Adenosine A2B receptors play an important role in bone homeostasis

Purinergic Signalling

Volumn 12, Issue 3, 2016, Pages 537-547

  Corciulo, Carmen ^a   Wilder, Tuere ^a   Cronstein, Bruce N ^a,b  

^a Dept Neurosci New York Stt P   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

A2BRKO mice; Adenosine A2B; Bone homeostasis

Indexed keywords

ADENOSINE A2B RECEPTOR; OSTEOCLAST DIFFERENTIATION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE HOMEOSTASIS; CELL DIFFERENTIATION; FEMALE; HOMEOSTASIS; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BONE; BONE DEVELOPMENT; C57BL MOUSE; CYTOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; BONE AND BONES; CELL DIFFERENTIATION; FEMALE; HOMEOSTASIS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; RECEPTOR, ADENOSINE A2B; X-RAY MICROTOMOGRAPHY;

EID: 84987757896     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-016-9519-2     Document Type: Article

References (26)

1. Mediero A, Cronstein BN (2013) Adenosine and bone metabolism. Trends Endocrinol Metab 24(6):290–300
2. He W, Cronstein BN (2012) Adenosine A1 receptor regulates osteoclast formation by altering TRAF6/TAK1 signaling. Purinergic Signal 8(2):327–337
3. He W et al (2013) Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J 27(9):3446–3454
4. He W, Wilder T, Cronstein BN (2013) Rolofylline, an adenosine A1 receptor antagonist, inhibits osteoclast differentiation as an inverse agonist. Br J Pharmacol 170(6):1167–1176
5. Mediero A et al (2012) Adenosine A2A receptor activation prevents wear particle-induced osteolysis. Sci Transl Med 4(135):135ra65
6. Mediero A et al (2012) Adenosine A(2A) receptor ligation inhibits osteoclast formation. Am J Pathol 180(2):775–786
7. Mediero A, Perez-Aso M, Cronstein BN (2013) Activation of adenosine A(2A) receptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFkappaB nuclear translocation. Br J Pharmacol 169(6):1372–1388
8. Mediero A et al (2015) Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2. FASEB J 29(4):1577–1590
9. Carroll SH et al (2012) A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo. J Biol Chem 287(19):15718–15727
10. Takedachi M et al (2012) CD73-generated adenosine promotes osteoblast differentiation. J Cell Physiol 227(6):2622–2631
11. Ciciarello M et al (2013) Extracellular purines promote the differentiation of human bone marrow-derived mesenchymal stem cells to the osteogenic and adipogenic lineages. Stem Cells Dev 22(7):1097–1111
12. Trincavelli ML et al (2014) Osteoblast differentiation and survival: a role for A2B adenosine receptor allosteric modulators. Biochim Biophys Acta 1843(12):2957–2966
13. Kang H, Shih YR, Varghese S (2015) Biomineralized matrices dominate soluble cues to direct osteogenic differentiation of human mesenchymal stem cells through adenosine signaling. Biomacromolecules 16(3):1050–1061
14. Kara FM et al (2010) Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function. FASEB J 24(7):2325–2333
15. Bakker AD, Klein-Nulend J (2012) Osteoblast isolation from murine calvaria and long bones. Methods Mol Biol 816:19–29
16. Raggatt LJ, Partridge NC (2010) Cellular and molecular mechanisms of bone remodeling. J Biol Chem 285(33):25103–25108
17. Noronha-Matos J.B., Correia-de-Sa P. Mesenchymal stem cells ageing: targeting the “purinome” to promote osteogenic differentiation and bone repair. J Cell Physiol. 2016.
18. Wei W et al (2013) Blocking A2B adenosine receptor alleviates pathogenesis of experimental autoimmune encephalomyelitis via inhibition of IL-6 production and Th17 differentiation. J Immunol 190(1):138–146
19. Volpini R et al (2003) Medicinal chemistry and pharmacology of A2B adenosine receptors. Curr Top Med Chem 3(4):427–443
20. Evans BA et al (2006) Human osteoblast precursors produce extracellular adenosine, which modulates their secretion of IL-6 and osteoprotegerin. J Bone Miner Res 21(2):228–236
21. Le Goff B et al (2010) Role for interleukin-6 in structural joint damage and systemic bone loss in rheumatoid arthritis. Joint Bone Spine 77(3):201–205
22. de Franca NA et al (2016) Dietary patterns and bone mineral density in Brazilian postmenopausal women with osteoporosis: a cross-sectional study. Eur J Clin Nutr 70(1):85–90
23. ToRo KOR (2013) A study of risk factors and T-score variability in Romanian women with postmenopausal osteoporosis. Iran J Public Health 42(12):1387–1397
24. Hallstrom H et al (2013) Long-term coffee consumption in relation to fracture risk and bone mineral density in women. Am J Epidemiol 178(6):898–909
25. Hallstrom H et al (2006) Coffee, tea and caffeine consumption in relation to osteoporotic fracture risk in a cohort of Swedish women. Osteoporos Int 17(7):1055–1064
26. Harris SS, Dawson-Hughes B (1994) Caffeine and bone loss in healthy postmenopausal women. Am J Clin Nutr 60(4):573–578