The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction

eLife

Volumn 5, Issue AUGUST, 2016, Pages

  Koizumi, Shun ^a   Irie, Taro ^a   Hirayama, Shoshiro ^a   Sakurai, Yasuyuki ^a   Yashiroda, Hideki ^a   Naguro, Isao ^a   Ichijo, Hidenori ^a   Hamazaki, Jun ^a   Murata, Shigeo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; DNA DAMAGE INDUCIBLE 1 HOMOLOG 2; PEPTIDES AND PROTEINS; PROTEASOME; PROTEIN P97; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF1; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; DDI2 PROTEIN, HUMAN; NRF1 PROTEIN, HUMAN; NUCLEAR RESPIRATORY FACTOR 1;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DEGLYCOSYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE ACTIVATION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; CELL LINE; GENE DELETION; GENETIC COMPLEMENTATION; GENETICS; METABOLISM;

ASPARTIC ACID PROTEASES; CELL LINE; GENE DELETION; GENETIC COMPLEMENTATION TEST; HUMANS; NUCLEAR RESPIRATORY FACTOR 1; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 84985910639     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.18357     Document Type: Article

References (15)

1. Iida Y, Fujimori T, Okawa K, Nagata K, Wada I, Hosokawa N. 2011. SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates. Journal of Biological Chemistry 286:16929–16939. doi:10.1074/jbc.M110.215871.
2. Konvalinka J, Kräusslich HG, Müller B. 2015. Retroviral proteases and their roles in virion maturation. Virology 479–480:403–417. doi:10.1016/j.virol.2015.03.021.
3. Krylov DM, Koonin EV. 2001. Correspondence. Current Biology 11:R584–R587. doi:10.1016/S0960-9822(01)00357-8.
4. Lee CS, Ho DV, Chan JY. 2013. Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice. FEBS Journal 280:3609–3620. doi:10.1111/febs.12350.
5. Lee CS, Lee C, Hu T, Nguyen JM, Zhang J, Martin MV, Vawter MP, Huang EJ, Chan JY. 2011. Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration. PNAS 108:8408–8413. doi:10.1073/pnas.1019209108.
6. Meyer H, Bug M, Bremer S. 2012. Emerging functions of the VCP/p97. AAA-ATPase in the ubiquitin system. Nature Cell Biology 14:117–123. doi:10.1038/ncb2407.
7. Nowicka U, Zhang D, Walker O, Krutauz D, Castañeda CA, Chaturvedi A, Chen TY, Reis N, Glickman MH, Fushman D. 2015. DNA-damage-inducible 1 protein (Ddi1) contains an uncharacteristic ubiquitin-like domain that binds ubiquitin. Structure 23:542–557. doi:10.1016/j.str.2015.01.010.
8. Radhakrishnan SK, den Besten W, Deshaies RJ. 2014. p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition. eLife 3:e01856. doi:10.7554/eLife.01856.
9. Radhakrishnan SK, Lee CS, Young P, Beskow A, Chan JY, Deshaies RJ. 2010. Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Molecular Cell 38:17–28. doi:10.1016/j.molcel.2010.02.029.
10. Sha Z, Goldberg AL. 2014. Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97. Current Biology 24:1573–1583. doi:10.1016/j.cub.2014.06.004.
11. Sirkis R, Gerst JE, Fass D. 2006. Ddi1, a eukaryotic protein with the retroviral protease fold. Journal of Molecular Biology 364:376–387. doi:10.1016/j.jmb.2006.08.086.
12. Steffen J, Seeger M, Koch A, Krüger E. 2010. Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop. Molecular Cell 40:147–158. doi:10.1016/j.molcel.2010.09.012.
13. Toes RE, Nussbaum AK, Degermann S, Schirle M, Emmerich NP, Kraft M, Laplace C, Zwinderman A, Dick TP, Müller J, Schönfisch B, Schmid C, Fehling HJ, Stevanovic S, Rammensee HG, Schild H. 2001. Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products. The Journal of Experimental Medicine 194:1–12. doi:10.1084/jem.194.1.1.
14. Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M, Kobayashi A. 2011. Dual regulation of the transcriptional activity of Nrf1 by b-TrCP-and Hrd1-dependent degradation mechanisms. Molecular and Cellular Biology 31:4500–4512. doi:10.1128/MCB.05663-11.
15. Zhang Y, Lucocq JM, Yamamoto M, Hayes JD. 2007. The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation. Biochemical Journal 408:161–172. doi:10.1042/BJ20070761