Targeted cancer immunotherapy via combination of designer bispecific antibody and novel gene-engineered T cells

Journal of Translational Medicine

Volumn 12, Issue 1, 2014, Pages

  Urbanska, Katarzyna ^b   Lynn, Rachel C ^b   Stashwick, Caitlin ^b   Thakur, Archana ^c   Lum, Lawrence G ^c   Powell, Daniel J ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adoptive T cell transfer; Bispecific antibody; Cancer; Chimeric immunoreceptor; Immunotherapy; Rituximab; Trastuzumab

Indexed keywords

BISPECIFIC ANTIBODY; CD28 ANTIGEN; FOLATE RECEPTOR; FOLATE RECEPTOR BISPECIFIC ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; RITUXIMAB; T LYMPHOCYTE RECEPTOR; TRASTUZUMAB; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER IMMUNOTHERAPY; CELL ACTIVITY; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; CYTOTOXICITY; EPITHELIAL CANCER CELL LINE; FETUS; GENETIC ENGINEERING; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; CELL LINE; IMMUNOLOGY; IMMUNOTHERAPY; NEOPLASMS;

ANTIBODIES, BISPECIFIC; CELL LINE; GENETIC ENGINEERING; HUMANS; IMMUNOTHERAPY; NEOPLASMS; T-LYMPHOCYTES;

EID: 84988589233     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-014-0347-2     Document Type: Article

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