Quantifying sympathetic neuro-haemodynamic transduction at rest in humans: insights into sex, ageing and blood pressure control

Journal of Physiology

Volumn 594, Issue 17, 2016, Pages 4753-4768

  Briant, L J B ^a   Burchell, A E ^a   Ratcliffe, L E K ^a   Charkoudian, N ^b   Nightingale, A K ^c   Paton, J F R ^a   Joyner, Michael J ^d   Hart, E C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^c UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR;

ADULT; AGING; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; DIASTOLIC BLOOD PRESSURE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MIDDLE AGED; MUSCLE SYMPATHETIC NERVE ACTIVITY; POSTMENOPAUSE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; SEX DIFFERENCE; SYMPATHETIC FUNCTION; SYMPATHETIC TRANSDUCTION; VASCULAR RESISTANCE; VASOCONSTRICTION; VASODILATATION;

EID: 84986320366     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/JP272167     Document Type: Article

References (48)

1. Barnes JN, Hart EC, Curry TB, Nicholson WT, Eisenach JH, Wallin BG, Charkoudian N & Joyner MJ (2014). Aging enhances autonomic support of blood pressure in women. Hypertension 63, 303–308.
2. Bell C, Seals DR, Monroe MB, Day DS, Shapiro LF, Johnson DG & Jones PP (2001). Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults. J Clin Endocrinol Metab 86, 4440–4444.
3. Blessing WW (1997). The Lower Brainstem and Bodily Homeostasis, pp. 165–268. Oxford University Press, New York.
4. Burnstock G (2008). Non-synaptic transmission at autonomic neuroeffector junctions. Neurochem Int 52, 14–25.
5. Burnstock G (2009). Purinergic cotransmission. Exp Physiol 94, 20–24.
6. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ & Labarthe D (1995). Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension 25, 305–313.
7. Carter JR & Ray CA (2009). Sympathetic neural responses to mental stress: responders, nonresponders and sex differences. Am J Physiol Heart Circ Physiol 296, H847–H853.
8. Christou DD, Jones PP, Jordan J, Diedrich A, Robertson D & Seals DR (2005). Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men. Circulation 111, 494–498.
9. Dinenno FA, Dietz NM & Joyner MJ (2002). Aging and forearm postjunctional α-adrenergic vasoconstriction in healthy men. Circulation 106, 1349–1354.
10. Dinenno FA, Jones PP, Seals DR & Tanaka H (1999). Limb blood flow and vascular conductance are reduced with age in healthy humans – Relation to elevations in sympathetic nerve activity and declines in oxygen demand. Circulation 100, 164–170.
11. Dinenno FA, Tanaka H, Stauffer BL & Seals DR (2001). Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented α-adrenergic vasoconstriction. J Physiol 536, 977–983.
12. Eckberg DL, Rea RF, Andersson OK, Hedner T, Pernow J, Lundberg JM & Wallin BG (1988). Baroreflex modulation of sympathetic activity and sympathetic neurotransmitters in humans. Acta Physiol Scand 133, 221–231.
13. Ellis JL & Burnstock G (1990). Neuropeptide Y neuromodulation of sympathetic co-transmission in the guinea-pig vas deferens. Br J Pharmacol 100, 457–462.
14. Fairfax ST, Credeur DP, Holwerda SW, Zuidema MY, Medley JH, Dyke PC 2nd & Wray DW (2013). The role of α-adrenergic receptors in mediating beat-by-beat sympathetic vascular transduction in resting humans. FASEB J 27, 1119.2. (Meeting Abstract.)
15. Fink GD (2009). Arthur C. Corcoran Memorial Lecture. Sympathetic activity, vascular capacitance, and long-term regulation of arterial pressure. Hypertension 53, 307–312.
16. Go AS, Bauman MA, Coleman King SM, Fonarow GC, Lawrence W, Williams KA & Sanchez E (2014). An effective approach to high blood pressure control: a science advisory from the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention. J Am Coll Cardiol 63, 1230–1238.
17. Gracia CR, Sammel MD, Freeman EW, Lin H, Langan E, Kapoor S & Nelson DB (2005). Defining menopause status: creation of a new definition to identify the early changes of the menopausal transition. Menopause 12, 128–135.
18. Grassi G, Mark A & Esler M (2015). The sympathetic nervous system alterations in human hypertension. Circ Res 116, 976–990.
19. Grassi G, Seravalle G & Quarti-Trevano F (2010). The ‘neuroadrenergic hypothesis’ in hypertension: current evidence. Exp Physiol 95, 581–586.
20. Guyenet PG (2006). The sympathetic control of blood pressure. Nat Rev Neurosci 7, 335–346.
21. Halliwill JR (2000). Segregated signal averaging of sympathetic baroreflex responses in humans. J Appl Physiol (1985) 88, 767–773.
22. Halliwill JR, Taylor JA & Eckberg DL (1996). Impaired sympathetic vascular regulation in humans after acute dynamic exercise. J Physiol 495, 279–288.
23. Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach J & Joyner MJ (2011). Sex and ageing differences in resting arterial pressure regulation: the role of the β-adrenergic receptors. J Physiol 589, 5285–5297.
24. Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach JH & Joyner MJ (2009a). Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation. Hypertension 53, 571–576.
25. Hart EC, Joyner MJ, Wallin BG, Johnson CP, Curry TB, Eisenach JH & Charkoudian N (2009b). Age-related differences in the sympathetic-hemodynamic balance in men. Hypertension 54, 127–133.
26. Hogarth AJ, Mackintosh AF & Mary DASG (2007). Gender-related differences in the sympathetic vasoconstrictor drive of normal subjects. Clin Sci 112, 353–361.
27. Huidobro-Toro JP & Donoso MV (2004). Sympathetic co-transmission: the coordinated action of ATP and noradrenaline and their modulation by neuropeptide Y in human vascular neuroeffector junctions. Eur J Pharmacol 500, 27–35.
28. Jarvis SS, Shibata S, Okada Y, Levine BD & Fu Q (2014). Neural-humoral responses during head-up tilt in healthy young white and black women. Front Physiol 5, 86.
29. Joyner MJ, Charkoudian N & Wallin BG (2008). A sympathetic view of the sympathetic nervous system and human blood pressure regulation. Exp Physiol 93, 715–724.
30. Kamiya A, Michikami D, Shiozawa T, Iwase S, Hayano J, Kawada T, Sunagawa K & Mano T (2004). Bed rest attenuates sympathetic and pressor responses to isometric exercise in antigravity leg muscles in humans. Am J Physiol Regul Integr Comp Physiol 286, R844–R850.
31. Kienbaum P, Karlssonn T, Sverrisdottir YB, Elam M & Wallin BG (2001). Two sites for modulation of human sympathetic activity by arterial baroreceptors? J Physiol 531, 861–869.
32. Kneale BJ, Chowienczyk PJ, Brett SE, Coltart DJ & Ritter JM (2000). Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature. J Am Coll Cardiol 36, 1233–1238.
33. Lautt WW (1989). Resistance or conductance for expression of arterial vascular tone. Microvasc Res 37, 230–236.
34. Minson CT, Halliwill JR, Young TM & Joyner MJ (2000). Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 101, 862–868.
35. NCHS (2010). Health, United States, 2009: with special feature on Medical Technology. Report No. 2010-1232. National Center for Health Statistics (US), Hyattsville, MD, USA.
36. Notarius CF, Murai H, Morris BL & Floras JS (2012). Effect of fitness on reflex sympathetic neurovascular transduction in middle-age men. Med Sci Sports Exerc 44, 232–237.
37. Okada Y, Galbreath MM, Shibata S, Jarvis SS, VanGundy TB, Meier RL, Wang WD, Vongpatanasin W, Levine BD & Fu Q (2011). Relationship between arterial stiffness and sympathetic baroreflex sensitivity in elderly men and women. FASEB J 25, 842.2. (Meeting Abstract.)
38. O'Leary DS (1991). Regional vascular-resistance vs conductance – which index for baroreflex responses. Am J Physiol 260, H632–H637.
39. Parati G & Esler M (2012). The human sympathetic nervous system: its relevance in hypertension and heart failure. Eur Heart J 33, 1058–1066.
40. Ray CA & Monahan KD (2002). Sympathetic vascular transduction is augmented in young normotensive blacks. J Appl Physiol (1985) 92, 651–656.
41. Smith EG, Voyles WF, Kirby BS, Markwald RR & Dinenno FA (2007). Ageing and leg postjunctional α-adrenergic vasoconstrictor responsiveness in healthy men. J Physiol 582, 63–71.
42. Sundlof G & Wallin BG (1977). The variability of muscle nerve sympathetic activity in resting recumbent man. J Physiol 272, 383–397.
43. Tan CO, Tamisier R, Hamner JW & Taylor JA (2013). Characterizing sympathetic neurovascular transduction in humans. PLoS One 8, e53769.
44. Vianna LC, Hart EC, Fairfax ST, Charkoudian N, Joyner MJ & Fadel PJ (2012). Influence of age and sex on the pressor response following a spontaneous burst of muscle sympathetic nerve activity. Am J Physiol Heart Circ Physiol 302, H2419–H2427.
45. Wallin BG, Burke D & Gandevia S (1994). Coupling between variations in strength and baroreflex latency of sympathetic discharges in human muscle nerves. J Physiol 474, 331–338.
46. Welch WJ, Smith ML, Rea RF, Bauernfeind RA & Eckberg DL (1989). Enhancement of sympathetic nerve activity by single premature ventricular beats in humans. J Am Coll Cardiol 13, 69–75.
47. 2+ signalling in rat arteries: ATP, noradrenaline and neuropeptide Y. Exp Physiol 94, 31–37.
48. Yang H, Drummer TD & Carter JR (2013). Sex differences in sympathetic neural and limb vascular reactivity to mental stress in humans. Am J Physiol Heart Circ Physiol 304, H436–H443.