Prospective Randomized Study on the Influence of Myoinositol in PCOS Women Undergoing IVF in the Improvement of Oocyte Quality, Fertilization Rate, and Embryo Quality

International Journal of Endocrinology

Volumn 2016, Issue , 2016, Pages

  Lesoine, Bernd ^a   Regidor, Pedro Antonio ^b  

^a Centre for Reproductive Medicine Bogenhausen   (Germany)

^b Frauenklinik München West   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; FOLIC ACID; FOLLITROPIN; GANIRELIX; GONADOTROPIN; INOSITOL; PLACEBO; TRIPTORELIN;

ARTICLE; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; EMBRYO (ANATOMY); EMBRYO QUALITY; FEMALE; FEMALE GENITAL TRACT PARAMETERS; FEMALE INFERTILITY; FERTILIZATION; HUMAN; IN VITRO FERTILIZATION; METAPHASE; OOCYTE; OOCYTE QUALITY; OVARY FOLLICLE CELL; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; TREATMENT DURATION; TREATMENT OUTCOME;

EID: 84986269142     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2016/4378507     Document Type: Article

References (29)

1. D. A. Ehrmann, "Polycystic ovary syndrome, " The New England Journal of Medicine, vol. 352, no. 12, pp. 1223-1236, 2005.
2. R. Homburg, "Polycystic ovary syndrome-from gynaecological curiosity to multisystem endocrinopathy, " Human Reproduction, vol. 11, no. 1, pp. 29-39, 1996.
3. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, "Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS), " Human Reproduction, vol. 19, no. 1, pp. 41-47, 2004.
4. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, "Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome, " Fertility and Sterility, vol. 81, no. 1, pp. 19-25, 2004.
5. D. A. Ehrmann, M. K. Cavaghan, R. B. Barnes, J. Imperial, and R. L. Rosenfield, "Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome, " Diabetes Care, vol. 22, no. 1, pp. 141-146, 1999.
6. A. D. Genazzani, C. Battaglia, B. Malavasi, C. Strucchi, F. Tor-tolani, and O. Gamba, "Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome, " Fertility and Sterility, vol. 81, no. 1, pp. 114-119, 2004.
7. M. Ciampelli, A. M. Fulghesu, F. Cucinelli et al., "Impact of insulin and body mass index on metabolic and endocrine variables in polycystic ovary syndrome, " Metabolism: Clinical and Experimental, vol. 48, no. 2, pp. 167-172, 1999.
8. A. S. Kennington, C. R. Hill, J. Craig et al., "Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus, " The New England Journal of Medicine, vol. 323, no. 6, pp. 373-378, 1990.
9. I. Asplin, G. Galasko, and J. Larner, "Chiro-inositol defciency and insulin resistance: a comparison of the chiro-inositol-and the myo-inositol-containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjects, " Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 13, pp. 5924-5928, 1993.
10. P. Cohen, "The twentieth century struggle to decipher insulin signalling, " Nature Reviews Molecular Cell Biology, vol. 7, no. 11, pp. 867-873, 2006.
11. J.-P. Baillargeon, J. E. Nestler, R. E. Ostlund, T. Apridonidze, and E. Diamanti-Kandarakis, "Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism, " Human Reproduction, vol. 23, no. 6, pp. 1439-1446, 2008.
12. J.-P. Baillargeon, E. Diamanti-Kandarakis, R. E. Ostlund Jr., T. Apridonidze, M. J. Iuorno, and J. E. Nestler, "Altered D-chiro-inositol urinary clearance in women with polycystic ovary syndrome, " Diabetes Care, vol. 29, no. 2, pp. 300-305, 2006.
13. E. Papaleo, V. Unfer, J.-P. Baillargeon et al., "Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction, " Gynecological Endocrinology, vol. 23, no. 12, pp. 700-703, 2007.
14. P. F. Serhal, D. M. Ranieri, A. Kinis, S. Marchant, M. Davies, and I. M. Khadum, "Oocyte morphology predicts outcome of intracytoplasmic sperm injection, " Human Reproduction, vol. 12, no. 6, pp. 1267-1270, 1997.
15. N. S. Macklon and B. C. J. M. Fauser, "Mild stimulation in in vitro fertilization, " Annals of the New York Academy of Sciences, vol. 997, no. 11, pp. 105-111, 2003.
16. T. T. Y. Chiu, M. S. Rogers, E. L. K. Law, C. M. Briton-Jones, L. P. Cheung, and C. J. Haines, "Follicular fuid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality, " Human Reproduction, vol. 17, no. 6, pp. 1591-1596, 2002.
17. T. T. Y. Chiu, M. S. Rogers, C. Briton-Jones, and C. Haines, "Effects of myo-inositol on the in-vitro maturation and subsequent development of mouse oocytes, " Human Reproduction, vol. 18, no. 2, pp. 408-416, 2003.
18. J. E. Nestler and V. Unfer, "Reffections on inositol(s) for PCOS therapy: steps toward success, " Gynecological Endocrinology, vol. 31, no. 7, pp. 501-505, 2015.
19. G. Carlomagno, V. Unfer, and S. Rosef, "The D-chiro-inositol paradox in the ovary, " Fertility and Sterility, vol. 95, no. 8, pp. 2515-2516, 2011.
20. F. Facchinetti, M. Bizzarri, S. Benvenga et al., "Results from the International Consensus Conference on Myo-inositol and d-chiro-inositol in Obstetrics and Gynecology: the link between metabolic syndrome and PCOS, " European Journal of Obstetrics Gynecology & Reproductive Biology, vol. 195, no. 12, pp. 72-76, 2015.
21. P. Rizzo, E. Rafone, and V. Benedetto, "Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial, " European Review for Medical and Pharmacological Sciences, vol. 14, no. 6, pp. 555-561, 2010.
22. V. Unfer, E. Rafone, P. Rizzo, and S. Bufo, "Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study, " Gynecological Endocrinology, vol. 27, no. 11, pp. 857-861, 2011.
23. M. J. Iuorno, D. J. Jakubowicz, J.-P. Baillargeon et al., "Effects of D-chiro-inositol in lean women with the polycystic ovary syndrome, " Endocrine Practice, vol. 8, no. 6, pp. 417-423, 2002.
24. J. E. Nestler, D. J. Jakubowicz, P. Reamer, R. D. Gunn, and G. Allan, "Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome, " The New England Journal of Medicine, vol. 340, no. 17, pp. 1314-1320, 1999.
25. S. Gerli, M. Mignosa, and G. C. Di Renzo, "Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial, " European Review for Medical and Pharmacological Sciences, vol. 7, no. 6, pp. 151-159, 2003.
26. V. Unfer, G. Carlomagno, G. Dante, and F. Facchinetti, "Effects of myo-Inositol in women with PCOS: a systematic review of randomized controlled trials, " Gynecological Endocrinology, vol. 28, no. 7, pp. 509-515, 2012.
27. C. Battaglia, F. Mancini, N. Persico, V. Zaccaria, and D. de Aloy-sio, "Ultrasound evaluation of PCO, PCOS and OHSS, " Reproductive BioMedicine Online, vol. 9, no. 6, pp. 614-619, 2004.
28. E. Papaleo, V. Unfer, J.-P. Baillargeon, F. Fusi, F. Occhi, and L. De Santis, "Myo-inositol may improve oocyte quality in intra-cytoplasmic sperm injection cycles. A prospective, controlled, randomized trial, " Fertility and Sterility, vol. 91, no. 5, pp. 1750-1754, 2009.
29. V. Unfer, E. Rafone, P. Rizzo, and S. Bufo, "Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: A Prospective, Longitudinal, Cohort Study, " Gynecological Endocrinology, vol. 27, no. 11, pp. 857-861, 2011.