Phytochemical and toxicological investigations of crude methanolic extracts, subsequent fractions and crude saponins of Isodon rugosuS

Biological Research

Volumn 47, Issue 1, 2014, Pages

  Zeb, Anwar ^a   Sadiq, Abdul ^a   Ullah, Farhat ^a   Ahmad, Sajjad ^a   Ayaz, Muhammad ^a  

^a UNIVERSITY OF MALAKAND   (Pakistan)

Author keywords

Brine shrimps; Cytotoxicity; Isodon rugosus; Phytotoxicity

Indexed keywords

ALKALOID; ANTHRAQUINONE DERIVATIVE; CHLOROFORM; CYTOTOXIN; FLAVONOID; GLYCOSIDE; HEXANE; METHANOL; N-HEXANE; PLANT EXTRACT; SAPONIN; TANNIN DERIVATIVE; TERPENE; VEGETABLE OIL;

ANIMAL; ARTEMIA; CHEMISTRY; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; ISODON; PHYTOTHERAPY; PLANT ROOT; PLANT STRUCTURES;

ALKALOIDS; ANIMALS; ANTHRAQUINONES; ARTEMIA; CHLOROFORM; CYTOTOXINS; FLAVONOIDS; GLYCOSIDES; HEXANES; ISODON; METHANOL; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PLANT OILS; PLANT ROOTS; SAPONINS; TANNINS; TERPENES;

EID: 84988447696     PISSN: 07169760     EISSN: 07176287     Source Type: Journal    
DOI: 10.1186/0717-6287-47-57     Document Type: Article

References (38)

1. Frumkin H: Beyond toxicity: human health and the natural environment. Am J Prev Med 2001, 20(3):234-240
2. Ames BN, Profet M, Gold LS: Nature's chemicals and synthetic chemicals: comparative toxicology. Proc Nat Acad Sci 1990, 87(19):7782-7786
3. Azmi MA, Naqvi S, Azmi MA, Aslam M: Effect of pesticide residues on health and different enzyme levels in the blood of farm workers from Gadap (rural area) Karachi-Pakistan. Chemosphere 2006, 64(10):1739-1744
4. Yousef M, Salem M, Ibrahim H, Helmi S, Seehy M, Bertheussen K: Toxic effects of carbofuran and glyphosate on semen characteristics in rabbits. J Environ Sci Health Part B 1995, 30(4):513-534
5. Pakulska D, Czerczak S: Hazardous effects of arsine: a short review. International J Occup Med Environ Health 2006, 19(1):36-44
6. Sher H, Elyemeni M, Sher H, Hussain K: Ethnobotanical and Economic Observations of Some Plant Resources from the Northern Parts of Pakistan. Ethnobot Res Appl 2011, 9:27-41
7. Khan S, Khan GM: In vitro antifungal activity of Rhazya stricta. Pak J Pharm Sci 2007, 20(4):279-284
8. Abbasi AM, Khan M, Ahmad M, Zafar M, Jahan S, Sultana S: Ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics among the tribal communities of North-West Frontier Province, Pakistan. J Ethnopharmacol 2010, 128(2):322-335
9. Plummer SM, Hill KA, Festing MF, Steward WP, Gescher AJ, Sharma RA: Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents. Cancer Epidemiol Biomarkers Prev 2001, 10(12):1295-1299
10. Haq F, Ahmad H, Ullah R, Iqbal Z: Species Diversity and Ethno Botanical Classes of the Flora of Allai Valley District Battagram Pakistan. Int J Plant Res 2012, 2(4):111-123
11. Zehnder G, Gurr GM, Kühne S, Wade MR, Wratten SD, Wyss E: Arthropod pest management in organic crops. Annu Rev Entomol 2007, 52:57-80
12. Jan G, Khan MA, Gul F, Ahmad M, Jan M, Zafar M: Ethnobotanical study of common weeds of Dir Kohistan valley, Khyber Pakhtoonkhwa, Pakistan. Pak J Weed Sci Res 2010, 16(1):81-88
13. Pichersky E, Gang DR: Genetics and biochemistry of secondary metabolites in plants: an evolutionary perspective. Trends Plant Sci 2000, 5(10):439-445
14. Naghibi F, Mosaddegh M, Mohammadi Motamed M, Ghorbani A: Labiatae family in folk medicine in Iran: from ethnobotany to pharmacology. Iranian J Pharm Res 2005, 2:63-79
15. Adnan M, Begum S, Latif A, Tareen AM, Lee L: Medicinal plants and their uses in selected temperate zones of Pakistani Hindukush-Himalaya. J Med Plants Res 2012, 6(24):4113-4127
16. Krishnaiah D, Devi T, Bono A, Sarbatly R: Studies on phytochemical constituents of six Malaysian medicinal plants. J Med Plants Res 2009, 3(2):067-072
17. Francis G, Kerem Z, Makkar HP, Becker K: The biological action of saponins in animal systems: a review. Br J Nutr 2002, 88(06):587-605
18. Yuan C-S, Wang C-Z, Wicks SM, Qi L-W: Chemical and pharmacological studies of saponins with a focus on American ginseng. J Ginseng Res 2010, 34(3):160
19. Lv X, Qiu S, Sun X, Li Z: Preliminary Study on the Capability of Antioxidation and Scavenging Free Radicals of Sasanqua saponins. Sci Food 2005, 11:86-90
20. Seth R, Sarin R: Analysis of the Phytochemical Content and Anti-microbial Activity of Jatropha gossypifolia L. Arch Appl Sci Res 2010, 2(5):285-291
21. Pal D, Sannigrahi S, Mazumder UK: Analgesic and anticonvulsant effects of saponin isolated from the leaves of Clerodendrum infortunatum Linn. in mice. Ind J Exp Biol 2009, 47(9):743
22. Man S, Gao W, Zhang Y, Huang L, Liu C: Chemical study and medical application of saponins as anti-cancer agents. Fitoterapia 2010, 81(7):703-714
23. Wang G-X, Jiang D-X, Li J, Han J, Liu Y-T, Liu X-L: Anthelmintic activity of steroidal saponins from Dioscorea zingiberensis CH Wright against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Parasitol Res 2010, 107(6):1365-1371
24. De Geyter E, Geelen D, Smagghe G: First results on the insecticidal action of saponins. Commu Agric Appl Biol Sci 2007, 72(3):645
25. Inderjit: Plant phenolics in allelopathy. The Bot Rev 1996, 62(2):186-202
26. Karadeniz B, Ulker Z, Alpsoy L: Genotoxic and cytotoxic effects of storax in vitro. Toxicol Ind Health 2013, 29(2):181-186
27. Mannan A, Inayatullah S, Akhtar MZ, Qayyum M, Mirza B: Biological evaluation of wild thyme (Thymus serpyllum). Pharm Biol 2009, 47(7):628-633
28. Louda SM, Kendall D, Connor J, Simberloff D: Ecological effects of an insect introduced for the biological control of weeds. Science 1997, 277(5329):1088-1090
29. Khuda F, Iqbal Z, Khan A, Nasir F, Muhammad N, Khan JA, Khan MS: Metal analysis, phytotoxic, insecticidal and cytotoxic activities of selected medicinal plants of Khyber Pakhtunkhwa. Pak J Pharm Sci 2012, 25(1):51-58
30. Sharp DS, Eskenazi B, Harrison R, Callas P, Smith AH: Delayed health hazards of pesticide exposure. Annual Rev Public Health 1986, 7(1):441-471
31. Kerwin S: Soy saponins and the anticancer effects of soybeans and soy-based foods. Curr Med Chem-Anti-Cancer Agents 2004, 4(3):263-272
32. Shao Y, Chin C-K, Ho C-T, Ma W, Garrison SA, Huang M-T: Anti-tumor activity of the crude saponins obtained from asparagus. Cancer letters 1996, 104(1):31-36
33. Padmaja R, Arun P, Prashanth D, Deepak M, Amit A, Anjana M: Brine shrimp lethality bioassay of selected Indian medicinal plants. Fitoterapia 2002, 73(6):508-510
34. Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H: Phytochemical screening and extraction: a review. Int Pharm Sci 2011, 1(1):98-106
35. Iqbal H, Moneeb URK, Riaz U, Zia M, Naeem K, Farhat AK, Zahoor U, Sajjad H: Phytochemicals screening and antimicrobial activities of selected medicinal plants of Khyberpakhtunkhwa Pakistan. Afr J Pharm Pharmacol 2011, 5(6):746-750
36. Meriga B, Mopuri R, MuraliKrishna T: Insecticidal, antimicrobial and antioxidant activities of bulb extracts of Allium sativum. Asian Pac J Trop Med 2012, 5(5):391-395
37. Turker AU, Camper N: Biological activity of common mullein, a medicinal plant. J Ethnopharmacol 2002, 82(2):117-125
38. Meyer B, Ferrigni N, Putnam J, Jacobsen L, Nichols D, McLaughlin J: Brine shrimp: a convenient general bioassay for active plant constituents. Planta medica 1982, 45(05):31-34