVES; MAMMALIA; MUSTELA;

EID: 84858374093     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06828-11     Document Type: Article

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