Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease

Hepatology

Volumn 57, Issue 2, 2013, Pages 590-600

  Adams, Leon A ^a,b,c   White, Scott W ^d   Marsh, Julie A ^d   Lye, Stephen J ^e   Connor, Kristin L ^e   Maganga, Richard ^d   Ayonrinde, Oyekoya T ^a,f,g   Olynyk, John K ^f,g,h   Mori, Trevor A ^a   Beilin, Lawrence J ^a   Palmer, Lyle J ^e,i   Hamdorf, Jeffrey M ^j   Pennell, Craig E ^c,d  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e MOUNT SINAI HOSPITAL   (Canada)

^f FREMANTLE HOSPITAL   (Australia)

^g CURTIN UNIVERSITY   (Australia)

^h UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

ⁱ ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

^j UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CELL PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID PHOSPHATE PHOSPHATASE RELATED PROTEIN TYPE 4; LYMPHOCYTE CYTOSOLIC PROTEIN 1; MESSENGER RNA; SOLUTE CARRIER FAMILY 38 MEMBER 8 PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; ECHOGRAPHY; FATTY LIVER; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN TISSUE; INSULIN BLOOD LEVEL; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; NERVE CELL; NONALCOHOLIC FATTY LIVER; OBESITY; PHENOTYPE; POPULATION BASED CASE CONTROL STUDY; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

ADOLESCENT; ADULT; AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; FATTY LIVER; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MICROFILAMENT PROTEINS; PHOSPHATIDATE PHOSPHATASE; POLYMORPHISM, SINGLE NUCLEOTIDE; VITAMIN D-BINDING PROTEIN;

EID: 84873312029     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26184     Document Type: Article

References (41)

1. Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 2008; 359: 2220-2232.
2. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010; 42: 937-948.
3. Schwimmer JB, Celedon MA, Lavine JE, Salem R, Campbell N, Schork NJ, et al. Heritability of nonalcoholic fatty liver disease. Gastroenterology 2009; 136: 1585-1592.
4. Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008; 40: 1461-1465.
5. Tian C, Stokowski RP, Kershenobich D, Ballinger DG, Hinds DA. Variant in PNPLA3 is associated with alcoholic liver disease. Nat Genet 2010; 42: 21-23.
6. Valenti L, Rumi M, Galmozzi E, Aghemo A, Del Menico B, De Nicola S, et al. Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C. HEPATOLOGY 2011; 53: 791-799.
7. Speliotes EK, Butler JL, Palmer CD, Voight BF, Hirschhorn JN. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. HEPATOLOGY 2010; 52: 904-912.
8. Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet 2011; 7: e1001324.
9. Brunt EM, Kleiner DE, Wilson LA, Unalp A, Behling CE, Lavine JE, et al. Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network. HEPATOLOGY 2009; 49: 809-820.
10. Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, Angulo P. The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 2009; 58: 1538-1544.
11. Newnham JP, Evans SF, Michael CA, Stanley FJ, Landau LI. Effects of frequent ultrasound during pregnancy: a randomised controlled trial. Lancet 1993; 342: 887-891.
12. Ayonrinde OT, Olynyk JK, Beilin LJ, Mori TA, Pennell CE, de Klerk N, et al. Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease. HEPATOLOGY 2011; 53: 800-809.
13. Robinson M, Oddy WH, McLean NJ, Jacoby P, Pennell CE, de Klerk NH, et al. Low-moderate prenatal alcohol exposure and risk to child behavioural development: a prospective cohort study. BJOG 2010; 117: 1139-1150.
14. Hamaguchi M, Kojima T, Itoh Y, Harano Y, Fujii K, Nakajima T, et al. The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation. Am J Gastroenterol 2007; 102: 2708-2715.
15. Fleiss JL. Statistical methods for rates and proportions. 2nd edX. New York: John Wiley & Sons; 1981.
16. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.
17. Li Y, Willer C, Sanna S, Abecasis G. Genotype imputation. Annu Rev Genomics Hum Genet 2009; 10: 387-406.
18. Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR. MaC H: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol 2010; 34: 816-834.
19. Fischer M, Skowron M, Berthold F. Reliable transcript quantification by real-time reverse transcriptase-polymerase chain reaction in primary neuroblastoma using normalization to averaged expression levels of the control genes HPRT1 and SDHA. J Mol Diagn 2005; 7: 89-96.
20. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. HEPATOLOGY 2005; 41: 1313-1321.
21. Giudice EM, Grandone A, Cirillo G, Santoro N, Amato A, Brienza C, et al. The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat. PLoS One 2011; 6: e27933.
22. Graff M, North KE, Franceschini N, Reiner AP, Feitosa M, Carr JJ, et al. PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: The NHLBI Family Heart Study. Int J Obes 2012 [Epub ahead of print].
23. Speeckaert M, Huang G, Delanghe JR, Taes YE. Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta 2006; 372: 33-42.
24. Zhou QG, Hou FF, Guo ZJ, Liang M, Wang GB, Zhang X. 1, 25-Dihydroxyvitamin D improved the free fatty-acid-induced insulin resistance in cultured C2C12 cells. Diabetes Metab Res Rev 2008; 24: 459-464.
25. Takiishi T, Gysemans C, Bouillon R, Mathieu C. Vitamin D and diabetes. Endocrinol Metab Clin North Am 2010; 39: 419-446.
26. Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA. Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr 2008; 88: 1519-1527.
27. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 2004; 27: 2813-2818.
28. Pittas AG, Dawson-Hughes B, Li T, Van Dam RM, Willett WC, Manson JE, et al. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 2006; 29: 650-656.
29. Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes 2008; 57: 2619-2625.
30. Targher G, Bertolini L, Scala L, Cigolini M, Zenari L, Falezza G, et al. Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 2007; 17: 517-524.
31. Bu FX, Armas L, Lappe J, Zhou Y, Gao G, Wang HW, et al. Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects. Hum Genet 2010; 128: 549-556.
32. Hirai M, Suzuki S, Hinokio Y, Chiba M, Kasuga S, Hirai A, et al. Group specific component protein genotype is associated with NIDDM in Japan. Diabetologia 1998; 41: 742-743.
33. Hirai M, Suzuki S, Hinokio Y, Hirai A, Chiba M, Akai H, et al. Variations in vitamin D-binding protein (group-specific component protein) are associated with fasting plasma insulin levels in Japanese with normal glucose tolerance. J Clin Endocrinol Metab 2000; 85: 1951-1953.
34. Delanote V, Vandekerckhove J, Gettemans J. Plastins: versatile modulators of actin organization in (patho)physiological cellular processes. Acta Pharmacol Sin 2005; 26: 769-779.
35. Luo W, Schork NJ, Marschke KB, Ng SC, Hermann TW, Zhang J, et al. Identification of polymorphisms associated with hypertriglyceridemia and prolonged survival induced by bexarotene in treating non-small cell lung cancer. Anticancer Res 2011; 31: 2303-2311.
36. Science WIo. GeneCards. 2011.
37. Nogueiras R, Lopez M, Dieguez C. Regulation of lipid metabolism by energy availability: a role for the central nervous system. Obes Rev 2010; 11: 185-201.
38. Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008; 40: 161-169.
39. Schwimmer JB, McGreal N, Deutsch R, Finegold MJ, Lavine JE. Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents. Pediatrics 2005; 115: e561-e565.
40. Imhof A, Kratzer W, Boehm B, Meitinger K, Trischler G, Steinbach G, et al. Prevalence of non-alcoholic fatty liver and characteristics in overweight adolescents in the general population. Eur J Epidemiol 2007; 22: 889-897.
41. Fraser A, Longnecker MP, Lawlor DA. Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004. Gastroenterology 2007; 133: 1814-1820.