Inverse correlation of genetic risk score with age at onset in bout-onset and progressiveonset multiple sclerosis

Multiple Sclerosis Journal

Volumn 21, Issue 11, 2015, Pages 1463-1467

  Sorosina, Melissa ^a   Esposito, Federica ^a   Guaschino, Clara ^a   Clarelli, Ferdinando ^a   Barizzone, Nadia ^a   Osiceanu, Ana Maria ^a   Brambilla, Paola ^a   Mascia, Elisabetta ^a   Cavalla, Paola ^a   Gallo, Paolo ^a   Martinelli, Vittorio ^a   Leone, Maurizio ^b   Comi, Giancarlo ^a   D'Alfonso, Sandra ^a   Boneschi, Filippo Martinelli ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Age of onset; Genetic risk; Multiple sclerosis; Primary progressive; Relapsing remitting; Weighted genetic risk score

Indexed keywords

HLA DRB1 ANTIGEN;

AGE; ARTICLE; CLINICAL FEATURE; DISEASE COURSE; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HLA SYSTEM; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL ANALYSIS; ADOLESCENT; ADULT; AGED; CHILD; CLINICAL TRIAL; COHORT ANALYSIS; GENETIC PREDISPOSITION; ITALY; MIDDLE AGED; MULTICENTER STUDY; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; ONSET AGE; PATHOPHYSIOLOGY; RISK; YOUNG ADULT;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; CHILD; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ITALY; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; RISK; YOUNG ADULT;

EID: 84985920199     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458514561910     Document Type: Article

References (13)

1. Ebers GC Natural history of primary progressive multiple sclerosis. Mult Scler 2004; 10: 8-15.
2. International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet 2013; 45: 1353-1360.
3. Harbo HF, Isobe N, Berg-Hansen P, et al. Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis. Mult Scler 2013; 20: 660-668.
4. Harding K, Ingram G, Cossburn M, et al. Genotype-phenotype correlation for non-HLA disease associated risk alleles in multiple sclerosis. Neurosci Lett 2012; 526: 15-19.
5. Jensen CJ, Stankovich J, Van der Walt A, et al. Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients. PLoS One 2010; 5: e10003.
6. International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, Sawcer S, et al. Genetic risk and a primary role for cellmediated immune mechanisms in multiple sclerosis. Nature 2011; 476: 214-219.
7. Poser CM The diagnosis and management of multiple sclerosis. Acta Neurol Scand 2005; 112: 199-201.
8. Sorosina M, Brambilla P, Clarelli F, et al. Genetic burden of common variants in progressive and bout-onset multiple sclerosis. Mult Scler 2013; 20: 802-811.
9. De Jager PL, Chibnik LB, Cui J, et al. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: A weighted genetic risk score. Lancet Neurol 2009; 8: 1111-1119.
10. Masterman T, Ligers A, Olsson T, et al. HLA-DR15 is associated with lower age at onset in multiple sclerosis. Ann Neurol 2000; 48: 211-219.
11. Scalfari A, Neuhaus A, Daumer M, et al. Onset of secondary progressive phase and long-term evolution of multiple sclerosis. J Neurol Neurosurg Psychiatry 2014; 85: 67-75.
12. Trojano M, Pellegrini F, Paolicelli D, et al. Real-life impact of early interferon beta therapy in relapsing multiple sclerosis. Ann Neurol 2009; 66: 513-520.
13. Isobe N, Damotte V, Lo Re V, et al. Genetic burden in multiple sclerosis families. Genes Immun 2013; 14: 434-440.