Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models

BMC Pulmonary Medicine

Volumn 14, Issue 1, 2014, Pages

  Myllärniemi, Marjukka ^a,b,d   Tikkanen, Jussi ^a,b   Hulmi, Juha J ^c   Pasternack, Arja ^a,b   Sutinen, Eva ^a   Rönty, Mikko ^a,b   Leppäranta, Outi ^a   Ma, Hongqiang ^c,d   Ritvos, Olli ^a,b   Koli, Katri ^a,b,d  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Activins; Follistatin; Idiopathic pulmonary fibrosis; Mouse fibrosis model

Indexed keywords

ACTIVIN A; FOLLISTATIN; HYBRID PROTEIN; MYELOPID; SOLUBLE ACTIVIN TYPE IIB RECEPTOR FUSED TO THE FC PORTION OF HUMAN IGG1 PROTEIN; TATA BINDING PROTEIN; UNCLASSIFIED DRUG; ACTIVIN; INHBB PROTEIN, MOUSE; INHIBIN; INHIBIN BETA A SUBUNIT; MESSENGER RNA; SACTRIIB-FC FUSION PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MARKER; ENERGY CONSUMPTION; ENZYME INHIBITION; FAT MASS; FIBROSING ALVEOLITIS; FORCED VITAL CAPACITY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUNG ALVEOLUS CELL; LUNG BIOPSY; MACROPHAGE; MALE; MIDDLE AGED; MUSCLE MASS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA ISOLATION; SIGNAL TRANSDUCTION; TRANSLATIONAL RESEARCH; UPREGULATION; ANATOMY AND HISTOLOGY; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; CELL COUNT; CELLULAR IMMUNITY; CHEMISTRY; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; GENETICS; IMMUNOLOGY; LUNG ALVEOLUS; LUNG FIBROSIS; METABOLISM; MOUSE; PROTEIN SYNTHESIS; QUADRICEPS FEMORIS MUSCLE; RESPIRATORY MUCOSA;

ACTIVINS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; DISEASE MODELS, ANIMAL; FOLLISTATIN; HUMANS; IMMUNITY, CELLULAR; INHIBIN-BETA SUBUNITS; MALE; MICE; MICE, INBRED C57BL; PROTEIN BIOSYNTHESIS; PULMONARY ALVEOLI; PULMONARY FIBROSIS; QUADRICEPS MUSCLE; RECOMBINANT FUSION PROTEINS; RESPIRATORY MUCOSA; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84988643301     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-14-170     Document Type: Article

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