메뉴 건너뛰기




Volumn 11, Issue , 2016, Pages 9-15

The TNBS-induced colitis animal model: An overview

Author keywords

Animal model; Colitis; Crohn's disease; TNBS

Indexed keywords

CALGRANULIN; CISAPRIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; NITRIC OXIDE SYNTHASE INHIBITOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRINITROBENZENESULFONIC ACID; VANILLOID RECEPTOR 1;

EID: 84984829207     PISSN: 20490801     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amsu.2016.07.019     Document Type: Review
Times cited : (248)

References (42)
  • 1
    • 84868212109 scopus 로고    scopus 로고
    • Crohn's disease
    • [PMID: 22914295]
    • [1] Baumgart, D.C., Sandborn, W.J., Crohn's disease. Lancet 380:9853 (2012), 1590–1605, 10.1016/S0140-6736(12)60026-9 [PMID: 22914295].
    • (2012) Lancet , vol.380 , Issue.9853 , pp. 1590-1605
    • Baumgart, D.C.1    Sandborn, W.J.2
  • 3
    • 0037479789 scopus 로고    scopus 로고
    • Mucin and Toll-like receptors in host defense against intestinal parasites
    • [PMID: 12855381]
    • [3] Moncada, D.M., Kammanadiminti, S.J., Chadee, K., Mucin and Toll-like receptors in host defense against intestinal parasites. Trends Parasitol. 19:7 (2003), 305–311 [PMID: 12855381].
    • (2003) Trends Parasitol. , vol.19 , Issue.7 , pp. 305-311
    • Moncada, D.M.1    Kammanadiminti, S.J.2    Chadee, K.3
  • 4
    • 67651247141 scopus 로고    scopus 로고
    • Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats
    • [PMID: 19370778 PMCID: 2670408]
    • [4] Zhang, H.Q., Ding, T.T., Zhao, J.S., Yang, X., Zhang, H.X., Zhang, J.J., Cui, Y.L., Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats. World J. Gastroenterol. WJG 15:15 (2009), 1821–1828 [PMID: 19370778 PMCID: 2670408].
    • (2009) World J. Gastroenterol. WJG , vol.15 , Issue.15 , pp. 1821-1828
    • Zhang, H.Q.1    Ding, T.T.2    Zhao, J.S.3    Yang, X.4    Zhang, H.X.5    Zhang, J.J.6    Cui, Y.L.7
  • 5
    • 66549098452 scopus 로고    scopus 로고
    • The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat
    • [PMID: 19638092]
    • [5] Iseri, S.O., Ersoy, Y., Ercan, F., Yuksel, M., Atukeren, P., Gumustas, K., Alican, I., The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat. J. Gastroenterol. Hepatol. 24:6 (2009), 1142–1148, 10.1111/j.1440-1746.2009.05797.x [PMID: 19638092].
    • (2009) J. Gastroenterol. Hepatol. , vol.24 , Issue.6 , pp. 1142-1148
    • Iseri, S.O.1    Ersoy, Y.2    Ercan, F.3    Yuksel, M.4    Atukeren, P.5    Gumustas, K.6    Alican, I.7
  • 6
    • 38849163741 scopus 로고    scopus 로고
    • Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
    • [PMID: 18188453 PMCID: 2176188]
    • [6] Watanabe, T., Asano, N., Murray, P.J., Ozato, K., Tailor, P., Fuss, I.J., Kitani, A., Strober, W., Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J. Clin. Investig. 118:2 (2008), 545–559, 10.1172/JCI33145 [PMID: 18188453 PMCID: 2176188].
    • (2008) J. Clin. Investig. , vol.118 , Issue.2 , pp. 545-559
    • Watanabe, T.1    Asano, N.2    Murray, P.J.3    Ozato, K.4    Tailor, P.5    Fuss, I.J.6    Kitani, A.7    Strober, W.8
  • 7
    • 35648995482 scopus 로고    scopus 로고
    • NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction
    • [PMID: 17915219 PMCID: 2134971]
    • [7] Yang, Z., Fuss, I.J., Watanabe, T., Asano, N., Davey, M.P., Rosenbaum, J.T., Strober, W., Kitani, A., NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction. Gastroenterology 133:5 (2007), 1510–1521, 10.1053/j.gastro.2007.07.025 [PMID: 17915219 PMCID: 2134971].
    • (2007) Gastroenterology , vol.133 , Issue.5 , pp. 1510-1521
    • Yang, Z.1    Fuss, I.J.2    Watanabe, T.3    Asano, N.4    Davey, M.P.5    Rosenbaum, J.T.6    Strober, W.7    Kitani, A.8
  • 8
    • 0024552818 scopus 로고
    • Hapten-induced model of chronic inflammation and ulceration in the rat colon
    • [PMID: 2914642]
    • [8] Morris, G.P., Beck, P.L., Herridge, M.S., Depew, W.T., Szewczuk, M.R., Wallace, J.L., Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 96:3 (1989), 795–803 [PMID: 2914642].
    • (1989) Gastroenterology , vol.96 , Issue.3 , pp. 795-803
    • Morris, G.P.1    Beck, P.L.2    Herridge, M.S.3    Depew, W.T.4    Szewczuk, M.R.5    Wallace, J.L.6
  • 9
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • [PMID: 7595199 PMCID: 2192205]
    • [9] Neurath, M.F., Fuss, I., Kelsall, B.L., Stuber, E., Strober, W., Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182:5 (1995), 1281–1290 [PMID: 7595199 PMCID: 2192205].
    • (1995) J. Exp. Med. , vol.182 , Issue.5 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 10
    • 44449134283 scopus 로고    scopus 로고
    • Simvastatin attenuates trinitrobenzene sulfonic acid-induced colitis, but not oxazalone-induced colitis
    • [PMID: 18049901]
    • [10] Ikeda, M., Takeshima, F., Isomoto, H., Shikuwa, S., Mizuta, Y., Ozono, Y., Kohno, S., Simvastatin attenuates trinitrobenzene sulfonic acid-induced colitis, but not oxazalone-induced colitis. Dig. Dis. Sci. 53:7 (2008), 1869–1875, 10.1007/s10620-007-0102-0 [PMID: 18049901].
    • (2008) Dig. Dis. Sci. , vol.53 , Issue.7 , pp. 1869-1875
    • Ikeda, M.1    Takeshima, F.2    Isomoto, H.3    Shikuwa, S.4    Mizuta, Y.5    Ozono, Y.6    Kohno, S.7
  • 11
    • 0013967697 scopus 로고
    • Preparation and characterization of antibodies specific for the 2,4,6-trinitrophenyl group
    • [PMID: 4165954]
    • [11] Little, J.R., Eisen, H.N., Preparation and characterization of antibodies specific for the 2,4,6-trinitrophenyl group. Biochemistry 5:11 (1966), 3385–3395 [PMID: 4165954].
    • (1966) Biochemistry , vol.5 , Issue.11 , pp. 3385-3395
    • Little, J.R.1    Eisen, H.N.2
  • 12
    • 0029127778 scopus 로고
    • Experimental models of inflammatory bowel disease
    • [PMID: 7557106]
    • [12] Elson, C.O., Sartor, R.B., Tennyson, G.S., Riddell, R.H., Experimental models of inflammatory bowel disease. Gastroenterology 109:4 (1995), 1344–1367 [PMID: 7557106].
    • (1995) Gastroenterology , vol.109 , Issue.4 , pp. 1344-1367
    • Elson, C.O.1    Sartor, R.B.2    Tennyson, G.S.3    Riddell, R.H.4
  • 14
    • 77957913463 scopus 로고    scopus 로고
    • Inhalation of carbon monoxide ameliorates TNBS-induced colitis in mice through the inhibition of TNF-alpha expression
    • [PMID: 20094779]
    • [14] Takagi, T., Naito, Y., Mizushima, K., Akagiri, S., Suzuki, T., Hirata, I., Omatsu, T., Handa, O., Kokura, S., Ichikawa, H., Yoshikawa, T., Inhalation of carbon monoxide ameliorates TNBS-induced colitis in mice through the inhibition of TNF-alpha expression. Dig. Dis. Sci. 55:10 (2010), 2797–2804, 10.1007/s10620-009-1112-x [PMID: 20094779].
    • (2010) Dig. Dis. Sci. , vol.55 , Issue.10 , pp. 2797-2804
    • Takagi, T.1    Naito, Y.2    Mizushima, K.3    Akagiri, S.4    Suzuki, T.5    Hirata, I.6    Omatsu, T.7    Handa, O.8    Kokura, S.9    Ichikawa, H.10    Yoshikawa, T.11
  • 16
    • 0034033440 scopus 로고    scopus 로고
    • Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-gamma receptor-deficient mice
    • [PMID: 10820397]
    • [16] Camoglio, L., te Velde, A.A., de Boer, A., ten Kate, F.J., Kopf, M., van Deventer, S.J., Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-gamma receptor-deficient mice. Eur. J. Immunol. 30:5 (2000), 1486–1495, 10.1002/(SICI)1521-4141(200005)30:5<1486::AID-IMMU1486>3.0.CO;2-8 [PMID: 10820397].
    • (2000) Eur. J. Immunol. , vol.30 , Issue.5 , pp. 1486-1495
    • Camoglio, L.1    te Velde, A.A.2    de Boer, A.3    ten Kate, F.J.4    Kopf, M.5    van Deventer, S.J.6
  • 17
    • 80655149205 scopus 로고    scopus 로고
    • New IBD genetics: common pathways with other diseases
    • [PMID: 21300624]
    • [17] Lees, C.W., Barrett, J.C., Parkes, M., Satsangi, J., New IBD genetics: common pathways with other diseases. Gut 60:12 (2011), 1739–1753, 10.1136/gut.2009.199679 [PMID: 21300624].
    • (2011) Gut , vol.60 , Issue.12 , pp. 1739-1753
    • Lees, C.W.1    Barrett, J.C.2    Parkes, M.3    Satsangi, J.4
  • 18
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • [PMID: 21677747 PMCID: 3204665]
    • [18] Khor, B., Gardet, A., Xavier, R.J., Genetics and pathogenesis of inflammatory bowel disease. Nature 474:7351 (2011), 307–317, 10.1038/nature10209 [PMID: 21677747 PMCID: 3204665].
    • (2011) Nature , vol.474 , Issue.7351 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 20
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • [PMID: 20393462 PMCID: 3796764]
    • [20] Buonocore, S., Ahern, P.P., Uhlig, H.H., Ivanov, I.I., Littman, D.R., Maloy, K.J., Powrie, F., Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464:7293 (2010), 1371–1375, 10.1038/nature08949 [PMID: 20393462 PMCID: 3796764].
    • (2010) Nature , vol.464 , Issue.7293 , pp. 1371-1375
    • Buonocore, S.1    Ahern, P.P.2    Uhlig, H.H.3    Ivanov, I.I.4    Littman, D.R.5    Maloy, K.J.6    Powrie, F.7
  • 22
    • 79952442161 scopus 로고    scopus 로고
    • Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats
    • [PMID: 20658190]
    • [22] Isik, F., Tunali Akbay, T., Yarat, A., Genc, Z., Pisiriciler, R., Caliskan-Ak, E., Cetinel, S., Altintas, A., Sener, G., Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats. Dig. Dis. Sci. 56:3 (2011), 721–730, 10.1007/s10620-010-1333-z [PMID: 20658190].
    • (2011) Dig. Dis. Sci. , vol.56 , Issue.3 , pp. 721-730
    • Isik, F.1    Tunali Akbay, T.2    Yarat, A.3    Genc, Z.4    Pisiriciler, R.5    Caliskan-Ak, E.6    Cetinel, S.7    Altintas, A.8    Sener, G.9
  • 23
  • 24
    • 79954440697 scopus 로고    scopus 로고
    • Systematic review of animal models of post-infectious/post-inflammatory irritable bowel syndrome
    • [PMID: 20848144]
    • [24] Qin, H.Y., Wu, J.C., Tong, X.D., Sung, J.J., Xu, H.X., Bian, Z.X., Systematic review of animal models of post-infectious/post-inflammatory irritable bowel syndrome. J. Gastroenterol. 46:2 (2011), 164–174, 10.1007/s00535-010-0321-6 [PMID: 20848144].
    • (2011) J. Gastroenterol. , vol.46 , Issue.2 , pp. 164-174
    • Qin, H.Y.1    Wu, J.C.2    Tong, X.D.3    Sung, J.J.4    Xu, H.X.5    Bian, Z.X.6
  • 27
    • 84890855866 scopus 로고    scopus 로고
    • Aquaporin 3 and 8 are down-regulated in TNBS-induced rat colitis
    • [PMID: 24286754]
    • [27] Zhao, G., Li, J., Wang, J., Shen, X., Sun, J., Aquaporin 3 and 8 are down-regulated in TNBS-induced rat colitis. Biochem. Biophys. Res. Commun. 443:1 (2014), 161–166, 10.1016/j.bbrc.2013.11.067 [PMID: 24286754].
    • (2014) Biochem. Biophys. Res. Commun. , vol.443 , Issue.1 , pp. 161-166
    • Zhao, G.1    Li, J.2    Wang, J.3    Shen, X.4    Sun, J.5
  • 28
    • 84877887426 scopus 로고    scopus 로고
    • Serum calprotectin levels correlate with biochemical and histological markers of disease activity in TNBS colitis
    • [PMID: 23685388 PMCID: 4080304]
    • [28] Cury, D.B., Mizsputen, S.J., Versolato, C., Miiji, L.O., Pereira, E., Delboni, M.A., Schor, N., Moss, A.C., Serum calprotectin levels correlate with biochemical and histological markers of disease activity in TNBS colitis. Cell. Immunol. 282:1 (2013), 66–70, 10.1016/j.cellimm.2013.04.004 [PMID: 23685388 PMCID: 4080304].
    • (2013) Cell. Immunol. , vol.282 , Issue.1 , pp. 66-70
    • Cury, D.B.1    Mizsputen, S.J.2    Versolato, C.3    Miiji, L.O.4    Pereira, E.5    Delboni, M.A.6    Schor, N.7    Moss, A.C.8
  • 29
    • 84871927177 scopus 로고    scopus 로고
    • Role of TRPV1 and TRPA1 in visceral hypersensitivity to colorectal distension during experimental colitis in rats
    • [PMID: 23099257]
    • [29] Vermeulen, W., De Man, J.G., De Schepper, H.U., Bult, H., Moreels, T.G., Pelckmans, P.A., De Winter, B.Y., Role of TRPV1 and TRPA1 in visceral hypersensitivity to colorectal distension during experimental colitis in rats. Eur. J. Pharmacol. 698:1–3 (2013), 404–412, 10.1016/j.ejphar.2012.10.014 [PMID: 23099257].
    • (2013) Eur. J. Pharmacol. , vol.698 , Issue.1-3 , pp. 404-412
    • Vermeulen, W.1    De Man, J.G.2    De Schepper, H.U.3    Bult, H.4    Moreels, T.G.5    Pelckmans, P.A.6    De Winter, B.Y.7
  • 30
    • 0037379777 scopus 로고    scopus 로고
    • Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease
    • [PMID: 12671893]
    • [30] Abad, C., Martinez, C., Juarranz, M.G., Arranz, A., Leceta, J., Delgado, M., Gomariz, R.P., Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease. Gastroenterology 124:4 (2003), 961–971, 10.1053/gast.2003.50141 [PMID: 12671893].
    • (2003) Gastroenterology , vol.124 , Issue.4 , pp. 961-971
    • Abad, C.1    Martinez, C.2    Juarranz, M.G.3    Arranz, A.4    Leceta, J.5    Delgado, M.6    Gomariz, R.P.7
  • 32
    • 16344370730 scopus 로고    scopus 로고
    • Activation of nuclear factor-kappa B and effects of pyrrolidine dithiocarbamate on TNBS-induced rat colitis
    • [PMID: 15770728 PMCID: 4305694]
    • [32] Chen, K., Long, Y.M., Wang, H., Lan, L., Lin, Z.H., Activation of nuclear factor-kappa B and effects of pyrrolidine dithiocarbamate on TNBS-induced rat colitis. World J. Gastroenterol. WJG 11:10 (2005), 1508–1514 [PMID: 15770728 PMCID: 4305694].
    • (2005) World J. Gastroenterol. WJG , vol.11 , Issue.10 , pp. 1508-1514
    • Chen, K.1    Long, Y.M.2    Wang, H.3    Lan, L.4    Lin, Z.H.5
  • 34
    • 33749355870 scopus 로고    scopus 로고
    • Molecular profiling of a rat model of colitis: validation of known inflammatory genes and identification of novel disease-associated targets
    • [PMID: 17012966]
    • [34] Rivera, E., Flores, I., Rivera, E., Appleyard, C.B., Molecular profiling of a rat model of colitis: validation of known inflammatory genes and identification of novel disease-associated targets. Inflamm. Bowel Dis. 12:10 (2006), 950–966, 10.1097/01.mib.0000231575.11678.8c [PMID: 17012966].
    • (2006) Inflamm. Bowel Dis. , vol.12 , Issue.10 , pp. 950-966
    • Rivera, E.1    Flores, I.2    Rivera, E.3    Appleyard, C.B.4
  • 35
  • 38
    • 84879915973 scopus 로고    scopus 로고
    • Evaluation of the usefulness of colonoscopy with mucosal biopsies in the follow-up of TNBS-induced colitis in rats
    • [PMID: 23778962]
    • [38] El-Salhy, M., Wendelbo, I.H., Gundersen, D., Hatlebakk, J.G., Hausken, T., Evaluation of the usefulness of colonoscopy with mucosal biopsies in the follow-up of TNBS-induced colitis in rats. Mol. Med. Rep. 8:2 (2013), 446–450, 10.3892/mmr.2013.1528 [PMID: 23778962].
    • (2013) Mol. Med. Rep. , vol.8 , Issue.2 , pp. 446-450
    • El-Salhy, M.1    Wendelbo, I.H.2    Gundersen, D.3    Hatlebakk, J.G.4    Hausken, T.5
  • 39
    • 84862952456 scopus 로고    scopus 로고
    • Antagonism of protease-activated receptor 2 protects against experimental colitis
    • [PMID: 22028393]
    • [39] Lohman, R.J., Cotterell, A.J., Suen, J., Liu, L., Do, A.T., Vesey, D.A., Fairlie, D.P., Antagonism of protease-activated receptor 2 protects against experimental colitis. J. Pharmacol. Exp. Ther. 340:2 (2012), 256–265, 10.1124/jpet.111.187062 [PMID: 22028393].
    • (2012) J. Pharmacol. Exp. Ther. , vol.340 , Issue.2 , pp. 256-265
    • Lohman, R.J.1    Cotterell, A.J.2    Suen, J.3    Liu, L.4    Do, A.T.5    Vesey, D.A.6    Fairlie, D.P.7
  • 40
    • 0035008079 scopus 로고    scopus 로고
    • Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production
    • [PMID: 11356911]
    • [40] Yue, G., Lai, P.S., Yin, K., Sun, F.F., Nagele, R.G., Liu, X., Linask, K.K., Wang, C., Lin, K.T., Wong, P.Y., Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production. J. Pharmacol. Exp. Ther. 297:3 (2001), 915–925 [PMID: 11356911].
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , Issue.3 , pp. 915-925
    • Yue, G.1    Lai, P.S.2    Yin, K.3    Sun, F.F.4    Nagele, R.G.5    Liu, X.6    Linask, K.K.7    Wang, C.8    Lin, K.T.9    Wong, P.Y.10
  • 42
    • 84873109169 scopus 로고    scopus 로고
    • Relevance of TNBS-colitis in rats: a methodological study with endoscopic, histologic and Transcriptomic [corrected] characterization and correlation to IBD
    • [PMID: 23382912 PMCID: 3561356]
    • [42] Brenna, O., Furnes, M.W., Drozdov, I., van Beelen Granlund, A., Flatberg, A., Sandvik, A.K., Zwiggelaar, R.T., Marvik, R., Nordrum, I.S., Kidd, M., Gustafsson, B.I., Relevance of TNBS-colitis in rats: a methodological study with endoscopic, histologic and Transcriptomic [corrected] characterization and correlation to IBD. PloS one, 8(1), 2013, e54543, 10.1371/journal.pone.0054543 [PMID: 23382912 PMCID: 3561356].
    • (2013) PloS one , vol.8 , Issue.1 , pp. e54543
    • Brenna, O.1    Furnes, M.W.2    Drozdov, I.3    van Beelen Granlund, A.4    Flatberg, A.5    Sandvik, A.K.6    Zwiggelaar, R.T.7    Marvik, R.8    Nordrum, I.S.9    Kidd, M.10    Gustafsson, B.I.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.