Focal and segmental glomerulosclerosis: Clinical and kidney biopsy correlations

Clinical Kidney Journal

Volumn 7, Issue 6, 2014, Pages 531-537

  Sethi, Sanjeev ^a   Zand, Ladan ^a   Nasr, Samih H ^a   Glassock, Richard J ^b   Fervenza, Fernando C ^a  

^a Mayo Clinic College of Medicine   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Focal and segmental glomerulosclerosis; Nephrotic range; Nephrotic syndrome; Primary; Secondary

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; CALCINEURIN INHIBITOR; CREATININE; CYCLOPHOSPHAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MYCOPHENOLATE MOFETIL; PREDNISONE;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ELECTRON MICROSCOPY; FEMALE; FOCAL GLOMERULOSCLEROSIS; HEMATURIA; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MALE; NEPHROTIC SYNDROME; PLASMAPHERESIS; PRIORITY JOURNAL;

EID: 84986882797     PISSN: 20488505     EISSN: 20488513     Source Type: Journal    
DOI: 10.1093/ckj/sfu100     Document Type: Article

References (37)

1. Maisonneuve P, Agodoa L, Gellert R et al. Distribution of primary renal diseases leading to end-stage renal failure in the United States, Europe, and Australia/New Zealand: results from an international comparative study. Am J Kidney Dis 2000; 35: 157-165
2. Korbet SM. Primary focal segmental glomerulosclerosis. J Am Soc Nephrol 1998; 9: 1333-1340
3. Savin VJ, Sharma R, Sharma M et al. Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N Engl J Med1996; 334: 878-883
4. Wei C, El Hindi S, Li J et al. Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med 2011; 17: 952-960
5. Hoyer JR, Vernier RL, Najarian JS et al. Recurrence of idiopathic nephrotic syndrome after renal transplantation. Lancet 1972; 2: 343-348
6. Le Berre L, Godfrin Y, Lafond-Puyet L et al. Effect of plasma fractions from patients with focal and segmental glomerulosclerosis on rat proteinuria. Kidney Int 2000; 58: 502-511
7. Glassock RJ, Fervenza FC, Hebert L et al. Nephrotic syndrome redux. Nephrol Dial Transplant 2014; doi:10.1093/ndt/gfu077
8. Praga M, Morales E, Herrero JC et al. Absence of hypoalbuminemia despite massive proteinuria in focal segmental glomerulosclerosis secondary to hyperfiltration. Am J Kidney Dis1999; 33: 52-58
9. D'Agati VD, Fogo AB, Bruijn JA et al. Pathologic classification of focal segmental glomerulosclerosis: a working proposal. Am J Kidney Dis 2004; 43: 368-382
10. Kambham N, Markowitz GS, Valeri AM et al. Obesity-related glomerulopathy: an emerging epidemic. Kidney Int 2001; 59: 1498-1509
11. D'Agati V. The many masks of focal segmental glomerulosclerosis. Kidney Int 1994; 46: 1223-1241
12. Deegens JK, Dijkman HB, Borm GF et al. Podocyte foot process effacement as a diagnostic tool in focal segmental glomerulosclerosis. Kidney Int 2008; 74: 1568-1576
13. Sethi S, Glassock RJ, Fervenza FC. Focal segmental glomerulosclerosis: towards a better understanding for the practicing nephrologist. Nephrol Dial Transplant 2014; doi:10.1093/ndt/gfu035
14. Glasser RJ, Velosa JA, Michael AF. Experimental model of focal sclerosis. I. Relationship to protein excretion in aminonucleoside nephrosis. Lab Invest 1977; 36: 519-526
15. Inokuchi S, Shirato I, Kobayashi N et al. Re-evaluation of foot process effacement in acute puromycin aminonucleoside nephrosis. Kidney Int 1996; 50: 1278-1287
16. Vernier RL, Papermaster BW, Good RA. Aminonucleoside nephrosis. I. Electron microscopic study of the renal lesion in rats. J Exp Med 1959; 109: 115-126
17. Chang JW, Pardo V, Sageshima J et al. Podocyte foot process effacement in postreperfusion allograft biopsies correlates with early recurrence of proteinuria in focal segmental glomerulosclerosis. Transplantation 2012; 93: 1238-1244
18. Cheong HI, Han HW, Park HW et al. Early recurrent nephrotic syndrome after renal transplantation in children with focal segmental glomerulosclerosis. Nephrol Dial Transplant 2000; 15: 78-81
19. D'Agati VD. Podocyte injury in focal segmental glomerulosclerosis: lessons from animal models (a play in five acts). Kidney Int 2008; 73: 399-406
20. Nagata M, Kriz W. Glomerular damage after uninephrectomy in young rats. II. Mechanical stress on podocytes as a pathway to sclerosis. Kidney Int 1992; 42: 148-160
21. Gipson DS, Trachtman H, Kaskel FJ et al. Clinical trial of focal segmental glomerulosclerosis in children and young adults. Kidney Int 2011; 80: 868-878
22. Trachtman H, Vento S, Gipson D et al. Novel therapies for resistant focal segmental glomerulosclerosis (FONT) phase II clinical trial: study design. BMC Nephrol 2011; 12: 8
23. Troyanov S, Wall CA, Miller JA et al. Focal and segmental glomerulosclerosis: definition and relevance of a partial remission. J Am Soc Nephrol 2005; 16: 1061-1068
24. Ramachandran R, Kumar V, Rathi M et al. Tacrolimus therapy in adult-onset steroid-resistant nephrotic syndrome due to a focal segmental glomerulosclerosis single-center experience. Nephrol Dial Transplant 2014; 29: 1918-1924
25. Black DA, Rose G, Brewer DB. Controlled trial of prednisone in adult patients with the nephrotic syndrome. Br Med J 1970; 3: 421-426
26. D'Agati VD, Kaskel FJ, Falk RJ. Focal segmental glomerulosclerosis. N Engl J Med 2011; 365: 2398-2411
27. Thomas DB, Franceschini N, Hogan SL et al. Clinical and pathologic characteristics of focal segmental glomerulosclerosis pathologic variants. Kidney Int 2006; 69: 920-926
28. Stokes MB, Valeri AM, Markowitz GS et al. Cellular focal segmental glomerulosclerosis: clinical and pathologic features. Kidney Int 2006; 70: 1783-1792
29. Santin S, Bullich G, Tazon-Vega B et al. Clinical utility of genetic testing in children and adults with steroid-resistant nephrotic syndrome. Clin J Am Soc Nephrol 2011; 6: 1139-1148
30. Rood IM, Deegens JK, Wetzels JF. Genetic causes of focal segmental glomerulosclerosis: implications for clinical practice. Nephrol Dial Transplant 2012; 27: 882-890
31. Chun MJ, Korbet SM, Schwartz MM et al. Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants. J Am Soc Nephrol 2004; 15: 2169-2177
32. Praga M, Hernandez E, Morales E et al. Clinical features and long-term outcome of obesity-associated focal segmental glomerulosclerosis. Nephrol Dial Transplant 2001; 16: 1790-1798
33. Fogo A, Breyer JA, Smith MC et al. Accuracy of the diagnosis of hypertensive nephrosclerosis in African Americans: a report from the African American Study of Kidney Disease (AASK) Trial. AASK Pilot Study Investigators. Kidney Int 1997; 51: 244-252
34. Toto RD. Proteinuria and hypertensive nephrosclerosis in African Americans. Kidney Int Suppl 2004; 66: S102-S104
35. Crook ED, Habeeb D, Gowdy O et al. Effects of steroids in focal segmental glomerulosclerosis in a predominantly African-American population. Am J Med Sci 2005; 330: 19-24
36. Velosa JA, Holley KE, Torres VE et al. Significance of proteinuria on the outcome of renal function in patients with focal segmental glomerulosclerosis. Mayo Clin Proc 1983; 58: 568-577
37. Kidney Disease: Improving Global Outcomes (KDIGO) glomerulonephritis Work Group. KDIGO Clinical Practice Guidelines for Glomerulonephritis. Kidney Int 2012; 2(Suppl 2): 139-274