Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease

European Journal of Endocrinology

Volumn 170, Issue 4, 2014, Pages 547-553

  Nobili, Valerio ^a   Giorgio, Valentina ^a   Liccardo, Daniela ^a   Bedogni, Giorgio ^a,b   Morino, Giuseppe ^a   Alisi, Anna ^a   Cianfarani, Stefano ^c,d  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^b Clinical Epidemiology Unit Liver Research Center ^*  (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; AMINOTRANSFERASE; PARATHYROID HORMONE;

ADOLESCENT; ADULT; AGE; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BODY MASS; BONE DENSITY; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; ECHOGRAPHY; FEMALE; GENDER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; LIVER INJURY; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; OBESITY; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; SCHOOL CHILD; VITAMIN BLOOD LEVEL; WAIST CIRCUMFERENCE;

ABSORPTIOMETRY, PHOTON; ADOLESCENT; BODY MASS INDEX; BONE DENSITY; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FATTY LIVER; FEMALE; FIBROSIS; HUMANS; LINEAR MODELS; LIVER; MALE; MULTIVARIATE ANALYSIS; OBESITY; OVERWEIGHT; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84896945009     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-13-0609     Document Type: Article

References (34)

1. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM & Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism 2011 96 1911-1930. (doi:10.1210/jc.2011-0385)
2. Bouillon R. Genetic and environmental determinants of vitamin D status. Lancet 2010 376 148-149. (doi:10.1016/S0140-6736 (10) 60635-6)
3. Ratziu V, Bellentani S, Cortez-Pinto H, Day C & Marchesini G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. Journal of Hepatology 2010 53 372-384. (doi:10.1016/j.jhep. 2010.04.008)
4. Caserta CA, Pendino GM, Amante A, Vacalebre C, Fiorillo MT, Surace P, Messineo A, Surace M, Alicante S, Cotichini R et al. Cardiovascular risk factors, nonalcoholic fatty liver disease, and carotid artery intima-media thickness in an adolescent population in southern Italy. American Journal of Epidemiology 2010 171 1195-1202. (doi:10.1093/aje/kwq073)
5. Imhof A, Kratzer W, Boehm B, Meitinger K, Trischler G, Steinbach G, Piechotowski I & Koenig W. Prevalence of non-alcoholic fatty liver and characteristics in overweight adolescents in the general population. European Journal of Epidemiology 2007 22 889-897. (doi:10.1007/s10654-007-9181-7)
6. Eliades M, Spyrou E, Agrawal N, Lazo M, Brancati FL, Potter JJ, Koteish AA, Clark JM, Guallar E & Hernaez R. Meta-analysis: vitamin D and non-alcoholic fatty liver disease. Alimentary Pharmacology & Therapeutics 2013 38 246-254. (doi:10.1111/apt.12377)
7. Turer CB, Lin H & Flores G. Prevalence of vitamin D deficiency among overweight and obese US children. Pediatrics 2013 131 e152-e161. (doi:10.1542/peds.2012-1711)
8. Targher G, Bertolini L, Scala L, Cigolini M, Zenari L, Falezza G & Arcaro G. Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutrition, Metabolism, and Cardiovascular Diseases 2007 17 517-524. (doi:10.1016/j.numecd. 2006.04.002)
9. Roth CL, Elfers CT, Figlewicz DP, Melhorn SJ, Morton GJ, Hoofnagle A, Yeh MM, Nelson JE & Kowdley KV. Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation. Hepatology 2012 55 1103-1111. (doi:10.1002/hep. 24737)
10. Kwok RM, Torres DM & Harrison SA. Vitamin D and NAFLD: is it more than just an association? Hepatology 2013 58 1166-1174. (doi:10.1002/hep. 26390)
11. Manco M, Ciampalini P & Nobili V. Low levels of 25-hydroxyvitamin D (3) in children with biopsy-proven nonalcoholic fatty liver disease. Hepatology 2010 51 2229. (doi:10.1002/hep. 23724)
12. Lohman TG, Roche AF & Martorell R. In Anthropometric Standardization Reference Manual. Champaign, IL, USA: Human Kinetics Books, 1988.
13. Cacciari E, Milani S, Balsamo A, Spada E, Bona G, Cavallo L, Cerutti F, Gargantini L, Greggio N, Tonini G et al. Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr). Journal of Endocrinological Investigation 2006 29 581-593.
14. Wallace TM, Levy JC & Matthews DR. Use and abuse of HOMA modeling. Diabetes Care 2004 27 1487-1495. (doi:10.2337/diacare.27. 6.1487)
15. Schwartz GJ, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA & Furth SL. New equations to estimate GFR in children with CKD. Journal of the American Society of Nephrology 2009 20 629-637. (doi:10.1681/ASN.2008030287)
16. Ross AC, Taylor CL, Yaktine AL & Del Valle HB. In Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC, USA: National Academies Press, 2011.
17. Zimmet P, Alberti KG, Kaufman F, Tajima N, Silink M, Arslanian S, Wong G, Bennett P, Shaw J, Caprio S et al. The metabolic syndrome in children and adolescents - an IDF consensus report. Pediatric Diabetes 2007 8 299-306. (doi:10.1111/j.1399-5448.2007. 00271.x)
18. Kelly TL, Wilson KE & Heymsfield SB. Dual energy X-ray absorptiometry body composition reference values from NHANES. PLoS ONE 2009 4 e7038. (doi:10.1371/journal.pone.0007038)
19. Shannon A, Alkhouri N, Carter-Kent C, Monti L, Devito R, Lopez R, Lopez R, Feldstein AE & Nobili V. Ultrasonographic quantitative estimation of hepatic steatosis in children with NAFLD. Journal of Pediatric Gastroenterology and Nutrition 2011 53 190-195. (doi:10.1097/MPG.0b013e31821b4b61)
20. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005 41 1313-1321. (doi:10.1002/hep. 20701)
21. Royston P & Sauerbrei W. In Multivariable Model-Building: A Pragmatic Approach to Regression Analysis based on Fractional Polynomials for Modeling Continuous Variables. Hoboken, NJ, USA: John Wiley, 2008.
22. Nobili V, Alisi A, Vania A, Tiribelli C, Pietrobattista A & Bedogni G. The pediatric NAFLD fibrosis index: a predictor of liver fibrosis in children with non-alcoholic fatty liver disease. BMC Medicine 2009 7 21. (doi:10.1186/1741-7015-7-21)
23. Yilmaz Y. Review article: Non-alcoholic fatty liver disease and osteoporosis - clinical and molecular crosstalk. Alimentary Pharmacology & Therapeutics 2012 36 345-352. (doi:10.1111/j.1365-2036.2012. 05196.x)
24. Rigby WF, Stacy T & Fanger MW. Inhibition of T lymphocyte mitogenesis by 1, 25-dihydroxyvitamin D3 (calcitriol). Journal of Clinical Investigation 1984 74 1451-1455. (doi:10.1172/JCI111557)
25. Barchetta I, Carotti S, Labbadia G, Gentilucci UV, Muda AO, Angelico F, Silecchia G, Leonetti F, Fraioli A, Picardi A et al. Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus. Hepatology 2012 56 2180-2187. (doi:10.1002/hep. 25930)
26. Abramovitch S, Dahan-Bachar L, Sharvit E, Weisman Y, Ben Tov A, Brazowski E & Reif S. Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamideinduced liver fibrosis in rats. Gut 2011 60 1728-1737. (doi:10.1136/gut. 2010.234666)
27. Tanaka A, Nezu S, Uegaki S, Kikuchi K, Shibuya A, Miyakawa H, Takahashi S, Bianchi I, Zermiani P, Podda M et al. Vitamin D receptor polymorphisms are associated with increased susceptibility to primary biliary cirrhosis in Japanese and Italian populations. Journal of Hepatology 2009 50 1202-1209. (doi:10.1016/j.jhep. 2009.01.015)
28. Arteh J, Narra S & Nair S. Prevalence of vitamin D deficiency in chronic liver disease. Digestive Diseases and Sciences 2010 55 2624-2628. (doi:10. 1007/s10620-009-1069-9)
29. Petta S, Cammà C, Scazzone C, Tripodo C, Di Marco V, Bono A, Cabibi D, Licata G, Porcasi R, Marchesini G et al. Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferonbased therapy in genotype 1 chronic hepatitis C. Hepatology 2010 51 1158-1167. (doi:10.1002/hep. 23489)
30. Rhee EJ, Kim MK, Park SE, Park CY, Baek KH, Lee WY, Kang MI, Park SW, Kim SW & Oh KW. High serum vitamin D levels reduce the risk for nonalcoholic fatty liver disease in healthy men independent of metabolic syndrome. Endocrine Journal 2013 60 743-752. (doi:10.1507/endocrj. EJ12-0387)
31. Gascon-Barré M, Demers C, Mirshahi A, Néron S, Zalzal S & Nanci A. The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells. Hepatology 2003 37 1034-1042. (doi:10.1053/jhep. 2003.50176)
32. Potter JJ, Liu X, Koteish A & Mezey E. 1, 25-Dihydroxyvitamin D3 and its nuclear receptor repress human a1 (I) collagen expression and type I collagen formation. Liver International 2013 33 677-686. (doi:10.1111/liv. 12122)
33. Nakano T, Cheng YF, Lai CY, Hsu LW, Chang YC, Deng JY, Huang YZ, Honda H, Chen KD, Wang CC et al. Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats. Journal of Hepatology 2011 55 415-425. (doi:10.1016/j.jhep. 2010.11.028)
34. Earthman CP, Beckman LM, Masodkar K & Sibley SD. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. International Journal of Obesity 2012 36 387-396. (doi:10.1038/ijo.2011.119)