Improved renal ischemia tolerance in females influences kidney transplantation outcomes

Journal of Clinical Investigation

Volumn 126, Issue 5, 2016, Pages 1968-1977

  Aufhauser, David D ^a   Wang, Zhonglin ^a   Murken, Douglas R ^a   Bhatti, Tricia R ^b   Wang, Yanfeng ^a   Guanghui, Ge ^a   Redfield, Robert R ^c   Abt, Peter L ^a,b   Wang, Liqing ^b   Svoronos, Nikolaos ^d   Thomasson, Arwin ^a   Reese, Peter P ^e   Hancock, Wayne W ^a,b   Levine, Matthew H ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d WISTAR INSTITUTE   (United States)

^e Renal Electrolyte and Hypertension Division   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLD ISCHEMIA; CONTROLLED STUDY; DELAYED GRAFT FUNCTION; ESTROGEN THERAPY; FEMALE; HUMAN; KIDNEY ISCHEMIA; KIDNEY TRANSPLANTATION; KNOCKOUT MOUSE; MALE; MOUSE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; SEX DIFFERENCE; ANIMAL; IMMUNOLOGY; PATHOLOGY; REPERFUSION INJURY; SEXUAL DEVELOPMENT; TRANSPLANTATION TOLERANCE;

ANIMALS; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; KIDNEY TRANSPLANTATION; MALE; MICE; MICE, KNOCKOUT; REPERFUSION INJURY; SEX CHARACTERISTICS; TRANSPLANTATION TOLERANCE;

EID: 84988528144     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI84712     Document Type: Article

References (34)

1. McGee J, et al. Donor-recipient gender and size mismatch affects graft success after kidney transplantation. J Am Coll Surg. 2010;210(5):718-725.
2. Gratwohl A, Dohler B, Stern M, Opelz G. H-Y as a minor histocompatibility antigen in kidney transplantation: a retrospective cohort study. Lancet. 2008;372(9632):49-53.
3. Zhou JY, Cheng J, Huang HF, Shen Y, Jiang Y, Chen JH. The effect of donor-recipient gender mismatch on short- and long-term graft survival in kidney transplantation: a systematic review and meta-analysis. Clin Transplant. 2013;27(5):764-771.
4. Kim SJ, Gill JS. H-Y incompatibility predicts short-term outcomes for kidney transplant recipients. J Am Soc Nephrol. 2009;20(9):2025-2033.
5. Siedlecki A, Irish W, Brennan DC. Delayed graft function in the kidney transplant. Am J Trans-plant. 2011;11(11):2279-2296.
6. Ojo AO, Port FK, Wolfe RA, Mauger EA, Williams L, Berling DP. Comparative mortality risks of chronic dialysis and cadaveric transplantation in black end-stage renal disease patients. Am J Kidney Dis. 1994;24(1):59-64.
7. Alves MG, Oliveira PJ, Carvalho RA. Substrate selection in hearts subjected to ischemia/reperfusion: role of cardioplegic solutions and gender. NMR Biomed. 2011;24(9):1029-1037.
8. Ardelt AA, et al. Estradiol modulates post-ischemic cerebral vascular remodeling and improves long-term functional outcome in a rat model of stroke. Brain Res. 2012;1461:76-86.
9. Eckhoff DE, Bilbao G, Frenette L, Thompson JA, Contreras JL. 17-β-estradiol protects the liver against warm ischemia/reperfusion injury and is associated with increased serum nitric oxide and decreased tumor necrosis factor-alpha. Surgery. 2002;132(2):302-309.
10. Gabel SA, Walker VR, London RE, Steenbergen C, Korach KS, Murphy E. Estrogen receptor beta mediates gender differences in ischemia/reperfusion injury. J Mol Cell Cardiol. 2005;38(2):289-297.
11. Peng X, et al. Gender differences affect blood flow recovery in a mouse model of hindlimb ischemia. Am J Physiol Heart Circ Physiol. 2011;300(6):H2027-H2034.
12. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. Cardiovasc Res. 2005;67(4):594-603.
13. Kher A, et al. Sex differences in the myocardial inflammatory response to acute injury. Shock. 2005;23(1):1-10.
14. Hu H, Wang G, Batteux F, Nicco C. Gender differences in the susceptibility to renal ischemia-reperfusion injury in BALB/c mice. Tohoku J Exp Med. 2009;218(4):325-329.
15. Muller V, et al. Sex hormones and gender-related differences: their influence on chronic renal allograft rejection. Kidney Int. 1999;55(5):2011-2020.
16. Muller V, et al. Sexual dimorphism in renal ischemia-reperfusion injury in rats: possible role of endothelin. Kidney Int. 2002;62(4):1364-1371.
17. Park KM, Kim JI, Ahn Y, Bonventre AJ, Bonventre JV. Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury. J Biol Chem. 2004;279(50):52282-52292.
18. Park KM, Cho HJ, Bonventre JV. Orchiectomy reduces susceptibility to renal ischemic injury: a role for heat shock proteins. Biochem Biophys Res Commun. 2005;328(1):312-317.
19. Robert R, Ghazali DA, Favreau F, Mauco G, Hauet T, Goujon JM. Gender difference and sex hormone production in rodent renal ischemia reperfusion injury and repair. J Inflamm (Lond). 2011;8:14.
20. Rusai K, et al. Gender differences in serum and glucocorticoid regulated kinase-1 (SGK-1) expression during renal ischemia/reperfusion injury. Cell Physiol Biochem. 2011;27(6):727-738.
21. Shen SQ, Zhang Y, Xiong CL. The protective effects of 17beta-estradiol on hepatic ischemia-reperfusion injury in rat model, associated with regulation of heat-shock protein expression. J Surg Res. 2007;140(1):67-76.
22. Soljancic A, et al. Protective role of testosterone in ischemia-reperfusion-induced acute kidney injury. Am J Physiol Regul Integr Comp Physiol. 2013;304(11):R951-R958.
23. Wittnich C, Belanger MP, Askin N, Boscarino C, Wallen WJ. Lower liver transplant success in females: gender differences in metabolic response to global ischemia. Transplant Proc. 2004;36(5):1485-1488.
24. Antus B, et al. Effects of progesterone and selective oestrogen receptor modulators on chronic allograft nephropathy in rats. Nephrol Dial Transplant. 2005;20(2):329-335.
25. Antus B, Yao Y, Song E, Liu S, Lutz J, Heemann U. Opposite effects of testosterone and estrogens on chronic allograft nephropathy. Transpl Int. 2002;15(9-10):494-501.
26. Levine MH, et al. Class-specific histone/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation. Am J Transplant. 2015;15(4):965-973.
27. Hutchens MP, Fujiyoshi T, Komers R, Herson PS, Anderson S. Estrogen protects renal endothelial barrier function from ischemia-reperfusion in vitro and in vivo. Am J Physiol Renal Physiol. 2012;303(3):F377-F385.
28. Hutchens MP, et al. Estrogen is renoprotective via a nonreceptor-dependent mechanism after cardiac arrest in vivo. Anesthesiology. 2010;112(2):395-405.
29. Baylis C. Age-dependent glomerular damage in the rat. Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor. J Clin Invest. 1994;94(5):1823-1829.
30. Delle H, Rocha JR, Cavaglieri RC, Vieira JM Jr, Malheiros DM, Noronha IL. Antifibrotic effect of tamoxifen in a model of progressive renal disease. J Am Soc Nephrol. 2012;23(1):37-48.
31. Bae S, Zhang L. Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: focus on Akt and protein kinase C signaling. J Pharmacol Exp Ther. 2005;315(3):1125-1135.
32. Ostadal B, Ostadal P. Sex-based differences in cardiac ischaemic injury and protection: therapeutic implications. Br J Pharmacol. 2014;171(3):541-554.
33. Li X, Blizzard KK, Zeng Z, DeVries AC, Hurn PD, McCullough LD. Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender. Exp Neurol. 2004;187(1):94-104.
34. Babiker FA, Hoteit LJ, Joseph S, Mustafa AS, Juggi JS. The role of 17-β-estradiol in ischemic preconditioning protection of the heart. Exp Clin Cardiol. 2012;17(3):95-100.