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Volumn 126, Issue 9, 2016, Pages 3219-3235

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

EPITHELIAL SPLICING REGULATORY PROTEIN 1; HERMES ANTIGEN; K RAS PROTEIN; MYC PROTEIN; REGULATOR PROTEIN; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; CD44 PROTEIN, HUMAN; ESRP1 PROTEIN, HUMAN; RNA BINDING PROTEIN; ZEB1 PROTEIN, HUMAN;

EID: 84987817765     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI76725     Document Type: Article
Times cited : (268)

References (53)
  • 2
    • 80555134650 scopus 로고    scopus 로고
    • Molecular biology of lung cancer: Clinical implications
    • Larsen JE, Minna JD. Molecular biology of lung cancer: clinical implications. Clin Chest Med. 2011;32(4):703-740
    • (2011) Clin Chest Med , vol.32 , Issue.4 , pp. 703-740
    • Larsen, J.E.1    Minna, J.D.2
  • 3
    • 33644507072 scopus 로고    scopus 로고
    • Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
    • Sato M, et al. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res. 2006;66(4):2116-2128
    • (2006) Cancer Res , vol.66 , Issue.4 , pp. 2116-2128
    • Sato, M.1
  • 4
    • 84876207852 scopus 로고    scopus 로고
    • Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations
    • Sato M, et al. Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol Cancer Res. 2013;11(6):638-650
    • (2013) Mol Cancer Res , vol.11 , Issue.6 , pp. 638-650
    • Sato, M.1
  • 5
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139(5):871-890
    • (2009) Cell , vol.139 , Issue.5 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 6
    • 84867578091 scopus 로고    scopus 로고
    • EMT-activating transcription factors in cancer: Beyond EMT and tumor invasiveness
    • Sanchez-Tillo E, et al. EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness. Cell Mol Life Sci. 2012;69(20):3429-3456
    • (2012) Cell Mol Life Sci , vol.69 , Issue.20 , pp. 3429-3456
    • Sanchez-Tillo, E.1
  • 7
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massague J. TGFbeta in Cancer. Cell. 2008;134(2):215-230
    • (2008) Cell , vol.134 , Issue.2 , pp. 215-230
    • Massague, J.1
  • 8
    • 77956230322 scopus 로고    scopus 로고
    • The ZEB/miR-200 feedback loop-A motor of cellular plasticity in development and cancer?
    • Brabletz S, Brabletz T. The ZEB/miR-200 feedback loop-A motor of cellular plasticity in development and cancer? EMBO Rep. 2010;11(9):670-677
    • (2010) EMBO Rep , vol.11 , Issue.9 , pp. 670-677
    • Brabletz, S.1    Brabletz, T.2
  • 9
    • 33744925683 scopus 로고    scopus 로고
    • Cyclooxygenase-2-dependent regulation of E-cadherin: Prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer
    • Dohadwala M, et al. Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. Cancer Res. 2006;66(10):5338-5345
    • (2006) Cancer Res , vol.66 , Issue.10 , pp. 5338-5345
    • Dohadwala, M.1
  • 10
    • 78549244727 scopus 로고    scopus 로고
    • ZEB1-responsive genes in non-small cell lung cancer
    • Gemmill RM, et al. ZEB1-responsive genes in non-small cell lung cancer. Cancer Lett. 2011;300(1):66-78
    • (2011) Cancer Lett , vol.300 , Issue.1 , pp. 66-78
    • Gemmill, R.M.1
  • 11
    • 84877041070 scopus 로고    scopus 로고
    • Protein expression of ZEB2 in renal cell carcinoma and its prognostic significance in patient survival
    • Fang Y, et al. Protein expression of ZEB2 in renal cell carcinoma and its prognostic significance in patient survival. PLoS ONE. 2013;8(5):e62558
    • (2013) PLoS ONE , vol.8 , Issue.5 , pp. e62558
    • Fang, Y.1
  • 12
    • 84878372324 scopus 로고    scopus 로고
    • Involvement of ZEB1 and E-cadherin in the invasion of lung squamous cell carcinoma
    • Zhang J, Lu C, Zhang J, Kang J, Cao C, Li M. Involvement of ZEB1 and E-cadherin in the invasion of lung squamous cell carcinoma. Mol Biol Rep. 2013;40(2):949-956
    • (2013) Mol Biol Rep , vol.40 , Issue.2 , pp. 949-956
    • Zhang, J.1    Lu, C.2    Zhang, J.3    Kang, J.4    Cao, C.5    Li, M.6
  • 13
    • 39049160267 scopus 로고    scopus 로고
    • The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer
    • Spaderna S, et al. The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res. 2008;68(2):537-544
    • (2008) Cancer Res , vol.68 , Issue.2 , pp. 537-544
    • Spaderna, S.1
  • 14
    • 0042337389 scopus 로고    scopus 로고
    • WNT7a induces E-cadherin in lung cancer cells
    • Ohira T, et al. WNT7a induces E-cadherin in lung cancer cells. Proc Natl Acad Sci U S A. 2003;100(18):10429-10434
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.18 , pp. 10429-10434
    • Ohira, T.1
  • 15
    • 77955270730 scopus 로고    scopus 로고
    • Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells
    • Takeyama Y, et al. Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells. Cancer Lett. 2010;296(2):216-224
    • (2010) Cancer Lett , vol.296 , Issue.2 , pp. 216-224
    • Takeyama, Y.1
  • 16
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • Rhim AD, et al. EMT and dissemination precede pancreatic tumor formation. Cell. 2012;148(1-2):349-361
    • (2012) Cell , vol.148 , Issue.1-2 , pp. 349-361
    • Rhim, A.D.1
  • 17
    • 0024509262 scopus 로고
    • Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-beta 1 and TGF-beta 2) secreted by cells in culture
    • Danielpour D, Dart LL, Flanders KC, Roberts AB, Sporn MB. Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-beta 1 and TGF-beta 2) secreted by cells in culture. J Cell Physiol. 1989;138(1):79-86
    • (1989) J Cell Physiol , vol.138 , Issue.1 , pp. 79-86
    • Danielpour, D.1    Dart, L.L.2    Flanders, K.C.3    Roberts, A.B.4    Sporn, M.B.5
  • 18
    • 77958498535 scopus 로고    scopus 로고
    • Depletion of TGF-β from fetal bovine serum
    • Oida T, Weiner HL. Depletion of TGF-β from fetal bovine serum. J Immunol Methods. 2010;362(1-2):195-198
    • (2010) J Immunol Methods , vol.362 , Issue.1-2 , pp. 195-198
    • Oida, T.1    Weiner, H.L.2
  • 19
    • 18344389705 scopus 로고    scopus 로고
    • Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling
    • Palmer HG, et al. Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol. 2001;154(2):369-387
    • (2001) J Cell Biol , vol.154 , Issue.2 , pp. 369-387
    • Palmer, H.G.1
  • 21
  • 22
    • 33845187907 scopus 로고    scopus 로고
    • Global mapping of c-Myc binding sites and target gene networks in human B cells
    • Zeller KI, et al. Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A. 2006;103(47):17834-17839
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.47 , pp. 17834-17839
    • Zeller, K.I.1
  • 23
    • 78650336901 scopus 로고    scopus 로고
    • Proteomic profiling of Myc-associated proteins
    • Agrawal P, Yu K, Salomon AR, Sedivy JM. Proteomic profiling of Myc-associated proteins. Cell Cycle. 2010;9(24):4908-4921
    • (2010) Cell Cycle , vol.9 , Issue.24 , pp. 4908-4921
    • Agrawal, P.1    Yu, K.2    Salomon, A.R.3    Sedivy, J.M.4
  • 24
    • 49149129916 scopus 로고    scopus 로고
    • Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study
    • Director's Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma, et al
    • Director's Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma, et al. Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat Med. 2008;14(8):822-827
    • (2008) Nat Med , vol.14 , Issue.8 , pp. 822-827
  • 25
    • 84905029258 scopus 로고    scopus 로고
    • Comprehensive molecular profiling of lung adenocarcinoma
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014;511(7511):543-550
    • (2014) Nature , vol.511 , Issue.7511 , pp. 543-550
  • 26
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012;489(7417):519-525
    • (2012) Nature , vol.489 , Issue.7417 , pp. 519-525
  • 27
    • 72549116879 scopus 로고    scopus 로고
    • Snail promotes CXCR2 ligand-dependent tumor progression in nonsmall cell lung carcinoma
    • Yanagawa J, et al. Snail promotes CXCR2 ligand-dependent tumor progression in nonsmall cell lung carcinoma. Clin Cancer Res. 2009;15(22):6820-6829
    • (2009) Clin Cancer Res , vol.15 , Issue.22 , pp. 6820-6829
    • Yanagawa, J.1
  • 28
    • 35548974844 scopus 로고    scopus 로고
    • The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
    • Aigner K, et al. The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene. 2007;26(49):6979-6988
    • (2007) Oncogene , vol.26 , Issue.49 , pp. 6979-6988
    • Aigner, K.1
  • 29
    • 0037227965 scopus 로고    scopus 로고
    • CD44: From adhesion molecules to signalling regulators
    • Ponta H, Sherman L, Herrlich PA. CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol. 2003;4(1):33-45
    • (2003) Nat Rev Mol Cell Biol , vol.4 , Issue.1 , pp. 33-45
    • Ponta, H.1    Sherman, L.2    Herrlich, P.A.3
  • 30
    • 84055207489 scopus 로고    scopus 로고
    • Understanding the dual nature of CD44 in breast cancer progression
    • Louderbough JM, Schroeder JA. Understanding the dual nature of CD44 in breast cancer progression. Mol Cancer Res. 2011;9(12):1573-1586
    • (2011) Mol Cancer Res , vol.9 , Issue.12 , pp. 1573-1586
    • Louderbough, J.M.1    Schroeder, J.A.2
  • 31
    • 84862517728 scopus 로고    scopus 로고
    • Cancer stem cells: Current status and evolving complexities
    • Visvader JE, Lindeman GJ. Cancer stem cells: current status and evolving complexities. Cell Stem Cell. 2012;10(6):717-728
    • (2012) Cell Stem Cell , vol.10 , Issue.6 , pp. 717-728
    • Visvader, J.E.1    Lindeman, G.J.2
  • 32
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133(4):704-715
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1
  • 33
    • 78649960144 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling
    • Sullivan JP, et al. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res. 2010;70(23):9937-9948
    • (2010) Cancer Res , vol.70 , Issue.23 , pp. 9937-9948
    • Sullivan, J.P.1
  • 34
    • 62549152644 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer
    • Jiang F, et al. Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer. Mol Cancer Res. 2009;7(3):330-338
    • (2009) Mol Cancer Res , vol.7 , Issue.3 , pp. 330-338
    • Jiang, F.1
  • 35
    • 84866742560 scopus 로고    scopus 로고
    • TGFβ signalling in context
    • Massague J. TGFβ signalling in context. Nat Rev Mol Cell Biol. 2012;13(10):616-630
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.10 , pp. 616-630
    • Massague, J.1
  • 36
    • 84879983245 scopus 로고    scopus 로고
    • Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
    • Chaffer CL, et al. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell. 2013;154(1):61-74
    • (2013) Cell , vol.154 , Issue.1 , pp. 61-74
    • Chaffer, C.L.1
  • 37
    • 84864319635 scopus 로고    scopus 로고
    • Zinc finger E-box binding homeobox 1 promotes invasion and bone metastasis of small cell lung cancer in vitro and in vivo
    • Liu Y, et al. Zinc finger E-box binding homeobox 1 promotes invasion and bone metastasis of small cell lung cancer in vitro and in vivo. Cancer Sci. 2012;103(8):1420-1428
    • (2012) Cancer Sci , vol.103 , Issue.8 , pp. 1420-1428
    • Liu, Y.1
  • 38
    • 84902152865 scopus 로고    scopus 로고
    • ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism
    • Yang Y, et al. ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. J Clin Invest. 2014;124(6):2696-2708
    • (2014) J Clin Invest , vol.124 , Issue.6 , pp. 2696-2708
    • Yang, Y.1
  • 39
    • 70349142665 scopus 로고    scopus 로고
    • Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression
    • Gibbons DL, et al. Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes Dev. 2009;23(18):2140-2151
    • (2009) Genes Dev , vol.23 , Issue.18 , pp. 2140-2151
    • Gibbons, D.L.1
  • 40
    • 84865973348 scopus 로고    scopus 로고
    • ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression
    • Ahn YH, et al. ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. J Clin Invest. 2012;122(9):3170-3183
    • (2012) J Clin Invest , vol.122 , Issue.9 , pp. 3170-3183
    • Ahn, Y.H.1
  • 41
    • 84876432144 scopus 로고    scopus 로고
    • Global decrease of histone H3K27 acetylation in ZEB1-Induced epithelial to mesenchymal transition in lung cancer cells
    • Roche J, et al. Global Decrease of Histone H3K27 Acetylation in ZEB1-Induced Epithelial to Mesenchymal Transition in Lung Cancer Cells. Cancers (Basel). 2013;5(2):334-356
    • (2013) Cancers (Basel) , vol.5 , Issue.2 , pp. 334-356
    • Roche, J.1
  • 42
    • 84863203049 scopus 로고    scopus 로고
    • TGF-β drives epithelialmesenchymal transition through δeF1-mediated downregulation of ESRP
    • Horiguchi K, et al. TGF-β drives epithelialmesenchymal transition through δEF1-mediated downregulation of ESRP. Oncogene. 2012;31(26):3190-3201
    • (2012) Oncogene , vol.31 , Issue.26 , pp. 3190-3201
    • Horiguchi, K.1
  • 43
    • 77957767273 scopus 로고    scopus 로고
    • An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition
    • Warzecha CC, et al. An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J. 2010;29(19):3286-3300
    • (2010) EMBO J , vol.29 , Issue.19 , pp. 3286-3300
    • Warzecha, C.C.1
  • 44
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer. 2013;13(2):97-110
    • (2013) Nat Rev Cancer , vol.13 , Issue.2 , pp. 97-110
    • De Craene, B.1    Berx, G.2
  • 45
    • 79952227361 scopus 로고    scopus 로고
    • CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression
    • Brown RL, et al. CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. J Clin Invest. 2011;121(3):1064-1074
    • (2011) J Clin Invest , vol.121 , Issue.3 , pp. 1064-1074
    • Brown, R.L.1
  • 46
    • 79961112978 scopus 로고    scopus 로고
    • Prognostic significance of CD44s expression in resected non-small cell lung cancer
    • Ko YH, et al. Prognostic significance of CD44s expression in resected non-small cell lung cancer. BMC Cancer. 2011;11:340
    • (2011) BMC Cancer , vol.11 , pp. 340
    • Ko, Y.H.1
  • 48
    • 84862777563 scopus 로고    scopus 로고
    • Role of microRNAs in the regulation of breast cancer stem cells
    • Liu S, Clouthier SG, Wicha MS. Role of microRNAs in the regulation of breast cancer stem cells. J Mammary Gland Biol Neoplasia. 2012;17(1):15-21
    • (2012) J Mammary Gland Biol Neoplasia , vol.17 , Issue.1 , pp. 15-21
    • Liu, S.1    Clouthier, S.G.2    Wicha, M.S.3
  • 49
    • 84857674413 scopus 로고    scopus 로고
    • Targeted inactivation of Snail family EMT regulatory factors by a Co(III)-Ebox conjugate
    • Harney AS, Meade TJ, LaBonne C. Targeted inactivation of Snail family EMT regulatory factors by a Co(III)-Ebox conjugate. PLoS ONE. 2012;7(2):e32318
    • (2012) PLoS ONE , vol.7 , Issue.2 , pp. e32318
    • Harney, A.S.1    Meade, T.J.2    LaBonne, C.3
  • 50
    • 10844284696 scopus 로고    scopus 로고
    • Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    • Ramirez RD, et al. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res. 2004; 64(24):9027-9034
    • (2004) Cancer Res , vol.64 , Issue.24 , pp. 9027-9034
    • Ramirez, R.D.1
  • 51
    • 33646953271 scopus 로고    scopus 로고
    • NCI-Navy Medical Oncology Branch cell line data base
    • Phelps RM, et al. NCI-Navy Medical Oncology Branch cell line data base. J Cell Biochem Suppl. 1996;24:32-91
    • (1996) J Cell Biochem Suppl , vol.24 , pp. 32-91
    • Phelps, R.M.1
  • 52
    • 84255192023 scopus 로고    scopus 로고
    • SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner
    • Greer RM, et al. SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner. Cancer Res. 2011;71(24):7640-7648
    • (2011) Cancer Res , vol.71 , Issue.24 , pp. 7640-7648
    • Greer, R.M.1
  • 53
    • 84876205922 scopus 로고    scopus 로고
    • NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM
    • Osborne JK, et al. NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. Proc Natl Acad Sci USA. 2013;110(16):6524-6529
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.16 , pp. 6524-6529
    • Osborne, J.K.1


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