Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study

Journal of Nutrition and Metabolism

Volumn 2016, Issue , 2016, Pages

  Oliver, Jonathan M ^a   Stoner, Lee ^b   Rowlands, David S ^b   Caldwell, Aaron R ^a   Sanders, Elizabeth ^a   Kreutzer, Andreas ^a   Mitchell, Joel B ^a   Purpura, Martin ^c   Jäger, Ralf ^c  

^a TEXAS CHRISTIAN UNIVERSITY   (United States)

^b MASSEY UNIVERSITY   (New Zealand)

^c Increnovo LLC ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84984791812     PISSN: 20900724     EISSN: 20900732     Source Type: Journal    
DOI: 10.1155/2016/1089653     Document Type: Article

References (34)

1. D. S. Celermajer, K. E. Sorensen, V. M. Gooch et al., "Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis, " The Lancet, vol. 340, no. 8828, pp. 1111-1115, 1992.
2. C. Napoli, F. de Nigris, S. Williams-Ignarro, O. Pignalosa, V. Sica, and L. J. Ignarro, "Nitric oxide and atherosclerosis: an update, " Nitric Oxide-Biology and Chemistry, vol. 15, no. 4, pp. 265-279, 2006.
3. M. C. Corretti, T. J. Anderson, E. J. Benjamin et al., "Guidelines for the ultrasound assessment of endothelial-dependent flowmediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force, " Journal of the American College of Cardiology, vol. 39, no. 2, pp. 257-265, 2002.
4. M. C. Klempel, C. M. Kroeger, E. Norkeviciute, M. Goslawski, S. A. Phillips, and K. A. Varady, "Benefit of a low-fat over high-fat diet on vascular health during alternate day fasting, " Nutrition and Diabetes, vol. 3, no. 5, article no. e71, 2013.
5. T. Neunteufl, U. Priglinger, S. Heher et al., "Effects of Vitamin E on chronic and acute endothelial dysfunction in smokers, " Journal of the American College of Cardiology, vol. 35, no. 2, pp. 277-283, 2000.
6. S. S. Thosar, S. L. Bielko, C. S. Wiggins, J. E. Klaunig, K. J. Mather, and J. P. Wallace, "Antioxidant Vitamin C prevents decline in endothelial function during sitting, " Medical Science Monitor, vol. 21, pp. 1015-1021, 2015.
7. W. Wongcharoen and A. Phrommintikul, "The protective role of curcumin in cardiovascular diseases, " International Journal of Cardiology, vol. 133, no. 2, pp. 145-151, 2009.
8. Z.-J. Liu, W. Liu, L. Liu, C. Xiao, Y. Wang, and J.-S. Jiao, "Curcumin protects neuron against cerebral ischemia-induced inflammation through improving PPAR-gamma function, " Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 470975, 10 pages, 2013.
9. J. L. Quiles, M. D. Mesa, C. L. Ramrez-Tortosa et al., "Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 22, no. 7, pp. 1225-1231, 2002.
10. S. Li, W. Yuan, G. Deng, P. Wang, and P. Yang, "Chemical composition and product quality control of turmeric (Curcuma longa L.), " Pharmaceutical Crops, vol. 2, pp. 28-54, 2011.
11. G. Ramaswami, H. Chai, Q. Yao, P. H. Lin, A. B. Lumsden, and C. Chen, "Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries, " Journal of Vascular Surgery, vol. 40, no. 6, pp. 1216-1222, 2004.
12. N. Akazawa, Y. Choi, A. Miyaki et al., "Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women, " Nutrition Research, vol. 32, no. 10, pp. 795-799, 2012.
13. Y. Inaba, J. A. Chen, and S. R. Bergmann, "Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis, " International Journal of Cardiovascular Imaging, vol. 26, no. 6, pp. 631-640, 2010.
14. American College of Sports Medicine, ACSM's Guidelines for Exercise Testing and Prescription, Lippincott Williams & Wilkins, 2013.
15. R. Jäger, R. P. Lowery, A. V. Calvanese, J. M. Joy, M. Purpura, and J. M. Wilson, "Comparative absorption of curcumin formulations, " Nutrition Journal, vol. 13, article 11, 2014.
16. L. Stoner andM. J. Sabatier, "Use of ultrasound for non-invasive assessment of flow-mediated dilation, " Journal of Atherosclerosis andThrombosis, vol. 19, no. 5, pp. 407-421, 2012.
17. D. J. Green, E. A. Dawson, H. M. M. Groenewoud, H. Jones, and D. H. J. Thijssen, "Is flow-mediated dilation nitric oxide mediated A meta-analysis, " Hypertension, vol. 63, no. 2, pp. 376-382, 2014.
18. L. Stoner, M. L. Erickson, J. M. Young et al., "There's more to flow-mediated dilation than nitric oxide, " Journal of Atherosclerosis andThrombosis, vol. 19, no. 7, pp. 589-600, 2012.
19. A. Greyling, A. C. van Mil, P. L. Zock, D. J. Green, L. Ghiadoni, andD. H. Thijssen, "Adherence to guidelines strongly improves reproducibility of brachial artery flow-mediated dilation, " Atherosclerosis, vol. 248, pp. 196-202, 2016.
20. W. G. Hopkins, "Measures of reliability in sports medicine and science, " Sports Medicine, vol. 30, no. 1, pp. 1-15, 2000.
21. J. A. Sterne and G. D. Smith, "Sifting the evidence-what's wrong with significance tests" Physical Therapy, vol. 81, no. 8, pp. 1464-1469, 2001.
22. P. R. Burton, L. C. Gurrin, andM. J. Campbell, "Clinical significance not statistical significance: a simple Bayesian alternative to p values, " Journal of Epidemiology and Community Health, vol. 52, no. 5, pp. 318-323, 1998.
23. W. G. Hopkins, S. W. Marshall, A. M. Batterham, and J. Hanin, "Progressive statistics for studies in sportsmedicine and exercise science, " Medicine & Science in Sports & Exercise, vol. 41, no. 1, pp. 3-13, 2009.
24. J. A. C. Sterne and G. D. Smith, "Sifting the evidence-what's wrong with significance tests" The BritishMedical Journal, vol. 322, no. 7280, pp. 226-231, 2001.
25. L. Stoner, D. Credeur, D. R. Dolbow, and D. R. Gater, "Vascular health toolbox for spinal cord injury: recommendations for clinical practice, " Atherosclerosis, vol. 243, no. 2, pp. 373-382, 2015.
26. D. S. Rowlands, A. R. Nelson, S. M. Phillips et al., "Proteinleucine fed dose effects on muscle protein synthesis after endurance exercise, " Medicine and Science in Sports and Exercise, vol. 47, no. 3, pp. 547-555, 2015.
27. S.-S. Han, Y.-S. Keum, H.-J. Seo, and Y.-J. Surh, "Curcumin suppresses activation of NF-B and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells, " BMB Reports, vol. 35, no. 3, pp. 337-342, 2002.
28. C. Jobin, C. A. Bradham, M. P. Russo et al., "Curcumin blocks cytokine-mediated NF-B activation and proinflammatory gene expression by inhibiting inhibitory factor I-B kinase activity, " The Journal of Immunology, vol. 163, no. 6, pp. 3474-3483, 1999.
29. A. Shehzad, T. Ha, F. Subhan, and Y. S. Lee, "New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases, " European Journal of Nutrition, vol. 50, no. 3, pp. 151-161, 2011.
30. S. Singh and B. B. Aggarwal, "Activation of transcription factor NF-B is suppressed by curcumin (diferuloylmethane), " The Journal of Biological Chemistry, vol. 270, no. 42, pp. 24995-25000, 1995.
31. G. Kang, P.-J. Kong, Y.-J. Yuh et al., "Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor B bindings in BV2 microglial cells, " Journal of Pharmacological Sciences, vol. 94, no. 3, pp. 325-328, 2004.
32. R. Motterlini, R. Foresti, R. Bassi, and C. J. Green, "Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress, " Free Radical Biology and Medicine, vol. 28, no. 8, pp. 1303-1312, 2000.
33. P. Anand, A. B. Kunnumakkara, R. A. Newman, andB. B. Aggarwal, "Bioavailability of curcumin: problems and promises, " Molecular Pharmaceutics, vol. 4, no. 6, pp. 807-818, 2007.
34. C. D. Lao, M. T. Ruffin IV, D. Normolle et al., "Dose escalation of a curcuminoid formulation, " BMC Complementary and Alternative Medicine, vol. 6, article 10, 2006.