Functional reorganization of neural networks during repeated exposure to the traumatic memory in posttraumatic stress disorder: An exploratory fMRI study

Journal of Psychiatric Research

Volumn 48, Issue 1, 2014, Pages 47-55

  Cisler, Josh M ^a   Steele, J Scott ^a   Lenow, Jennifer K ^a   Smitherman, Sonet ^a   Everett, Betty ^a   Messias, Erick ^a   Kilts, Clinton D ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Exposure therapy; Fear extinction; Neuroimaging; PTSD

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; ANTERIOR INSULA; ANXIETY; ARTICLE; CINGULATE GYRUS; CLINICAL ARTICLE; CORPUS STRIATUM; DISEASE SEVERITY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HUMAN; INSULA; NERVE CELL NETWORK; ORBITAL CORTEX; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSYCHOTHERAPY; REPEATED EXPOSURE TO THE TRAUMATIC MEMORY;

EXPOSURE THERAPY; FEAR EXTINCTION; NEUROIMAGING; PTSD;

ADULT; BRAIN; BRAIN MAPPING; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MEMORY DISORDERS; OXYGEN; STRESS DISORDERS, POST-TRAUMATIC; YOUNG ADULT;

EID: 84888431921     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2013.09.013     Document Type: Article

References (55)

1. APA Diagnostic and statistical manual of mental health disorders 2000, APA, Washington, DC. 4th ed.
2. Beck A.T., Steer R.A., Brown G.K. Manual for the BDI-II 1996, The Psychological Corporation, San Antonio, TX.
3. Behrens T.E., Woolrich M.W., Walton M.E., Rushworth M.F. Learning the value of information in an uncertain world. Nature Neuroscience 2007, 10:1214-1221.
4. Blanchard E.B., Jones-Alexander J., Buckley T.C., Forneris C.A. Psychometric properties of the PTSD Checklist (PCL). Behaviour Research and Therapy 1996, 34:669-673.
5. Bossaerts P. Risk and risk prediction error signals in anterior insula. Brain Structure and Function 2010, 214:645-653.
6. Botvinick M.M., Braver T.S., Barch D.M., Carter C.S., Cohen J.D. Conflict monitoring and cognitive control. Psychological Review 2001, 108:624-652.
7. Bryk A.S., Raudenbush S.W. Application of hierarchical linear-models to assessing change. Psychological Bulletin 1987, 101:147-158.
8. Davis M., Whalen P.J. The amygdala: vigilance and emotion. Molecular Psychiatry 2001, 6:13-34.
9. Delgado M.R., Nearing K.I., LeDoux J.E., Phelps E.A. Neural circuitry underlying the regulation of conditioned fear and its relation to extinction. Neuron 2008, 59:829-838.
10. Etkin A., Egner T., Peraza D.M., Kandel E.R., Hirsch J. Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron 2006, 51:871-882.
11. First M.B., Spitzer Robert L., Gibbon Miriam, Williams Janet B.W. Structured clinical interview for DSM-IV-TR axis I disorders, research version, non-patient Edition 2002, Biometrics Research, New York State Psychiatric Institute, New York.
12. Foa E.B., Dancu C.V., Hembree E.A., Jaycox L.H., Meadows E.A., Street G.P. Acomparison of exposure therapy, stress inoculation training, and their combination for reducing posttraumatic stress disorder in female assault victims. Journal of Consulting and Clinical Psychology 1999, 67:194-200.
13. Foa E.B., Kozak M.J. Emotional processing of fear: exposure to corrective information. Psychological Bulletin 1986, 99:20-35.
14. Foa E.B., Rothbaum B.O., Riggs D.S., Murdock T.B. Treatment of posttraumatic stress disorder in rape victims: a comparison between cognitive-behavioral procedures and counseling. Journal of Consulting and Clinical Psychology 1991, 59:715-723.
15. Foa E.B., Zoellner L.A., Feeny N.C., Hembree E.A., Alvarez-Conrad J. Does imaginal exposure exacerbate PTSD symptoms?. Journal of Consulting and Clinical Psychology 2002, 70:1022-1028.
16. Forman S.D., Cohen J.D., Fitzgerald M., Eddy W.F., Mintun M.A., Noll D.C. Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magnetic Resonance in Medicine 1995, 33:636-647.
17. Ghashghaei H.T., Hilgetag C.C., Barbas H. Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala. Neuroimage 2007, 34:905-923.
18. Hayes J.P., Hayes S.M., Mikedis A.M. Quantitative meta-analysis of neural activity in posttraumatic stress disorder. Biology of Mood and Anxiety Disorders 2012, 2:9.
19. Karatzias A., Power K., McGoldrick T., Brown K., Buchanan R., Sharp D., et al. Predicting treatment outcome on three measures for post-traumatic stress disorder. European Archives of Psychiatry and Clinical Neuroscience 2007, 257:40-46.
20. Kerns J.G., Cohen J.D., MacDonald A.W., Cho R.Y., Stenger V.A., Carter C.S. Anterior cingulate conflict monitoring and adjustments in control. Science 2004, 303:1023-1026.
21. Kilpatrick D.G., Acierno R., Saunders B., Resnick H.S., Best C.L., Schnurr P.P. Risk factors for adolescent substance abuse and dependence: data from a national sample. Journal of Consulting and Clinical Psychology 2000, 68:19-30.
22. Kilpatrick D.G., Ruggiero K.J., Acierno R., Saunders B.E., Resnick H.S., Best C.L. Violence and risk of PTSD, major depression, substance abuse/dependence, and comorbidity: results from the National Survey of Adolescents. Journal of Consulting and Clinical Psychology 2003, 71:692-700.
23. Li J., Schiller D., Schoenbaum G., Phelps E.A., Daw N.D. Differential roles of human striatum and amygdala in associative learning. Nature Neuroscience 2011, 14:1250-1252.
24. Maren S., Phan K.L., Liberzon I. The contextual brain: implications for fear conditioning, extinction and psychopathology. Nature Reviews Neuroscience 2013, 14:417-428.
25. Milad M.R., Wright C.I., Orr S.P., Pitman R.K., Quirk G.J., Rauch S.L. Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biological Psychiatry 2007, 62:446-454.
26. Morgan M.A., LeDoux J.E. Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Behavioral Neuroscience 1995, 109:681-688.
27. Morgan M.A., Romanski L.M., LeDoux J.E. Extinction of emotional learning: contribution of medial prefrontal cortex. Neuroscience Letters 1993, 163:109-113.
28. Morgan M.A., Schulkin J., LeDoux J.E. Ventral medial prefrontal cortex and emotional perseveration: the memory for prior extinction training. Behavioural Brain Research 2003, 146:121-130.
29. Myers K.M., Davis M. Mechanisms of fear extinction. Molecular Psychiatry 2007, 12:120-150.
30. Olatunji B.O., Cisler J.M., Tolin D.F. Quality of life in the anxiety disorders: a meta-analytic review. Clinical Psychology Review 2007, 27:572-581.
31. Orr S.P., Lasko N.B., Metzger L.J., Berry N.J., Ahern C.E., Pitman R.K. Psychophysiologic assessment of women with posttraumatic stress disorder resulting from childhood sexual abuse. Journal of Consulting and Clinical Psychology 1998, 66:906-913.
32. Orr S.P., Pitman R.K., Lasko N.B., Herz L.R. Psychophysiological assessment of posttraumatic stress disorder imagery in World War II and Korean combat veterans. Journal of Abnormal Psychology 1993, 102:152-159.
33. Orsini C.A., Kim J.H., Knapska E., Maren S. Hippocampal and prefrontal projections to the basal amygdala mediate contextual regulation of fear after extinction. Journal of Neuroscience 2011, 31:17269-17277.
34. Oyama K., Hernadi I., Iijima T., Tsutsui K. Reward prediction error coding in dorsal striatal neurons. Journal of Neuroscience 2010, 30:11447-11457.
35. Patel R., Spreng R.N., Shin L.M., Girard T.A. Neurocircuitry models of posttraumatic stress disorder and beyond: a meta-analysis of functional neuroimaging studies. Neuroscience and Biobehavioral Reviews 2012, 36:2130-2142.
36. Phelps E.A., Delgado M.R., Nearing K.I., LeDoux J.E. Extinction learning in humans: role of the amygdala and vmPFC. Neuron 2004, 43:897-905.
37. Pitman R.K., Orr S.P., Forgue D.F., de Jong J.B., Claiborn J.M. Psychophysiologic assessment of posttraumatic stress disorder imagery in Vietnam combat veterans. Archives of General Psychiatry 1987, 44:970-975.
38. Preuschoff K., Quartz S.R., Bossaerts P. Human insula activation reflects risk prediction errors as well as risk. Journal of Neuroscience 2008, 28:2745-2752.
39. Quirk G.J., Beer J.S. Prefrontal involvement in the regulation of emotion: convergence of rat and human studies. Current Opinion in Neurobiology 2006, 16:723-727.
40. Rauch S.L., van der Kolk B.A., Fisler R.E., Alpert N.M., Orr S.P., Savage C.R., et al. Asymptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. Archives of General Psychiatry 1996, 53:380-387.
41. Raudenbush S., Byrk A. Hierarchical linear models 2002, Sage Publications, Thousand Oaks. 2nd ed.
42. Resick P.A., Nishith P., Weaver T.L., Astin M.C., Feuer C.A. Acomparison of cognitive-processing therapy with prolonged exposure and a waiting condition for the treatment of chronic posttraumatic stress disorder in female rape victims. Journal of Consulting and Clinical Psychology 2002, 70:867-879.
43. Resnick H.S., Kilpatrick D.G., Dansky B.S., Saunders B.E., Best C.L. Prevalence of civilian trauma and posttraumatic stress disorder in a representative national sample of women. Journal of Consulting and Clinical Psychology 1993, 61:984-991.
44. Rothbaum B.O., Davis M. Applying learning principles to the treatment of post-trauma reactions. Annals of the New York Academy of Sciences 2003, 1008:112-121.
45. Rushworth M.F., Behrens T.E. Choice, uncertainty and value in prefrontal and cingulate cortex. Nature Neuroscience 2008, 11:389-397.
46. Sartory G., Cwik J., Knuppertz H., Schurholt B., Lebens M., Seitz R.J., et al. In search of the trauma memory: a meta-analysis of functional neuroimaging studies of symptom provocation in posttraumatic stress disorder (PTSD). PLoS ONE 2013, 8:e58150.
47. Schiller D., Delgado M.R. Overlapping neural systems mediating extinction, reversal and regulation of fear. Trends in Cognitive Sciences 2010, 14:268-276.
48. Schiller D., Levy I., Niv Y., LeDoux J.E., Phelps E.A. From fear to safety and back: reversal of fear in the human brain. Journal of Neuroscience 2008, 28:11517-11525.
49. Schnurr P.P., Friedman M.J., Engel C.C., Foa E.B., Shea M.T., Chow B.K., et al. Cognitive behavioral therapy for posttraumatic stress disorder in women: a randomized controlled trial. Journal of the American Medical Association 2007, 297:820-830.
50. Schultz W., Dickinson A. Neuronal coding of prediction errors. Annual Review of Neuroscience 2000, 23:473-500.
51. Shalev A.Y., Orr S.P., Pitman R.K. Psychophysiologic response during script-driven imagery as an outcome measure in posttraumatic stress disorder. Journal of Clinical Psychiatry 1992, 53:324-326.
52. Shalev A.Y., Orr S.P., Pitman R.K. Psychophysiologic assessment of traumatic imagery in Israeli civilian patients with posttraumatic stress disorder. American Journal of Psychiatry 1993, 150:620-624.
53. Sotres-Bayon F., Cain C.K., LeDoux J.E. Brain mechanisms of fear extinction: historical perspectives on the contribution of prefrontal cortex. Biological Psychiatry 2006, 60:329-336.
54. Squire L.R. Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychological Review 1992, 99:195-231.
55. Stalnaker T.A., Calhoon G.G., Ogawa M., Roesch M.R., Schoenbaum G. Reward prediction error signaling in posterior dorsomedial striatum is action specific. Journal of Neuroscience 2012, 32:10296-10305.