New Easy-to-Use Hybrid System for Extracellular Potential and Impedance Recordings

Journal of Laboratory Automation

Volumn 20, Issue 2, 2015, Pages 175-188

  Doerr, Leo ^a   Thomas, Ulrich ^a   Guinot, David R ^a   Bot, Corina T ^a   Stoelzle Feix, Sonja ^a   Beckler, Matthias ^a   George, Michael ^a   Fertig, Niels ^a  

^a NANION TECHNOLOGIES GMBH   (Germany)

Author keywords

arrhythmia; automated biology; cardiac; CiPA initiative; high throughput screening; HTS; impedance pharmacology; MEA; microelectrode array; stem cells

Indexed keywords

CELLS; DATA HANDLING; DIGITAL STORAGE; ELECTRODES; ELECTROPHYSIOLOGY; HEART; HYBRID SYSTEMS; MICROELECTRODES; RISK ASSESSMENT; SAFETY ENGINEERING; STEM CELLS; THROUGHPUT;

ARRHYTHMIA; CARDIAC; CIPA INITIATIVE; HIGH THROUGHPUT SCREENING; HTS; MEA; MICROELECTRODE ARRAY;

CYTOLOGY;

COMPUTER PROGRAM; CYTOLOGY; DEVICES; DRUG EFFECTS; DRUG SCREENING; ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HIGH THROUGHPUT SCREENING; HUMAN; PHYSIOLOGY; PROCEDURES;

CYTOLOGICAL TECHNIQUES; DRUG EVALUATION, PRECLINICAL; ELECTROPHYSIOLOGICAL PHENOMENA; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MYOCYTES, CARDIAC; SOFTWARE;

EID: 84947774508     PISSN: 22110682     EISSN: 22110690     Source Type: Journal    
DOI: 10.1177/2211068214562832     Document Type: Article

References (20)

1. A.M.BrownDrugs, hERG and Sudden Death. Cell Calcium2004, 35, 543–547.
2. I.GussakJ.LitwinR.Kleiman. Drug-Induced Cardiac Toxicity: Emphasizing the Role of Electrocardiography in Clinical Research and Drug Development. J. Electrocardiol. 2004, 37, 19–24.
3. H.-T.YangM.ZhangJ.Huang. Cardiomyocytes Derived from Pluripotent Stem Cells: Progress and Prospects from China. Exp. Cell Res. 2013, 319, 120–125.
4. C.W.ScottM.F.PetersY.P.DraganHuman Induced Pluripotent Stem Cells and Their Use in Drug Discovery for Toxicity Testing. Toxicol. Lett. 2013, 219, 49–58.
5. T.TanakaS.TohyamaM.Murata. In Vitro Pharmacologic Testing Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Biochem. Biophys. Res. Commun. 2009, 385, 497–502.
6. I.L.JonesP.LiviM.K.Lewandowska. The Potential of Microelectrode Arrays and Microelectronics for Biomedical Research and Diagnostics. Anal. Bioanal. Chem. 2011, 399, 2313–2329.
7. M.ClementsN.ThomasHigh-Throughput Multi-Parameter Profiling of Electrophysiological Drug Effects in Human Embryonic Stem Cell Derived Cardiomyocytes Using Multi-Electrode Arrays. Toxicol. Sci. 2014.
8. J.HeschelerM.HalbachU.Egert. Determination of Electrical Properties of ES Cell-Derived Cardiomyocytes Using MEAs. J. Electrocardiol. 2004, 37, 110–116.
9. P.UpadhyayS.BhaskarReal Time Monitoring of Lymphocyte Proliferation by an Impedance Method. J. Immunol. Methods. 2000, 244, 133–137.
10. F.NguemoT.ŠaricK.Pfannkuche. In Vitro Model for Assessing Arrhythmogenic Properties of Drugs Based on High-Resolution Impedance Measurements. Cell Physiol. Biochem. 2012, 29, 819–832.
11. Y.A.AbassiB.XiN.Li. Dynamic Monitoring of Beating Periodicity of Stem Cell-Derived Cardiomyocytes as a Predictive Tool for Preclinical Safety Assessment. Br. J. Pharmacol. 2012, 165, 1424–1441.
12. L.GuoR.M.C.AbramsJ.E.Babiarz. Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Toxicol. Sci. 2011, 123, 281–289.
13. D.GuinotT.SchwarzenbergerS.Stoelzle. Exciting New Impedance and Automated Patch Clamp for Safety Screening and Drug Discovery, SPS 13th Annual Meeting, Rotterdam, the Netherlands, Sept 16–19, 2013.
14. D.SteelU.ThomasS.Danielsson. Adverse Cardiotoxic Side Effects on Contractility analyzed with Impedance Technology in a Human Stem Cell-Derived 3D Model, SPS 13th Annual Meeting, Rotterdam, the Netherlands, Sept 16–19, 2013.
15. E.G.NavarreteP.LiangF.Lan. Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays. Circulation2013, 128, S3.
16. M.KovacsJ.TothC.Hetenyi. Mechanism of Blebbistatin Inhibition of Myosin II. J. Biol. Chem. 2004, 279, 35557–35563.
17. J.C.DavilaUse and Application of Stem Cells in Toxicology. Toxicol. Sci. 2004, 79, 214–223.
18. R.KettenhofenH.BohlenPreclinical Assessment of Cardiac Toxicity. Drug Discov. Today2008, 13, 702–707.
19. T.J.KampG.E.LyonsOn the Road to iPS Cell Cardiovascular Applications. Circ. Res. 2009, 105, 617–619.
20. I.CaveroH.HolzgrefeComprehensive In Vitro Proarrhythmia Assay, a Novel In Vitro/In Silico Paradigm to Detect Ventricular Proarrhythmic Liability: A Visionary 21st Century Initiative. Expert Opin. Drug Saf. 2014, 13, 745–758.