Gut microbial alterations associated with protection from autoimmune uveitis

Investigative Ophthalmology and Visual Science

Volumn 57, Issue 8, 2016, Pages 3747-3758

  Nakamura, Yukiko K ^a   Metea, Christina ^a   Karstens, Lisa ^a   Asquith, Mark ^b   Gruner, Henry ^a   Moscibrocki, Cathleen ^a   Lee, Iris ^a   Brislawn, Colin J ^c   Jansson, Janet K ^c   Rosenbaum, James T ^a,b,d   Lin, Phoebe ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^d DEVERS EYE INSTITUTE   (United States)

Author keywords

Antibiotics; Microbiome; Regulatory T cells; Uveitis

Indexed keywords

AMPICILLIN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; METRONIDAZOLE; NEOMYCIN; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR; VANCOMYCIN; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; DRUG COMBINATION; EYE PROTEIN; INTERSTITIAL RETINOL-BINDING PROTEIN; RETINOL BINDING PROTEIN;

ALPHAPROTEOBACTERIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE UVEITIS; BACTEROIDETES; CD4+ T LYMPHOCYTE; CELL ISOLATION; CLOSTRIDIUM; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE SEQUENCE; INTESTINE FLORA; LACTOBACILLUS; LAMINA PROPRIA; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL; ANIMAL; AUTOIMMUNE DISEASES; CELL CULTURE; DRUG COMBINATION; DRUG EFFECTS; IMMUNOLOGY; INBRED MOUSE STRAIN; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; MICROBIOLOGY; ORAL DRUG ADMINISTRATION; RETINA; UVEITIS;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; AUTOIMMUNE DISEASES; BIOMARKERS; CELLS, CULTURED; CYTOKINES; DRUG COMBINATIONS; EYE PROTEINS; FEMALE; GASTROINTESTINAL MICROBIOME; INJECTIONS, INTRAPERITONEAL; MICE, INBRED STRAINS; RETINA; RETINOL-BINDING PROTEINS; T-LYMPHOCYTES, REGULATORY; UVEITIS;

EID: 84988410542     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.16-19733     Document Type: Article

References (28)

1. Berer K, Mues M, Koutrolos M, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011;479:538–541.
2. Brown CT, Davis-Richardson AG, Giongo A, et al. Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One. 2011;6:e25792.
3. Cantarel BL, Waubant E, Chehoud C, et al. Gut microbiota in multiple sclerosis: possible influence of immunomodulators. J Investig Med. 2015;63:729–730.
4. Ivanov II, Atarashi K, Manel N, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 2009;139: 485–498.
5. Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2011;108:4615–4622.
6. Ochoa-Reparaz J, Mielcarz DW, Ditrio LE, et al. Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis. J Immunol. 2009;183:6041-6050.
7. Scher JU, Sczesnak A, Longman RS, et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife. 2013;2:e01202.
8. Vijay-Kumar M, Aitken JD, Carvalho FA, et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science. 2010;328:228–231.
9. Costello ME, Ciccia F, Willner D, et al. Intestinal dysbiosis in ankylosing spondylitis [published online ahead of print November 21, 2014]. Arthritis Rheumatol. doi:10.1002/art.38967.
10. Taurog JD, Richardson JA, Croft JT, et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med. 1994;180:2359–2364.
11. Lin P, Bach M, Asquith M, et al. HLA-B27 and human beta2microglobulin affect the gut microbiota of transgenic rats. PLoS One. 2014;9:e105684.
12. Kezic JM, Glant TT, Rosenbaum JT, Rosenzweig HL. Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis. Arthritis Res Ther. 2012;14:R18.
13. Lewis GP, Fisher SK. Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression. Int Rev Cytol. 2003;230:263–290.
14. Luger D, Silver PB, Tang J, et al. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med. 2008;205:799–810.
15. Caspi RR, Roberge FG, Chan CC, et al. A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J Immunol. 1988;140:1490–1495.
16. Gilbert JA, Meyer F, Jansson J, et al. The Earth Microbiome Project: meeting report of the “1 EMP meeting on sample selection and acquisition” at Argonne National Laboratory October 6 2010. Stand Genomic Sci. 2010;3:249–253.
17. Caporaso JG, Kuczynski J, Stombaugh J, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010;7:335–336.
18. Edgar RC. Search and clustering orders of magnitude faster than BLAST. Bioinformatics. 2010;26:2460–2461.
19. Wang Q, Garrity GM, Tiedje JM, Cole JR. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol. 2007;73:5261-5267.
20. McMurdie PJ, Holmes S. phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. PLoS One. 2013;8:e61217.
21. Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550.
22. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004; 118:229–241.
23. Thornton AM, Korty PE, Tran DQ, et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol. 2010;184:3433–3441.
24. Chen J, Qian H, Horai R, Chan CC, Falick Y, Caspi RR. Comparative analysis of induced vs. spontaneous models of autoimmune uveitis targeting the interphotoreceptor retinoid binding protein. PLoS One. 2013;8:e72161.
25. Horai R, Zarate-Blades CR, Dillenburg-Pilla P, et al. Microbiotadependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site. Immunity. 2015;43:343–353.
26. Morton AM, Sefik E, Upadhyay R, Weissleder R, Benoist C, Mathis D. Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut. Proc Natl Acad Sci U S A. 2014;111:6696–6701.
27. Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A. 2010;107:12204–12209.
28. Sefik E, Geva-Zatorsky N, Oh S, et al. Mucosal immunology. Individual intestinal symbionts induce a distinct population of RORgamma(+) regulatory T cells. Science. 2015;349:993–997.