Corpus callosum atrophy is strongly associated with cognitive impairment in multiple sclerosis: Results of a 17-year longitudinal study

Multiple Sclerosis

Volumn 21, Issue 9, 2015, Pages 1151-1158

  Granberg, Tobias ^a   Martola, Juha ^a   Bergendal, Gösta ^b   Shams, Sara ^a   Damangir, Soheil ^b   Aspelin, Peter ^a   Fredrikson, Sten ^a,b   Kristoffersen Wiberg, Maria ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

atrophy; cognitive impairment; Corpus callosum; MRI; multiple sclerosis

Indexed keywords

ADULT; ARTICLE; ASSESSMENT OF HUMANS; BRAIN ATROPHY; BRAIN DAMAGE; BRAIN PARENCHYMA; BRAIN REGION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CORPUS CALLOSUM; CORPUS CALLOSUM ATROPHY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE MARKER; EXPANDED DISABILITY STATUS SCALE; FEMALE; FOLLOW UP; GRAY MATTER; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PARENCHYMA; SYMBOL DIGIT MODALITY TEST; WHITE MATTER; ATROPHY; COGNITION DISORDERS; COMPLICATION; DISABILITY; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; CLINICAL ARTICLE; CLINICAL ASSESSMENT; NORMAL HUMAN; PACED AUDITORY SERIAL ADDITION TEST; PHYSICAL DISABILITY; REY AUDITORY VERBAL LEARNING TEST; SYMBOL DIGIT MODALITIES TEST;

ADULT; ATROPHY; COGNITION DISORDERS; CORPUS CALLOSUM; DISABILITY EVALUATION; FEMALE; HUMANS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; NEUROPSYCHOLOGICAL TESTS;

EID: 84985995983     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458514560928     Document Type: Article

References (25)

1. Amato MP, Zipoli V, Portaccio E,. Multiple sclerosis-related cognitive changes: A review of cross-sectional and longitudinal studies. J Neurol Sci 2006; 245: 41-46.
2. Langdon DW, Amato MP, Boringa J,. Recommendations for a Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Mult Scler J 2012; 18: 891-898.
3. Bakshi R, Thompson AJ, Rocca MA,. MRI in multiple sclerosis: Current status and future prospects. Lancet Neurol 2008; 7: 615-625.
4. Filippi M, Rocca MA,. MR imaging of multiple sclerosis. Radiology 2011; 259: 659-681.
5. Bermel RA, Bakshi R,. The measurement and clinical relevance of brain atrophy in multiple sclerosis. Lancet Neurol 2006; 5: 158-170.
6. Mooshagian E,. Anatomy of the corpus callosum reveals its function. J Neurosci 2008; 28: 1535-1536.
7. Evangelou N, Konz D, Esiri MM,. Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis. Brain 2000; 123: 1845-1849.
8. Sullivan EV, Rosenbloom MJ, Desmond JE,. Sex differences in corpus callosum size: Relationship to age and intracranial size. Neurobiol Aging 2001; 22: 603-611.
9. Mitchell TN, Free SL, Merschhemke M,. Reliable callosal measurement: Population normative data confirm sex-related differences. Am J Neuroradiol 2003; 24: 410-418.
10. Jäncke L, Mérillat S, Liem F,. Brain size, sex, and the aging brain. Hum Brain Mapp. Epub ahead of print 27 2014. DOI: 10.1002/hbm.22619.
11. Martola J, Stawiarz L, Fredrikson S,. Progression of non-age-related callosal brain atrophy in multiple sclerosis: A 9-year longitudinal MRI study representing four decades of disease development. J Neurol Neurosurg Psychiatr 2007; 78: 375-380.
12. Yaldizli Ö Atefy R, Gass A,. Corpus callosum index and long-term disability in multiple sclerosis patients. J Neurol 2010; 257: 1256-1264.
13. Vaneckova M, Kalincik T, Krasensky J,. Corpus callosum atrophy-a simple predictor of multiple sclerosis progression: A longitudinal 9-year study. Eur Neurol 2012; 68: 23-27.
14. Figueira FF, Santos VS, Figueira GM,. Corpus callosum index: A practical method for long-term follow-up in multiple sclerosis. Arq Neuropsiquiatr 2007; 65: 931-935.
15. Klawiter EC, Ceccarelli A, Arora A,. Corpus callosum atrophy correlates with gray matter atrophy in patients with multiple sclerosis. J Neuroimaging. Epub ahead of print 9 2014. DOI: 10.1111/jon.12124.
16. Barkhof FJ, Elton M, Lindeboom J,. Functional correlates of callosal atrophy in relapsing-remitting multiple sclerosis patients. A preliminary MRI study. J Neurol 1998; 245: 153-158.
17. Sánchez MP, Nieto A, Barroso J,. Brain atrophy as a marker of cognitive impairment in mildly disabling relapsing-remitting multiple sclerosis. Eur J Neurol 2008; 15: 1091-1099.
18. Lin X, Tench CR, Morgan PS,. Use of combined conventional and quantitative MRI to quantify pathology related to cognitive impairment in multiple sclerosis. J Neurol Neurosurg Psychiatr 2008; 79: 437-441.
19. Yaldizli Ö Penner IK, Frontzek K,. The relationship between total and regional corpus callosum atrophy, cognitive impairment and fatigue in multiple sclerosis patients. Mult Scler 2013; 20: 356-364.
20. Bergendal G, Martola J, Stawiarz L,. Callosal atrophy in multiple sclerosis is related to cognitive speed. Acta Neurol Scand 2013; 127: 281-289.
21. Schreiber K, Sørensen PS, Koch-Henriksen N,. Correlations of brain MRI parameters to disability in multiple sclerosis. Acta Neurol Scand 2001; 104: 24-30.
22. Lezak MD, (ed.) Neuropsychological assessment. 5th ed. New York: Oxford University Press, 2012.
23. Reuter M, Schmansky NJ, Rosas HD,. Within-subject template estimation for unbiased longitudinal image analysis. Neuroimage 2012; 61: 1402-1418.
24. Schmidt P, Gaser C, Arsic M,. An automated tool for detection of FLAIR-hyperintense white-matter lesions in multiple sclerosis. Neuroimage 2012; 59: 3774-3783.
25. Kuhlmann T, Lingfeld G, Bitsch A,. Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain 2002; 125 (10): 2202-2212.