Interleukin-1β regulates the expression of glucocorticoid receptor isoforms in nasal polyps in vitro via p38 MAPK and JNK signal transduction pathways

Journal of Inflammation (United Kingdom)

Volumn 12, Issue 1, 2015, Pages

  Wang, Zhenlin ^a   Li, Peng ^b   Zhang, Qiuhang ^a   Lv, Haili ^a   Liu, Junqi ^a   Si, Jinyuan ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Chronic rhinosinusitis (CRS); Mitogen activated protein kinase (MAPK); Nasal polyp (NP); Signal transduction

Indexed keywords

GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MALE; NOSE POLYP; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING ASSAY; SIGNAL TRANSDUCTION;

EID: 84988905465     PISSN: None     EISSN: 14769255     Source Type: Journal    
DOI: 10.1186/s12950-014-0046-z     Document Type: Article

References (28)

1. Hamilos DL. Chronic rhinosinusitis: epidemiology and medical management. J Allergy Clin Immunol. 2011;128:693-707.
2. Wang X, Cutting GR. Chronic rhinosinusitis. Adv Otorhinolaryngol. 2011;70:114-21.
3. Joe SA, Thambi R, Huang J. A systematic review of the use of intranasal steroids in the treatment of chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2008;139:340-7.
4. Cope D, Bova R. Steroids in otolaryngology. Laryngoscope. 2008;118:1556-60.
5. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012: a summary for otorhinolaryngologists. Rhinology. 2012;50:1-12.
6. Pujolsa L, Mullol J, Picado C. Glucocorticoid receptor in human respiratory epithelial cells. Neuroimmunomodulation. 2009;16:290-9.
7. Li P, Li Y, Li YQ, Yang QT, Zhang GH. Glucocorticoid receptor expression and glucocorticoid therapeutic effect in nasal polyps. Clin Invest Med. 2010;33:E181-8.
8. Liberman AC, Druker J, Garcia FA, Holsboer F, Arzt E. Intracellular molecular signaling: basis for specificity to glucocorticoid anti-inflammatory actions. Ann N Y Acad Sci. 2009;1153:6-13.
9. Strehl C, Spies CM, Buttgereit F. Pharmacodynamics of glucocorticoids. Clin Exp Rheumatol. 2011;29:S13-8.
10. Pujols L, Alobid I, Benitez P, Martinez-Anton A, Roca-Ferrer J, Fokkens WJ, et al. Regulation of glucocorticoid receptor in nasal polyps by systemic and intranasal glucocorticoids. Allergy. 2008;63:1377-86.
11. Takeda K, Takeno S, Hirakawa K, Ishino T. Expression and distribution of glucocorti⋯ [Auris Nasus Larynx. 2010]-PubMed-NCBI, vol. 2013. 2013.
12. Aversa S, Ondolo C, Abbadessa G, Piccione F, Carriero V, Fulcheri A, et al. Steroid resistance in nasal polyposis: role of glucocorticoid receptor and TGF-beta1. Rhinology. 2012;50:427-35.
13. Szatmary Z, Kebis A. Promoter-context as a determinant of glucocorticoid receptor-responsiveness to activation of p38 and JNK mitogen-activated protein (MAP) kinases. Gen Physiol Biophys. 2012;31:309-22.
14. Kuntzsch D, Bergann T, Dames P, Fromm A, Fromm M, Davis RA, et al. The plant-derived glucocorticoid receptor agonist Endiandrin A acts as co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and MAPKs. PLoS One. 2012;7:e49426.
15. Hu A, Josephson MB, Diener BL, Nino G, Xu S, Paranjape C, et al. Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in airway smooth muscle. PLoS One. 2013;8:e60452.
16. Fokkens W, Lund V, Mullol J. European position paper on rhinosinusitis and nasal polyps. Rhinol Suppl. 2007;2007:1-136.
17. Jankowski R, Schrewelius C, Bonfils P, Saban Y, Gilain L, Prades JM, et al. Efficacy and tolerability of budesonide aqueous nasal spray treatment in patients with nasal polyps. Arch Otolaryngol Head Neck Surg. 2001;127:447-52.
18. Tan L, Rogers TJ, Hatzirodos N, Baker LM, Ooi E, Wormald PJ. Immunomodulatory effect of cytosine-phosphate-guanosine (CpG)-oligonucleotides in nonasthmatic chronic rhinosinusitis: an explant model. Am J Rhinol Allergy. 2009;23:123-9.
19. Bonnans C, Chanez P, Meziane H, Godard P, Bousquet J, Vachier I. Glucocorticoid receptor-binding characteristics in severe asthma. Eur Respir J. 2003;21:985-8.
20. Robertson S, Rohwer JM, Hapgood JP, Louw A. Impact of glucocorticoid receptor density on ligand-independent dimerization, cooperative ligand-binding and basal priming of transactivation: a cell culture model. PLoS One. 2013;8:e64831.
21. Furukido K, Takeno S, Ueda T, Yajin K. Cytokine profile in paranasal effusions in patients with chronic sinusitis using the YAMIK sinus catheter with and without betamethasone. Eur Arch Otorhinolaryngol. 2005;262:50-4.
22. Tuszynska A, Krzeski A, Postuba M, Paczek L, Wyczalkowska-Tomasik A, Gornicka B, et al. Inflammatory cytokines gene expression in bone tissue from patients with chronic rhinosinusitis-a preliminary study. Rhinology. 2010;48:415-9.
23. Raddatz D, Toth S, Schworer H, Ramadori G. Glucocorticoid receptor signaling in the intestinal epithelial cell lines IEC-6 and Caco-2: evidence of inhibition by interleukin-1beta. Int J Colorectal Dis. 2001;16:377-83.
24. Engler H, BaileyMT, Engler A, Stiner-Jones LM, Quan N, Sheridan JF. Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen. Psychoneuroendocrinology. 2008;33:108-17.
25. Rider CF, King EM, Holden NS, Giembycz MA, Newton R. Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. J Pharmacol Exp Ther. 2011;338:860-9.
26. Budziszewska B, Szymanska M, Leskiewicz M, Basta-Kaim A, Jaworska-Feil L, Kubera M, et al. The decrease in JNK-and p38-MAP kinase activity is accompanied by the enhancement of PP2A phosphate level in the brain of prenatally stressed rats. J Physiol Pharmacol. 2010;61:207-15.
27. Zijlstra GJ, Ten HN, Hoffmann RF, van Oosterhout AJ, Heijink IH. Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells. Eur Respir J. 2012;39:439-45.
28. Miller AL, Garza AS, Johnson BH, Thompson EB. Pathway interactions between MAPKs, mTOR, PKA, and the glucocorticoid receptor in lymphoid cells. Cancer Cell Int. 2007;7:3.