Trauma-specific grey matter alterations in PTSD

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Meng, Linghui ^a,b   Jiang, Jing ^a   Jin, Changfeng ^c   Liu, Jia ^a   Zhao, Youjin ^a   Wang, Weina ^a   Li, Kaiming ^a   Gong, Qiyong ^a  

^a SICHUAN UNIVERSITY   (China)

^b HEBEI MEDICAL UNIVERSITY   (China)

^c SHANDONG MENTAL HEALTH CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN INJURY; FEMALE; GRAY MATTER; HUMAN; MALE; META ANALYSIS; METABOLISM; PATHOLOGY; POSTTRAUMATIC STRESS DISORDER;

BRAIN INJURIES; FEMALE; GRAY MATTER; HUMANS; MALE; STRESS DISORDERS, POST-TRAUMATIC;

EID: 84988615454     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep33748     Document Type: Article

References (60)

1. Pitman, R. K. et al. Biological studies of post-traumatic stress disorder. Nature reviews. Neuroscience 13, 769-787 (2012).
2. American Psychiatric Association. Diagnostic And Statistical Manual Of Mental Disorders (5th end) 274 (2013).
3. Santiago, P. N. et al. A systematic review of PTSD prevalence and trajectories in DSM-5 defined trauma exposed populations: intentional and non-intentional traumatic events. Plos one 8, e59236 (2013).
4. van der Kolk, B. A., Roth, S., Pelcovitz, D., Sunday, S. & Spinazzola, J. Disorders of extreme stress: The empirical foundation of a complex adaptation to trauma. Journal of traumatic stress 18, 389-399 (2005).
5. Terr, L. C. Childhood traumas: an outline and overview. The American journal of psychiatry 148, 10-20 (1991).
6. Cody, M. W. & Beck, J. G. Physical injury, PTSD symptoms, and medication use: examination in two trauma types. Journal of traumatic stress 27, 74-81 (2014).
7. Breslau, N. Epidemiologic studies of trauma, posttraumatic stress disorder, and other psychiatric disorders. Canadian journal of psychiatry. Revue canadienne de psychiatrie 47, 923-929 (2002).
8. Perrin, M. et al. Determinants of the development of post-traumatic stress disorder, in the general population. Soc Psychiatry Psychiatr Epidemiol 49, 447-457 (2014).
9. Husarewycz, M. N., El-Gabalawy, R., Logsetty, S. & Sareen, J. The association between number and type of traumatic life experiences and physical conditions in a nationally representative sample. General hospital psychiatry 36, 26-32 (2014).
10. Ditlevsen, D. N. & Elklit, A. Gender, trauma type, and PTSD prevalence: a re-analysis of 18 nordic convenience samples. Annals of general psychiatry 11, 26 (2012).
11. Boccia, M. et al. Different neural modifications underpin PTSD after different traumatic events: an fMRI meta-analytic study. Brain imaging and behavior 10, 226-237 (2016).
12. Li, L. et al. Grey matter reduction associated with posttraumatic stress disorder and traumatic stress. Neuroscience and biobehavioral reviews 43, 163-172 (2014).
13. Zhang, J. et al. Decreased gray matter volume in the left hippocampus and bilateral calcarine cortex in coal mine flood disaster survivors with recent onset PTSD. Psychiatry Res 192, 84-90 (2011).
14. Kasai, K. et al. Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder. Biological psychiatry 63, 550-556 (2008).
15. Ashburner, J. & Friston, K. J. Voxel-Based Morphometry-The Methods. NeuroImage 11, 805-821 (2000).
16. Schmidt-Wilcke, T., Poljansky, S., Hierlmeier, S., Hausner, J. & Ibach, B. Memory performance correlates with gray matter density in the ento-/perirhinal cortex and posterior hippocampus in patients with mild cognitive impairment and healthy controls - A voxel based morphometry study. NeuroImage 47, 1914-1920 (2009).
17. Sasaki, H. et al. Structural and diffusional brain abnormality related to relatively low level alcohol consumption. NeuroImage 46, 505-510 (2009).
18. Li, L. et al. Magnetic resonance imaging and magnetic resonance spectroscopy study of deficits in hippocampal structure in fire victims with recent-onset posttraumatic stress disorder. Can J Psychiatry 51, 431-437 (2006).
19. Herringa, R., Phillips, M., Almeida, J., Insana, S. & Germain, A. Post-traumatic stress symptoms correlate with smaller subgenual cingulate, caudate, and insula volumes in unmedicated combat veterans. Psychiatry Res. 203, 139-145 (2012).
20. Meng, Y. et al. Anatomical deficits in adult posttraumatic stress disorder: a meta-analysis of voxel-based morphometry studies. Behav Brain Res. 270, 307-315 (2014).
21. Kuhn, S. & Gallinat, J. Gray matter correlates of posttraumatic stress disorder: a quantitative meta-analysis. Biological psychiatry 73, 70-74 (2013).
22. Chen, S. et al. Gray matter density reduction in the insula in fire survivors with posttraumatic stress disorder: a voxel-based morphometric study. Psychiatry research 146, 65-72 (2006).
23. Chen, S., Li, L., Xu, B. & Liu, J. Insular cortex involvement in declarative memory deficits in patients with post-traumatic stress disorder. BMC psychiatry 9, 39 (2009).
24. Chen, Y. et al. Different regional gray matter loss in recent onset PTSD and non PTSD after a single prolonged trauma exposure. PLoS One 7, e48298 (2012).
25. Bryant, R. A. et al. Rostral anterior cingulate volume predicts treatment response to cognitive-behavioural therapy for posttraumatic stress disorder. J Psychiatry Neurosci 33, 142-146 (2008).
26. Chao, L. L., Lenoci, M. & Neylan, T. C. Effects of post-traumatic stress disorder on occipital lobe function and structure. Neuroreport 23, 412-419 (2012).
27. Cortese, B. M., McConnell, P. A., Froeliger, B., Leslie, K. & Uhde, T. W. Burning odor-elicited anxiety in OEF/OIF combat veterans: Inverse relationship to gray matter volume in olfactory cortex. Journal of psychiatric research 70, 58-66 (2015).
28. Eckart, C. et al. Structural alterations in lateral prefrontal, parietal and posterior midline regions of men with chronic posttraumatic stress disorder. J Psychiatry Neurosci 36, 176-186 (2011).
29. Felmingham, K. et al. Duration of posttraumatic stress disorder predicts hippocampal grey matter loss. Neuroreport 20, 1402-1406 (2009).
30. Hakamata, Y. et al. Structure of orbitofrontal cortex and its longitudinal course in cancer-related post-traumatic stress disorder. Neurosci Res 59, 383-389 (2007).
31. Nardo, D. et al. Gray matter volume alterations related to trait dissociation in PTSD and traumatized controls. Acta Psychiatr Scand 128, 222-233 (2013).
32. Nardo, D. et al. Gray matter density in limbic and paralimbic cortices is associated with trauma load and EMDR outcome in PTSD patients. Journal of psychiatric research 44, 477-485 (2010).
33. Rocha-Rego, V. et al. Decreased premotor cortex volume in victims of urban violence with posttraumatic stress disorder. PloS one 7, e42560 (2012).
34. Tan, L. et al. Brain structure in post-traumatic stress disorder: A voxel-based morphometry analysis. Neural regeneration research 8, 2405-2414 (2013).
35. Yamasue, H. et al. Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism. Proceedings of the National Academy of Sciences of the United States of America 100, 9039-9043 (2003).
36. Sui, S. G. et al. Abnormal grey matter in victims of rape with PTSD in Mainland China: a voxel-based morphometry study. Acta neuropsychiatrica 22, 118-126 (2010).
37. Lanius, R. A. et al. Emotion modulation in PTSD: Clinical and neurobiological evidence for a dissociative subtype. Am J Psychiatry 167, 640-647 (2010).
38. Patel, R., Spreng, R. N., Shin, L. M. & Girard, T. A. Neurocircuitry models of posttraumatic stress disorder and beyond: a metaanalysis of functional neuroimaging studies. Neuroscience and biobehavioral reviews 36, 2130-2142 (2012).
39. Cisler, J. M. et al. Functional reorganization of neural networks during repeated exposure to the traumatic memory in posttraumatic stress disorder: an exploratory fMRI study. Journal of psychiatric research 48, 47-55 (2014).
40. Hoexter, M. Q. et al. Higher striatal dopamine transporter density in PTSD: an in vivo SPECT study with [(99 m)Tc]TRODAT-1. Psychopharmacology 224, 337-345 (2012).
41. Lui, S. et al. Brain structural plasticity in survivors of a major earthquake. J Psychiatry Neurosci 38, 381-387 (2013).
42. Lui, S. et al. High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China. Proceedings of the National Academy of Sciences of the United States of America 106, 15412-15417 (2009).
43. Du, M. Y. et al. Altered functional connectivity in the brain default-mode network of earthquake survivors persists after 2 years despite recovery from anxiety symptoms. Soc Cogn Affect Neurosci 10, 1497-1505 (2015).
44. Arnsten, A. F. Stress signalling pathways that impair prefrontal cortex structure and function. Nature reviews. Neuroscience 10, 410-422 (2009).
45. Kim, J. J. & Yoon, K. S. Stress: metaplastic effects in the hippocampus. Trends in neurosciences 21, 505-509 (1998).
46. Elliott, A. E. & Packard, M. G. Intra-amygdala anxiogenic drug infusion prior to retrieval biases rats towards the use of habit memory. Neurobiology of learning and memory 90, 616-623 (2008).
47. Packard, M. G. & Teather, L. A. Amygdala modulation of multiple memory systems: hippocampus and caudate-putamen. Neurobiology of learning and memory 69, 163-203 (1998).
48. Cardenas, V. A. et al. Changes in brain anatomy during the course of posttraumatic stress disorder. Psychiatry research 193, 93-100 (2011).
49. Arruda-Carvalho, M. & Clem, R. L. Prefrontal-amygdala fear networks come into focus. Frontiers in systems neuroscience 9, 145 (2015).
50. Mickleborough, M. J. et al. Effects of trauma-related cues on pain processing in posttraumatic stress disorder: an fMRI investigation. J Psychiatry Neurosci 36, 6-14 (2011).
51. Nicholson, A. A. et al. Unique insula subregion resting-state functional connectivity with amygdala complexes in posttraumatic stress disorder and its dissociative subtype. Psychiatry Res 250, 61-72 (2016).
52. van Wingen, G. A., Geuze, E., Vermetten, E. & Fernandez, G. Perceived threat predicts the neural sequelae of combat stress. Molecular psychiatry 16, 664-671 (2011).
53. Shvil, E. et al. Sex differences in extinction recall in posttraumatic stress disorder: a pilot fMRI study. Neurobiology of learning and memory 113, 101-108 (2014).
54. Chao, L. L., Yaffe, K., Samuelson, K. & Neylan, T. C. Hippocampal volume is inversely related to PTSD duration. Psychiatry research 222, 119-123 (2014).
55. Chen, G. et al. Disorganization of white matter architecture in major depressive disorder: a meta-analysis of diffusion tensor imaging with tract-based spatial statistics. Scientific reports 6, 21825 (2016).
56. Shepherd, A. M., Matheson, S. L., Laurens, K. R., Carr, V. J. & Green, M. J. Systematic meta-analysis of insula volume in schizophrenia. Biological psychiatry 72, 775-784 (2012).
57. Radua, J. et al. A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps. European psychiatry: the journal of the Association of European Psychiatrists 27, 605-611 (2012).
58. Radua, J. et al. Anisotropic kernels for coordinate-based meta-analyses of neuroimaging studies. Frontiers in psychiatry 5, 13 (2014).
59. Egger, M., Davey Smith, G., Schneider, M. & Minder, C. Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical research ed.) 315, 629-634 (1997).
60. Radua, J. & Mataix-Cols, D. Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder. The British journal of psychiatry: the journal of mental science 195, 393-402 (2009).