Does physical activity moderate the association between alcohol drinking and all-cause, cancer and cardiovascular diseases mortality? A pooled analysis of eight British population cohorts

British Journal of Sports Medicine

Volumn 51, Issue 8, 2017, Pages 651-657

  Perreault, K ^a,b   Bauman, A ^b,c   Johnson, N ^b,d   Britton, A ^e   Rangul, V ^c   Stamatakis, E ^b,d,e  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF SYDNEY   (Australia)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^d UNIVERSITY OF SYDNEY   (Australia)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cancer; Epidemiology; Physical activity; Public health

Indexed keywords

ADULT; ADVERSE EFFECTS; AGED; CARDIOVASCULAR DISEASE; DRINKING BEHAVIOR; ENGLAND; EXERCISE; FEMALE; HEALTH SURVEY; HUMAN; MALE; MIDDLE AGED; MORTALITY; NEOPLASM; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; RISK FACTOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ALCOHOL DRINKING; CARDIOVASCULAR DISEASES; ENGLAND; EXERCISE; FEMALE; HEALTH SURVEYS; HUMANS; MALE; MIDDLE AGED; MORTALITY; NEOPLASMS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84984994007     PISSN: 03063674     EISSN: 14730480     Source Type: Journal    
DOI: 10.1136/bjsports-2016-096194     Document Type: Article

References (74)

1. Office for National Statistics. General lifestyle survey overview. UK: Office for National Statistics, 2010.
2. Lifestyle Statistics Health and Social Care Information Centre. Statistics on Alcohol England, 2014. England, 2014.
3. Di Castelnuovo A, Costanzo S, Bagnardi V, et al. Alcohol dosing and total mortality in men and women: An updated meta-Analysis of 34 prospective studies. Arch Intern Med 2006;166:2437-45.
4. Boffetta P, Hashibe M. Alcohol and cancer. Lancet Oncol 2006;7:149-56.
5. Nelson DE, Jarman DW, Rehm J, et al. Alcohol-Attributable cancer deaths and years of potential life lost in the United States. Am J Public Health 2013;103:641-8.
6. Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 2007;7:599-612.
7. Ronksley PE, Brien SE, Turner BJ, et al. Association of alcohol consumption with selected cardiovascular disease outcomes: A systematic review and meta-Analysis. BMJ 2011;342:d671.
8. Thompson PL. J-curve revisited: cardiovascular benefits of moderate alcohol use cannot be dismissed. Med J Aust 2013;198:419-22.
9. UK House of Commons Health Committee. Written evidence from Alcohol Concern (GAS 62). Secondary Written evidence from Alcohol Concern (GAS 62), 2012. http://www.publications.parliament.uk/pa/cm201213/cmselect/cmhealth/132/132we09.htm
10. Wagenaar AC, Salois MJ, Komro KA. Effects of beverage alcohol price and tax levels on drinking: A meta-Analysis of 1003 estimates from 112 studies. Addiction 2009;104:179-90.
11. Shiroma EJ, Lee IM. Physical activity and cardiovascular health: lessons learned from epidemiological studies across age, gender, and race/ethnicity. Circulation 2010;122:743-52.
12. Sofi F, Capalbo A, Cesari F, et al. Physical activity during leisure time and primary prevention of coronary heart disease: An updated meta-Analysis of cohort studies. Eur J Cardiovasc Prev Rehabil 2008;15:247-57.
13. Nocon M, Hiemann T, Möller-Riemenschneider F, et al. Association of physical activity with all-cause and cardiovascular mortality: A systematic review and meta-Analysis. Eur J Cardiovasc Prev Rehabil 2008;15:239-46.
14. Sabia S, Dugravot A, Kivimaki M, et al. Effect of intensity and type of physical activity on mortality: results from the Whitehall II cohort study. Am J Public Health 2012;102:698-704.
15. Sadarangani KP, Hamer M, Mindell JS, et al. Physical activity and risk of all-cause and cardiovascular disease mortality in diabetic adults from Great Britain: pooled analysis of 10 population-based cohorts. Diabetes care 2014;37:1016-23.
16. Samitz G, Egger M, Zwahlen M. Domains of physical activity and all-cause mortality: systematic review and dose-response meta-Analysis of cohort studies. Int J Epidemiol 2011;40:1382-400.
17. Stamatakis E, Hamer M, Lawlor DA. Physical activity, mortality, and cardiovascular disease: is domestic physical activity beneficial? The Scottish Health Survey-1995, 1998, and 2003. Am J Epidemiol 2009;169:1191-200.
18. Wolin KY, Yan Y, Colditz GA, et al. Physical activity and colon cancer prevention: A meta-Analysis. Br J Cancer 2009;100:611-16.
19. Wu Y, Zhang D, Kang S. Physical activity and risk of breast cancer: A meta-Analysis of prospective studies. Breast Cancer Res Treat 2013;137:869-82.
20. Hamer M, Ingle L, Carroll S, et al. Physical activity and cardiovascular mortality risk: possible protective mechanisms? Med Sci Sports Exerc 2012;44:84-8.
21. Hallal PC, Andersen LB, Bull FC, et al. Global physical activity levels: surveillance progress, pitfalls, and prospects. Lancet 2012;380:247-57.
22. Townsend N BP, Wickramasinghe K, Scarborough P, et al. Physical activity statistics 2012. London: British Heart Foundation, 2012.
23. CDC. Nutrition, physical activity and obesity: data, trends and maps. In: Department of Health and Human Services, ed. Atlanta, GA: Centers for Disease Control and Prevention (CDC), National Center for Chronic Disease Prevention and Health Promotion, Division of Nutrition, Physical Activity and Obesity, 2013.
24. Scoccianti C, Cecchini M, Anderson AS, et al. European Code against Cancer 4th Edition: Alcohol drinking and cancer. Cancer Epidemiol 2015;39(Suppl 1):S67-74.
25. Friedenreich CM, Neilson HK, Lynch BM. State of the epidemiological evidence on physical activity and cancer prevention. Eur J Cancer 2010;46:2593-604.
26. McTiernan A. Mechanisms linking physical activity with cancer. Nat Rev Cancer 2008;8:205-11.
27. Westerlind KC. Physical activity and cancer prevention-mechanisms. Med Sci Sports Exerc 2003;35:1834-40.
28. Shuval K, Barlow CE, Chartier KG, et al. Cardiorespiratory fitness, alcohol, and mortality in men: The Cooper Center Longitudinal Study. Am J Prev Med 2012;42:460-7.
29. Soedamah-Muthu SS, De Neve M, Shelton NJ, et al. Joint associations of alcohol consumption and physical activity with all-cause and cardiovascular mortality. Am J Cardiol 2013;112:380-6.
30. Knott CS, Coombs N, Stamatakis E, et al. All cause mortality and the case for age specific alcohol consumption guidelines: pooled analyses of up to 10 population based cohorts. BMJ 2015;350:h384.
31. Mindell J, Biddulph JP, Hirani V, et al. Cohort profile: The Health Survey for England. Int J Epidemiol 2012;41:1585-93.
32. Gray L, Batty GD, Craig P, et al. Cohort profile: The Scottish Health Surveys Cohort: linkage of study participants to routinely collected records for mortality, hospital discharge, cancer and offspring birth characteristics in three nationwide studies. Int J Epidemiol 2010;39:345-50.
33. House of Commons. Alcohol guidelines. In: Science and Technology Committee, ed. London: Science and Technology Committee, The Stationery Office, 2012:130.
34. NIAAA. A pocket guide for alcohol screening and brief intervention. Rockville, Maryland, USA: U.S. Department of Health and Human Services, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, 2005:34.
35. Cabinet Office. Alcohol harm reduction strategy for England. In: Prime Ministers Strategy Unit, ed. London: Cabinet Office, Prime Ministers Strategy Unit, 2004:92.
36. Scholes S, Coombs N, Pedisic Z, et al. Age-And sex-specific criterion validity of the Health Survey for England Physical Activity and Sedentary Behavior Assessment Questionnaire as compared with accelerometry. Am J Epidemiol 2014;179:1493-502.
37. ODonovan G, Blazevich AJ, Boreham C, et al. The ABC of physical activity for health: A consensus statement from the British Association of Sport and Exercise Sciences. J Sports Sci 2010;28:573-91.
38. Arem H, Moore SC, Patel A, et al. Leisure time physical activity and mortality: A detailed pooled analysis of the dose-response relationship. JAMA Intern Med 2015;175:959-67.
39. Department of Health. Sensible Drinking: The Report of an Inter-departmental Working Group. London: HMSO, 1995.
40. Committee on Carcinogenicity of Chemicals in Food Consumer Products and the Environment (COC). Statement on consumption of alcoholic beverages and risk of cancer. In: Department of Health, ed. UK government ©Crown copyright, 2015:69.
41. Wei M, Kampert JB, Barlow CE, et al. Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA 1999;282:1547-53.
42. Ferrari P, Licaj I, Muller DC, et al. Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nutrition (EPIC) study. BMJ Open 2014;4:e005245.
43. Batty D, Thune I. Does physical activity prevent cancer? Evidence suggests protection against colon cancer and probably breast cancer. BMJ 2000;321:1424-5.
44. Friedenreich CM, Orenstein MR. Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 2002;132(11 Suppl):3456S-64S.
45. Moore SC, Lee IM, Weiderpass E, et al. Association of leisure-Time physical activity with risk of 26 types of cancer in 1.44 million adults. JAMA Intern Med 2016;176:816-25.
46. Hoek JB, Pastorino JG. Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol 2002;27:63-8.
47. Pikarsky E, Porat RM, Stein I, et al. NF-kappaB functions as a tumour promoter in inflammation-Associated cancer. Nature 2004;431:461-6.
48. Seitz HK, Stickel F. Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem 2006;387:349-60.
49. Tilg H, Diehl AM. Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 2000;343:1467-76.
50. Campbell KL, McTiernan A. Exercise and biomarkers for cancer prevention studies. J Nutr 2007;137(1 Suppl):161S-9S.
51. Esposito K, Pontillo A, Di Palo C, et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: A randomized trial. JAMA 2003;289:1799-804.
52. Kretzschmar M, Muller D. Aging, training and exercise. A review of effects on plasma glutathione and lipid peroxides. Sports Med 1993;15:196-209.
53. Radak Z, Taylor AW, Ohno H, et al. Adaptation to exercise-induced oxidative stress: from muscle to brain. Exerc Immunol Rev 2001;7:90-107.
54. Fernandez SV. Estrogen, alcohol consumption, and breast cancer. Alcohol Clin Exp Res 2011;35:389-91.
55. Singletary KW, Gapstur SM. Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA 2001;286:2143-51.
56. Chan MF, Dowsett M, Folkerd E, et al. Usual physical activity and endogenous sex hormones in postmenopausal women: The European prospective investigation into cancer-norfolk population study. Cancer Epidemiol Biomarkers Prev 2007;16:900-5.
57. McTiernan A, Tworoger SS, Ulrich CM, et al. Effect of exercise on serum estrogens in postmenopausal women: A 12-month randomized clinical trial. Cancer Res 2004;64:2923-8.
58. Verkasalo PK, Thomas HV, Appleby PN, et al. Circulating levels of sex hormones and their relation to risk factors for breast cancer: A cross-sectional study in 1092 pre-And postmenopausal women (United Kingdom). Cancer Causes Control 2001;12:47-59.
59. Cook RT. Alcohol abuse, alcoholism, and damage to the immune system-A review. Alcohol Clin Exp Res 1998;22:1927-42.
60. Wu WJ, Pruett SB. Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system. J Pharmacol Exp Ther 1996;278:1331-9.
61. Brines R, Hoffman-Goetz L, Pedersen BK. Can you exercise to make your immune system fitter? Immunol Today 1996;17:252-4.
62. Mazzeo RS. The influence of exercise and aging on immune function. Med Sci Sports Exerc 1994;26:586-92.
63. Shephard RJ, Shek PN. Cancer, immune function, and physical activity. Can J Appl Physiol 1995;20:1-25.
64. Pedersen L, Idorn M, Olofsson GH, et al. Voluntary running suppresses tumor growth through epinephrine-And IL-6-dependent NK cell mobilization and redistribution. Cell Metab 2016;23:554-62.
65. Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: A common denominator approach to cancer therapy. Cancer Cell 2015;27:450-61.
66. Physical Activity Guidelines Advisory Committee. Physical Activity Guidelines Advisory Committee report, 2008. To the Secretary of Health and Human Services. Part A: executive summary. Nutr Rev 2009;67:114-20.
67. Mukamal KJ, Chen CM, Rao SR, et al. Alcohol consumption and cardiovascular mortality among U.S. adults, 1987 to 2002. J Am Coll Cardiol 2010;55:1328-35.
68. Rehm J, Room R, Graham K, et al. The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease: An overview. Addiction 2003;98:1209-28.
69. Criqui MH, Ringel BL. Does diet or alcohol explain the French paradox? Lancet 1994;344:1719-23.
70. Knoops KT, de Groot LC, Kromhout D, et al. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: The HALE project. JAMA 2004;292:1433-9.
71. Davis CG, Thake J, Vilhena N. Social desirability biases in self-reported alcohol consumption and harms. Addict Behav 2010;35:302-11.
72. Klatsky AL, Udaltsova N. Alcohol drinking and total mortality risk. Ann Epidemiol 2007;17(5 Suppl):S63-7.
73. Britton A, Ben-Shlomo Y, Benzeval M, et al. Life course trajectories of alcohol consumption in the United Kingdom using longitudinal data from nine cohort studies. BMC Med 2015;13:47.
74. Andersen LB. Relative risk of mortality in the physically inactive is underestimated because of real changes in exposure level during follow-up. Am J Epidemiol 2004;160:189-95.