Vitamin D is Not Associated with Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis

American Journal of Gastroenterology

Volumn 111, Issue 11, 2016, Pages 1591-1598

  Patel, Yuval A ^a   Henao, Ricardo ^b   Moylan, Cynthia A ^a   Guy, Cynthia D ^c   Piercy, Dawn L ^a   Diehl, Anna Mae ^a   Abdelmalek, Manal F ^a  

^a Division of Gastroenterology   (United States)

^b Department of Electrical and Computer Engineering ^*  (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C; VITAMIN D;

ADULT; ARTICLE; CHI SQUARE TEST; CONTROLLED STUDY; DISEASE SEVERITY; FATTY LIVER; FEMALE; FISHER EXACT TEST; GENE EXPRESSION PROFILING; HISTOLOGY; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER CELL; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NONALCOHOLIC FATTY LIVER; PREDICTIVE VALUE; PRIORITY JOURNAL; RANK SUM TEST; RISK FACTOR; STUDENT T TEST; VITAMIN D DEFICIENCY; VITAMIN METABOLISM;

EID: 84988568633     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2016.406     Document Type: Article

References (37)

1. Rinella ME. Nonalcoholic fatty liver disease: a systematic review. JAMA 2015; 313: 2263-73.
2. Williams CD, Stengel J, Asike MI et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 2011; 140: 124-31.
3. Chalasani N, Younossi Z, Lavine JE et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 2012; 142: 1592-609.
4. Kleiner DE, Brunt EM, Van Natta M et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-21.
5. Ludwig J, Viggiano TR, McGill DB et al. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980; 55: 434-8.
6. Ganji V, Zhang X, Tangpricha V. Serum 25-hydroxyvitamin D concentrations and prevalence estimates of hypovitaminosis D in the U.S. population based on assay-adjusted data. J Nutr 2012; 142: 498-507.
7. Kayaniyil S, Vieth R, Retnakaran R et al. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care 2010; 33: 1379-81.
8. Kwok RM, Torres DM, Harrison SA. Vitamin D and nonalcoholic fatty liver disease (NAFLD): is it more than just an association? Hepatology 2013; 58: 1166-74.
9. Targher G, Bertolini L, Scala L et al. Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 2007; 17: 517-24.
10. Nobili V, Giorgio V, Liccardo D et al. Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease. Eur J Endocrinol 2014; 170: 547-53.
11. Manco M, Ciampalini P, Nobili V. Low levels of 25-hydroxyvitamin D(3) in children with biopsy-proven nonalcoholic fatty liver disease. Hepatology 2010; 51: 2229; author reply 2230.
12. Dasarathy J, Periyalwar P, Allampati S et al. Hypovitaminosis D is associated with increased whole body fat mass and greater severity of non-alcoholic fatty liver disease. Liver Int 2014; 34: e118-7.
13. Nelson JE, Roth CL, Wilson LA et al. Vitamin D deficiency is associated with increased risk of non-alcoholic steatohepatitis in adults with nonalcoholic fatty liver disease: possible role for MAPK and NF-kappaB? Am J Gastroenterol 2016; 111: 852-63.
14. Ding N, Yu RT, Subramaniam N et al. A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell 2013; 153: 601-13.
15. Beilfuss A, Sowa JP, Sydor S et al. Vitamin D counteracts fibrogenic TGFbeta signalling in human hepatic stellate cells both receptor-dependently and independently. Gut 2015; 64: 791-9.
16. Baeke F, Takiishi T, Korf H et al. Vitamin D: modulator of the immune system. Curr Opin Pharmacol 2010; 10: 482-96.
17. Bril F, Maximos M, Portillo-Sanchez P et al. Relationship of vitamin D with insulin resistance and disease severity in non-alcoholic steatohepatitis. J Hepatol 2015; 62: 405-11.
18. Anty R, Hastier A, Canivet CM et al. Severe vitamin D deficiency is not associated with liver damage in morbidly obese patients. Obes Surg 2016; 26: 2138-43.
19. Diez Rodriguez R, Ballesteros Pomar MD, Calleja Fernandez A et al. Vitamin D levels and bone turnover markers are not related to non-alcoholic fatty liver disease in severely obese patients. Nutr Hosp 2014; 30: 1256-62.
20. Youssef NA, Abdelmalek MF, Binks M et al. Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease. Liver Int 2013; 33: 1062-70.
21. Yimlamai D, Christodoulou C, Galli GG et al. Hippo pathway activity influences liver cell fate. Cell 2014; 157: 1324-38.
22. Clemens TL, Adams JS, Henderson SL et al. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. Lancet 1982; 1: 74-6.
23. Kasahara AK, Singh RJ, Noymer A. Vitamin D (25OHD) serum seasonality in the United States. PLoS One 2013; 8: e65785.
24. Moylan CA, Pang H, Dellinger A et al. Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease. Hepatology 2014; 59: 471-82.
25. Levey AS, Stevens LA, Schmid CH et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-12.
26. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 80: 1678s - 88s.
27. Seo JA, Eun CR, Cho H et al. Low vitamin D status is associated with nonalcoholic Fatty liver disease independent of visceral obesity in Korean adults. PLoS One 2013; 8: e75197.
28. Danziger J, Biggs ML, Niemi M et al. de Boer IH, et al. Circulating 25-hydroxyvitamin D is associated with insulin resistance cross-sectionally but not longitudinally in older adults: The Cardiovascular Health Study. Metabolism 2013; 62: 1788-94.
29. Manco M, Calvani M, Nanni G et al. Low 25-hydroxyvitamin D does not affect insulin sensitivity in obesity aft er bariatric surgery. Obes Res 2005; 13: 1692-700.
30. Jablonski KL, Jovanovich A, Holmen J et al. Low 25-hydroxyvitamin D level is independently associated with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 2013; 23: 792-8.
31. Barchetta I, Angelico F, Del Ben M et al. Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes. BMC Med 2011; 9 85.
32. Liangpunsakul S, Chalasani N. Serum vitamin D concentrations and unexplained elevation in ALT among US adults. Dig Dis Sci 2011; 56: 2124-9.
33. Barchetta I, Carotti S, Labbadia G et al. Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus. Hepatology 2012; 56: 2180-7.
34. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol 2014; 21: 319-29.
35. Speeckaert M, Huang G, Delanghe JR et al. Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta 2006; 372: 33-42.
36. Bu FX, Armas L, Lappe J et al. Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects. Hum Genet 2010; 128: 549-56.
37. Adams LA, White SW, Marsh JA et al. Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. Hepatology 2013; 57: 590-600.