-
1
-
-
60249086665
-
Deaths: Preliminary Data for 2008
-
In; Centers for Disease Control and Prevention: Atlanta, GA, USA
-
Miniño, A.M.; Xu, J.; Kochanek, K.D. Deaths: Preliminary Data for 2008. In National Vital Statistics Reports; Centers for Disease Control and Prevention: Atlanta, GA, USA, 2010; Volume 59.
-
(2010)
National Vital Statistics Reports
, vol.59
-
-
Miniño, A.M.1
Xu, J.2
Kochanek, K.D.3
-
2
-
-
0024314702
-
Amyloid beta protein precursor and the pathogenesis of Alzheimer's disease
-
Selkoe, D.J. Amyloid beta protein precursor and the pathogenesis of Alzheimer's disease. Cell 1989, 58, 611-612.
-
(1989)
Cell
, vol.58
, pp. 611-612
-
-
Selkoe, D.J.1
-
3
-
-
0027367764
-
Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease
-
Selkoe, D.J. Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurosci. 1993, 16, 403-409.
-
(1993)
Trends Neurosci.
, vol.16
, pp. 403-409
-
-
Selkoe, D.J.1
-
4
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal, I.; Iqbal, K.; Tung, Y.C.; Quinlan, M.; Wisniewski, H.M.; Binder, L.I. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. USA 1986, 83, 4913-4917.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
5
-
-
0009364134
-
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease
-
Kosik, K.S.; Joachim, C.L.; Selkoe, D.J. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc. Natl. Acad. Sci. USA 1986, 83, 4044-4048
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 4044-4048
-
-
Kosik, K.S.1
Joachim, C.L.2
Selkoe, D.J.3
-
6
-
-
1842685948
-
Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)
-
Wood, J.G.; Mirra, S.S.; Pollock, N.J.; Binder, L.I. Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau). Proc. Natl. Acad. Sci. USA 1986, 83, 4040-4043.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 4040-4043
-
-
Wood, J.G.1
Mirra, S.S.2
Pollock, N.J.3
Binder, L.I.4
-
7
-
-
84868677556
-
Biochemistry and cell biology of tau protein in neurofibrillary degeneration
-
doi:10.1101/cshperspect.a006247
-
Mandelkow, E.-M.; Mandelkow, E. Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb. Perspect. Med. 2012, 2, doi:10.1101/cshperspect.a006247.
-
(2012)
Cold Spring Harb. Perspect. Med.
, vol.2
-
-
Mandelkow, E.-M.1
Mandelkow, E.2
-
8
-
-
84866975410
-
Immunotherapy for Alzheimer's disease
-
Wang, W.; Fan, L.; Xu, D.; Wen, Z.; Yu, R.; Ma, Q. Immunotherapy for Alzheimer's disease. Acta Biochim. Biophys. Sin. 2012, 44, 807-814.
-
(2012)
Acta Biochim. Biophys. Sin.
, vol.44
, pp. 807-814
-
-
Wang, W.1
Fan, L.2
Xu, D.3
Wen, Z.4
Yu, R.5
Ma, Q.6
-
9
-
-
84878769054
-
Therapeutic strategies for tau mediated neurodegeneration
-
Yoshiyama, Y.; Lee, V.M.Y.; Trojanowski, J.Q. Therapeutic strategies for tau mediated neurodegeneration. J. Neurol. Neurosurg. Psychiatry 2013, 84, 784-795.
-
(2013)
J. Neurol. Neurosurg. Psychiatry
, vol.84
, pp. 784-795
-
-
Yoshiyama, Y.1
Lee, V.M.Y.2
Trojanowski, J.Q.3
-
10
-
-
77955927938
-
Tau protein and tau aggregation inhibitors
-
Bulic, B.; Pickhardt, M.; Mandelkow, E.-M.; Mandelkow, E. Tau protein and tau aggregation inhibitors. Neuropharmacology 2010, 59, 276-289.
-
(2010)
Neuropharmacology
, vol.59
, pp. 276-289
-
-
Bulic, B.1
Pickhardt, M.2
Mandelkow, E.-M.3
Mandelkow, E.4
-
11
-
-
77952548786
-
Tau-directed drug discovery for Alzheimer's disease and related tauopathies: A focus on tau assembly inhibitors
-
Brunden, K.R.; Ballatore, C.; Crowe, A.; Smith, A.B.; Lee, V.M.-Y.; Trojanowski, J.Q. Tau-directed drug discovery for Alzheimer's disease and related tauopathies: A focus on tau assembly inhibitors. Exp. Neurol. 2010, 223, 304-310.
-
(2010)
Exp. Neurol.
, vol.223
, pp. 304-310
-
-
Brunden, K.R.1
Ballatore, C.2
Crowe, A.3
Smith, A.B.4
Lee, V.M.-Y.5
Trojanowski, J.Q.6
-
12
-
-
84655160770
-
Clinical trials in Alzheimer's disease: Immunotherapy approaches
-
Delrieu, J.; Ousset, P.J.; Caillaud, C.; Vellas, B.-Clinical trials in Alzheimer's disease: Immunotherapy approaches. J. Neurochem. 2012, 120, 186-193.
-
(2012)
J. Neurochem.
, vol.120
, pp. 186-193
-
-
Delrieu, J.1
Ousset, P.J.2
Caillaud, C.3
Vellas, B.4
-
13
-
-
34548146119
-
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
-
Asuni, A.A.; Boutajangout, A.; Quartermain, D.; Sigurdsson, E.M. Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J. Neurosci. 2007, 27, 9115-9129.
-
(2007)
J. Neurosci.
, vol.27
, pp. 9115-9129
-
-
Asuni, A.A.1
Boutajangout, A.2
Quartermain, D.3
Sigurdsson, E.M.4
-
14
-
-
77954656871
-
Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice
-
Boimel, M.; Grigoriadis, N.; Lourbopoulos, A.; Haber, E.; Abramsky, O.; Rosenmann, H. Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice. Exp. Neurol. 2010, 224, 472-485.
-
(2010)
Exp. Neurol.
, vol.224
, pp. 472-485
-
-
Boimel, M.1
Grigoriadis, N.2
Lourbopoulos, A.3
Haber, E.4
Abramsky, O.5
Rosenmann, H.6
-
15
-
-
79960563632
-
Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
-
Boutajangout, A.; Ingadottir, J.; Davies, P.; Sigurdsson, E.M. Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. J. Neurochem. 2011, 118, 658-667.
-
(2011)
J. Neurochem.
, vol.118
, pp. 658-667
-
-
Boutajangout, A.1
Ingadottir, J.2
Davies, P.3
Sigurdsson, E.M.4
-
16
-
-
78650065372
-
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model
-
Boutajangout, A.; Quartermain, D.; Sigurdsson, E.M. Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J. Neurosci. 2010, 30, 16559-16566.
-
(2010)
J. Neurosci.
, vol.30
, pp. 16559-16566
-
-
Boutajangout, A.1
Quartermain, D.2
Sigurdsson, E.M.3
-
17
-
-
84860531636
-
Targeting phospho-Ser422 by active Tau immunotherapy in the THYTau22 mouse model: A suitable therapeutic approach
-
Troquier, L.; Caillierez, R.; Burnouf, S.; Fernandez-Gomez, F.J.; Grosjean, M.-E.; Zommer, N.; Sergeant, N.; Schraen-Maschke, S.; Blum, D.; Buee, L. Targeting phospho-Ser422 by active Tau immunotherapy in the THYTau22 mouse model: A suitable therapeutic approach. Curr. Alzheimer Res. 2012, 9, 397-405.
-
(2012)
Curr. Alzheimer Res.
, vol.9
, pp. 397-405
-
-
Troquier, L.1
Caillierez, R.2
Burnouf, S.3
Fernandez-Gomez, F.J.4
Grosjean, M.-E.5
Zommer, N.6
Sergeant, N.7
Schraen-Maschke, S.8
Blum, D.9
Buee, L.10
-
18
-
-
83255175500
-
Vaccination with M2e-Based Multiple antigenic peptides: Characterization of the B cell response and protection efficacy in inbred and outbred mice
-
Wolf, A.I.; Mozdzanowska, K.; Williams, K.L.; Singer, D.; Richter, M.; Hoffmann, R.; Caton, A.J.; Otvos, L.; Erikson, J.; Tompkins, S.M. Vaccination with M2e-Based Multiple antigenic peptides: characterization of the B cell response and protection efficacy in inbred and outbred mice. PLoS One 2011, 6, e28445.
-
(2011)
PLoS One
, vol.6
-
-
Wolf, A.I.1
Mozdzanowska, K.2
Williams, K.L.3
Singer, D.4
Richter, M.5
Hoffmann, R.6
Caton, A.J.7
Otvos, L.8
Erikson, J.9
Tompkins, S.M.10
-
19
-
-
0036412623
-
Synthetic peptides as cancer vaccines
-
Sundaram, R.; Dakappagari, N.K.; Kaumaya, P.T.P. Synthetic peptides as cancer vaccines. Biopolymers 2002, 66, 200-216.
-
(2002)
Biopolymers
, vol.66
, pp. 200-216
-
-
Sundaram, R.1
Dakappagari, N.K.2
Kaumaya, P.T.P.3
-
20
-
-
79953295579
-
Immunotherapy for Alzheimer's disease: Rational basis in ongoing clinical trials
-
Menendez-Gonzalez, M.; Perez-Pinera, P.; Martinez-Rivera, M.; Muniz, A.L.; Vega, J.A. Immunotherapy for Alzheimer's disease: Rational basis in ongoing clinical trials. Curr. Pharm. Des. 2011, 17, 508-520.
-
(2011)
Curr. Pharm. Des.
, vol.17
, pp. 508-520
-
-
Menendez-Gonzalez, M.1
Perez-Pinera, P.2
Martinez-Rivera, M.3
Muniz, A.L.4
Vega, J.A.5
-
21
-
-
79951732094
-
Therapeutic potential of vaccines for Alzheimer's disease
-
Shah, S.; Federoff, H.J. Therapeutic potential of vaccines for Alzheimer's disease. Immunotherapy 2011, 3, 287-298.
-
(2011)
Immunotherapy
, vol.3
, pp. 287-298
-
-
Shah, S.1
Federoff, H.J.2
-
22
-
-
0025765185
-
Functional heterogeneity of CD4-positive T-cell subsets: The correlation between effector functions and lymphokine secretion is limited
-
Erb, P.; Troxler, M.; Fluri, M.; Grogg, D.; Alkan, S.S. Functional heterogeneity of CD4-positive T-cell subsets: The correlation between effector functions and lymphokine secretion is limited. Cell. Immunol. 1991, 135, 232-244.
-
(1991)
Cell. Immunol.
, vol.135
, pp. 232-244
-
-
Erb, P.1
Troxler, M.2
Fluri, M.3
Grogg, D.4
Alkan, S.S.5
-
23
-
-
0024320351
-
Collaboration of Th1 and Th2 T cell clones in specific antibody responses: Regulation of the IgM response to phosphorylcholine
-
Infante, A.J.; Currier, P.F. Collaboration of Th1 and Th2 T cell clones in specific antibody responses: Regulation of the IgM response to phosphorylcholine. Cell. Immunol. 1989, 122, 146-153.
-
(1989)
Cell. Immunol.
, vol.122
, pp. 146-153
-
-
Infante, A.J.1
Currier, P.F.2
-
24
-
-
3242694207
-
An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives
-
Sigurdsson, E.M.; Knudsen, E.; Asuni, A.; Fitzer-Attas, C.; Sage, D.; Quartermain, D.; Goni, F.; Frangione, B.; Wisniewski, T. An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives. J. Neurosci. 2004, 24, 6277-6282.
-
(2004)
J. Neurosci.
, vol.24
, pp. 6277-6282
-
-
Sigurdsson, E.M.1
Knudsen, E.2
Asuni, A.3
Fitzer-Attas, C.4
Sage, D.5
Quartermain, D.6
Goni, F.7
Frangione, B.8
Wisniewski, T.9
-
25
-
-
3242758909
-
Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS
-
Raghavendra, V.; Tanga, F.Y.; DeLeo, J.A. Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS. Eur. J. Neurosci. 2004, 20, 467-473.
-
(2004)
Eur. J. Neurosci.
, vol.20
, pp. 467-473
-
-
Raghavendra, V.1
Tanga, F.Y.2
DeLeo, J.A.3
-
26
-
-
84882793431
-
Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation
-
Rozenstein-Tsalkovich, L.; Grigoriadis, N.; Lourbopoulos, A.; Nousiopoulou, E.; Kassis, I.; Abramsky, O.; Karussis, D.; Rosenmann, H. Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation. Exp. Neurol. 2013, 248, 451-456.
-
(2013)
Exp. Neurol.
, vol.248
, pp. 451-456
-
-
Rozenstein-Tsalkovich, L.1
Grigoriadis, N.2
Lourbopoulos, A.3
Nousiopoulou, E.4
Kassis, I.5
Abramsky, O.6
Karussis, D.7
Rosenmann, H.8
-
27
-
-
42649093469
-
Alum boosts TH2-type antibody responses to whole-inactivated virus influenza vaccine in mice but does not confer superior protection
-
Bungener, L.; Geeraedts, F.; ter Veer, W.; Medema, J.; Wilschut, J.; Huckriede, A. Alum boosts TH2-type antibody responses to whole-inactivated virus influenza vaccine in mice but does not confer superior protection. Vaccine 2008, 26, 2350-2359.
-
(2008)
Vaccine
, vol.26
, pp. 2350-2359
-
-
Bungener, L.1
Geeraedts, F.2
ter Veer, W.3
Medema, J.4
Wilschut, J.5
Huckriede, A.6
-
28
-
-
84878975788
-
T-cell epitope-dependent immune response in inbred (C57BL/6J, SJL/J, and C3H/HeN) and transgenic P301S and Tg2576 mice
-
Richter, M.; Hoffmann, R.; Singer, D. T-cell epitope-dependent immune response in inbred (C57BL/6J, SJL/J, and C3H/HeN) and transgenic P301S and Tg2576 mice. J. Pept. Sci. 2013, 19, 441-451.
-
(2013)
J. Pept. Sci.
, vol.19
, pp. 441-451
-
-
Richter, M.1
Hoffmann, R.2
Singer, D.3
-
29
-
-
84896881646
-
Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy
-
Maurin, H.; Chong, S.-A.; Kraev, I.; Davies, H.; Kremer, A.; Seymour, C.M.; Lechat, B.; Jaworski, T.; Borghgraef, P.; Devijver, H.; et al. Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy. PLoS One 2014, 9, e87605.
-
(2014)
PLoS One
, vol.9
-
-
Maurin, H.1
Chong, S.-A.2
Kraev, I.3
Davies, H.4
Kremer, A.5
Seymour, C.M.6
Lechat, B.7
Jaworski, T.8
Borghgraef, P.9
Devijver, H.10
-
30
-
-
85048233747
-
Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments
-
doi:10.1186/2051-5960-1-34
-
Levenga, J.; Krishnamurthy, P.; Rajamohamedsait, H.; Wong, H.; Franke, T.F.; Cain, P.; Sigurdsson, E.M.; Hoeffer, C.A. Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments. Acta Neuropathol. Commun. 2013, 1, doi:10.1186/2051-5960-1-34.
-
(2013)
Acta Neuropathol. Commun.
, vol.1
-
-
Levenga, J.1
Krishnamurthy, P.2
Rajamohamedsait, H.3
Wong, H.4
Franke, T.F.5
Cain, P.6
Sigurdsson, E.M.7
Hoeffer, C.A.8
-
31
-
-
28844469348
-
Characterization of phosphorylation dependent antibodies to study the phosphorylation status of the Tau protein
-
Singer, D.; Volke, D.; Hoffmann, R. Characterization of phosphorylation dependent antibodies to study the phosphorylation status of the Tau protein. Int. J. Pept. Res. Ther. 2005, 11, 279-289.
-
(2005)
Int. J. Pept. Res. Ther.
, vol.11
, pp. 279-289
-
-
Singer, D.1
Volke, D.2
Hoffmann, R.3
-
32
-
-
33846538660
-
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
-
Yoshiyama, Y.; Higuchi, M.; Zhang, B.; Huang, S.-M.; Iwata, N.; Saido, T.C.; Maeda, J.; Suhara, T.; Trojanowski, J.Q.; Lee, V.M.-Y. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 2007, 53, 337-351.
-
(2007)
Neuron
, vol.53
, pp. 337-351
-
-
Yoshiyama, Y.1
Higuchi, M.2
Zhang, B.3
Huang, S.-M.4
Iwata, N.5
Saido, T.C.6
Maeda, J.7
Suhara, T.8
Trojanowski, J.Q.9
Lee, V.M.-Y.10
-
33
-
-
0034884382
-
Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
-
Sigurdsson, E.M.; Scholtzova, H.; Mehta, P.D.; Frangione, B.; Wisniewski, T. Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am. J. Pathol. 2001, 159, 439-447.
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 439-447
-
-
Sigurdsson, E.M.1
Scholtzova, H.2
Mehta, P.D.3
Frangione, B.4
Wisniewski, T.5
-
34
-
-
33745458418
-
Neighbored phosphorylation sites as PHF-tau specific markers in Alzheimer's disease
-
Singer, D.; Lehmann, J.; Hanisch, K.; Hartig, W.; Hoffmann, R. Neighbored phosphorylation sites as PHF-tau specific markers in Alzheimer's disease. Biochem. Biophys. Res. Commun. 2006, 346, 819-828.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.346
, pp. 819-828
-
-
Singer, D.1
Lehmann, J.2
Hanisch, K.3
Hartig, W.4
Hoffmann, R.5
-
35
-
-
79958829010
-
P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating
-
Takeuchi, H.; Iba, M.; Inoue, H.; Higuchi, M.; Takao, K.; Tsukita, K.; Karatsu, Y.; Iwamoto, Y.; Miyakawa, T.; Suhara, T.; et al. P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS One 2011, 6, e21050.
-
(2011)
PLoS One
, vol.6
-
-
Takeuchi, H.1
Iba, M.2
Inoue, H.3
Higuchi, M.4
Takao, K.5
Tsukita, K.6
Karatsu, Y.7
Iwamoto, Y.8
Miyakawa, T.9
Suhara, T.10
-
36
-
-
35148829836
-
Motor coordination and balance in rodents
-
doi:10.1002/0471142301.ns0812s15
-
Carter, R.J.; Morton, J.; Dunnett, S.B. Motor coordination and balance in rodents. Curr. Protoc. Neurosci. 2001, 8, doi:10.1002/0471142301.ns0812s15.
-
(2001)
Curr. Protoc. Neurosci.
, vol.8
-
-
Carter, R.J.1
Morton, J.2
Dunnett, S.B.3
-
37
-
-
83855163091
-
Chapter 5 Anxiety-Related Behaviors in Mice
-
In, 2nd ed.; Buccafusco, J.J., Ed.; CRC Press: Boca Raton, FL, USA
-
Bailey, K.R.; Crawley, J.N. Chapter 5 Anxiety-Related Behaviors in Mice. In Methods of Behavior Analysis in Neuroscience, 2nd ed.; Buccafusco, J.J., Ed.; CRC Press: Boca Raton, FL, USA, 2009.
-
(2009)
Methods of Behavior Analysis in Neuroscience
-
-
Bailey, K.R.1
Crawley, J.N.2
-
38
-
-
34248525053
-
Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein
-
Porzig, R.; Singer, D.; Hoffmann, R. Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein. Biochem. Biophys. Res. Commun. 2007, 358, 644-649.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.358
, pp. 644-649
-
-
Porzig, R.1
Singer, D.2
Hoffmann, R.3
-
39
-
-
0030750558
-
Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites
-
Hoffmann, R.; Lee, V.M.-Y.; Leight, S.; Varga, I.; Otvos, L., Jr. Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites. Biochemistry 1997, 36, 8114-8124.
-
(1997)
Biochemistry
, vol.36
, pp. 8114-8124
-
-
Hoffmann, R.1
Lee, V.M.-Y.2
Leight, S.3
Varga, I.4
Otvos Jr., L.5
-
40
-
-
0033213319
-
Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
-
Hiesberger, T.; Trommsdorff, M.; Howell, B.W.; Goffinet, A.; Mumby, M.C.; Cooper, J.A.; Herz, J. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron 1999, 24, 481-489.
-
(1999)
Neuron
, vol.24
, pp. 481-489
-
-
Hiesberger, T.1
Trommsdorff, M.2
Howell, B.W.3
Goffinet, A.4
Mumby, M.C.5
Cooper, J.A.6
Herz, J.7
-
41
-
-
61849088424
-
Tau phosphorylation: The therapeutic challenge for neurodegenerative disease
-
Hanger, D.P.; Anderton, B.H.; Noble, W. Tau phosphorylation: The therapeutic challenge for neurodegenerative disease. Trends Mol. Med. 2009, 15, 112-119.
-
(2009)
Trends Mol. Med.
, vol.15
, pp. 112-119
-
-
Hanger, D.P.1
Anderton, B.H.2
Noble, W.3
-
42
-
-
0003698235
-
-
2nd ed.; Academic Press: San Diego, CA, USA
-
Paxinos, G.; Franklin, K.B.J. The Mouse Brain in Stereotaxic Coordinates, 2nd ed.; Academic Press: San Diego, CA, USA, 2001.
-
(2001)
The Mouse Brain in Stereotaxic Coordinates
-
-
Paxinos, G.1
Franklin, K.B.J.2
-
43
-
-
85043057993
-
-
version 1.46r. U.S. National Institutes of Health: Bethesda, MD, USA
-
ImageJ, version 1.46r. U.S. National Institutes of Health: Bethesda, MD, USA, 2012.
-
(2012)
Image J
-
-
-
44
-
-
0031807109
-
Use of thiourea to increase the solubility of membrane proteins in two-dimensional electrophoresis
-
Rabilloud, T. Use of thiourea to increase the solubility of membrane proteins in two-dimensional electrophoresis. Electrophoresis 1998, 19, 758-760.
-
(1998)
Electrophoresis
, vol.19
, pp. 758-760
-
-
Rabilloud, T.1
-
45
-
-
0041358797
-
Sample preparation for two-dimensional gel electrophoresis
-
Shaw, M.M.; Riederer, B.M. Sample preparation for two-dimensional gel electrophoresis. Proteomics 2003, 3, 1408-1417.
-
(2003)
Proteomics
, vol.3
, pp. 1408-1417
-
-
Shaw, M.M.1
Riederer, B.M.2
-
47
-
-
0025129294
-
Synthesis and biophysical characterization of engineered topographic immunogenic determinants with alpha alpha topology
-
Kaumaya, P.T.P.; Berndt, K.D.; Heidorn, D.B.; Trewhella, J.; Kezdy, F.J.; Goldberg, E. Synthesis and biophysical characterization of engineered topographic immunogenic determinants with alpha alpha topology. Biochemistry 1990, 29, 13-23.
-
(1990)
Biochemistry
, vol.29
, pp. 13-23
-
-
Kaumaya, P.T.P.1
Berndt, K.D.2
Heidorn, D.B.3
Trewhella, J.4
Kezdy, F.J.5
Goldberg, E.6
-
48
-
-
80355148410
-
Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice
-
Dumont, M.; Stack, C.; Elipenahli, C.; Jainuddin, S.; Gerges, M.; Starkova, N.N.; Yang, L.; Starkov, A.A.; Beal, F. Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice. FASEB J. 2011, 25, 4063-4072.
-
(2011)
FASEB J.
, vol.25
, pp. 4063-4072
-
-
Dumont, M.1
Stack, C.2
Elipenahli, C.3
Jainuddin, S.4
Gerges, M.5
Starkova, N.N.6
Yang, L.7
Starkov, A.A.8
Beal, F.9
-
49
-
-
80052940324
-
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice
-
Yamada, K.; Cirrito, J.R.; Stewart, F.R.; Jiang, H.; Finn, M.B.; Holmes, B.B.; Binder, L.I.; Mandelkow, E.-M.; Diamond, M.I.; Lee, V.M.-Y.; et al. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J. Neurosci. 2011, 31, 13110-13117.
-
(2011)
J. Neurosci.
, vol.31
, pp. 13110-13117
-
-
Yamada, K.1
Cirrito, J.R.2
Stewart, F.R.3
Jiang, H.4
Finn, M.B.5
Holmes, B.B.6
Binder, L.I.7
Mandelkow, E.-M.8
Diamond, M.I.9
Lee, V.M.-Y.10
-
50
-
-
84885783467
-
Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo
-
Yanamandra, K.; Kfoury, N.; Jiang, H.; Mahan, T.E.; Ma, S.; Maloney, S.E.; Wozniak, D.F.; Diamond, M.I.; Holtzman, D.M. Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron 2013, 80, 402-414.
-
(2013)
Neuron
, vol.80
, pp. 402-414
-
-
Yanamandra, K.1
Kfoury, N.2
Jiang, H.3
Mahan, T.E.4
Ma, S.5
Maloney, S.E.6
Wozniak, D.F.7
Diamond, M.I.8
Holtzman, D.M.9
-
54
-
-
85043044987
-
Study Evaluating The Safety Of AAB-003 (PF-05236812)
-
In; Available online (accessed on 2 February 2014)
-
Study Evaluating The Safety Of AAB-003 (PF-05236812) In Subjects With Alzheimer's Disease; Available online: http://clinicaltrials.gov/ (accessed on 2 February 2014).
-
Subjects With Alzheimer's Disease
-
-
-
55
-
-
85043035368
-
Open Label Extension Study Evaluating Safety and Tolerability of AAB-003 (PF-05236812)
-
in; Available online (accessed on 2 February 2014)
-
Open Label Extension Study Evaluating Safety and Tolerability of AAB-003 (PF-05236812) in Subject With Mild to Moderate Alzheimer's Disease; Available online: http://clinicaltrials.gov/ (accessed on 2 February 2014).
-
Subject With Mild to Moderate Alzheimer's Disease
-
-
-
56
-
-
82955194797
-
Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice
-
Bi, M.; Ittner, A.; Ke, Y.D.; Götz, J.; Ittner, L.M.; Ferreira, S.T. Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice. PLoS One 2011, 6, e26860.
-
(2011)
PLoS One
, vol.6
-
-
Bi, M.1
Ittner, A.2
Ke, Y.D.3
Götz, J.4
Ittner, L.M.5
Ferreira, S.T.6
-
57
-
-
80053202160
-
Passive immunization with anti-tau antibodies in two transgenic models: Reduction of tau pathology and delay of disease progression
-
Chai, X.; Wu, S.; Murray, T.K.; Kinley, R.; Cella, C.V.; Sims, H.; Buckner, N.; Hanmer, J.; Davies, P.; O'Neill, M.J.; et al. Passive immunization with anti-tau antibodies in two transgenic models: Reduction of tau pathology and delay of disease progression. J. Biol. Chem. 2011, 286, 34457-34467.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 34457-34467
-
-
Chai, X.1
Wu, S.2
Murray, T.K.3
Kinley, R.4
Cella, C.V.5
Sims, H.6
Buckner, N.7
Hanmer, J.8
Davies, P.9
O'Neill, M.J.10
-
58
-
-
33749614555
-
Tauopathy-like Abnormalities and neurologic deficits in mice immunized with neuronal tau protein
-
Rosenmann, H.; Grigoriadis, N.; Karussis, D.; Boimel, M.; Touloumi, O.; Ovadia, H.; Abramsky, O. Tauopathy-like Abnormalities and neurologic deficits in mice immunized with neuronal tau protein. Arch Neurol. 2006, 63, 1459-1467.
-
(2006)
Arch Neurol.
, vol.63
, pp. 1459-1467
-
-
Rosenmann, H.1
Grigoriadis, N.2
Karussis, D.3
Boimel, M.4
Touloumi, O.5
Ovadia, H.6
Abramsky, O.7
-
59
-
-
43749108819
-
Adjuvant modulation of the cytokine balance in Mycobacterium tuberculosis subunit vaccines; immunity, pathology and protection
-
Agger, E.M.; Cassidy, J.P.; Brady, J.; Korsholm, K.S.; Vingsbo-Lundberg, C.; Andersen, P. Adjuvant modulation of the cytokine balance in Mycobacterium tuberculosis subunit vaccines; immunity, pathology and protection. Immunology 2008, 124, 175-185.
-
(2008)
Immunology
, vol.124
, pp. 175-185
-
-
Agger, E.M.1
Cassidy, J.P.2
Brady, J.3
Korsholm, K.S.4
Vingsbo-Lundberg, C.5
Andersen, P.6
-
60
-
-
63149126030
-
Towards an understanding of the adjuvant action of aluminium
-
Marrack, P.; McKee, A.S.; Munks, M.W. Towards an understanding of the adjuvant action of aluminium. Nat. Rev. Immunol. 2009, 9, 287-293.
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 287-293
-
-
Marrack, P.1
McKee, A.S.2
Munks, M.W.3
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