Severe brown fat lipoatrophy aggravates atherosclerotic process in male mice

Endocrinology

Volumn 157, Issue 9, 2016, Pages 3517-3528

  Gómez Hernández, Almudena ^a   Beneit, Nuria ^a   Escribano, Óscar ^a   Díaz Castroverde, Sabela ^a   García Gómez, Gema ^a   Fernández, Silvia ^a   Benito, Manuel ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; APOLIPOPROTEIN E; CHAPERONIN 60; CHOLESTEROL; ENDOTHELIN 1; FIBROBLAST GROWTH FACTOR 21; GLUCOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INTERCELLULAR ADHESION MOLECULE 1; LEPTIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PORIN; PROTEIN KINASE B; SOMATOMEDIN C RECEPTOR; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; UNCOUPLING PROTEIN 1; BIOLOGICAL MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; BROWN ADIPOSE TISSUE; CELL INFILTRATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE EXACERBATION; FATTY ACID OXIDATION; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; HYPOINSULINEMIA; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAPERITONEAL FAT; LIPOATROPHY; MACROPHAGE; MALE; MOUSE; NONHUMAN; OBESITY; PERIVASCULAR ADIPOSE TISSUE; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; VASCULITIS; WHITE ADIPOSE TISSUE; ANIMAL; ATHEROSCLEROSIS; C57BL MOUSE; COMPLICATION; EXPERIMENTAL DIABETES MELLITUS; GENETICS; KNOCKOUT MOUSE; LIPID METABOLISM; LIPOATROPHIC DIABETES MELLITUS; METABOLISM;

ADIPONECTIN; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ADIPOSITY; ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BIOMARKERS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, LIPOATROPHIC; GLUCOSE; INSULIN RESISTANCE; LEPTIN; LIPID METABOLISM; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, INSULIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84985916819     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2016-1148     Document Type: Article

References (43)

1. Barquera S, Pedroza-Tobías A, Medina C, et al. Global overview of the epidemiology of atherosclerotic cardiovascular disease. Arch Med Res. 2015;46:328-338.
2. Leon BM, Maddox TM. Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 2015;6:1246-1258.
3. Anderson TJ, Mancini GB, Genest J Jr, Grégoire J, Lonn EM, Hegele RA. The new dyslipidemia guidelines: What is the debate? Can J Cardiol. 2015;31:605-612.
4. Husain K, Hernandez W, Ansari RA, Ferder L. Inflammation, oxidative stress and renin angiotensin system in atherosclerosis. World J Biol Chem. 2015;6:209-217.
5. Zhang PY, Xu X, Li XC. Eur Rev Cardiovascular diseases: oxidative damage and antioxidant protection. Med Pharmacol Sci. 2014;18: 3091-3096.
6. Lazar MA. How obesity causes diabetes: not a tall tale. Science. 2005;307:373-375.
7. Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: An update. Clin Endocrinol (Oxf). 2006;64:355-365.
8. Ozen G, Daci A, Norel X, Topal G. Human perivascular adipose tissue dysfunction as a cause of vascular disease: focus on vascular tone and wall remodeling. Eur J Pharmacol. 2015;766:16-24.
9. Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006;444:847-853.
10. Ghorbani M, Claus TH, Himms-Hagen. Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of dietinduced obesity in rats treated with a β3- Adrenoceptor agonist. J Biochem Pharmacol. 1997;54:121-131.
11. Guerra C, Koza RA, Yamashita H, Walsh K, Kozak LP. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest. 1998;102:412-420.
12. Aquila H, Link TA, Klingenberg M. The uncoupling protein from brown fat mitochondria is related to the mitochondrial ADP/ATP carrier. Analysis of sequence homologies and of folding of the protein in the membrane. EMBO J. 1985;4:2369-2376.
13. Kontani Y, Wang Y, Kimura K, et al. UCP1 deficiency increases susceptibility to diet-induced obesity with age. Aging Cell. 2005;4: 147-155.
14. Park A, Kim WK, Bae KH. Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells. World J Stem Cells. 2014;6:33-42.
15. Brown NK, Zhou Z, Zhang J, et al. Perivascular adipose tissue in vascular function and disease: A review of current research and animal models. Arterioscler Thromb Vasc Biol. 2014;34:1621-1630.
16. Ozen G, Daci A, Norel X, Topal G. Human perivascular adipose tissue dysfunction as a cause of vascular disease: focus on vascular tone and wall remodeling. Eur J Pharmacol. 2015;766:16-24.
17. Omar A, Chatterjee TK, Tang Y, Hui DY, Weintraub NL. Proinflammatory phenotype of perivascular adipocytes. Arterioscler Thromb Vasc Biol. 2014;34:1631-1636.
18. Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans.NEngl J Med. 2009; 360:1509-1517.
19. Gómez-Hernández A, Otero YF, de las Heras N, et al. Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction. Endocrinology. 2012;153:1242-1255.
20. Escribano O, Guillén C, Nevado C, Gómez-Hernández A, Kahn CR, Benito M. β-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreatic endocrine axis through insulin receptor a isoform. Diabetes. 2009;58:820-828.
21. Lowell BB, S-Susulic V, Hamann A, et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature. 1993;366:740-742.
22. Poekes L, Lanthier N, Leclercq IA. Brown adipose tissue: A potential target in the fight against obesity and the metabolic syndrome. Clin Sci (Lond). 2015;129:933-491.
23. Sanchez-Delgado G, Martinez-Tellez B, Olza J, Aguilera CM, Gil Á, Ruiz JR. Role of exercise in the activation of brown adipose tissue. Ann Nutr Metab. 2015;67:21-32.
24. McMillan AC, White MD.Inductionofthermogenesisinbrownandbeige adipose tissues: molecular markers, mild cold exposure and novel therapies. Curr Opin Endocrinol Diabetes Obes. 2015;22:347-352.
25. Sidossis LS, Porter C, Saraf MK, et al. Browning of subcutaneous white adipose tissue in humans alter severe adrenergic stress. Cell Metab. 2015;22:219-227.
26. Campioli E, Carnevale G, Avallone R, Guerra D, Baraldi M. Morphological and receptorial changes in the epididymal adipose tissue of rats subjected to a stressful stimulus. Obesity (Silver Spring). 2011;19:703-708.
27. Warner A, Mittag J. Breaking BAT: can browning create a better white? J Endocrinol. 2016;228:R19-R29.
28. Schulz TJ, Huang TL, Tran TT, et al. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci USA. 2011;108:143-148.
29. Bartelt A, Bruns OT, Reimer R, et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med. 2011;17:200-205.
30. Festuccia WT, Blanchard PG, Deshaies Y. Control of brown adipose tissue glucose and lipid metabolism by PPARγ. Front Endocrinol (Lausanne). 2011;2:84.
31. Berbée JF, Boon MR, Khedoe PP, et al. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun. 2015;6:6356.
32. Geach T. Dyslipidaemia: Active BAT reduces atherosclerosis. Nat Rev Endocrinol. 2015;11:317.
33. Peirce V, Vidal-Puig A. Regulation of glucose homoeostasis by brown adipose tissue. Lancet Diabetes Endocrinol. 2013;1:353-360.
34. Yoneshiro T, Saito M. Activation and recruitment of brown adipose tissue as anti-obesity regimens in humans. Ann Med. 2015;47:133- 141.
35. Jacene HA, Cohade CC, Zhang Z, Wahl RL. The relationship between patients' serum glucose levels and metabolically active brown adipose tissue detected by PET/CT. Mol Imaging Biol. 2011;13: 1278-1283.
36. Lee P, Greenfield JR, Ho KK, Fulham MJ. A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab. 2010;299:E601-E606.
37. Vernochet C, Damilano F, Mourier A, et al. Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications. FASEB J. 2014;28:4408-4419.
38. Apovian CM, Bigornia S, Mott M, et al. Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol. 2008;28:1654-1659.
39. Soret MG, Kupiecki FP, Wyse BM. Epididymal fat pad alterations in mice with spontaneous obesity and diabetes and with chemically induced obesity. Diabetologia. 1974;10:639-648.
40. Padilla J, Jenkins NT, Vieira-Potter VJ, Laughlin MH. Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues. Am J Physiol Regul Integr Comp Physiol. 2013;304:R543- R552.
41. Gil-Ortega M, Somoza B, Huang Y, Gollasch M, Fernández-Alfonso MS. Regional differences in perivascular adipose tissue impacting vascular homeostasis. Trends Endocrinol Metab. 2015;26: 367-375.
42. Miao CY, Li ZY. The role of perivascular adipose tissue in vascular smooth muscle cell growth. Br J Pharmacol. 2012;165: 643-658.
43. Payne GA, Tune JD, Knudson JD. Leptin-induced endothelial dysfunction: A target for therapeutic interventions. Curr Pharm Des. 2014;20:603-608.