Prolonged activation of innate antiviral gene signature after childbirth is determined by IFNL3 genotype

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 38, 2016, Pages 10678-10683

  Price, Aryn A ^a,b   Tedesco, Dana ^a,b   Prasad, Mona R ^c   Workowski, Kimberly A ^a   Walker, Christopher M ^c,d   Suthar, Mehul S ^a,b   Honegger, Jonathan R ^c,d   Grakoui, Arash ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

Antiviral genes; CD14; Interferon|innate immunity; Postpartum

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CD14 ANTIGEN; CD19 ANTIGEN; INTERLEUKIN 28B; OLIGOADENYLATE SYNTHETASE 1; RIBONUCLEASE L; STAT1 PROTEIN; STAT2 PROTEIN; TETRATRICOPEPTIDE REPEAT 1 PROTEIN; TETRATRICOPEPTIDE REPEAT 2 PROTEIN; TETRATRICOPEPTIDE REPEAT 3 PROTEIN; TOLL LIKE RECEPTOR 7; UNCLASSIFIED DRUG; CARRIER PROTEIN; IFIT1 PROTEIN, HUMAN; IFIT2 PROTEIN, HUMAN; IFIT3 PROTEIN, HUMAN; LIPOPOLYSACCHARIDE RECEPTOR; PROTEIN; SIGNAL PEPTIDE;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHILDBIRTH; CHRONIC HEPATITIS C; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC VARIATION; GENOTYPE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INNATE IMMUNITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PUERPERIUM; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; UPREGULATION; ADULT; GENE EXPRESSION REGULATION; GENETICS; HEPACIVIRUS; HEPATITIS C; IMMUNOLOGY; METABOLISM; MONONUCLEAR CELL; MOTHER FETUS RELATIONSHIP; PATHOGENICITY; PREGNANCY; VIROLOGY;

ADULT; CARRIER PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GENOTYPE; HEPACIVIRUS; HEPATITIS C; HUMANS; IMMUNITY, INNATE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDE RECEPTORS; MATERNAL-FETAL RELATIONS; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTPARTUM PERIOD; PREGNANCY; PROTEINS;

EID: 84988638310     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1602319113     Document Type: Article

References (44)

1. Erlebacher A (2013) Mechanisms of T cell tolerance towards the allogeneic fetus. Nat Rev Immunol 13(1):23-33.
2. Aluvihare VR, Kallikourdis M, Betz AG (2004) Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 5(3):266-271.
3. Kourtis AP, Read JS, Jamieson DJ (2014) Pregnancy and infection. N Engl J Med 371(11):1077.
4. Silasi M, et al. (2015) Viral infections during pregnancy. Am J Reprod Immunol 73(3):199-213.
5. Louie JK, et al. (2015) Pregnancy and severe influenza infection in the 2013-2014 influenza season. Obstet Gynecol 125(1):184-192.
6. Chertow DS, et al. (2014) Ebola virus disease in West Africa - Clinical manifestations and management. N Engl J Med 371(22):2054-2057.
7. Zhang HJ, Patenaude V, Abenhaim HA (2015) Maternal outcomes in pregnancies affected by varicella zoster virus infections: Population-based study on 7.7 million pregnancy admissions. J Obstet Gynaecol Res 41(1):62-68.
8. Sacks G, Sargent I, Redman C (1999) An innate view of human pregnancy. Immunol Today 20(3):114-118.
9. Faas MM, Spaans F, De Vos P (2014) Monocytes and macrophages in pregnancy and pre-eclampsia. Front Immunol 5:298.
10. Pozzilli C, Pugliatti M; ParadigMS Group (2015) An overview of pregnancy-related issues in patients with multiple sclerosis. Eur J Neurol 22(Suppl 2):34-39.
11. Honegger JR, et al. (2013) Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses. Nat Med 19(11):1529-1533.
12. Ruiz-Extremera A, et al. (2013) Variation of transaminases, HCV-RNA levels and Th1/Th2 cytokine production during the post-partum period in pregnant women with chronic hepatitis C. PLoS One 8(10):e75613.
13. Lin HH, Wu WY, Kao JH, Chen DS (2006) Hepatitis B post-partum e antigen clearance in hepatitis B carrier mothers: Correlation with viral characteristics. J Gastroenterol Hepatol 21(3):605-609.
14. Watanabe M, et al. (1997) Changes in T, B, and NK lymphocyte subsets during and after normal pregnancy. Am J Reprod Immunol 37(5):368-377.
15. Kraus TA, et al. (2012) Characterizing the pregnancy immune phenotype: Results of the viral immunity and pregnancy (VIP) study. J Clin Immunol 32(2):300-311.
16. Diamond MS, Farzan M (2013) The broad-spectrum antiviral functions of IFIT and IFITM proteins. Nat Rev Immunol 13(1):46-57.
17. Sadler AJ, Williams BR (2008) Interferon-inducible antiviral effectors. Nat Rev Immunol 8(7):559-568.
18. Urban TJ, et al. (2010) IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology 52(6):1888-1896.
19. Suppiah V, et al. (2009) IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet 41(10):1100-1104.
20. Tanaka Y, et al. (2009) Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 41(10):1105-1109.
21. Thomas DL, et al. (2009) Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461(7265):798-801.
22. Ge D, et al. (2009) Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 461(7262):399-401.
23. Teijaro JR, et al. (2013) Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science 340(6129):207-211.
24. Wilson EB, et al. (2013) Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science 340(6129):202-207.
25. Tilton JC, et al. (2006) Diminished production of monocyte proinflammatory cytokines during human immunodeficiency virus viremia is mediated by type I interferons. J Virol 80(23):11486-11497.
26. Buddeberg BS, Aveling W (2015) Puerperal sepsis in the 21st century: Progress, new challenges and the situation worldwide. Postgrad Med J 91(1080):572-578.
27. Parker D, Planet PJ, Soong G, Narechania A, Prince A (2014) Induction of type I interferon signaling determines the relative pathogenicity of Staphylococcus aureus strains. PLoS Pathog 10(2):e1003951.
28. Dejager L, et al. (2014) Pharmacological inhibition of type I interferon signaling protects mice against lethal sepsis. J Infect Dis 209(6):960-970.
29. López de Padilla CM, Niewold TB (2016) The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases. Gene 576(1 Pt 1):14-21.
30. Baer AN, Witter FR, Petri M (2011) Lupus and pregnancy. Obstet Gynecol Surv 66(10):639-653.
31. Hoyo-Becerra C, Schlaak JF, Hermann DM (2014) Insights from interferon-α-related depression for the pathogenesis of depression associated with inflammation. Brain Behav Immun 42:222-231.
32. Groer ME, Jevitt C, Ji M (2015) Immune changes and dysphoric moods across the postpartum. Am J Reprod Immunol 73(3):193-198.
33. Prokunina-Olsson L, et al. (2013) A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat Genet 45(2):164-171.
34. O'Brien TR, et al. (2015) Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance. J Hepatol 63(5):1103-1110.
35. Moffett A, Loke C (2006) Immunology of placentation in eutherian mammals. Nat Rev Immunol 6(8):584-594.
36. Bayer A, et al. (2016) Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection. Cell Host Microbe 19(5):705-712.
37. Xiao J, et al. (1997) ICAM-1-mediated adhesion of peripheral blood monocytes to the maternal surface of placental syncytiotrophoblasts: Implications for placental villitis. Am J Pathol 150(5):1845-1860.
38. Garcia-Lloret MI, Winkler-Lowen B, Guilbert LJ (2000) Monocytes adhering by LFA-1 to placental syncytiotrophoblasts induce local apoptosis via release of TNF-alpha. A model for hematogenous initiation of placental inflammations. J Leukoc Biol 68(6):903-908.
39. Siwetz M, et al. (2015) Placental fractalkine mediates adhesion of THP-1 monocytes to villous trophoblast. Histochem Cell Biol 143(6):565-574.
40. Bianchi DW, Zickwolf GK, Weil GJ, Sylvester S, DeMaria MA (1996) Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc Natl Acad Sci USA 93(2):705-708.
41. Tsai KW, Kao HW, Chen HC, Chen SJ, Lin WC (2009) Epigenetic control of the expression of a primate-specific microRNA cluster in human cancer cells. Epigenetics 4(8):587-592.
42. Noguer-Dance M, et al. (2010) The primate-specific microRNA gene cluster (C19MC) is imprinted in the placenta. Hum Mol Genet 19(18):3566-3582.
43. Kaur S, et al. (2008) Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc Natl Acad Sci USA 105(12):4808-4813.
44. Grandvaux N, et al. (2002) Transcriptional profiling of interferon regulatory factor 3 target genes: Direct involvement in the regulation of interferon-stimulated genes. J Virol 76(11):5532-5539.