Podocyte foot process effacement as a diagnostic tool in focal segmental glomerulosclerosis

Kidney International

Volumn 74, Issue 12, 2008, Pages 1568-1576

  Deegens, Jeroen K J ^a   Dijkman, Henry B P M ^a   Borm, George F ^a   Steenbergen, Eric J ^a   Van Den Berg, José G ^b   Weening, Jan J ^a   Wetzels, Jack F M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Focal segmental glomerulosclerosis; Foot process; Pathology; Podocyte; Proteinuria; Renal morphology

Indexed keywords

SERUM ALBUMIN;

ALBUMIN BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; ELECTRON MICROSCOPY; FOCAL GLOMERULOSCLEROSIS; HUMAN; HUMAN TISSUE; IDIOPATHIC DISEASE; MORPHOMETRICS; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA;

ADULT; AGED; DIAGNOSIS, DIFFERENTIAL; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; MICROSCOPY, ELECTRON; MIDDLE AGED; NEPHROSIS, LIPOID; PODOCYTES;

EID: 57049180117     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.413     Document Type: Article

References (36)

1. D'Agati V. Pathologic classification of focal segmental glomerulosclerosis. Semin Nephrol 2003; 23: 117-134.
2. van den Berg JG, van den Bergh Weerman MA, Assmann KJ et al. Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies. Kidney Int 2004; 66: 1901-1906.
3. Pagtalunan M, Miller P, Jumping-Eagle S et al. Podocyte loss and progressive glomerular injury in type II diabetes. J Clin Invest 1997; 99: 342-348.
4. Dantal J, Bigot E, Bogers W et al. Effect of plasma protein adsorption on protein excretion in kidney-transplant recipients with recurrent nephrotic syndrome. N Engl J Med 1994; 330: 7-14.
5. Savin VJ, Sharma R, Sharma M et al. Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N Engl J Med 1996; 334: 878-883.
6. Koyama A, Fujisaki M, Kobayashi M et al. A glomerular permeability factor produced by human T cell hybridomas. Kidney Int 1991; 40: 453-460.
7. Deegens JK, Steenbergen EJ, Borm GF et al. Pathological variants of focal segmental glomerulosclerosis in an adult Dutch population epidemiology and outcome. Nephrol Dial Transplant 2008; 23: 186-192.
8. Stokes MB, Markowitz GS, Lin J et al. Glomerular tip lesion: a distinct entity within the minimal change disease/focal segmental glomerulosclerosis spectrum. Kidney Int 2004; 65: 1690-1702.
9. Regele HM, Fillipovic E, Langer B et al. Glomerular expression of dystroglycans is reduced in minimal change nephrosis but not in focal segmental glomerulosclerosis. J Am Soc Nephrol 2000; 11: 403-412.
10. Kambham N, Markowitz G, Valeri A et al. Obesity-related glomerulopathy: An emerging epidemic. Kidney Int 2001; 59: 1498-1509.
11. D'Agati V. The many masks of focal glomerulosclerosis. Kidney Int 1994; 46: 1223-1241.
12. Praga M, Morales E, Herrero J et al. Absence of hypoalbuminemia despite massive proteinuria in focal segmental glomerulosclerosis secondary to hyperfiltration. Am J Kidney Dis 1999; 33: 52-58.
13. Shankland SJ. The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 2006; 69: 2131-2147.
14. Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev 2003; 83: 253-307.
15. Asanuma K, Mundel P. The role of podocytes in glomerular pathobiology. Clin Exp Nephrol 2003; 7: 255-259.
16. Dijkman H, Gerlofs-Nijland M, van der Laak A et al. Podocyte changes after induction of acute albuminuria in mice by anti-aminopeptidase A Mab. Nephron Exp Nephrol 2003; 94: e85-e93.
17. Seefeldt T, Bohman S, Jorgen H et al. Quantitative relationship between glomerular foot process width and proteinuria in glomerulonephritis. Lab Invest 1981; 44: 541-546.
18. Branten A, van den Born J, Jansen J et al. Familial nephropathy differing from minimal change nephropathy and focal glomerulosclerosis. Kidney Int 2001; 59: 693-701.
19. Hoffmann S, Podlich D, Hahnel B et al. Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats. J Am Soc Nephrol 2004; 15: 1475-1487.
20. Mundel P, Shankland S. Podocyte biology and response. J Am Soc Nephrol 2002; 13: 3005-3015.
21. Brenchley PE. Vascular permeability factors in steroid-sensitive nephrotic syndrome and focal segmental glomerulosclerosis. Nephrol Dial Transplant 2003; 18(Suppl 6): vi21-vi25.
22. Orikasa M, Matsui K, Oite T et al. Massive proteinuria induced in rats by a single intravenous injection of a monoclonal antibody. J Immunol 1988; 141: 807-814.
23. Kikuchi H, Kawachi H, Ito Y et al. Severe proteinuria, sustained for 6 months, induces tubular epithelial cell injury and cell infiltration in rats but not progressive interstitial fibrosis. Nephrol Dial Transplant 2000; 15: 799-810.
24. Howie AJ, Pankhurst T, Sarioglu S et al. Evolution of nephrotic-associated focal segmental glomerulosclerosis and relation to the glomerular tip lesion. Kidney Int 2005; 67: 987-1001.
25. Dijkman H, Smeets B, van der LJ et al. The parietal epithelial cell is crucially involved in human idiopathic focal segmental glomerulosclerosis. Kidney Int 2005; 68: 1562-1572.
26. Kuusniemi AM, Merenmies J, Lahdenkari AT et al. Glomerular sclerosis in kidneys with congenital nephrotic syndrome (NPHS1). Kidney Int 2006; 70: 1423-1431.
27. Caridi G, Bertelli R, Scolari F et al. Podocin mutations in sporadic focal-segmental glomerulosclerosis occurring in adulthood. Kidney Int 2003; 64: 365.
28. Aucella F, De BP, Gatta G et al. Molecular analysis of NPHS2 and ACTN4 genes in a series of 33 Italian patients affected by adult-onset nonfamilial focal segmental glomerulosclerosis. Nephron Clin Pract 2005; 99: c31-c36.
29. He N, Zahirieh A, Mei Y et al. Recessive NPHS2 (Podocin) mutations are rare in adult-onset idiopathic focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 2007; 2: 31-37.
30. Praga M, Hernandez E, Morales E et al. Clinical features and long-term outcome of obesity-associated focal segmental glomerulosclerosis. Nephrol Dial Transplant 2001; 16: 1790-1798.
31. Praga M, Borstein B, Andres G et al. Nephrotic proteinuria without hypoalbuminemia: clinical characteristics and response to angiotensin- converting enzyme inhibition. Am J Kidney Dis 1991; 17: 330-338.
32. Schmidt A, Mayer G. The diagnostic trash bin of focal and segmental glomerulosclerosis - an effort to provide rational clinical guidelines. Nephrol Dial Transplant 1999; 14: 550-552.
33. Korbet S. Angiotensin antagonists and steroids in the treatment of focal segmental glomerulosclerosis. Semin Nephrol 2003; 23: 229-233.
34. D'Agati V, Fogo A, Bruijn J et al. Pathologic classification of focal segmental glomerulosclerosis: a working proposal. Am J Kidney Dis 2004; 43: 368-382.
35. Pagtalunan M, Rasch R, Rennke H et al. Morphometric analysis of effects of angiotensin II on glomerular structure in rats. Am J Physiol 1995; 268: F82-F88.
36. Gundersen HJ, Seefeldt T, Osterby R. Glomerular epithelial foot processes in normal man and rats. Distribution of true width and its intra- and inter-individual variation. Cell Tissue Res 1980; 205: 147-155.