-
1
-
-
84863116827
-
Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment
-
Abassi, Y.A, Xi, B, Li, N, Ouyang, W, Seiler, A, Watzele, M, Kettenhofen, R, Bohlen, H, Ehlich, A, Kolossov, E, Wang, X, and Xu, X. 2012. Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment. Br. J. Pharmacol. 165:1424-1441. doi: 10.1111/j.1476-5381.2011.01623.x.
-
(2012)
Br. J. Pharmacol.
, vol.165
, pp. 1424-1441
-
-
Abassi, Y.A.1
Xi, B.2
Li, N.3
Ouyang, W.4
Seiler, A.5
Watzele, M.6
Kettenhofen, R.7
Bohlen, H.8
Ehlich, A.9
Kolossov, E.10
Wang, X.11
Xu, X.12
-
2
-
-
79955482429
-
Opportunities for use of human iPS cells in predictive toxicology
-
Anson, B.D, Kolaja, K.L, and Kamp, T.J. 2011. Opportunities for use of human iPS cells in predictive toxicology. Clin. Pharmacol. Ther. 89:754-758. doi: 10.1038/clpt.2011.9.
-
(2011)
Clin. Pharmacol. Ther.
, vol.89
, pp. 754-758
-
-
Anson, B.D.1
Kolaja, K.L.2
Kamp, T.J.3
-
3
-
-
0038414021
-
A method for QT correction based on beat-to-beat analysis of the QT/RR interval relationship in conscious telemetred beagle dogs
-
Batey, A.J. and Doe, C.P. 2002. A method for QT correction based on beat-to-beat analysis of the QT/RR interval relationship in conscious telemetred beagle dogs. J. Pharmacol. Toxicol. Methods 48:11-19. doi: 10.1016/S1056-8719(03)00009-1.
-
(2002)
J. Pharmacol. Toxicol. Methods
, vol.48
, pp. 11-19
-
-
Batey, A.J.1
Doe, C.P.2
-
4
-
-
84906264443
-
Comprehensive in vitro proarrhythmia assay, a novel in vitro/in silico paradigm to detect ventricular proarrhythmic liability: A visionary 21st century initiative
-
Cavero, I. and Holzgrefe, H. 2014. Comprehensive in vitro proarrhythmia assay, a novel in vitro/in silico paradigm to detect ventricular proarrhythmic liability: A visionary 21st century initiative. Expert. Opin. Drug. Saf. 13:745-758. doi: 10.1517/14740338.2014.940310.
-
(2014)
Expert. Opin. Drug. Saf.
, vol.13
, pp. 745-758
-
-
Cavero, I.1
Holzgrefe, H.2
-
5
-
-
84947774508
-
New easy-to-use hybrid system for extracellular potential and impedance recordings
-
Doerr, L, Thomas, U, Guinot, D.R, Bot, C.T, Stoelzle-Feix, S, Beckler, M, George, M, and Fertig, N. 2015. New easy-to-use hybrid system for extracellular potential and impedance recordings. J. Lab. Autom. 20:175-188. doi: 10.1177/2211068214562832.
-
(2015)
J. Lab. Autom.
, vol.20
, pp. 175-188
-
-
Doerr, L.1
Thomas, U.2
Guinot, D.R.3
Bot, C.T.4
Stoelzle-Feix, S.5
Beckler, M.6
George, M.7
Fertig, N.8
-
6
-
-
0028140468
-
Electrophysiologic effects of intravenous E-4031, a novel class III antiarrhythmic agent, in patients with supraventricular tachyarrhythmias
-
Fujiki, A, Tani, M, Mizumaki, K, Shimono, M, and Inoue, H. 1994. Electrophysiologic effects of intravenous E-4031, a novel class III antiarrhythmic agent, in patients with supraventricular tachyarrhythmias. J. Cardiovasc. Pharmacol. 23:374-378. doi: 10.1097/00005344-199423030-00003.
-
(1994)
J. Cardiovasc. Pharmacol.
, vol.23
, pp. 374-378
-
-
Fujiki, A.1
Tani, M.2
Mizumaki, K.3
Shimono, M.4
Inoue, H.5
-
7
-
-
84928897709
-
Human stem cell-derived cardiomyocytes detect drug-mediated changes in action potentials and ion currents
-
Gibson, J.K, Yue, Y, Bronson, J, Palmer, C, and Numann, R. 2014. Human stem cell-derived cardiomyocytes detect drug-mediated changes in action potentials and ion currents. J. Pharmacol. Toxicol. Methods 70:255-267. doi: 10.1016/j.vascn.2014.09.005.
-
(2014)
J. Pharmacol. Toxicol. Methods
, vol.70
, pp. 255-267
-
-
Gibson, J.K.1
Yue, Y.2
Bronson, J.3
Palmer, C.4
Numann, R.5
-
8
-
-
80052487012
-
Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes
-
Guo, L, Abrams, R.M, Babiarz, J.E, Cohen, J.D, Kameoka, S, Sanders, M.J, Chiao, E, and Kolaja, K.L. 2011. Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol. Sci. 123:281-289. doi: 10.1093/toxsci/kfr158.
-
(2011)
Toxicol. Sci.
, vol.123
, pp. 281-289
-
-
Guo, L.1
Abrams, R.M.2
Babiarz, J.E.3
Cohen, J.D.4
Kameoka, S.5
Sanders, M.J.6
Chiao, E.7
Kolaja, K.L.8
-
9
-
-
84890320017
-
Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model
-
Guo, L, Coyle, L, Abrams, R.M, Kemper, R, Chiao, E.T, and Kolaja, K.L. 2013. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol. Sci. 136:581-594. doi: 10.1093/toxsci/kft205.
-
(2013)
Toxicol. Sci.
, vol.136
, pp. 581-594
-
-
Guo, L.1
Coyle, L.2
Abrams, R.M.3
Kemper, R.4
Chiao, E.T.5
Kolaja, K.L.6
-
10
-
-
0242353365
-
Estimation of action potential changes from field potential recordings in multicellular mouse cardiac myocyte cultures
-
Halbach, M, Egert, U, Hescheler, J, and Banach, K. 2003. Estimation of action potential changes from field potential recordings in multicellular mouse cardiac myocyte cultures. Cell Physiol. Biochem. 13:271-284. doi: 10.1159/000074542.
-
(2003)
Cell Physiol. Biochem.
, vol.13
, pp. 271-284
-
-
Halbach, M.1
Egert, U.2
Hescheler, J.3
Banach, K.4
-
11
-
-
84880678710
-
Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays
-
Harris, K, Aylott, M, Cui, Y, Louttit, J.B, McMahon, N.C, and Sridhar, A. 2013. Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays. Toxicol. Sci. 134:412-426. doi: 10.1093/toxsci/kft113.
-
(2013)
Toxicol. Sci.
, vol.134
, pp. 412-426
-
-
Harris, K.1
Aylott, M.2
Cui, Y.3
Louttit, J.B.4
McMahon, N.C.5
Sridhar, A.6
-
12
-
-
84876888499
-
The case for induced pluripotent stem cell-derived cardiomyocytes in pharmacological screening
-
Khan, J.M, Lyon, A.R, and Harding, S.E. 2013. The case for induced pluripotent stem cell-derived cardiomyocytes in pharmacological screening. Br. J. Pharmacol. 169:304-317. doi: 10.1111/j.1476-5381.2012.02118.x.
-
(2013)
Br. J. Pharmacol.
, vol.169
, pp. 304-317
-
-
Khan, J.M.1
Lyon, A.R.2
Harding, S.E.3
-
13
-
-
84940250126
-
Functional characterization of human stem cell−derived cardiomyocytes
-
Kirsch, G.E, Obejero-Paz, C.A, and Bruening-Wright, A. 2014. Functional characterization of human stem cell−derived cardiomyocytes. Curr. Protoc. Pharmacol. 64:11.12.1-11.12.26.
-
(2014)
Curr. Protoc. Pharmacol.
, vol.64
, pp. 11.12.1-11.12.26
-
-
Kirsch, G.E.1
Obejero-Paz, C.A.2
Bruening-Wright, A.3
-
14
-
-
19944429871
-
Pentamidine-induced long QT syndrome and block of hERG trafficking
-
Kuryshev, Y.A, Ficker, E, Wang, L, Hawryluk, P, Dennis, A.T, Wible, B.A, Brown, A.M, Kang, J, Chen, X.L, Sawamura, K, Reynolds, W, and Rampe, D. 2005. Pentamidine-induced long QT syndrome and block of hERG trafficking. J. Pharmacol. Exp. Ther. 312:316-323. doi: 10.1124/jpet.104.073692.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.312
, pp. 316-323
-
-
Kuryshev, Y.A.1
Ficker, E.2
Wang, L.3
Hawryluk, P.4
Dennis, A.T.5
Wible, B.A.6
Brown, A.M.7
Kang, J.8
Chen, X.L.9
Sawamura, K.10
Reynolds, W.11
Rampe, D.12
-
15
-
-
79958021542
-
How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines
-
Laverty, H, Benson, C, Cartwright, E, Cross, M, Garland, C, Hammond, T, Holloway, C, McMahon, N, Milligan, J, Park, B, Pirmohamed, M, Pollard, C, Radford, J, Roome, N, Sager, P, Singh, S, Suter, T, Suter, W, Trafford, A, Volders, P, Wallis, R, Weaver, R, York, M, and Valentin, J. 2011. How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? Br. J. Pharmacol. 163:675-693. doi: 10.1111/j.1476-5381.2011.01255.x.
-
(2011)
Br. J. Pharmacol.
, vol.163
, pp. 675-693
-
-
Laverty, H.1
Benson, C.2
Cartwright, E.3
Cross, M.4
Garland, C.5
Hammond, T.6
Holloway, C.7
McMahon, N.8
Milligan, J.9
Park, B.10
Pirmohamed, M.11
Pollard, C.12
Radford, J.13
Roome, N.14
Sager, P.15
Singh, S.16
Suter, T.17
Suter, W.18
Trafford, A.19
Volders, P.20
Wallis, R.21
Weaver, R.22
York, M.23
Valentin, J.24
more..
-
16
-
-
33845194767
-
A rabbit Langendorff heart proarrhythmia model: Predictive value for clinical identification of Torsades de Pointes
-
Lawrence, C.L, Bridgland-Taylor, M.H, Pollard, C.E, Hammond, T.G, and Valentin, J.P. 2006. A rabbit Langendorff heart proarrhythmia model: Predictive value for clinical identification of Torsades de Pointes. Br. J. Pharmacol. 149:845-860. doi: 10.1038/sj.bjp.0706894.
-
(2006)
Br. J. Pharmacol.
, vol.149
, pp. 845-860
-
-
Lawrence, C.L.1
Bridgland-Taylor, M.H.2
Pollard, C.E.3
Hammond, T.G.4
Valentin, J.P.5
-
17
-
-
33746294441
-
Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias
-
Liu, T, Brown, B.S, Wu, Y, Antzelevitch, C, Kowey, P.R, and Yan, G.X. 2006. Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias. Heart Rhythm 3:948-956. doi: 10.1016/j.hrthm.2006.04.021.
-
(2006)
Heart Rhythm
, vol.3
, pp. 948-956
-
-
Liu, T.1
Brown, B.S.2
Wu, Y.3
Antzelevitch, C.4
Kowey, P.R.5
Yan, G.X.6
-
18
-
-
80455164810
-
High purity human-induced pluripotent stem cell-derived cardiomyocytes: Electrophysiological properties of action potentials and ionic currents
-
Ma, J, Guo, L, Fiene, S.J, Anson, B.D, Thomson, J.A, Kamp, T.J, Kolaja, K.L, Swanson, B.J, and January, C.T. 2011. High purity human-induced pluripotent stem cell-derived cardiomyocytes: Electrophysiological properties of action potentials and ionic currents. Am. J. Physiol. Heart Circ. Physiol. 301:H2006-H2017. doi: 10.1152/ajpheart.00694.2011.
-
(2011)
Am. J. Physiol. Heart Circ. Physiol.
, vol.301
, pp. H2006-H2017
-
-
Ma, J.1
Guo, L.2
Fiene, S.J.3
Anson, B.D.4
Thomson, J.A.5
Kamp, T.J.6
Kolaja, K.L.7
Swanson, B.J.8
January, C.T.9
-
19
-
-
4544254897
-
Micro-electrode arrays in cardiac safety pharmacology: A novel tool to study QT interval prolongation
-
Meyer, T, Boven, K.H, Gunther, E, and Fejtl, M. 2004. Micro-electrode arrays in cardiac safety pharmacology: A novel tool to study QT interval prolongation. Drug Saf. 27:763-772. doi: 10.2165/00002018-200427110-00002.
-
(2004)
Drug Saf.
, vol.27
, pp. 763-772
-
-
Meyer, T.1
Boven, K.H.2
Gunther, E.3
Fejtl, M.4
-
20
-
-
84883791986
-
Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays
-
Navarrete, E.G, Liang, P, Lan, F, Sanchez-Freire, V, Simmons, C, Gong, T, Sharma, A, Burridge, P.W, Patlolla, B, Lee, A.S, Wu, H, Beygui, R.E, Wu, S.M, Robbins, R.C, Bers, D.M, and Wu, J.C. 2013. Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation 128:S3-13. doi: 10.1161/CIRCULATIONAHA.112.000570.
-
(2013)
Circulation
, vol.128
, pp. 3-13
-
-
Navarrete, E.G.1
Liang, P.2
Lan, F.3
Sanchez-Freire, V.4
Simmons, C.5
Gong, T.6
Sharma, A.7
Burridge, P.W.8
Patlolla, B.9
Lee, A.S.10
Wu, H.11
Beygui, R.E.12
Wu, S.M.13
Robbins, R.C.14
Bers, D.M.15
Wu, J.C.16
-
21
-
-
84899785990
-
Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation
-
Nozaki, Y, Honda, Y, Tsujimoto, S, Watanabe, H, Kunimatsu, T, and Funabashi, H. 2014. Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation. Toxicol. Appl. Pharmacol. 278:72-77. doi: 10.1016/j.taap.2014.04.007.
-
(2014)
Toxicol. Appl. Pharmacol.
, vol.278
, pp. 72-77
-
-
Nozaki, Y.1
Honda, Y.2
Tsujimoto, S.3
Watanabe, H.4
Kunimatsu, T.5
Funabashi, H.6
-
22
-
-
33645065611
-
QT PRODACT: Comparison of non-clinical studies for drug-induced delay in ventricular repolarization and their role in safety evaluation in humans
-
Omata, T, Kasai, C, Hashimoto, M, Hombo, T, and Yamamoto, K. 2005. QT PRODACT: Comparison of non-clinical studies for drug-induced delay in ventricular repolarization and their role in safety evaluation in humans. J. Pharmacol. Sci. 99:531-541. doi: 10.1254/jphs.QT-C12.
-
(2005)
J. Pharmacol. Sci.
, vol.99
, pp. 531-541
-
-
Omata, T.1
Kasai, C.2
Hashimoto, M.3
Hombo, T.4
Yamamoto, K.5
-
23
-
-
74549165352
-
An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk
-
Pollard, C.E, Abi, G.N, Bridgland-Taylor, M.H, Easter, A, Hammond, T.G, and Valentin, J.P. 2010. An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk. Br. J. Pharmacol. 159:12-21. doi: 10.1111/j.1476-5381.2009.00207.x.
-
(2010)
Br. J. Pharmacol.
, vol.159
, pp. 12-21
-
-
Pollard, C.E.1
Abi, G.N.2
Bridgland-Taylor, M.H.3
Easter, A.4
Hammond, T.G.5
Valentin, J.P.6
-
24
-
-
0344492207
-
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development
-
Redfern, W.S, Carlsson, L, Davis, A.S, Lynch, W.G, MacKenzie, I, Palethorpe, S, Siegl, P.K, Strang, I, Sullivan, A.T, Wallis, R, Camm, A.J, and Hammond, T.G. 2003. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development. Cardiovasc. Res. 58:32-45. doi: 10.1016/S0008-6363(02)00846-5.
-
(2003)
Cardiovasc. Res.
, vol.58
, pp. 32-45
-
-
Redfern, W.S.1
Carlsson, L.2
Davis, A.S.3
Lynch, W.G.4
MacKenzie, I.5
Palethorpe, S.6
Siegl, P.K.7
Strang, I.8
Sullivan, A.T.9
Wallis, R.10
Camm, A.J.11
Hammond, T.G.12
-
25
-
-
84896692500
-
Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium
-
Sager, P.T, Gintant, G, Turner, J.R, Pettit, S, and Stockbridge, N. 2014. Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium. Am. Heart J. 167:292-300. doi: 10.1016/j.ahj.2013.11.004.
-
(2014)
Am. Heart J.
, vol.167
, pp. 292-300
-
-
Sager, P.T.1
Gintant, G.2
Turner, J.R.3
Pettit, S.4
Stockbridge, N.5
-
26
-
-
84909981167
-
Action potential characterization of human induced pluripotent stem cell-derived cardiomyocytes using automated patch-clamp technology
-
Scheel, O, Frech, S, Amuzescu, B, Eisfeld, J, Lin, K.H, and Knott, T. 2014. Action potential characterization of human induced pluripotent stem cell-derived cardiomyocytes using automated patch-clamp technology. Assay Drug Dev. Technol. 12:457-469. doi: 10.1089/adt.2014.601.
-
(2014)
Assay Drug Dev. Technol.
, vol.12
, pp. 457-469
-
-
Scheel, O.1
Frech, S.2
Amuzescu, B.3
Eisfeld, J.4
Lin, K.H.5
Knott, T.6
-
27
-
-
67349123365
-
In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes
-
Tanaka, T, Tohyama, S, Murata, M, Nomura, F, Kaneko, T, Chen, H, Hattori, F, Egashira, T, Seki, T, Ohno, Y, Koshimizu, U, Yuasa, S, Ogawa, S, Yamanaka, S, Yasuda, K, and Fukuda, K. 2009. In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes. Biochem. Biophys. Res. Commun. 385:497-502. doi: 10.1016/j.bbrc.2009.05.073.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.385
, pp. 497-502
-
-
Tanaka, T.1
Tohyama, S.2
Murata, M.3
Nomura, F.4
Kaneko, T.5
Chen, H.6
Hattori, F.7
Egashira, T.8
Seki, T.9
Ohno, Y.10
Koshimizu, U.11
Yuasa, S.12
Ogawa, S.13
Yamanaka, S.14
Yasuda, K.15
Fukuda, K.16
-
28
-
-
68749083601
-
A framework to assess the translation of safety pharmacology data to humans
-
Valentin, J.P, Bialecki, R, Ewart, L, Hammond, T, Leishmann, D, Lindgren, S, Martinez, V, Pollard, C, Redfern, W, and Wallis, R. 2009. A framework to assess the translation of safety pharmacology data to humans. J. Pharmacol. Toxicol. Methods 60:152-158. doi: 10.1016/j.vascn.2009.05.011.
-
(2009)
J. Pharmacol. Toxicol. Methods
, vol.60
, pp. 152-158
-
-
Valentin, J.P.1
Bialecki, R.2
Ewart, L.3
Hammond, T.4
Leishmann, D.5
Lindgren, S.6
Martinez, V.7
Pollard, C.8
Redfern, W.9
Wallis, R.10
-
29
-
-
74549140187
-
Integrated risk assessment and predictive value to humans of non-clinical repolarization assays
-
Wallis, R.M. 2010. Integrated risk assessment and predictive value to humans of non-clinical repolarization assays. Br. J. Pharmacol. 159:115-121. doi: 10.1111/j.1476-5381.2009.00395.x.
-
(2010)
Br. J. Pharmacol.
, vol.159
, pp. 115-121
-
-
Wallis, R.M.1
|