The Arab genome: Health and wealth

Gene

Volumn 591, Issue 2, 2016, Pages 239-243

  Zayed, Hatem ^a  

^a Qatar University ^*  (Qatar)

Author keywords

Arab countries; Consanguinity; Endogamous marriage; Human genome sequencing; Novel genes; Novel variants; Whole exome sequencing

Indexed keywords

AFRICA; ARAB; ARAB WORLD; COMMUNITY; GENE POOL; GENE SEQUENCE; GENE STRUCTURE; GENETIC DISORDER; GENOME; GENOME ANALYSIS; GENOTYPE PHENOTYPE CORRELATION; HEALTH STATUS; HUMAN; HUMAN GENOME; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; REVIEW; SEQUENCE ANALYSIS; ECONOMICS; GENETICS; HAPLOTYPE MAP; HUMAN GENOME PROJECT;

ARABS; GENOME, HUMAN; HAPMAP PROJECT; HUMAN GENOME PROJECT; HUMANS;

EID: 84987679917     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2016.07.007     Document Type: Review

References (29)

1. Abu-Elmagd, M., Assidi, M., Schulten, H.J., Dallol, A., Pushparaj, P., Ahmed, F., Scherer, S.W., Al-Qahtani, M., Individualized medicine enabled by genomics in Saudi Arabia. BMC Med. Genet., 8(Suppl. 1), 2015, S3.
2. Abumansour, I.S., Hijazi, H., Alazmi, A., Alzahrani, F., Bashiri, F.A., Hassan, H., Alhaddab, M., Alkuraya, F.S., ARL6IP6, a susceptibility locus for ischemic stroke, is mutated in a patient with syndromic Cutis Marmorata Telangiectatica Congenita. Hum. Genet. 134 (2015), 815–822.
3. Alazami, A.M., Patel, N., Shamseldin, H.E., Anazi, S., Al-Dosari, M.S., Alzahrani, F., Hijazi, H., Alshammari, M., Aldahmesh, M.A., Salih, M.A., Faqeih, E., Alhashem, A., Bashiri, F.A., Al-Owain, M., Kentab, A.Y., Sogaty, S., Al Tala, S., Temsah, M.-H., Tulbah, M., Aljelaify, R.F., Alshahwan, S.A., Seidahmed, M.Z., Alhadid, A.A., Aldhalaan, H., AlQallaf, F., Kurdi, W., Alfadhel, M., Babay, Z., Alsogheer, M., Kaya, N., Al-Hassnan, Z.N., Abdel-Salam, G.M.H., Al-Sannaa, N., Al Mutairi, F., El Khashab, H.Y., Bohlega, S., Jia, X., Nguyen, H.C., Hammami, R., Adly, N., Mohamed, J.Y., Abdulwahab, F., Ibrahim, N., Naim, E.A., Al-Younes, B., Meyer, B.F., Hashem, M., Shaheen, R., Xiong, Y., Abouelhoda, M., Aldeeri, A.A., Monies, D.M., Alkuraya, F.S., Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families. Cell Rep. 10 (2015), 148–161.
4. Al-Mulla, F., The locked genomes: a perspective from Arabia. Applied & Translational Genomics 3 (2014), 132–133.
5. Alsmadi, O., Thareja, G., Alkayal, F., Rajagopalan, R., John, S.E., Hebbar, P., Behbehani, K., Thanaraj, T.A., Genetic substructure of Kuwaiti population reveals migration history. PLoS One, 8, 2013, e74913.
6. Alsmadi, O., John, S.E., Thareja, G., Hebbar, P., Antony, D., Behbehani, K., Thanaraj, T.A., Genome at juncture of early human migration: a systematic analysis of two whole genomes and thirteen exomes from Kuwaiti population subgroup of inferred Saudi Arabian tribe ancestry. PLoS One, 9, 2014, e99069.
7. Bener, A., Alali, K.A., Consanguineous marriage in a newly developed country: the Qatari population. J. Biosoc. Sci. 38 (2006), 239–246.
8. Bittles, A.H., Black, M.L., Evolution in health and medicine Sackler colloquium: consanguinity, human evolution, and complex diseases. Proc. Natl. Acad. Sci. U. S. A. 107:Suppl. 1 (2010), 1779–1786.
9. Buchanan, C.C., Torstenson, E.S., Bush, W.S., Ritchie, M.D., A comparison of cataloged variation between International HapMap Consortium and 1000 Genomes Project data. J. Am. Med. Inform. Assoc. 19 (2012), 289–294.
10. Fernandes, V., Alshamali, F., Alves, M., Costa, M.D., Pereira, J.B., Silva, N.M., Cherni, L., Harich, N., Cerny, V., Soares, P., Richards, M.B., Pereira, L., The Arabian cradle: mitochondrial relicts of the first steps along the southern route out of Africa. Am. J. Hum. Genet. 90 (2012), 347–355.
11. Giles, J., Islam and science: oil rich, science poor. Nature, 444, 2006, 28.
12. Henn, B.M., Botigue, L.R., Gravel, S., Wang, W., Brisbin, A., Byrnes, J.K., Fadhlaoui-Zid, K., Zalloua, P.A., Moreno-Estrada, A., Bertranpetit, J., Bustamante, C.D., Comas, D., Genomic ancestry of North Africans supports back-to-Africa migrations. PLoS Genet., 8, 2012, e1002397.
13. International HapMap Consortium, The International HapMap Project. Nature 426 (2003), 789–796.
14. International Human Genome Sequencing Consortium, Finishing the euchromatic sequence of the human genome. Nature 431 (2004), 931–945.
15. Kopp, G.H., Roos, C., Butynski, T.M., Wildman, D.E., Alagaili, A.N., Groeneveld, L.F., Zinner, D., Out of Africa, but how and when? The case of hamadryas baboons (Papio hamadryas). J. Hum. Evol. 76 (2014), 154–164.
16. Lander, E.S., Linton, L.M., Birren, B., Nusbaum, C., Zody, M.C., Baldwin, J., Devon, K., Dewar, K., Doyle, M., FitzHugh, W., Funke, R., Gage, D., et al. Initial sequencing and analysis of the human genome. Nature 409 (2001), 860–921.
17. Editorial, The germinating seed of Arab genomics. Nat. Genet., 38, 2006, 851.
18. Pagani, L., Schiffels, S., Gurdasani, D., Danecek, P., Scally, A., Chen, Y., Xue, Y., Haber, M., Ekong, R., Oljira, T., Mekonnen, E., Luiselli, D., Bradman, N., Bekele, E., Zalloua, P., Durbin, R., Kivisild, T., Tyler-Smith, C., Tracing the route of modern humans out of Africa by using 225 human genome sequences from Ethiopians and Egyptians. Am. J. Hum. Genet. 96 (2015), 986–991.
19. Rudan, I., Rudan, D., Campbell, H., Carothers, A., Wright, A., Smolej-Narancic, N., Janicijevic, B., Jin, L., Chakraborty, R., Deka, R., Rudan, P., Inbreeding and risk of late onset complex disease. J. Med. Genet. 40 (2003), 925–932.
20. Shaheen, R., Faqeih, E., Alshammari, M.J., Swaid, A., Al-Gazali, L., Mardawi, E., Ansari, S., Sogaty, S., Seidahmed, M.Z., AlMotairi, M.I., Farra, C., Kurdi, W., Al-Rasheed, S., Alkuraya, F.S., Genomic analysis of Meckel-Gruber syndrome in Arabs reveals marked genetic heterogeneity and novel candidate genes. Eur. J. Hum. Genet. 21 (2013), 762–768.
21. Shaheen, R., Almoisheer, A., Faqeih, E., Babay, Z., Monies, D., Tassan, N., Abouelhoda, M., Kurdi, W., Al Mardawi, E., Khalil, M.M., Seidahmed, M.Z., Alnemer, M., Alsahan, N., Sogaty, S., Alhashem, A., Singh, A., Goyal, M., Kapoor, S., Alomar, R., Ibrahim, N., Alkuraya, F.S., Identification of a novel MKS locus defined by TMEM107 mutation. Hum. Mol. Genet. 24 (2015), 5211–5218.
22. Shamseldin, H.E., Tulbah, M., Kurdi, W., Nemer, M., Alsahan, N., Al Mardawi, E., Khalifa, O., Hashem, A., Kurdi, A., Babay, Z., Bubshait, D.K., Ibrahim, N., Abdulwahab, F., Rahbeeni, Z., Hashem, M., Alkuraya, F.S., Identification of embryonic lethal genes in humans by autozygosity mapping and exome sequencing in consanguineous families. Genome Biol., 16, 2015, 116.
23. Tadmouri, G.O., Nair, P., Obeid, T., Al Ali, M.T., Al Khaja, N., Hamamy, H.A., Consanguinity and reproductive health among Arabs. Reprod. Health, 6, 2009, 17.
24. Teebi, A.S., Teebi, S.A., Genetic diversity among the Arabs. Community Genet. 8 (2005), 21–26.
25. Thareja, G., John, S.E., Hebbar, P., Behbehani, K., Thanaraj, T.A., Alsmadi, O., Sequence and analysis of a whole genome from Kuwaiti population subgroup of Persian ancestry. BMC Genomics, 16, 2015, 92.
26. Venter, J.C., Adams, M.D., Myers, E.W., Li, P.W., Mural, R.J., Sutton, G.G., Smith, H.O., Yandell, M., Evans, C.A., Holt, R.A., Gocayne, J.D., Amanatides, P., Ballew, R.M., Huson, D.H., Wortman, J.R., Zhang, Q., Kodira, C.D., Zheng, X.H., Chen, L., Skupski, M., Subramanian, G., Thomas, P.D., Zhang, J., Gabor Miklos, G.L., Nelson, C., Broder, S., Clark, A.G., Nadeau, J., McKusick, V.A., Zinder, N., Levine, A.J., Roberts, R.J., Simon, M., Slayman, C., Hunkapiller, M., Bolanos, R., Delcher, A., Dew, I., Fasulo, D., Flanigan, M., Florea, L., Halpern, A., Hannenhalli, S., Kravitz, S., Levy, S., Mobarry, C., Reinert, K., Remington, K., Abu-Threideh, J., Beasley, E., Biddick, K., Bonazzi, V., Brandon, R., Cargill, M., Chandramouliswaran, I., Charlab, R., Chaturvedi, K., Deng, Z., Di Francesco, V., Dunn, P., Eilbeck, K., Evangelista, C., Gabrielian, A.E., Gan, W., Ge, W., Gong, F., Gu, Z., Guan, P., Heiman, T.J., Higgins, M.E., Ji, R.R., Ke, Z., Ketchum, K.A., Lai, Z., Lei, Y., Li, Z., Li, J., Liang, Y., Lin, X., Lu, F., Merkulov, G.V., Milshina, N., Moore, H.M., Naik, A.K., Narayan, V.A., Neelam, B., Nusskern, D., Rusch, D.B., Salzberg, S., Shao, W., Shue, B., Sun, J., Wang, Z., Wang, A., Wang, X., Wang, J., Wei, M., Wides, R., Xiao, C., Yan, C., Yao, A., Ye, J., Zhan, M., Zhang, W., Zhang, H., Zhao, Q., Zheng, L., Zhong, F., Zhong, W., Zhu, S., Zhao, S., Gilbert, D., Baumhueter, S., Spier, G., Carter, C., Cravchik, A., Woodage, T., Ali, F., An, H., Awe, A., Baldwin, D., Baden, H., Barnstead, M., Barrow, I., Beeson, K., Busam, D., Carver, A., Center, A., Cheng, M.L., Curry, L., Danaher, S., Davenport, L., Desilets, R., Dietz, S., Dodson, K., Doup, L., Ferriera, S., Garg, N., Gluecksmann, A., Hart, B., Haynes, J., Haynes, C., Heiner, C., Hladun, S., Hostin, D., Houck, J., Howland, T., Ibegwam, C., Johnson, J., Kalush, F., Kline, L., Koduru, S., Love, A., Mann, F., May, D., McCawley, S., McIntosh, T., McMullen, I., Moy, M., Moy, L., Murphy, B., Nelson, K., Pfannkoch, C., Pratts, E., Puri, V., Qureshi, H., Reardon, M., Rodriguez, R., Rogers, Y.H., Romblad, D., Ruhfel, B., Scott, R., Sitter, C., Smallwood, M., Stewart, E., Strong, R., Suh, E., Thomas, R., Tint, N.N., Tse, S., Vech, C., Wang, G., Wetter, J., Williams, S., Williams, M., Windsor, S., Winn-Deen, E., Wolfe, K., Zaveri, J., Zaveri, K., Abril, J.F., Guigo, R., Campbell, M.J., Sjolander, K.V., Karlak, B., Kejariwal, A., Mi, H., Lazareva, B., Hatton, T., Narechania, A., Diemer, K., Muruganujan, A., Guo, N., Sato, S., Bafna, V., Istrail, S., Lippert, R., Schwartz, R., Walenz, B., Yooseph, S., Allen, D., Basu, A., Baxendale, J., Blick, L., Caminha, M., Carnes-Stine, J., Caulk, P., Chiang, Y.H., Coyne, M., Dahlke, C., Mays, A., Dombroski, M., Donnelly, M., Ely, D., Esparham, S., Fosler, C., Gire, H., Glanowski, S., Glasser, K., Glodek, A., Gorokhov, M., Graham, K., Gropman, B., Harris, M., Heil, J., Henderson, S., Hoover, J., Jennings, D., Jordan, C., Jordan, J., Kasha, J., Kagan, L., Kraft, C., Levitsky, A., Lewis, M., Liu, X., Lopez, J., Ma, D., Majoros, W., McDaniel, J., Murphy, S., Newman, M., Nguyen, T., Nguyen, N., Nodell, M., Pan, S., Peck, J., Peterson, M., Rowe, W., Sanders, R., Scott, J., Simpson, M., Smith, T., Sprague, A., Stockwell, T., Turner, R., Venter, E., Wang, M., Wen, M., Wu, D., Wu, M., Xia, A., Zandieh, A., Zhu, X., The sequence of the human genome. Science 291 (2001), 1304–1351.
27. Verge, C.F., Vardi, P., Babu, S., Bao, F., Erlich, H.A., Bugawan, T., Tiosano, D., Yu, L., Eisenbarth, G.S., Fain, P.R., Evidence for oligogenic inheritance of type 1 diabetes in a large Bedouin Arab family. J Clin Invest. 102:8 (1998 Oct 15), 1569–1575.
28. Yavarna, T., Al-Dewik, N., Al-Mureikhi, M., Ali, R., Al-Mesaifri, F., Mahmoud, L., Shahbeck, N., Lakhani, S., AlMulla, M., Nawaz, Z., Vitazka, P., Alkuraya, F.S., Ben-Omran, T., High diagnostic yield of clinical exome sequencing in Middle Eastern patients with Mendelian disorders. Hum. Genet. 134 (2015), 967–980.
29. Zayed, H., Ouhtit, A., Accredited genetic testing in the Arab Gulf region: reinventing the wheel. J. Hum. Genet., 2016, 10.1038/jhg.2016.22 (Epub ahead of print).