Airway CD8+ T cells are associated with lung injury during infant viral respiratory tract infection

American Journal of Respiratory Cell and Molecular Biology

Volumn 54, Issue 6, 2016, Pages 822-830

  Connors, Thomas J ^a   Ravindranath, Thyyar M ^a   Bickham, Kara L ^a   Gordon, Claire L ^a   Zhang, Feifan ^b   Levin, Bruce ^b   Baird, John S ^a   Farber, Donna L ^a  

^a Department of Medicine   (United States)

^b Department of Medicine   (United States)

Author keywords

Immunopathology; Infant immunity; Lung injury; Viral pneumonia

Indexed keywords

INTERLEUKIN 6;

AIRWAY CELL; ARTICLE; ARTIFICIAL VENTILATION; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COMPOSITION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; EFFECTOR CELL; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INFANT; LUNG INJURY; LYMPHOCYTE DIFFERENTIATION; MALE; MEMORY T LYMPHOCYTE; PRESCHOOL CHILD; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VIRAL RESPIRATORY TRACT INFECTION; ACUTE LUNG INJURY; AGE; CELL DIFFERENTIATION; COMPLICATION; DEMOGRAPHY; IMMUNOLOGY; IMMUNOPHENOTYPING; LUNG; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; METABOLISM; PATHOLOGY; RESPIRATORY TRACT INFECTION; STATISTICAL MODEL; VIROLOGY;

ACUTE LUNG INJURY; AGE FACTORS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; DEMOGRAPHY; FEMALE; HUMANS; IMMUNOPHENOTYPING; INFANT; INTERLEUKIN-6; LUNG; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; MALE; MODELS, STATISTICAL; RESPIRATORY TRACT INFECTIONS;

EID: 84988851006     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2015-0297OC     Document Type: Article

References (43)

1. Tregoning JS, Schwarze J. Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology. Clin Microbiol Rev 2010;23:74-98.
2. Pavia AT. Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis. Clin Infect Dis 2011;52: S284-S289.
3. Spaeder MC, Custer JW, Bembea MM, Aganga DO, Song X, Scafidi S. A multicenter outcomes analysis of children with severe viral respiratory infection due to human metapneumovirus. Pediatr Crit Care Med 2013;14:268-272.
4. Levy O. Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol 2007;7:379-390.
5. Gervassi AL, Horton H. Is infant immunity actively suppressed or immature? Virology (Auckl) 2014;2014:1-9.
6. Roe MF, Bloxham DM, Cowburn AS, O'Donnell DR. Changes in helper lymphocyte chemokine receptor expression and elevation of ip-10 during acute respiratory syncytial virus infection in infants. Pediatr Allergy Immunol 2011;22:229-234.
7. Remakus S, Sigal LJ. Memory CD81 T cell protection. Adv Exp Med Biol 2013;785:77-86.
8. Adkins B, Leclerc C, Marshall-Clarke S. Neonatal adaptive immunity comes of age. Nat Rev Immunol 2004;4:553-564.
9. Hassan J, Reen DJ. Cord blood CD41 CD45RA1 T cells achieve a lower magnitude of activation when compared with their adult counterparts. Immunology 1997;90:397-401.
10. Zaghouani H, Hoeman CM, Adkins B. Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells. Trends Immunol 2009;30:585-591.
11. McCarron MJ, Reen DJ. Neonatal CD81 T-cell differentiation is dependent on interleukin-12. Hum Immunol 2010;71:1172-1179.
12. Teijaro JR, Turner D, Pham Q, Wherry EJ, Lefrançois L, Farber DL. Cutting edge: tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection. J Immunol 2011;187: 5510-5514.
13. Hogan RJ, Zhong W, Usherwood EJ, Cookenham T, Roberts AD, Woodland DL. Protection from respiratory virus infections can be mediated by antigen-specific CD4(1) T cells that persist in the lungs. J Exp Med 2001;193:981-986.
14. Xu L, Yoon H, Zhao MQ, Liu J, Ramana CV, Enelow RI. Cutting edge: pulmonary immunopathology mediated by antigen-specific expression of TNF-a by antiviral CD81 T cells. J Immunol 2004;173:721-725.
15. Sathaliyawala T, Kubota M, Yudanin N, Turner D, Camp P, Thome JJ, Bickham KL, Lerner H, Goldstein M, Sykes M, et al. Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity 2013;38:187-197.
16. Autissier P, Soulas C, Burdo TH, Williams KC. Evaluation of a 12-color flow cytometry panel to study lymphocyte, monocyte, and dendritic cell subsets in humans. Cytometry A 2010;77:410-419.
17. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994;149:818-824.
18. Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS; ARDS Definition Task Force. Acute respiratory distress syndrome: the Berlin definition. JAMA 2012;307: 2526-2533.
19. Heidema J, Lukens MV, van Maren WW, van Dijk ME, Otten HG, van Vught AJ, van der Werff DB, van Gestel SJ, Semple MG, Smyth RL, et al. CD81 T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections. J Immunol 2007;179: 8410-8417.
20. Everard ML, Swarbrick A, Wrightham M, McIntyre J, Dunkley C, James PD, Sewell HF, Milner AD. Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection. Arch Dis Child 1994;71:428-432.
21. Lukens MV, van de Pol AC, Coenjaerts FE, Jansen NJ, Kamp VM, Kimpen JL, Rossen JW, Ulfman LH, Tacke CE, Viveen MC, et al. A systemic neutrophil response precedes robust CD8(1) T-cell activation during natural respiratory syncytial virus infection in infants. J Virol 2010;84:2374-2383.
22. Denny T, Yogev R, Gelman R, Skuza C, Oleske J, Chadwick E, Cheng SC, Connor E. Lymphocyte subsets in healthy children during the first 5 years of life. JAMA 1992;267:1484-1488.
23. Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M, Koup RA. Sensitive and viable identification of antigen-specific CD81 T cells by a flow cytometric assay for degranulation. J Immunol Methods 2003;281:65-78.
24. Gibbons D, Fleming P, Virasami A, Michel ML, Sebire NJ, Costeloe K, Carr R, Klein N, Hayday A. Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants. Nat Med 2014;20:1206-1210.
25. Chalmers IM, Janossy G, Contreras M, Navarrete C. Intracellular cytokine profile of cord and adult blood lymphocytes. Blood 1998;92:11-18.
26. Peoples JD, Cheung S, Nesin M, Lin H, Tatad AM, Hoang D, Perlman JM, Cunningham-Rundles S. Neonatal cord blood subsets and cytokine response to bacterial antigens. Am J Perinatol 2009;26: 647-657.
27. Aberle JH, Aberle SW, Rebhandl W, Pracher E, Kundi M, Popow-Kraupp T. Decreased interferon-g response in respiratory syncytial virus compared to other respiratory viral infections in infants. Clin Exp Immunol 2004;137:146-150.
28. Raiden S, Pandolfi J, Payasliàn F, Anderson M, Rivarola N, Ferrero F, Urtasun M, Fainboim L, Geffner J, Arruvito L. Depletion of circulating regulatory T cells during severe respiratory syncytial virus infection in young children. Am J Respir Crit Care Med 2014;189: 865-868.
29. Kristjansson S, Bjarnarson SP, Wennergren G, Palsdottir AH, Arnadottir T, Haraldsson A, Jonsdottir I. Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local Th2-like response. J Allergy Clin Immunol 2005;116:805-811.
30. Brand HK, Ferwerda G, Preijers F, de Groot R, Neeleman C, Staal FJ, Warris A, Hermans PW. CD41 T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection. Pediatr Res 2013;73:187-193.
31. Heidema J, Rossen JW, Lukens MV, Ketel MS, Scheltens E, Kranendonk ME, van Maren WW, van Loon AM, Otten HG, Kimpen JL, et al. Dynamics of human respiratory virus-specific CD81 T cell responses in blood and airways during episodes of common cold. J Immunol 2008;181:5551-5559.
32. Stoppelenburg AJ, de Roock S, Hennus MP, Bont L, Boes M. Elevated Th17 response in infants undergoing respiratory viral infection. Am J Pathol 2014;184:1274-1279.
33. Ramana CV, DeBerge MP, Kumar A, Alia CS, Durbin JE, Enelow RI. Inflammatory impact of IFN-g in CD81 T cell-mediated lung injury is mediated by both Stat1-dependent and -independent pathways. Am J Physiol Lung Cell Mol Physiol 2015;308:L650-L657.
34. Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS. The histopathology of fatal untreated human respiratory syncytial virus infection. Mod Pathol 2007;20:108-119.
35. Mauad T, Hajjar LA, Callegari GD, da Silva LF, Schout D, Galas FR, Alves VA, Malheiros DM, Auler JO Jr, Ferreira AF, et al. Lung pathology in fatal novel human influenza A (H1N1) infection. Am J Respir Crit Care Med 2010;181:72-79.
36. Goulding J, Abboud G, Tahiliani V, Desai P, Hutchinson TE, Salek-Ardakani S. CD8 T cells use IFN-g to protect against the lethal effects of a respiratory poxvirus infection. J Immunol 2014;192: 5415-5425.
37. Wherry EJ. T cell exhaustion. Nat Immunol 2011;12:492-499.
38. Van Snick J. Interleukin-6: an overview. Annu Rev Immunol 1990;8: 253-278.
39. Khong WX, Foo DG, Trasti SL, Tan EL, Alonso S. Sustained high levels of interleukin-6 contribute to the pathogenesis of enterovirus 71 in a neonate mouse model. J Virol 2011;85:3067-3076.
40. Paquette SG, Banner D, Zhao Z, Fang Y, Huang SS, Leomicronn AJ, Ng DC, Almansa R, Martin-Loeches I, Ramirez P, et al. Interleukin-6 is a potential biomarker for severe pandemic H1N1 influenza A infection. PLoS One 2012;7:e38214.
41. Hall MW, Geyer SM, Guo CY, Panoskaltsis-Mortari A, Jouvet P, Ferdinands J, Shay DK, Nateri J, Greathouse K, Sullivan R, et al.; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network PICFlu Study Investigators. Innate immune function and mortality in critically ill children with influenza: a multicenter study. Crit Care Med 2013;41:224-236.
42. Cornfield DN. Acute respiratory distress syndrome in children: physiology and management. Curr Opin Pediatr 2013;25:338-343.
43. Asner SA, Petrich A, Hamid JS, Mertz D, Richardson SE, Smieja M. Clinical severity of rhinovirus/enterovirus compared to other respiratory viruses in children. Influenza Other Respi Viruses 2014;8: 436-442.