K19 capsular polysaccharide of acinetobacter baumannii is produced via a Wzy polymerase encoded in a small genomic island rather than the KL19 capsule gene cluster

Microbiology (United Kingdom)

Volumn 162, Issue 8, 2016, Pages 1479-1489

  Kenyon, Johanna J ^a,b   Shneider, Mikhail M ^c   Senchenkova, Sofya N ^d   Shashkov, Alexander S ^d   Siniagina, Maria N ^e   Malanin, Sergey Y ^e   Popova, Anastasiya V ^f,g   Miroshnikov, Konstantin A ^c   Hall, Ruth M ^a   Knirel, Yuriy A ^d  

^a UNIVERSITY OF SYDNEY   (Australia)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^c SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^d N D ZELINSKY INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^e KAZAN FEDERAL UNIVERSITY   (Russian Federation)

^f MOSCOW INSTITUTE OF PHYSICS AND TECHNOLOGY   (Russian Federation)

^g STATE RESEARCH CENTER FOR APPLIED MICROBIOLOGY AND BIOTECHNOLOGY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; BACTERIAL ENZYME; BACTERIAL POLYSACCHARIDE; UNCLASSIFIED DRUG; WZY POLYMERASE; GLYCOSYLTRANSFERASE; K19 CAPSULAR POLYSACCHARIDE, ACINETOBACTER BAUMANNII;

ACETYLATION; ACINETOBACTER BAUMANNII; ARTICLE; AUSTRALIA; BACTERIAL GENE; BACTERIAL GENOME; BACTERIUM ISOLATE; BIOSYNTHESIS; GENE CLUSTER; GENE INSERTION SEQUENCE; GENOMIC ISLAND; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RUSSIAN FEDERATION; ACINETOBACTER INFECTION; BACTERIAL CAPSULE; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MULTIGENE FAMILY;

ACETYLTRANSFERASES; ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; BACTERIAL CAPSULES; GENOMIC ISLANDS; GLYCOSYLTRANSFERASES; HUMANS; MULTIGENE FAMILY; POLYSACCHARIDES, BACTERIAL;

EID: 84986893095     PISSN: 13500872     EISSN: 14652080     Source Type: Journal    
DOI: 10.1099/mic.0.000313     Document Type: Article

References (38)

1. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. (1990). Basic local alignment search tool. J Mol Biol 215, 403–410.
2. Arbatsky, N. P., Shneider, M. M., Kenyon, J. J., Shashkov, A. S., Popova, A. V., Miroshnikov, K. A., Volozhantsev, N. V. & Knirel, Y. A. (2015). Structure of the neutral capsular polysaccharide of Acinetobacter baumannii NIPH146 that carries the KL37 capsule gene cluster. Carbohydr Res 413, 12–15.
3. De Castro, C., Parrilli, M., Holst, O. & Molinaro, A. (2010). Microbeassociated molecular patterns in innate immunity: extraction and chemical analysis of Gram-negative bacterial lipopolysaccharides. Methods Enzymol 480, 89–115.
4. Finn, R. D., Bateman, A., Clements, J., Coggill, P., Eberhardt, R. Y., Eddy, S. R., Heger, A., Hetherington, K., Holm, L. & other authors (2014). Pfam: the protein families database. Nucleic Acids Res 42, D222–D230.
5. Geisinger, E. & Isberg, R. R. (2015). Antibiotic modulation of capsular exopolysaccharide and virulence in Acinetobacter baumannii. PLoS Pathog 11, e1004691.
6. Hamidian, M. & Hall, R. M. (2013). ISAba1 targets a specific position upstream of the intrinsic ampC gene of Acinetobacter baumannii leading to cephalosporin resistance. J Antimicrob Chemother 68, 2682–2683.
7. Hamidian, M., Kenyon, J. J., Holt, K. E., Pickard, D. J. & Hall, R. M. (2014). A conjugative plasmid carrying the carbapenem resistance gene blaOXA-23 in AbaR4 in an extensively resistant GC1 Acinetobacter baumannii isolate. J Antimicrob Chemother 69, 2625–2628.
8. Holt, K. E., Hamidian, M., Kenyon, J. J., Wynn, M. T., Hawkey, J., Pickard, D. & Hall, R. M. (2015). Genome sequence of Acinetobacter baumannii strain A1, an early example of antibiotic-resistant global clone 1. Genome Announc 3, e00032–15.
9. Holt, K., Kenyon, J. J., Hamidian, M., Schultz, M. B., Pickard, D. J., Dougan, G. & Hall, R. M. (2016). Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant Acinetobacter baumannii global clone 1. Microb Genom 2, 2.
10. Hu, D., Liu, B., Dijkshoorn, L., Wang, L. & Reeves, P. R. (2013). Diversity in the major polysaccharide antigen of Acinetobacter baumannii assessed by DNA sequencing, and development of a molecular serotyping scheme. PLoS One 8, e70329.
11. Kenyon, J. J. & Hall, R. M. (2013). Variation in the complex carbohydrate biosynthesis loci of Acinetobacter baumannii genomes. PLoS One 8, e62160.
12. Kenyon, J. J. & Reeves, P. R. (2013). The Wzy O-antigen polymerase of Yersinia pseudotuberculosis O: 2a has a dependence on the Wzz chainlength determinant for efficient polymerization. FEMS Microbiol Lett 349, 163–170.
13. Kenyon, J. J., Marzaioli, A. M., Hall, R. M. & De Castro, C. (2014). Structure of the K2 capsule associated with the KL2 gene cluster of Acinetobacter baumannii. Glycobiology 24, 554–563.
14. Kenyon, J. J., Marzaioli, A. M., Hall, R. M. & De Castro, C. (2015a). Structure of the K6 capsular polysaccharide from Acinetobacter baumannii isolate RBH4. Carbohydr Res 409, 30–35.
15. Kenyon, J. J., Marzaioli, A. M., Hall, R. M. & De Castro, C. (2015b). Structure of the K12 capsule containing 5,7-Di-N-acetylacinetaminic acid from Acinetobacter baumannii isolate D36. Glycobiology 25, 881–887.
16. Kenyon, J. J., Hall, R. M. & De Castro, C. (2015c). Structural determination of the K14 capsular polysaccharide from an ST25 Acinetobacter baumannii isolate, D46. Carbohydr Res 417, 52–56.
17. Kenyon, J. J., Marzaioli, A. M., De Castro, C. & Hall, R. M. (2015d). 5,7- di-N-acetyl-acinetaminic acid – a novel non-2-ulosonic acid found in the capsule of an Acinetobacter baumannii isolate. Glycobiology 25, 644–654.
18. Knirel, Y. A., Vinogradov, E. V., Shashkov, A. S., Wilkinson, S. G., Tahara, Y., Dmitriev, B. A., Kochetkov, N. K., Stanislavsky, E. S. & Mashilova, G. M. (1986). Somatic antigens of Pseudomonas aeruginosa. The structure of O-specific polysaccharide chains of the lipopolysaccharides from P. aeruginosa O1 (Lányi), O3 (Habs), O13 and O14 (Wokatsch), and the serologically related strain NCTC 8505. Eur J Biochem 155, 659–669.
19. Knirel, Y. A., Kocharova, N. A., Shashkov, A. S., Kochetkov, N. K., Kholodkova, E. V. & Stanislavsky, E. S. (1987). Somatic antigens of Pseudomonas aeruginosa. The structure of O-specific polysaccharide chains of the lipopolysaccharides from P. aeruginosa II (Sandvik) and V (IM-1, Verder-Evans). Eur J Biochem 166, 189–197.
20. Leontein, K. & Lönngren, J. (1993). Determination of the absolute configuration of sugars by gas-liquid chromatography of their acetylated 2-octyl glycosides. Meth Carbohydr Chem 9, 87–89.
21. Lipkind, G. M., Shashkov, A. S., Knirel, Y. A., Vinogradov, E. V. & Kochetkov, N. K. (1988). A computer-assisted structural analysis of regular polysaccharides on the basis of 13C-n.m.r. data. Carbohydr Res 175, 59–75.
22. Morrison, M. J. & Imperiali, B. (2013). Biosynthesis of UDP-N,N'-diacetylbacillosamine in Acinetobacter baumannii: biochemical characterization and correlation to existing pathways. Arch Biochem Biophys 536, 72–80.
23. Roca, I., Espinal, P., Vila-Farres, X. & Vila, J. (2012). The Acinetobacter baumannii oxymoron: commensal hospital dweller turned pan-drug-resistant menace. Front Microbiol 3, 148.
24. Runnegar, N., Sidjabat, H., Goh, H. M. S., Nimmo, G. R., Schembri, M. A. & Paterson, D. L. (2010). Molecular epidemiology of multidrug-resistant Acinetobacter baumannii in a single institution over a 10-year period. J Clin Microbiol 48, 4051–4056.
25. Russo, T. A., Luke, N. R., Beanan, J. M., Olson, R., Sauberan, S. L., MacDonald, U., Schultz, L. W., Umland, T. C. & Campagnari, A. A. (2010). The K1 capsular polysaccharide of Acinetobacter baumannii strain 307-0294 is a major virulence factor. Infect Immun 78, 3993–4000.
26. Russo, T. A., Beanan, J. M., Olson, R., MacDonald, U., Cox, A. D., St Michael, F., Vinogradov, E. V., Spellberg, B., Luke-Marshall, N. R. & Campagnari, A. A. (2013). The K1 capsular polysaccharide from Acinetobacter baumannii is a potential therapeutic target via passive immunization. Infect Immun 81, 915–922.
27. Sawardeker, J. S., Sloneker, J. H. & Jeanes, A. (1965). Quantitative determination of monosaccharides as their alditol acetates by gas liquid chromatography. Anal Chem 37, 1602–1603.
28. Schultz, M. B., Thanh, D. P., Hoan, N. T. D., Wick, R. R., Ingle, D. J., Hawkey, J., Edwards, D. J., Kenyon, J. J., Lan, N. P. H. & other authors (2016). Repeated local emergence of carbapenem-resistant Acinetobacter baumannii in a single hospital ward. Microbial Genomics 2, 3.
29. Senchenkova, S. N., Shashkov, A. S., Shneider, M. M., Arbatsky, N. P., Popova, A. V., Miroshnikov, K. A., Volozhantsev, N. V. & Knirel, Y. A. (2014). Structure of the capsular polysaccharide of Acinetobacter baumannii ACICU containing di-N-acetylpseudaminic acid. Carbohydr Res 391, 89–92.
30. Senchenkova, S. N., Popova, A. V., Shashkov, A. S., Shneider, M. M., Mei, Z., Arbatsky, N. P., Liu, B., Miroshnikov, K. A., Volozhantsev, N. V. & Knirel, Y. A. (2015a). Structure of a new pseudaminic acid-containing capsular polysaccharide of Acinetobacter baumannii LUH5550 having the KL42 capsule biosynthesis locus. Carbohydr Res 407, 154–157.
31. Senchenkova, S. N., Shashkov, A. S., Popova, A. V., Shneider, M. M., Arbatsky, N. P., Miroshnikov, K. A., Volozhantsev, N. V. & Knirel, Y. A. (2015b). Structure elucidation of the capsular polysaccharide of Acinetobacter baumannii AB5075 having the KL25 capsule biosynthesis locus. Carbohydr Res 408, 8–11.
32. Shashkov, A. S., Lipkind, G. M., Knirel, Y. A. & Kochetkov, N. K. (1988). Stereochemical factors determining the effects of glycosylation on the 13C chemical shifts in carbohydrates. Magnetic Resonance Chem 26, 735–747.
33. Shashkov, A. S., Shneider, M. M., Senchenkova, S. N., Popova, A. V., Nikitina, A. S., Babenko, V. V., Kostryukova, E. S., Miroshnikov, K. A., Volozhantsev, N. V. & Knirel, Y. A. (2015a). Structure of the capsular polysaccharide of Acinetobacter baumannii 1053 having the KL91 capsule biosynthesis gene locus. Carbohydr Res 404, 79–82.
34. Shashkov, A. S., Kenyon, J. J., Arbatsky, N. P., Shneider, M. M., Popova, A. V., Miroshnikov, K. A., Volozhantsev, N. V. & Knirel, Y. A. (2015b). Structures of three different neutral polysaccharide of Acinetobacter baumannii, NIPH190, NIPH201, and NIPH615, assigned to K30, K45, and K48 capsule types, respectively, based on capsule biosynthesis gene clusters. Carbohydr Res 417, 81–88.
35. Shashkov, A. S., Kenyon, J. J., Senchenkova, S. N., Shneider, M. M., Popova, A. V., Arbatsky, N. P., Miroshnikov, K. A., Volozhantsev, N. V., Hall, R. M. & Knirel, Y. A. (2015c). Acinetobacter baumannii K27 and K44 capsular polysaccharides have the same K unit but different structures due to the presence of distinct wzy genes in otherwise closely related K gene clusters. Glycobiology 26, 501–508.
36. Shashkov, A. S., Senchenkova, S. N., Popova, A. V., Mei, Z., Shneider, M. M., Liu, B., Miroshnikov, K. A., Volozhantsev, N. V. & Knirel, Y. A. (2015d). Revised structure of the capsular polysaccharide of Acinetobacter baumannii LUH5533 (serogroup O1) containing di-N-acetyllegionaminic acid. Russ Chem B 64, 1196–1199.
37. Snitkin, E. S., Zelazny, A. M., Montero, C. I., Stock, F., Mijares, L., Murray, P. R., Segre, J. A., Mullikin, J., Blakesley, R. & other authors (2011). Genome-wide recombination drives diversification of epidemic strains of Acinetobacter baumannii. Proc Natl Acad Sci U S A 108, 13758–13763.
38. Zhou, Y., Liang, Y., Lynch, K. H., Dennis, J. J. & Wishart, D. S. (2011). PHAST: a fast phage search tool. Nucleic Acids Res 39, W347–W352.