Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer

Journal of Translational Medicine

Volumn 12, Issue 1, 2014, Pages

  Xiang, Jun ^a   Fang, Lekun ^a   Luo, Yanxin ^a   Yang, Zuli ^a   Liao, Yi ^a   Cui, Ji ^a   Huang, Meijin ^a   Yang, Zihuan ^a   Huang, Yan ^a   Fan, Xinjuan ^a   Wang, Huashe ^a   Wang, Lei ^a   Peng, Junsheng ^a   Wang, Jianping ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cell cycle; Colorectal cancer; Prognosis; Replication factor C4

Indexed keywords

MESSENGER RNA; REPLICATION FACTOR C; REPLICATION FACTOR C4; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; RFC4 PROTEIN, HUMAN;

ADULT; ARTICLE; BIOLOGICAL FUNCTIONS; CANCER INHIBITION; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CELL CYCLE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CLINICAL OUTCOME; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE FREE SURVIVAL; DNA SYNTHESIS; DOWN REGULATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OVERALL SURVIVAL; PATHOLOGY; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RNA EXTRACTION; S PHASE CELL CYCLE CHECKPOINT; SENSITIVITY AND SPECIFICITY; TISSUE MICROARRAY; TUMOR GROWTH; UPREGULATION; WESTERN BLOTTING; AGED; COLORECTAL TUMOR; DISEASE COURSE; METABOLISM; PROGNOSIS;

AGED; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; REPLICATION PROTEIN C;

EID: 84988643332     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-014-0320-0     Document Type: Article

References (21)

1. Network CGA: Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012, 487:330-337.
2. Luo Y, Wong CJ, Kaz AM, Dzieciatkowski S, Carter KT, Morris SM, Wang J, Willis JE, Makar KW, Ulrich CM, Lutterbaugh JD, Shrubsole MJ, Zheng W, Markowitz SD, Grady WM: Differences in DNA Methylation Signatures Reveal Multiple Pathways of Progression from Adenoma to Colorectal Cancer. Gastroenterology 2014, 147:418-429. e8.
3. Yao NY, O'Donnell M: The RFC clamp loader: structure and function. In The Eukaryotic Replisome: A Guide to Protein Structure and Function. Chapter 14. Edited by MacNeill S. Dordrecht: Springer Netherlands; 2012:259-279.
4. Johnson A, Yao NY, Bowman GD, Kuriyan J, O'Donnell M: The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem 2006, 281:35531-35543.
5. Oku T, Ikeda S, Sasaki H, Fukuda K, Morioka H, Ohtsuka E, Yoshikawa H, Tsurimoto T: Functional sites of human PCNA which interact with p21 (Cip1/Waf1), DNA polymerase delta and replication factor C. Genes Cells 1998, 3:357-369.
6. Tsurimoto T, Stillman B: Purification of a cellular replication factor, RF-C, that is required for coordinated synthesis of leading and lagging strands during simian virus 40 DNA replication in vitro. Mol Cell Biol 1989, 9:609-619.
7. Tsurimoto T, Stillman B: Functions of replication factor C and proliferating-cell nuclear antigen: functional similarity of DNA polymerase accessory proteins from human cells and bacteriophage T4. Proc Natl Acad Sci U S A 1990, 87:1023-1027.
8. Kim HS, Brill SJ: Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Mol Cell Biol 2001, 21:3725-3737.
9. Krause SA, Loupart ML, Vass S, Schoenfelder S, Harrison S, Heck MM: Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants. Mol Cell Biol 2001, 21:5156-5168.
10. Erdogan E, Klee EW, Thompson EA, Fields AP: Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma. Clin Cancer Res 2009, 15:1527-1533.
11. Kang BY, You H, Bandyopadhyay S, Agrawal N, Melchert RB, Basnakian AG, Liu Y, Hermonat PL: Cervical cancer isolate PT3, super-permissive for adeno-associated virus replication, over-expresses DNA polymerase delta, PCNA, RFC and RPA. BMC Microbiol 2009, 9:79-89.
12. Narayan G, Bourdon V, Chaganti S, Arias-Pulido H, Nandula SV, Rao PH, Gissmann L, Dürst M, Schneider A, Pothuri B, Mansukhani M, Basso K, Chaganti RS, Murty VV: Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: identification of candidate amplified and overexpressed genes. Genes Chromosomes Cancer 2007, 46:373-384.
13. Slebos RJ, Yi Y, Ely K, Carter J, Evjen A, Zhang X, Shyr Y, Murphy BM, Cmelak AJ, Burkey BB, Netterville JL, Levy S, Yarbrough WG, Chung CH: Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma. Clin Cancer Res 2006, 12:701-709.
14. Fan XJ, Wan XB, Huang Y, Cai HM, Fu XH, Yang ZL, Chen DK, Song SX, Wu PH, Liu Q, Wang L, Wang JP: Epithelial-mesenchymal transition biomarkers and support vector machine guided model in preoperatively predicting regional lymph node metastasis for rectal cancer. Br J Cancer 2012, 106:1735-1741.
15. Mayer ML, Gygi SP, Aebersold R, Hieter P: Identification of RFC (Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Molecular cell 2001, 7:959-970.
16. Kanellis P, Agyei R, Durocher D: Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability. Current biology 2003, 13:1583-1595.
17. Lockwood WW, Thu KL, Lin L, Pikor LA, Chari R, Lam WL, Beer DG: Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma. Clin Cancer Res 2012, 18:1936-1946.
18. Xiong S, Wang Q, Zheng L, Gao F, Li J: Identification of candidate molecular markers of nasopharyngeal carcinoma by tissue microarray and in situ hybridization. Med Oncol 2011, 28(Suppl 1):341-348.
19. Arai M, Kondoh N, Imazeki N, Hada A, Hatsuse K, Matsubara O, Yamamoto M: The knockdown of endogenous replication factor C4 decreases the growth and enhances the chemosensitivity of hepatocellular carcinoma cells. Liver Int 2009, 29:55-62.
20. Corrette-Bennett SE, Borgeson C, Sommer D, Burgers PM, Lahue RS: DNA polymerase delta, RFC and PCNA are required for repair synthesis of large looped heteroduplexes in Saccharomyces cerevisiae. Nucleic Acids Res 2004, 32:6268-6275.
21. Overmeer RM, Gourdin AM, Giglia-Mari A, Kool H, Houtsmuller AB, Siegal G, Fousteri MI, Mullenders LH, Vermeulen W: Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment. Mol Cell Biol 2010, 30:4828-4839.